WO2007129328A3 - Process for preparing 2-[pyridinyl]sulfinyl-substituted benzimidazoles - Google Patents

Process for preparing 2-[pyridinyl]sulfinyl-substituted benzimidazoles Download PDF

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Publication number
WO2007129328A3
WO2007129328A3 PCT/IN2007/000158 IN2007000158W WO2007129328A3 WO 2007129328 A3 WO2007129328 A3 WO 2007129328A3 IN 2007000158 W IN2007000158 W IN 2007000158W WO 2007129328 A3 WO2007129328 A3 WO 2007129328A3
Authority
WO
WIPO (PCT)
Prior art keywords
sulfinyl
pyridinyl
group
preparing
substituted
Prior art date
Application number
PCT/IN2007/000158
Other languages
French (fr)
Other versions
WO2007129328A2 (en
Inventor
Niraj Shyamlal Shah
Shriprakash Dhar Dwivedi
Original Assignee
Cadila Healthcare Ltd
Niraj Shyamlal Shah
Shriprakash Dhar Dwivedi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd, Niraj Shyamlal Shah, Shriprakash Dhar Dwivedi filed Critical Cadila Healthcare Ltd
Publication of WO2007129328A2 publication Critical patent/WO2007129328A2/en
Publication of WO2007129328A3 publication Critical patent/WO2007129328A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

A process for the preparation of 2-[(pyridinyl)methyl]sulfinyl-benzimidazole of Formula (I) or a pharmaceutically acceptable salt, hydrate, or solvate thereof, wherein R1 is selected from the group consisting of hydrogen or substituted or unsubstituted C1-C4 alkoxy; R2 and R4 are independently selected from the group consisting of hydrogen, C1-C4alkyl or C1-C4alkoxy; R3 is selected from the group consisting of substituted or unsubstituted C1-C4alkoxy is disclosed. The process comprises oxidizing thioether compound of formula (II) in absence of base, wherein R1, R2, R3 and R4 is same as described above, with N-halosuccinimide in presence of water, optionally converting into a pharmaceutically acceptable salt, hydrate, or solvate thereof.
PCT/IN2007/000158 2006-05-09 2007-04-23 Process for preparing 2-[pyridinyl]sulfinyl-substituted benzimidazoles WO2007129328A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN721MU2006 2006-05-09
IN721/MUM/2006 2006-05-09

Publications (2)

Publication Number Publication Date
WO2007129328A2 WO2007129328A2 (en) 2007-11-15
WO2007129328A3 true WO2007129328A3 (en) 2008-01-03

Family

ID=38624388

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000158 WO2007129328A2 (en) 2006-05-09 2007-04-23 Process for preparing 2-[pyridinyl]sulfinyl-substituted benzimidazoles

Country Status (1)

Country Link
WO (1) WO2007129328A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006514108A (en) 2002-12-19 2006-04-27 テバ ファーマシューティカル インダストリーズ リミティド Solid state of pantoprazole sodium, process for preparing them, and process for preparing known pantoprazole sodium hydrate
CN104418837A (en) * 2013-08-19 2015-03-18 长沙市如虹医药科技有限公司 Method for oxidizing thioether into sulfoxide

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018895A1 (en) * 1990-06-07 1991-12-12 Aktiebolaget Astra Improved method for synthesis
EP0997461A1 (en) * 1997-07-11 2000-05-03 Eisai Co., Ltd. Processes for the preparation of pyridine derivatives
WO2003008406A1 (en) * 2001-07-16 2003-01-30 Janssen Pharmaceutica N.V. Improved process for preparing benzimidazole-type compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018895A1 (en) * 1990-06-07 1991-12-12 Aktiebolaget Astra Improved method for synthesis
EP0997461A1 (en) * 1997-07-11 2000-05-03 Eisai Co., Ltd. Processes for the preparation of pyridine derivatives
US6313303B1 (en) * 1997-07-11 2001-11-06 Eisai Co., Ltd. Process for the preparation of pyridine derivatives
WO2003008406A1 (en) * 2001-07-16 2003-01-30 Janssen Pharmaceutica N.V. Improved process for preparing benzimidazole-type compounds

Also Published As

Publication number Publication date
WO2007129328A2 (en) 2007-11-15

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