WO2007128545A3 - Mac30 gene - Google Patents

Mac30 gene Download PDF

Info

Publication number
WO2007128545A3
WO2007128545A3 PCT/EP2007/004009 EP2007004009W WO2007128545A3 WO 2007128545 A3 WO2007128545 A3 WO 2007128545A3 EP 2007004009 W EP2007004009 W EP 2007004009W WO 2007128545 A3 WO2007128545 A3 WO 2007128545A3
Authority
WO
WIPO (PCT)
Prior art keywords
mac30
gene
cholesterol
provides isolated
statins
Prior art date
Application number
PCT/EP2007/004009
Other languages
French (fr)
Other versions
WO2007128545A9 (en
WO2007128545A2 (en
Inventor
Birgit Ebner
Dagmar Kratky
Gerhard M Kostner
Sanja Levak-Frank
Original Assignee
Birgit Ebner
Dagmar Kratky
Gerhard M Kostner
Sanja Levak-Frank
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Birgit Ebner, Dagmar Kratky, Gerhard M Kostner, Sanja Levak-Frank filed Critical Birgit Ebner
Publication of WO2007128545A2 publication Critical patent/WO2007128545A2/en
Publication of WO2007128545A3 publication Critical patent/WO2007128545A3/en
Publication of WO2007128545A9 publication Critical patent/WO2007128545A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention relates to the field of cholesterol-regulated genes, specifically, to the MAC 30 gene and its regulation by cholesterol and statins. The invention provides isolated nucleic acids encoding a MAC30, characterized in that the coding sequence of said gene is at least 70% homologous to SEQ ID No. 1 provided herein. The invention further provides isolated proteins having MAC30 activity encoded by the nucleic acid of the invention. The invention also provides antibodies directed against the said protein.
PCT/EP2007/004009 2006-05-05 2007-05-07 Mac30 gene WO2007128545A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79765706P 2006-05-05 2006-05-05
US60/797,657 2006-05-05

Publications (3)

Publication Number Publication Date
WO2007128545A2 WO2007128545A2 (en) 2007-11-15
WO2007128545A3 true WO2007128545A3 (en) 2008-04-03
WO2007128545A9 WO2007128545A9 (en) 2008-10-02

Family

ID=38668114

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/004009 WO2007128545A2 (en) 2006-05-05 2007-05-07 Mac30 gene

Country Status (1)

Country Link
WO (1) WO2007128545A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200000822A1 (en) * 2017-02-23 2020-01-02 Board Of Regents, The University Of Texas System Methods of treatment for cancer, sterol homeostasis, and neurological diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011618A2 (en) * 2002-07-29 2004-02-05 Hmgene, Inc. Methods of identifying adipocyte specific genes, the genes identified, and their uses
WO2004043361A2 (en) * 2002-11-08 2004-05-27 Genentech, Inc. Compositions and methods for the treatment of natural killer cell related diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011618A2 (en) * 2002-07-29 2004-02-05 Hmgene, Inc. Methods of identifying adipocyte specific genes, the genes identified, and their uses
WO2004043361A2 (en) * 2002-11-08 2004-05-27 Genentech, Inc. Compositions and methods for the treatment of natural killer cell related diseases

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; May 2004 (2004-05-01), EBNER BIRGIT ET AL: "Identification of novel genes in murine peritoneal macrophages and foam cells involved in cholesterol homeostasis", XP002466369, Database accession no. PREV200510186311 *
DATABASE EM_HUM 11 February 2003 (2003-02-11), "Homo sapiens transmembrane protein 97", XP002466367, retrieved from EBI Database accession no. BC045655 *
DATABASE GENBANK NIH; 23 February 2006 (2006-02-23), "Mus musculus transmembrane protein 97", XP002466365, retrieved from NIH Database accession no. NM_133706 *
DATABASE Geneseq 12 August 2004 (2004-08-12), "Human PRO polypeptide #389", XP002466368, retrieved from EBI Database accession no. ADO19857 *
DATABASE Geneseq 3 June 2004 (2004-06-03), "Murine adipocyte specific DNA SeqID 175", XP002466366, retrieved from EBI Database accession no. ADM67040 *
FASEB JOURNAL, vol. 18, no. 8, Suppl. S, May 2004 (2004-05-01), ANNUAL MEETING OF THE AMERICAN-SOCIETY-FOR-BIOCHEMISTRY-AND-MOLECULAR BIOLOGY/8TH CONGRESS OF THE IN; BOSTON, MA, USA; JUNE 12 -16, 2004, pages C262, ISSN: 0892-6638 *

Also Published As

Publication number Publication date
WO2007128545A9 (en) 2008-10-02
WO2007128545A2 (en) 2007-11-15

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