WO2007124382A3 - Inhaled imipenem - Google Patents
Inhaled imipenem Download PDFInfo
- Publication number
- WO2007124382A3 WO2007124382A3 PCT/US2007/067002 US2007067002W WO2007124382A3 WO 2007124382 A3 WO2007124382 A3 WO 2007124382A3 US 2007067002 W US2007067002 W US 2007067002W WO 2007124382 A3 WO2007124382 A3 WO 2007124382A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- imipenem
- inhaled
- relates
- present
- formulations containing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The present invention relates to inhaled formulations containing imipenem for increased efficacy and decreased toxicity in treating microbial infections.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79369206P | 2006-04-19 | 2006-04-19 | |
US60/793,692 | 2006-04-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007124382A2 WO2007124382A2 (en) | 2007-11-01 |
WO2007124382A3 true WO2007124382A3 (en) | 2008-05-29 |
Family
ID=38625745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/067002 WO2007124382A2 (en) | 2006-04-19 | 2007-04-19 | Inhaled imipenem |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2007124382A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW465235B (en) | 1998-09-17 | 2001-11-21 | United Video Properties Inc | Electronic program guide with digital storage |
JP2009510077A (en) | 2005-09-29 | 2009-03-12 | ネクター セラピューティックス | Antibiotic formulations, unit doses, kits and methods |
AU2014205483B2 (en) | 2013-01-10 | 2017-11-30 | Gilead Sciences, Inc. | Non-selective kinase inhibitors |
CN104208075A (en) * | 2013-05-29 | 2014-12-17 | 天津金耀集团有限公司 | Compound inhalation preparation containing carbapenem antibiotic and glucocorticoid |
CN104208046A (en) * | 2013-05-29 | 2014-12-17 | 天津金耀集团有限公司 | Carbapenem antibiotic inhalation preparation |
CN111743901B (en) | 2013-10-11 | 2023-09-12 | 普尔莫凯恩股份有限公司 | Spray-dried formulations |
KR102543227B1 (en) | 2016-10-27 | 2023-06-13 | 풀모킨 인코포레이티드 | Combination therapy to treat pulmonary hypertension |
WO2021221101A1 (en) * | 2020-04-30 | 2021-11-04 | デンカ株式会社 | Liquid formulation and pharmaceutical product containing cilastatin |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040009126A1 (en) * | 2002-03-05 | 2004-01-15 | Transave, Inc. | Inhalation system for prevention and treatment of intracellular infections |
WO2004075874A1 (en) * | 2003-02-28 | 2004-09-10 | Anbics Patents-Licences Ag | Method for treatment and prevention of acute and chronic pseudomonas aeruginosa airway infections with inhalable macrolides |
US20060062738A1 (en) * | 2004-01-27 | 2006-03-23 | Thomas Hofmann | Method for improvement of tolerance for therapeutically effective agents delivered by inhalation |
-
2007
- 2007-04-19 WO PCT/US2007/067002 patent/WO2007124382A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040009126A1 (en) * | 2002-03-05 | 2004-01-15 | Transave, Inc. | Inhalation system for prevention and treatment of intracellular infections |
WO2004075874A1 (en) * | 2003-02-28 | 2004-09-10 | Anbics Patents-Licences Ag | Method for treatment and prevention of acute and chronic pseudomonas aeruginosa airway infections with inhalable macrolides |
US20060062738A1 (en) * | 2004-01-27 | 2006-03-23 | Thomas Hofmann | Method for improvement of tolerance for therapeutically effective agents delivered by inhalation |
Non-Patent Citations (5)
Title |
---|
BADIA JOAN R ET AL: "Disposition of instilled versus nebulized tobramycin and imipenem in ventilated intensive care unit (ICU) patients", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 54, no. 2, August 2004 (2004-08-01), pages 508 - 514, XP002473338, ISSN: 0305-7453 * |
FAWZIAH MARRA ET AL.: "Piperacillin/Tazobactam versus Imipenem: A double-blind, randomized formulary feasibility study at a major teaching hospital", DIAGN MICROBIOL INFECT DIS, 1998, pages 355 - 368, XP002473340 * |
HASHIMOTO S. ET AL.: "Aerolization of imipenem/cilastatin prevents pseudomonas-induced acute lung injury", J. ANTIMICROBIAL CHEMOTHERAPY, vol. 38, 1996, pages 809 - 818, XP002473339 * |
KATIYAR SK & S. PRAKASH: "Bio-availability of imipenum in bronchial epithelial lining fluid, alveolar macrophages and serum on administration via inhaled and intravenous route", NCCP YOUNG SCIENTIST AWARD SESSION, 23 November 2007 (2007-11-23), pages 41 - 42, XP002473341 * |
RODLOFF A C ET AL: "Two decades of imipenem therapy", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 58, no. 5, November 2006 (2006-11-01), pages 916 - 929, XP002473342, ISSN: 0305-7453 * |
Also Published As
Publication number | Publication date |
---|---|
WO2007124382A2 (en) | 2007-11-01 |
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