WO2007124284A3 - Bombesin receptor anatogonists with anti-cancer activity - Google Patents

Bombesin receptor anatogonists with anti-cancer activity Download PDF

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Publication number
WO2007124284A3
WO2007124284A3 PCT/US2007/066615 US2007066615W WO2007124284A3 WO 2007124284 A3 WO2007124284 A3 WO 2007124284A3 US 2007066615 W US2007066615 W US 2007066615W WO 2007124284 A3 WO2007124284 A3 WO 2007124284A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer activity
bombesin receptor
anatogonists
peptides
receptor anatogonists
Prior art date
Application number
PCT/US2007/066615
Other languages
French (fr)
Other versions
WO2007124284B1 (en
WO2007124284A2 (en
Inventor
Rhoda Maneckjee
Original Assignee
Univ Oregon Health & Science
Rhoda Maneckjee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Oregon Health & Science, Rhoda Maneckjee filed Critical Univ Oregon Health & Science
Publication of WO2007124284A2 publication Critical patent/WO2007124284A2/en
Publication of WO2007124284A3 publication Critical patent/WO2007124284A3/en
Publication of WO2007124284B1 publication Critical patent/WO2007124284B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/086—Bombesin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Synthetic peptides that inhibit ligand-binding by bombesin receptors are provided. Methods for inhibiting growth and inducing apoptosis of neoplastic cells using these peptides are also provided. Methods for treating cancer by administering the peptides are also provided.
PCT/US2007/066615 2006-04-13 2007-04-13 Bombesin receptor anatogonists with anti-cancer activity WO2007124284A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79201106P 2006-04-13 2006-04-13
US60/792,011 2006-04-13

Publications (3)

Publication Number Publication Date
WO2007124284A2 WO2007124284A2 (en) 2007-11-01
WO2007124284A3 true WO2007124284A3 (en) 2008-02-28
WO2007124284B1 WO2007124284B1 (en) 2008-05-08

Family

ID=38625704

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/066615 WO2007124284A2 (en) 2006-04-13 2007-04-13 Bombesin receptor anatogonists with anti-cancer activity

Country Status (1)

Country Link
WO (1) WO2007124284A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106749596A (en) * 2017-03-06 2017-05-31 天津医科大学 Bombina orientalis biologically active peptide, gene and its application in pharmacy
CN109422810A (en) * 2017-08-24 2019-03-05 孙立春 The exploitation and application of full source of people or humanization bombesin receptor GRPR monoclonal antibody drug or diagnostic reagent

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000542A1 (en) * 1993-06-18 1995-01-05 Peptide Technologies Corporation Bombesin receptor antagonists and uses thereof
US5723578A (en) * 1987-09-24 1998-03-03 The Administrators Of Tulane Educational Fund Peptide analogs of bombesin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723578A (en) * 1987-09-24 1998-03-03 The Administrators Of Tulane Educational Fund Peptide analogs of bombesin
WO1995000542A1 (en) * 1993-06-18 1995-01-05 Peptide Technologies Corporation Bombesin receptor antagonists and uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FATHI Z ET AL: "BOMBESIN RECEPTOR STRUCTURE AND EXPRESSION IN HUMAN LUNG CARCINOMA CELL LINES", JOURNAL OF CELLULAR BIOCHEMISTRY - SUPPLEMENT, WILEY-LISS, US, vol. 24, 1996, pages 237 - 246, XP001071138, ISSN: 0730-2312 *
RUDOLPH MARKUS G ET AL: "A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: Functional and structural aspects.", JOURNAL OF IMMUNOLOGY, vol. 172, no. 5, 1 March 2004 (2004-03-01), pages 2994 - 3002, XP002460238, ISSN: 0022-1767 *
TOKITA K ET AL: "TYROSINE 220 IN THE 5TH TRANSMEMBRANE DOMAIN OF THE NEUROMEDIN B RECEPTOR IS CRITICAL FOR THE HIGH SELECTIVITY OF THE PEPTOID ANTAGONIST PD168368", JOURNAL OF BIOLOGICAL CHEMISTRY, THE AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, INC.,, US, vol. 276, no. 1, January 2001 (2001-01-01), pages 495 - 504, XP001020363, ISSN: 0021-9258 *
ZHOU JIEHUA ET AL: "Targeting gastrin-releasing peptide receptors for cancer treatment", ANTI-CANCER DRUGS, vol. 15, no. 10, November 2004 (2004-11-01), pages 921 - 927, XP009092915, ISSN: 0959-4973 *

Also Published As

Publication number Publication date
WO2007124284B1 (en) 2008-05-08
WO2007124284A2 (en) 2007-11-01

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