WO2007124171A3 - Compositions and methods for treating trinucleotide repeat disorders - Google Patents

Compositions and methods for treating trinucleotide repeat disorders Download PDF

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Publication number
WO2007124171A3
WO2007124171A3 PCT/US2007/009938 US2007009938W WO2007124171A3 WO 2007124171 A3 WO2007124171 A3 WO 2007124171A3 US 2007009938 W US2007009938 W US 2007009938W WO 2007124171 A3 WO2007124171 A3 WO 2007124171A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions
trinucleotide repeat
repeat disorders
treating
Prior art date
Application number
PCT/US2007/009938
Other languages
French (fr)
Other versions
WO2007124171A2 (en
Inventor
Myra Coufal
Ruth A Bodner
David E Housman
Aleksey G Kazantsev
Original Assignee
Massachusetts Inst Technology
Myra Coufal
Ruth A Bodner
David E Housman
Aleksey G Kazantsev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Myra Coufal, Ruth A Bodner, David E Housman, Aleksey G Kazantsev filed Critical Massachusetts Inst Technology
Publication of WO2007124171A2 publication Critical patent/WO2007124171A2/en
Publication of WO2007124171A3 publication Critical patent/WO2007124171A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/10—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C07C251/16—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

This invention relates to compositions and methods for treating disorders resulting from protein-misfolding. We describe exemplary compounds, which may be contained in pharmaceutical compositions, the screening methods by which they were discovered, and their use as therapeutic or prophylactic agents.
PCT/US2007/009938 2006-04-20 2007-04-20 Compositions and methods for treating trinucleotide repeat disorders WO2007124171A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79347406P 2006-04-20 2006-04-20
US60/793,474 2006-04-20

Publications (2)

Publication Number Publication Date
WO2007124171A2 WO2007124171A2 (en) 2007-11-01
WO2007124171A3 true WO2007124171A3 (en) 2008-11-20

Family

ID=38625675

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/009938 WO2007124171A2 (en) 2006-04-20 2007-04-20 Compositions and methods for treating trinucleotide repeat disorders

Country Status (1)

Country Link
WO (1) WO2007124171A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9145376B2 (en) * 2011-01-20 2015-09-29 The Rockefeller University Quinazolinone inhibitors of dynein

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HOSHIURA R. ET AL.: "Preparation and Anticancer Activity of 4-Amino-6-hexylresorcinol on Erlich Carcinoma in Mice", CHEM. PHARM. BULL., vol. 10, 1962, pages 528 - 532 *
LI F. ET AL.: "Chinikomycins A and B: Isolation, Structure Elucidation and Biological Activity of Novel Antibiotics from Marine Streptomyces sp. Isolate M045", J. NAT. PROD., vol. 68, 2005, pages 349 - 353 *

Also Published As

Publication number Publication date
WO2007124171A2 (en) 2007-11-01

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