WO2007117398A3 - Non-peptidic molecules for detecting and treating tumors - Google Patents

Non-peptidic molecules for detecting and treating tumors Download PDF

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Publication number
WO2007117398A3
WO2007117398A3 PCT/US2007/008215 US2007008215W WO2007117398A3 WO 2007117398 A3 WO2007117398 A3 WO 2007117398A3 US 2007008215 W US2007008215 W US 2007008215W WO 2007117398 A3 WO2007117398 A3 WO 2007117398A3
Authority
WO
WIPO (PCT)
Prior art keywords
onco
tool
tumors
cells
detecting
Prior art date
Application number
PCT/US2007/008215
Other languages
French (fr)
Other versions
WO2007117398B1 (en
WO2007117398A2 (en
Inventor
James E Summerton
Original Assignee
James E Summerton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/395,487 external-priority patent/US20070231256A1/en
Priority claimed from US11/449,508 external-priority patent/US20080124274A1/en
Priority claimed from US11/449,495 external-priority patent/US8084610B2/en
Priority to EP07754699A priority Critical patent/EP1998760A2/en
Priority to MX2008012282A priority patent/MX2008012282A/en
Priority to CA002647502A priority patent/CA2647502A1/en
Priority to AU2007235575A priority patent/AU2007235575A1/en
Priority to JP2009503073A priority patent/JP2009536152A/en
Priority to BRPI0710026-4A priority patent/BRPI0710026A2/en
Priority to PCT/US2007/008215 priority patent/WO2007117398A2/en
Application filed by James E Summerton filed Critical James E Summerton
Priority to AU2007350326A priority patent/AU2007350326A1/en
Priority to CA002682567A priority patent/CA2682567A1/en
Priority to PCT/US2007/021002 priority patent/WO2008121126A1/en
Priority to MX2009010621A priority patent/MX2009010621A/en
Publication of WO2007117398A2 publication Critical patent/WO2007117398A2/en
Publication of WO2007117398A3 publication Critical patent/WO2007117398A3/en
Publication of WO2007117398B1 publication Critical patent/WO2007117398B1/en
Priority to CR11069A priority patent/CR11069A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

One of the most universal characteristics of malignant tumors is their acidity. Onco-tools are small non-peptide synthetic molecules designed to exploit this acidity for early detection and destruction of tumors. Each onco-tool has a structure which is anionic and hydrophilic at pH 7.4 and so repels from the negatively-charged surfaces of cells in normal tissues. When an onco-tool enters an acidic environment, such as in a tumor, a portion of the onco-tool molecules switch to their non-ionic lipophilic form which is designed to enter cells, such as cells in acidic areas of tumors. Prior to use of an onco-tool, a selected radioisotope is linked to the onco-tool. If that radioisotope emits radiation which can be detected outside the body, then the onco-tool can serve for detecting tumors. If that radioisotope emits radiation effective to kill cells, then the onco-tool can serve for treating tumors.
PCT/US2007/008215 2006-03-30 2007-03-30 Non-peptidic molecules for detecting and treating tumors WO2007117398A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
EP07754699A EP1998760A2 (en) 2006-03-30 2007-03-25 Non peptidic molecules for detecting and treating tumors
MX2008012282A MX2008012282A (en) 2006-03-30 2007-03-30 Non-peptidic molecules for detecting and treating tumors.
CA002647502A CA2647502A1 (en) 2006-03-30 2007-03-30 Onco-tool compositions and methods of use for detecting and treating tumors
AU2007235575A AU2007235575A1 (en) 2006-03-30 2007-03-30 Non-peptidic molecules for detecting and treating tumors
JP2009503073A JP2009536152A (en) 2006-03-30 2007-03-30 Non-peptide molecules for detecting and treating tumors
BRPI0710026-4A BRPI0710026A2 (en) 2006-03-30 2007-03-30 precursor structure, compositions and methods for detecting and treating acidic areas in an individual
PCT/US2007/008215 WO2007117398A2 (en) 2006-03-30 2007-03-30 Non-peptidic molecules for detecting and treating tumors
AU2007350326A AU2007350326A1 (en) 2007-03-30 2007-09-29 Non-peptidic molecules for detecting and treating tumors
MX2009010621A MX2009010621A (en) 2007-03-30 2007-09-29 Non-peptidic molecules for detecting and treating tumors.
PCT/US2007/021002 WO2008121126A1 (en) 2007-03-30 2007-09-29 Non-peptidic molecules for detecting and treating tumors
CA002682567A CA2682567A1 (en) 2007-03-30 2007-09-29 Non-peptidic molecules for detecting and treating tumors
CR11069A CR11069A (en) 2007-03-30 2009-10-19 NON-PEPTIDIC MOLECULES FOR THE DETECTION AND TREATMENT OF TUMORS

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US11/395,487 2006-03-30
US11/395,487 US20070231256A1 (en) 2006-03-30 2006-03-30 Compositions and methods for detecting and treating tumors containing acidic areas
US11/449,508 2006-06-07
US11/449,495 US8084610B2 (en) 2006-06-07 2006-06-07 Compositions and methods for detecting and treating tumors containing acidic areas
US11/449,495 2006-06-07
US11/449,508 US20080124274A1 (en) 2006-06-07 2006-06-07 Compositions and methods for detecting and treating tumors containing acidic areas
PCT/US2007/008215 WO2007117398A2 (en) 2006-03-30 2007-03-30 Non-peptidic molecules for detecting and treating tumors

Publications (3)

Publication Number Publication Date
WO2007117398A2 WO2007117398A2 (en) 2007-10-18
WO2007117398A3 true WO2007117398A3 (en) 2007-12-06
WO2007117398B1 WO2007117398B1 (en) 2008-02-07

Family

ID=41343282

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/008215 WO2007117398A2 (en) 2006-03-30 2007-03-30 Non-peptidic molecules for detecting and treating tumors

Country Status (6)

Country Link
EP (1) EP1998760A2 (en)
JP (1) JP2009536152A (en)
AU (1) AU2007235575A1 (en)
CA (1) CA2647502A1 (en)
MX (1) MX2008012282A (en)
WO (1) WO2007117398A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007350326A1 (en) * 2007-03-30 2008-10-09 James E. Summerton Non-peptidic molecules for detecting and treating tumors

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0952148A1 (en) * 1998-04-10 1999-10-27 Pfizer Products Inc. Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives
US20030083505A1 (en) * 2000-05-30 2003-05-01 Jackson Paul F. Benzenedicarboxylic acid derivatives
US20040167128A1 (en) * 2002-10-08 2004-08-26 Comess Kenneth M. Sulfonamides having antiangiogenic and anticancer activity
WO2004089415A2 (en) * 2003-04-11 2004-10-21 Novo Nordisk A/S COMBINATIONS OF AN 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITOR AND A GLUCOCORTICOID RECEPTOR AGONIST
US20060193775A1 (en) * 2005-02-28 2006-08-31 Summerton James E Embedder compositions and methods for detecting and killing cells in acidic areas of tumors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0952148A1 (en) * 1998-04-10 1999-10-27 Pfizer Products Inc. Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives
US20030083505A1 (en) * 2000-05-30 2003-05-01 Jackson Paul F. Benzenedicarboxylic acid derivatives
US20040167128A1 (en) * 2002-10-08 2004-08-26 Comess Kenneth M. Sulfonamides having antiangiogenic and anticancer activity
WO2004089415A2 (en) * 2003-04-11 2004-10-21 Novo Nordisk A/S COMBINATIONS OF AN 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITOR AND A GLUCOCORTICOID RECEPTOR AGONIST
US20060193775A1 (en) * 2005-02-28 2006-08-31 Summerton James E Embedder compositions and methods for detecting and killing cells in acidic areas of tumors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TAYLOR G M ET AL: "On The Ritter Reaction of Cyclic Hydroxyamines: Synthesis of Conformationally-Restricted Reduced Amide Dipeptide Isosteres", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 37, no. 8, 19 February 1996 (1996-02-19), pages 1297 - 1300, XP004030131, ISSN: 0040-4039 *

Also Published As

Publication number Publication date
AU2007235575A1 (en) 2007-10-18
WO2007117398B1 (en) 2008-02-07
EP1998760A2 (en) 2008-12-10
CA2647502A1 (en) 2007-10-18
JP2009536152A (en) 2009-10-08
MX2008012282A (en) 2008-11-12
WO2007117398A2 (en) 2007-10-18

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