WO2007115805A3 - Aurora kinase inhibitors - Google Patents
Aurora kinase inhibitors Download PDFInfo
- Publication number
- WO2007115805A3 WO2007115805A3 PCT/EP2007/003136 EP2007003136W WO2007115805A3 WO 2007115805 A3 WO2007115805 A3 WO 2007115805A3 EP 2007003136 W EP2007003136 W EP 2007003136W WO 2007115805 A3 WO2007115805 A3 WO 2007115805A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aurora kinase
- kinase inhibitors
- kinase activity
- compounds
- ameliorating
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides novel compounds that inhibit cell proliferation, in particular by inhibiting Aurora kinase activity and uses of these compounds for treating, ameliorating or preventing diseases, conditions or disorders benefiting from the inhibition of Aurora kinase activity, in particular hyperproliferative diseases.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EPPCT/EP2006/003111 | 2006-04-05 | ||
EP2006003111 | 2006-04-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007115805A2 WO2007115805A2 (en) | 2007-10-18 |
WO2007115805A3 true WO2007115805A3 (en) | 2008-06-05 |
Family
ID=36636565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2007/003136 WO2007115805A2 (en) | 2006-04-05 | 2007-04-05 | Aurora kinase inhibitors |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2007115805A2 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
US8822513B2 (en) | 2010-03-01 | 2014-09-02 | Gtx, Inc. | Compounds for treatment of cancer |
US9029408B2 (en) | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
PT3289876T (en) | 2008-06-16 | 2022-10-28 | Univ Tennessee Res Found | Compounds for treatment of cancer |
MX2011003151A (en) | 2008-10-01 | 2011-04-27 | Bayer Cropscience Ag | Heterocyclyl-substituted thiazoles as plant protection agents. |
ES2422718T3 (en) | 2009-04-02 | 2013-09-13 | Merck Patent Gmbh | Piperidine and piperazine derivatives as autotaxin inhibitors |
RU2581367C2 (en) | 2010-03-01 | 2016-04-20 | Джи Ти Икс, ИНК. | Compounds for treating cancer |
LT2850075T (en) * | 2012-04-25 | 2017-05-10 | Theravance Biopharma R&D Ip, Llc | Piperazine-piperidine compounds as hepatitis c virus inhibitors |
WO2015005305A1 (en) * | 2013-07-09 | 2015-01-15 | 小野薬品工業株式会社 | Alxr agonist compound |
AU2014318821B2 (en) * | 2013-09-10 | 2018-04-19 | Board Of Regents Of The University Of Texas System | Therapeutics targeting truncated Adenomatous Polyposis Coli (APC) proteins |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996026923A1 (en) * | 1995-03-02 | 1996-09-06 | Pierre Fabre Medicament | Novel bi-tryptaminic derivatives, preparation process and utilization as drugs |
EP1057815A1 (en) * | 1998-02-19 | 2000-12-06 | Kowa Co., Ltd. | Cyclic amide compounds |
US6344449B1 (en) * | 1996-09-10 | 2002-02-05 | Dr. Karl Thomae Gmbh | Modified aminoacids, pharmaceuticals containing these compounds and method for their production |
WO2003097855A2 (en) * | 2002-05-14 | 2003-11-27 | Baylor College Of Medicine | Small molecule inhibitors of her2 expression |
WO2003103671A1 (en) * | 2002-06-07 | 2003-12-18 | Menarini Ricerche S.P.A. | Basic non-peptide bradykinin antagonists and pharmaceutical compositions therefrom |
FR2856685A1 (en) * | 2003-06-25 | 2004-12-31 | Merck Sante Sas | THIAZOLYLPIPERIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
WO2005116653A2 (en) * | 2004-04-13 | 2005-12-08 | Arena Pharmaceuticals, Inc. | Modulators of human g protein-coupled receptors for the treatment of hyperglycemia and related disorders |
EP1637529A1 (en) * | 2004-09-20 | 2006-03-22 | 4Sc Ag | Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof |
EP1832586A1 (en) * | 2006-03-10 | 2007-09-12 | Oridis Biomed Forschungs- und Entwicklungs GmbH | Thiazole-piperidine derivatives in treatment of diseases of liver and the pancreas |
WO2007104557A2 (en) * | 2006-03-15 | 2007-09-20 | 4Sc Ag | Novel heterocyclic nf-kb inhibitors |
WO2007104558A1 (en) * | 2006-03-15 | 2007-09-20 | 4Sc Ag | Thiazoles as nf-kb inhibitors (proteasome inhibitors) |
-
2007
- 2007-04-05 WO PCT/EP2007/003136 patent/WO2007115805A2/en active Application Filing
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996026923A1 (en) * | 1995-03-02 | 1996-09-06 | Pierre Fabre Medicament | Novel bi-tryptaminic derivatives, preparation process and utilization as drugs |
US6344449B1 (en) * | 1996-09-10 | 2002-02-05 | Dr. Karl Thomae Gmbh | Modified aminoacids, pharmaceuticals containing these compounds and method for their production |
EP1057815A1 (en) * | 1998-02-19 | 2000-12-06 | Kowa Co., Ltd. | Cyclic amide compounds |
WO2003097855A2 (en) * | 2002-05-14 | 2003-11-27 | Baylor College Of Medicine | Small molecule inhibitors of her2 expression |
WO2003103671A1 (en) * | 2002-06-07 | 2003-12-18 | Menarini Ricerche S.P.A. | Basic non-peptide bradykinin antagonists and pharmaceutical compositions therefrom |
FR2856685A1 (en) * | 2003-06-25 | 2004-12-31 | Merck Sante Sas | THIAZOLYLPIPERIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
WO2005116653A2 (en) * | 2004-04-13 | 2005-12-08 | Arena Pharmaceuticals, Inc. | Modulators of human g protein-coupled receptors for the treatment of hyperglycemia and related disorders |
EP1637529A1 (en) * | 2004-09-20 | 2006-03-22 | 4Sc Ag | Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof |
US20060069102A1 (en) * | 2004-09-20 | 2006-03-30 | 4 Sc Ag | Novel heterocyclic NF-kB inhibitors |
EP1832586A1 (en) * | 2006-03-10 | 2007-09-12 | Oridis Biomed Forschungs- und Entwicklungs GmbH | Thiazole-piperidine derivatives in treatment of diseases of liver and the pancreas |
WO2007104557A2 (en) * | 2006-03-15 | 2007-09-20 | 4Sc Ag | Novel heterocyclic nf-kb inhibitors |
WO2007104558A1 (en) * | 2006-03-15 | 2007-09-20 | 4Sc Ag | Thiazoles as nf-kb inhibitors (proteasome inhibitors) |
Non-Patent Citations (5)
Title |
---|
KING HAROLD ET AL: "Antiplasmodial action and chemical constitution. III. Carbinolamines derivedfrom naphthalene and quinoline", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL SOCIETY. LETCHWORTH, GB, 1940, pages 1307 - 1315, XP008090078, ISSN: 0368-1769 * |
NIELSEN, ARNOLD T. ET AL: "1,1'-Diacetyl-1,1'-dihydro-4,4'-bipyridine and the yellow and colorless modifications of 1,1'-diacetyl-1,1' ,4,4'-tetrahydro-4,4'-bipyridine. The 1,1'-diacetyl-4,4'-bipyridine radical cation", JOURNAL OF ORGANIC CHEMISTRY , 29(8), 2175-9 CODEN: JOCEAH; ISSN: 0022-3263, 1964, XP002476438 * |
PIATTI, S. E. ET AL: "Synthesis of bisquinoxaline derivatives with potential neoplastic activity", ANALES DE QUIMICA, SERIE C: QUIMICA ORGANICA Y BIOQUIMICA , 82(2), 85-8 CODEN: AQSBD6; ISSN: 0211-1357, 1986, XP008090352 * |
SHIMOGAWA, HIROKI ET AL: "A Wrench-Shaped Synthetic Molecule that Modulates a Transcription Factor-Coactivator Interaction", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 126(11), 3461-3471 CODEN: JACSAT; ISSN: 0002-7863, 2004, XP002476439 * |
TUMIATTI, VINCENZO ET AL: "Structure-Activity Relationships of Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone. 3. Effect of Replacing the Inner Polymethylene Chain with Cyclic Moieties", JOURNAL OF MEDICINAL CHEMISTRY , 47(26), 6490-6498 CODEN: JMCMAR; ISSN: 0022-2623, 2004, XP002476440 * |
Also Published As
Publication number | Publication date |
---|---|
WO2007115805A2 (en) | 2007-10-18 |
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