WO2007113561A1 - Sample preparation - Google Patents
Sample preparation Download PDFInfo
- Publication number
- WO2007113561A1 WO2007113561A1 PCT/GB2007/001238 GB2007001238W WO2007113561A1 WO 2007113561 A1 WO2007113561 A1 WO 2007113561A1 GB 2007001238 W GB2007001238 W GB 2007001238W WO 2007113561 A1 WO2007113561 A1 WO 2007113561A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ingredient
- dispensed
- sample
- motive means
- weight
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/84—Mixing plants with mixing receptacles receiving material dispensed from several component receptacles, e.g. paint tins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/712—Feed mechanisms for feeding fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/7174—Feed mechanisms characterised by the means for feeding the components to the mixer using pistons, plungers or syringes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/80—Forming a predetermined ratio of the substances to be mixed
- B01F35/88—Forming a predetermined ratio of the substances to be mixed by feeding the materials batchwise
- B01F35/881—Forming a predetermined ratio of the substances to be mixed by feeding the materials batchwise by weighing, e.g. with automatic discharge
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/30—Mixing paints or paint ingredients, e.g. pigments, dyes, colours, lacquers or enamel
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00207—Handling bulk quantities of analyte
- G01N2035/00217—Handling bulk quantities of analyte involving measurement of weight
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
Definitions
- This invention relates to the preparation of samples, especially the preparation of multiple samples for use in high throughput testing.
- Colour may be conveniently defined using CIE (L*a*b*) 1976 standard (CIELAB) and differences from a defined point in the colour space defined using CIEDE2000 ( ⁇ E2000).
- paint recipes (or other coloured liquids such as inks) may be defined by measuring the CIELAB values of films formed using the paint (or inks etc) made to a particular recipe and variations from such recipes, for example, owing to changes in ingredients or ingredient sources, may be identified by determining ⁇ E2000 values for films. In determining ⁇ E2000 values for films, a ⁇ E2000 value of around 1 is noticeable to a human observer. Accordingly, ⁇ E2000 values of less than 1, more preferably less than 0.5, are desirable when comparing films with reference CIELAB parameters.
- the accuracy with which such samples are formulated may have a significant effect on whether a particular recipe or colour is acceptable. Consequently, the potential variability in the amounts of ingredients that are used to make the samples may significantly affect the quality of data generated from the analysis of such samples.
- the viscosities of liquids vary with fluctuations in ambient temperature. Although the change in viscosity in real terms may be relatively small, it may result in the amount, ie weight, of a sample ingredient used to make the sample being significantly different, for example of the order of 4-5 wt%, and at times up to 15-20 wt%, on a day-to-day basis.
- a method of sample preparation comprises generating a liquid sample comprising at least two liquid ingredients by dispensing said ingredients to a sample preparation location, gravimetrically controlling the dispensation of at least one of said ingredients and, if necessary, mixing said sample ingredients.
- the method comprises volumetrically dispensing a major ingredient of said sample and gravimetrically controlling the dispensation of at least one minor ingredient of said sample. More preferably, said major ingredient comprises at least 50 wt% and up to 99 wt%, more especially at least 70 wt% of a target weight for said sample.
- said at least one minor ingredient is dispensed under gravimetric control in two stages, wherein, in the first stage, a major proportion of said minor ingredient is dispensed at a faster rate than the rate at which a remaining minor proportion of said minor ingredient is dispensed in the second stage.
- the first gravimetrically-controlled stage of sample generation between 50 wt% and 98 wt%, more preferably between 50 wt% and 96 wt%, and more especially between 50 wt% and 95 wt% of the ingredient target weight is dispensed.
- up to 2 wt% more preferably up to 4 wt%, and more especially up to 5 wt% of the ingredient target weight is dispensed.
- the weight of a first ingredient dispensed is measured and used to adjust the weight of a second ingredient dispensed to the sample preparation location wherein the required relative proportions of said ingredients in the sample is achieved.
- the target weight(s) of the or each minor ingredient is adjusted and the or each minor ingredient is added to the major ingredient under gravimetric control.
- the target weight(s) of the or each minor ingredient is adjusted and the or each minor ingredient is added to the major ingredient under gravimetric control provided that, if the total weight to be dispensed it greater than a predetermined figure, the sample is aborted.
- the first volumetric dispensation occurs in not more than 15 seconds/gram (s/g) of sample dispensed, more preferably in not more than 12 s/g, and is typically about 8 s/g.
- the first gravimetrically-controlled stage occurs at a rate of at least 1.5 mg/s, more preferably at a rate of at least 2 mg/s.
- the second gravimetrically-controlled stage occurs at a rate of not more than 1 mg/s, more preferably at a rate of not more than 0.6 mg/s.
- the major ingredient of said sample may also be dispensed under gravimetric control, if desired, also using a two-stage process as described in the preceding paragraphs.
- the major ingredient of said sample may dispensed in two stages, a first volumetric stage and a second gravimetric stage.
- the first stage is a volumetric dispensation as described in the preceding paragraphs wherein preferably at least 70% by weight, more preferably at least 80% by weight and, more especially at least 90% by weight, of the major ingredient is dispensed volumetrically.
- the second stage is a gravimetric stage which may be a single stage or a two-stage process as described in the preceding paragraphs wherein not more than 30% by weight, more preferably not more than 20% by weight and, more especially not more than 10% by weight of the minor ingredient is dispensed gravimetrically.
- Some applications may require the preparation of relatively large amounts of samples: such applications may include, for example, identical samples that may be subjected to varying processing conditions such as curing, drying or polymerisation or to varying environmental conditions such as wear testing or weathering of the samples.
- the prepared liquid sample weight is not more than 50Og, more preferably not more than 25Og.
- the prepared liquid sample weight is not more than 100g, more preferably not more than 1Og, and especially not more than 5g.
- target weights of less than 0.1g may be envisaged in some applications, in applications relating to relatively viscous and/or thixotropic systems, such as paints etc, realistically, the target weight is preferably not less than 0.1g, more particularly not less than 1g.
- Samples prepared in accordance with the invention may be used in a variety of high throughput testing techniques.
- an amount of sample greater than that to be dispensed for testing purposes is prepared.
- Each sample may be prepared individually and/or serially; alternatively, a number of samples may be prepared in parallel.
- the sample preparation may include a mixing step if required.
- the sample may be stirred, shaken, vibrated or otherwise agitated to effect mixing.
- effective mixing may be particularly difficult to achieve, especially in small samples.
- apparatus for preparing samples comprises an ingredient dispensing system for dispensing at least two liquid ingredients, said system being operable to control gravimetrically the dispensation of at least one of said ingredients.
- the ingredient dispensing system preferably comprises a reservoir for containing a liquid ingredient, a motive means for dispensing, during use, a liquid ingredient from said reservoir, a balance mechanism on which is beatable an ingredient receptacle, a feedback loop connected between said balance mechanism and said motive means and including a computer means for controlling said motive means whereby, in use, said motive means is controlled by said computer means to dispense a target weight of at least one ingredient, the final amount of ingredient dispensed being controlled in response to weight changes detected by the balance mechanism.
- said motive means is controlled by said computer means such that, in use, the rate at which the ingredient is dispensed is controlled.
- said reservoir comprises a syringe locatable relative to said motive means such that the plunger thereof is movable by said motive means.
- the motive means comprises a stepper motor.
- Other, less preferred, motive means may be for example hydraulically- or gas-operated piston and cylinder mechanisms.
- said apparatus also comprises a tray mechanism interposable between said reservoir and the balance mechanism whereby, in use, extraneous drips of liquid from said reservoir are prevented from reaching an ingredient receptacle on said balance mechanism.
- the ingredient dispensing system comprises a second reservoir for containing a liquid ingredient, a second motive means for dispensing, during use, a liquid ingredient from said second reservoir, said computer means, in use, controlling said second motive means to dispense a liquid ingredient volumetrically from said second reservoir and controlling said first motive means to dispense a liquid ingredient gravimetrically from said first reservoir using feedback from said balance mechanism.
- the second motive means comprises a peristaltic pump.
- second motive means may be for example an HPLC or a hydraulically- or gas-operated piston and cylinder mechanism.
- said computer means is programmed to adjust the weight of at least one ingredient dispensed by operation of said first motive means in response to a weight signal receivable from the balance mechanism representing the weight of an first ingredient dispensed by operation of said second motive means wherein the required relative proportions of said ingredients in the sample is achieved.
- said computer means is programmed to control said first motive means to dispense at least one ingredient gravimetrically using feedback from said balance mechanism in two stages, wherein, in the first stage, a major proportion of said minor ingredient is dispensed at a faster rate than the rate at which a remaining minor proportion of said minor ingredient is dispensed in the second stage.
- said computer is programmed to control said first motive means, in the first gravimetrically-controlled stage, to dispense between 50 wt% and 98 wt%, more preferably between 50 wt% and 96 wt%, and more especially between 50 wt% and 95 wt% of a target weight for an ingredient.
- said computer is programmed to control said first motive means, in the second gravimetrically-controlled stage, to dispense up to 2 wt%, more preferably up to 4 wt%, and more especially up to 5 wt% of a target weight for an ingredient.
- said computer is programmed to control said second motive means to dispense an ingredient volumetrically in not more than 15 s/g of sample dispensed, more preferably in not more than 12 s/g and is typically about 8 s/g.
- said computer is programmed to control said first motive means to dispense a first portion of a target weight of an ingredient in a first gravimetrically-controlled stage at a rate of at least 1.5 mg/s, more preferably at a rate of at least 2 mg/s.
- said computer is programmed to control said first motive means to dispense a second portion of a target weight of an ingredient in a second gravimetrically-controlled stage at a rate of not more than 1 mg/s, more preferably at a rate of not more than 0.6 mg/s.
- said computer is programmed to control said second motive means to dispense a major ingredient under gravimetric control, preferably using a two-stage process as described in the preceding paragraphs.
- said sample receptacle comprises a well plate containing a plurality of wells each capable of receiving ingredients of samples.
- Sample ingredients are dispensed, for example as described previously, in the wells and the wells are sealed.
- the samples in the wells are then subjected to a mixing step.
- individual receptacles eg pots, having a capacity of for example up to 55Og may be used. If preferred, such individual receptacles may be supported in racks for parallel or serial processing.
- the well plate is sealed using a heat sealable foil. The sealed well plate may then be subjected to an appropriate motion, as hereinbefore described, to effect mixing of the sample ingredients.
- the foil used to seal a well plate is penetrable by for example a dispensing tip whereby, in use, quantities of liquid samples in the wells may be aspirated into said dispensing system for dispensing on a surface of a substrate for subsequent testing.
- sealing means for the wells, or for individual pots may be used.
- a sealing plate having individual seals for surrounding each well may be clamped to the well plate.
- the sealing plate may be provided with a plurality of sample ports or other sample access means positioned to permit samples in the wells to be accessed.
- Individual pots may be fitted with lids, again with sample access means being provided.
- a particularly preferred application for the methods and apparatus of the present invention is in the formation and characterisation of films of coating compositions.
- coating compositions particularly include paints, lacquers, varnishes and the like.
- Paints is used to mean coatings for painting the interior and exterior surfaces of structures such as buildings, fences and bridges, for both decorative and/or protective purposes.
- Paints typically comprise a carrier liquid and a film forming binder polymer together with other components such as additives including thickeners and for coloured paints, pigments.
- the carrier liquid can comprise water, organic solvent or a mixture of water and organic solvent.
- the binder polymer may be in the form of a dispersion of particles in the carrier liquid, whereby the polymer exists in particulate form or it may be dissolved in the carrier liquid and be a solution.
- the present invention may be used to explore new recipes or to reformulate recipes following changes in ingredients or ingredient sources or to check in-store formulation practises easily and rapidly.
- Figure 1 is a schematic plan view of a sample preparation station
- Figure 2 is a schematic side view of apparatus for gravimetrically dispensing sample ingredients
- a sample preparation station 10 is shown in Figure 1.
- the station 10 has a base plate 11 on which is mounted an automated XYZ handling system 12, for example a robotic movement arm available from Tecan UK Limited which services two dispense stations 14, 16.
- the system 12 is provided with two sets of grippers (not shown).
- the first set of grippers is used to load/unload well plates 18 (see Figure 2) from a well plate storage unit 20 located between the dispense stations 14, 16 to each of the dispense stations 14, 16.
- the second set of grippers is used to load/unload syringes 22 (see Figure 2) from a syringe storage unit 24 located between the dispense stations 14, 16 to each of the dispense stations 14, 16.
- a pneumatically-operated heated foil plate sealer 26 for example a plate sealer model number AB-0384-240 available from Abgene for sealing well plates 18 is provided at one end of the station 10.
- the well plate storage unit 20 is designed to accommodate thirty five well plates 18.
- the well plates 18 are conveniently clear plastic microtitre plates each having twenty four wells 28 available from VWR International.
- the wells 28 are arranged in a 6x4 array and each well 28 has a capacity of about 3.5g.
- the well plates 18 are bar coded to enable well plate/sample tracking to be performed.
- the syringe storage unit 24 is designed to hold up to one hundred 10ml syringes 22, each containing a liquid paint tinter solution 30 (see Figure 2).
- the unit 24 is temperature and humidity controlled to prevent the paint tinter solutions from drying out.
- Each dispense station 14, 16 has a four decimal place rapid response balance 32, for example a Mettler SAG 40 available from Mettler Limited.
- a well plate holder 34 is provided on the balance 32 for holding a well plate 18 in a fixed location.
- Each dispense station 14, 16 has an automated XY handling system (not shown) on which is mounted a syringe carrier 36 consisting of a frame 38 on which is mounted a micro-stepping stepper motor 40, for example VEXTA 2-phase, 2 amp stepper motor available from The Oriental Motor Company.
- the motor 40 is mounted on the frame 38 for reciprocating movement towards and away from the frame 38.
- a flange (not shown) on the upper end of the syringe plunger 42 engages a slot in the body of the motor 40 and a flange 46 on the upper end of the syringe body 44 engages the frame whereby movement of the motor 40 towards the frame 38 causes liquid to be dispensed from the syringe 22 and slight movement of the motor 40 away from the frame 38 imposes a slight negative pressure on the liquid in the syringe 22 to prevent the formation of extraneous drops of liquid on the nozzle 48 of the syringe 22.
- the frame 38 also has mounted thereon a drip tray 50 which is pneumatically operable to be interposed between the nozzle 48 and a well plate 18.
- Each dispense station 14, 16 is provided with at least one peristaltic pump (not shown), for example a peristaltic pump model number 520S/R available from VWR ⁇
- the peristaltic pumps are connected to a base paint reservoir (not shown) which may be either mounted on the base plate 11 of the station 10 or externally thereof.
- the peristaltic pump(s) at each dispense station 14, 16 are mounted on the base plate 11 with the or each outlet nozzle (not shown) being mounted on the respective XY handling system.
- a bar code reader (not shown) is also provided on the base plate 11 of the station 10.
- a computer 52 (see Figure 2) is provided to control operation of the sample preparation station 10.
- the computer system controls the peristaltic pumps and the stepper motors 40 and the drip trays 50 and is provided with a feedback loop 54 from the balance 32.
- the computer also records the well plate bar codes and maintains a record of the sample recipes located in each well 28 of the well plates 18.
- an operator loads the station 10 with the well plates 18, foil seals, base paint and disposable tinter syringes 22.
- the computer 52 is programmed with the required sample recipes and operation of the system is initiated.
- the XYZ handling system 12 loads each balance 32 at the respective dispensing stations 14, 16 with a well plate 18, each well plate 18 being passed by the bar code reader on route to the dispensing station 14, 16.
- the computer 52 calculates a dispense volume for each well based on the required base paint ingredient weight for each recipe and controls the XY handling system to move the discharge nozzle of the peristaltic pump over each well 28 in the well plate
- the computer 52 calculates, based on the final weight of base paint ingredient in each well 18, the weight(s) of tinter ingredient(s) that has to be added to each well 28 to complete the recipe for each well 28.
- the XYZ handling system 12 is then operated to load each dispense station 14, 16 with a syringe 22 containing the required tinter ingredient 30.
- the XY handling system at each dispense station 14, 16 is then operated to position the syringe 22 over each well in sequence to dispense using the stepper motor 40 the required weight of tinter ingredient 30 in each well 28.
- the drip tray 50 is withdrawn from beneath the nozzle 48 of the syringe 22 and at the end of the dispense of the tinter ingredient 30, the drip tray 50 is replaced beneath the nozzle 48 of the syringe 22.
- the computer 52 controls the stepper motor 40 to dispense the tinter ingredient 30 from the syringe 22 relatively rapidly until a major proportion of the tinter ingredient 30 is dispensed and then to control it to dispense the tinter ingredient 30 relatively slowly until the target weight for the tinter ingredient 30 is achieved.
- the stepper motor 40 is reversed to impose a slightly negative pressure on the tinter ingredient 30 remaining in the syringe 22 to prevent drips. The final weight of the tinter ingredient 30 dispensed into a well 28 is recorded.
- the XYZ handling system 12 is operated to remove the exhausted syringe from the relevant dispense station 14, 16, dispose of it and to collect and insert a fresh syringe 22.
- paint recipes may well require the inclusion of say up to five or more tinter ingredients, but more typically two or three tinter ingredients, to achieve a particular colour, for example.
- the computer 52 will operate the apparatus to locate in sequence syringes 22 containing different tinter ingredients 30 for dispensation into at least one of the wells 28.
- the XYZ handling system 12 is operated to remove the completed well plate 18 from the respective dispense station 14, 16 and move it to the plate sealer 26 at which it is sealed with a foil lid.
- the well plates 18 are manually loaded in batches of, for example, ten in a paint shaker device, for example a VIBA 25 available from Collomix, which is then operated to shake the well plates 18 to mix the ingredients of each sample therein.
- a paint shaker device for example a VIBA 25 available from Collomix
- samples may then be tested, for example by being dispensed onto a substrate to form films which are then characterised.
- tinters used were made up as 1% weight of pigment in base paint to avoid trying to dispense very small quantities of pigments.
- the actual weights of tinters dispensed was the weights dispensed following adjustment of the target weights by the computer based on the actual weight of the base paint dispensed and gravimetric control of the weights of tinters being dispensed. As can be seen, good control of the target weights was achieved.
- solvent-based alkyd resin paint recipes were formulated.
- the tinter used was made up as 1% weight of pigment in base paint to avoid handling very small quantities of pigment.
- the actual weight of tinter dispensed was the weight dispensed following adjustment of the target weight by the computer based on the actual weight of the base paint dispensed and gravimetric control of the weight of tinter being dispensed. As can be seen, good control of the target weights was achieved.
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0818410A GB2450822B (en) | 2006-04-04 | 2007-04-04 | Sample preparation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0606754.0 | 2006-04-04 | ||
GBGB0606754.0A GB0606754D0 (en) | 2006-04-04 | 2006-04-04 | Sample preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2007113561A1 true WO2007113561A1 (en) | 2007-10-11 |
Family
ID=36425211
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2007/001238 WO2007113561A1 (en) | 2006-04-04 | 2007-04-04 | Sample preparation |
Country Status (2)
Country | Link |
---|---|
GB (2) | GB0606754D0 (en) |
WO (1) | WO2007113561A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009144226A1 (en) * | 2008-05-30 | 2009-12-03 | Aes Chemunex | Device for diluting a sample |
WO2012078211A1 (en) * | 2010-12-07 | 2012-06-14 | Seymour Of Sycamore Inc. | Aerosol container filling system |
US9045723B2 (en) | 2009-08-07 | 2015-06-02 | Aes Chemunex | Device and method for dispensing a product into a petri dish |
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US4350186A (en) * | 1981-02-09 | 1982-09-21 | Spinal Systems Inc. | Gravimetric diluter |
EP0403964A2 (en) * | 1989-06-22 | 1990-12-27 | Hoechst Aktiengesellschaft | Proportioning and filling apparatus |
WO1992007760A1 (en) * | 1990-10-26 | 1992-05-14 | The Dow Chemical Company | Net weight dispensing system and method |
EP0651306A1 (en) * | 1993-10-25 | 1995-05-03 | Alfatech S.R.L. | Apparatus for preparing solutions |
US6053218A (en) * | 1998-11-10 | 2000-04-25 | X-Pert Paint Mixing Systems, Inc. | Semi-automated system for dispensing automotive paint |
US20040017728A1 (en) * | 2000-07-18 | 2004-01-29 | Dietmar Becker | Method and device for carrying out the automated preparation and characterization of liquid multi-constituent systems |
US20060093515A1 (en) * | 2004-11-03 | 2006-05-04 | Fermier Adam M | Automated solution generator |
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US5375634A (en) * | 1993-10-07 | 1994-12-27 | Graco Inc. | Variable mass flow rate fluid dispensing control |
US20030010792A1 (en) * | 1998-12-30 | 2003-01-16 | Randy Forshey | Chemical mix and delivery systems and methods thereof |
US6991004B2 (en) * | 2003-10-30 | 2006-01-31 | Fluid Management, Inc. | Combination gravimetric and volumetric dispenser for multiple fluids |
US7625115B2 (en) * | 2006-06-23 | 2009-12-01 | Exxonmobil Research And Engineering Company | Method of blending lubricants using positive displacement liquid-handling equipment |
GB2440932A (en) * | 2006-08-15 | 2008-02-20 | Ici Plc | Method and apparatus for generating multiple samples |
TW200846637A (en) * | 2007-01-16 | 2008-12-01 | Rohm & Haas | System and method for making paints from prepaints |
-
2006
- 2006-04-04 GB GBGB0606754.0A patent/GB0606754D0/en not_active Ceased
-
2007
- 2007-04-04 GB GB0818410A patent/GB2450822B/en not_active Expired - Fee Related
- 2007-04-04 WO PCT/GB2007/001238 patent/WO2007113561A1/en active Application Filing
Patent Citations (7)
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US4350186A (en) * | 1981-02-09 | 1982-09-21 | Spinal Systems Inc. | Gravimetric diluter |
EP0403964A2 (en) * | 1989-06-22 | 1990-12-27 | Hoechst Aktiengesellschaft | Proportioning and filling apparatus |
WO1992007760A1 (en) * | 1990-10-26 | 1992-05-14 | The Dow Chemical Company | Net weight dispensing system and method |
EP0651306A1 (en) * | 1993-10-25 | 1995-05-03 | Alfatech S.R.L. | Apparatus for preparing solutions |
US6053218A (en) * | 1998-11-10 | 2000-04-25 | X-Pert Paint Mixing Systems, Inc. | Semi-automated system for dispensing automotive paint |
US20040017728A1 (en) * | 2000-07-18 | 2004-01-29 | Dietmar Becker | Method and device for carrying out the automated preparation and characterization of liquid multi-constituent systems |
US20060093515A1 (en) * | 2004-11-03 | 2006-05-04 | Fermier Adam M | Automated solution generator |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009144226A1 (en) * | 2008-05-30 | 2009-12-03 | Aes Chemunex | Device for diluting a sample |
FR2931942A1 (en) * | 2008-05-30 | 2009-12-04 | Aes Chemunex | APPARATUS FOR DILUTION OF A SAMPLE |
US8459129B2 (en) | 2008-05-30 | 2013-06-11 | Stéphane Seznec | Device for diluting of a sample |
US9045723B2 (en) | 2009-08-07 | 2015-06-02 | Aes Chemunex | Device and method for dispensing a product into a petri dish |
WO2012078211A1 (en) * | 2010-12-07 | 2012-06-14 | Seymour Of Sycamore Inc. | Aerosol container filling system |
CN103339030A (en) * | 2010-12-07 | 2013-10-02 | 西卡摩尔之西摩股份有限公司 | Aerosol container filling system |
US8839827B2 (en) | 2010-12-07 | 2014-09-23 | Seymour Of Sycamore, Inc. | Aerosol container filling system |
US8985163B2 (en) | 2010-12-07 | 2015-03-24 | Seymour Of Sycamore Inc. | Aerosol container filling system |
Also Published As
Publication number | Publication date |
---|---|
GB0818410D0 (en) | 2008-11-12 |
GB0606754D0 (en) | 2006-05-10 |
GB2450822B (en) | 2011-02-23 |
GB2450822A (en) | 2009-01-07 |
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