WO2007112356A3 - Core-shell nanocapsules and applications thereof - Google Patents

Core-shell nanocapsules and applications thereof Download PDF

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Publication number
WO2007112356A3
WO2007112356A3 PCT/US2007/064941 US2007064941W WO2007112356A3 WO 2007112356 A3 WO2007112356 A3 WO 2007112356A3 US 2007064941 W US2007064941 W US 2007064941W WO 2007112356 A3 WO2007112356 A3 WO 2007112356A3
Authority
WO
WIPO (PCT)
Prior art keywords
oil
core
emulsion
water
nanocapsules
Prior art date
Application number
PCT/US2007/064941
Other languages
French (fr)
Other versions
WO2007112356A2 (en
Inventor
Aleksa Vito Jovanovic
Randolph Stephen Duran
Original Assignee
Univ Florida
Aleksa Vito Jovanovic
Randolph Stephen Duran
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida, Aleksa Vito Jovanovic, Randolph Stephen Duran filed Critical Univ Florida
Publication of WO2007112356A2 publication Critical patent/WO2007112356A2/en
Publication of WO2007112356A3 publication Critical patent/WO2007112356A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/501—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars

Abstract

Core-shell nanocapsules containing a silica shell that is generally porous surrounds an oil core. A method to prepare the nanocapsules by preparing an oil-in-water-in-oil emulsion and carrying out a sol-gel synthesis of the silica from a tetraalkoxysilane in the water phase of the double micelle is described. The central oil core is prepared by the formation of a stabilized oil-in-water emulsion where an alkyltrialkoxysilane is included with the emulsion. The stabilized oil-in-water emulsion is then used as the aqueous phase to prepare the oil-in- water-in-oil emulsion. The nanocapsules can be used for drug detoxification applications.
PCT/US2007/064941 2006-03-24 2007-03-26 Core-shell nanocapsules and applications thereof WO2007112356A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78573406P 2006-03-24 2006-03-24
US60/785,734 2006-03-24

Publications (2)

Publication Number Publication Date
WO2007112356A2 WO2007112356A2 (en) 2007-10-04
WO2007112356A3 true WO2007112356A3 (en) 2008-10-30

Family

ID=38541847

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/064941 WO2007112356A2 (en) 2006-03-24 2007-03-26 Core-shell nanocapsules and applications thereof

Country Status (1)

Country Link
WO (1) WO2007112356A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2335818A1 (en) * 2009-07-09 2011-06-22 Altachem Holdings NV Leach-proof microcapsules, the method for preparation and use of leach-proof microcapsules
CN102755868A (en) * 2011-03-18 2012-10-31 国际香料和香精公司 Microcapsules produced from blended sol-gel precursors and method for producing the same
WO2015035475A1 (en) * 2013-09-16 2015-03-19 The University Of Queensland Silica micro- and nano-capsules and methods for making them
GB201416354D0 (en) 2014-09-16 2014-10-29 Ecole Polytech Monolayer nanocapsules

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548264B1 (en) * 2000-05-17 2003-04-15 University Of Florida Coated nanoparticles

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548264B1 (en) * 2000-05-17 2003-04-15 University Of Florida Coated nanoparticles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
UNDERHILL: "Oil-Filled Silica Nanocapsules for Lipophilic Drug Uptake: Implications for Drug Detoxification Therapy", CHEM. MATTER, vol. 14, 2002, pages 4919 - 4925, XP002591583, DOI: doi:10.1021/CM0202299 *

Also Published As

Publication number Publication date
WO2007112356A2 (en) 2007-10-04

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