WO2007110767A3 - Interactive dressings for treatment of dermatological diseases - Google Patents

Interactive dressings for treatment of dermatological diseases Download PDF

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Publication number
WO2007110767A3
WO2007110767A3 PCT/IB2007/000803 IB2007000803W WO2007110767A3 WO 2007110767 A3 WO2007110767 A3 WO 2007110767A3 IB 2007000803 W IB2007000803 W IB 2007000803W WO 2007110767 A3 WO2007110767 A3 WO 2007110767A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
hydrogel
liposomes
tissue
ulcers
Prior art date
Application number
PCT/IB2007/000803
Other languages
French (fr)
Other versions
WO2007110767A2 (en
Inventor
Paola Perugini
Khaole Hassan
Claudia Colonna
Ida Genta
Tiziana Modena
Franca Pavanetto
Paolo Iadarola
Bice Conti
Original Assignee
Univ Pavia
Paola Perugini
Khaole Hassan
Claudia Colonna
Ida Genta
Tiziana Modena
Franca Pavanetto
Paolo Iadarola
Bice Conti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pavia, Paola Perugini, Khaole Hassan, Claudia Colonna, Ida Genta, Tiziana Modena, Franca Pavanetto, Paolo Iadarola, Bice Conti filed Critical Univ Pavia
Publication of WO2007110767A2 publication Critical patent/WO2007110767A2/en
Publication of WO2007110767A3 publication Critical patent/WO2007110767A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/38—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254—Enzymes, proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/626—Liposomes, micelles, vesicles

Abstract

Object of the invention is an interactive dressing the treatment of dermatological disorders. The invention comprises: a support, preferably a tissue non-tissue gauze, a hydrogel of a bioadhesive polymer like chitosan or hydroxyethylcellulose and liposomal systems containing an active principle of protein nature. It is a solid therapeutic system consisting of a dispersion of liposomes in hydrogel adsorbed on a tissue non-tissue gauze. The association of hydrogel with liposomal systems allows the site specific and prolonged release of active substances, through intracellular transfer of liposomes and therefore of the encapsulated drug. In addition to act as a storage form, liposomes protect the drug from enzymatic attacks, thus preserving its activity. The therapeutic system containing preferably the prolidase enzyme is used for the treatment, in human and mammals, of dermatological disorders with or without epithelial ulcers, preferably for treatment of ulcers in subjects affected by genetic prolidase deficiency.
PCT/IB2007/000803 2006-03-24 2007-03-22 Interactive dressings for treatment of dermatological diseases WO2007110767A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2006A000556 2006-03-24
ITMI20060556 ITMI20060556A1 (en) 2006-03-24 2006-03-24 INTERACTIVE MEDICATIONS FOR THE CARE OF DERMATOLOGICAL DISEASES

Publications (2)

Publication Number Publication Date
WO2007110767A2 WO2007110767A2 (en) 2007-10-04
WO2007110767A3 true WO2007110767A3 (en) 2008-02-07

Family

ID=38541508

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/000803 WO2007110767A2 (en) 2006-03-24 2007-03-22 Interactive dressings for treatment of dermatological diseases

Country Status (2)

Country Link
IT (1) ITMI20060556A1 (en)
WO (1) WO2007110767A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011075623A1 (en) 2009-12-18 2011-06-23 Latitude Pharmaceuticals, Inc. One - phase gel compos ition compri s ing phos pholi pids
CA2922570A1 (en) * 2013-08-26 2015-03-05 Health Research, Inc. Method for prophylaxis and/or treatment of erbb2 positive cancers
CN103800939B (en) * 2014-02-14 2015-09-02 武汉烺祺生物科技有限公司 A kind of antibacterial healing functional dressing and preparation method thereof
CA2958568A1 (en) 2014-08-20 2016-02-25 Health Research, Inc. Methods for prophylaxis and/or treatment of erbb1 positive cancers

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001790A1 (en) * 1987-09-04 1989-03-09 Biocompatibles Limited A dressing material comrpising a pharmacological active agent entrapped in liposomes
WO1998046287A2 (en) * 1997-04-15 1998-10-22 Uroteq Inc. Drug delivery via therapeutic hydrogels
WO2001015750A1 (en) * 1999-08-27 2001-03-08 Department Of National Defence Hydrogel wound dressing containing liposome-encapsulated therapeutic agent
WO2005035012A1 (en) * 2003-10-10 2005-04-21 Coloplast A/S A dressing

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001790A1 (en) * 1987-09-04 1989-03-09 Biocompatibles Limited A dressing material comrpising a pharmacological active agent entrapped in liposomes
WO1998046287A2 (en) * 1997-04-15 1998-10-22 Uroteq Inc. Drug delivery via therapeutic hydrogels
WO2001015750A1 (en) * 1999-08-27 2001-03-08 Department Of National Defence Hydrogel wound dressing containing liposome-encapsulated therapeutic agent
WO2005035012A1 (en) * 2003-10-10 2005-04-21 Coloplast A/S A dressing

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PERUGINI P ET AL: "Intracellular delivery of liposome-encapsulated prolidase in cultured fibroblasts from prolidase-deficient patients", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 102, no. 1, 20 January 2005 (2005-01-20), pages 181 - 190, XP004744268, ISSN: 0168-3659 *

Also Published As

Publication number Publication date
WO2007110767A2 (en) 2007-10-04
ITMI20060556A1 (en) 2007-09-25

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