WO2007110003A3 - Micellar carriers for drugs with anti-cancer activity - Google Patents

Micellar carriers for drugs with anti-cancer activity Download PDF

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Publication number
WO2007110003A3
WO2007110003A3 PCT/CZ2007/000020 CZ2007000020W WO2007110003A3 WO 2007110003 A3 WO2007110003 A3 WO 2007110003A3 CZ 2007000020 W CZ2007000020 W CZ 2007000020W WO 2007110003 A3 WO2007110003 A3 WO 2007110003A3
Authority
WO
WIPO (PCT)
Prior art keywords
drugs
cancer activity
micellar
micellar carriers
micelle
Prior art date
Application number
PCT/CZ2007/000020
Other languages
French (fr)
Other versions
WO2007110003A2 (en
Inventor
Petr Chytil
Tomas Etrych
Martin Hruby
Karel Ulbrich
Blanka Rihova
Original Assignee
Zentiva As
Petr Chytil
Tomas Etrych
Martin Hruby
Karel Ulbrich
Blanka Rihova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva As, Petr Chytil, Tomas Etrych, Martin Hruby, Karel Ulbrich, Blanka Rihova filed Critical Zentiva As
Publication of WO2007110003A2 publication Critical patent/WO2007110003A2/en
Publication of WO2007110003A3 publication Critical patent/WO2007110003A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A micellar system destined for controlled release of medical drug is formed by a micellar structure, constituted by a hydrophilic or amphiphilic polymer, to which the drug is bound by a covalent linkage, the molecules of which are arranged on the hydrophilic surface of the micelle, while the nucleus of the micelle is constituted by hydrophobic components of the system, which are linked with the polymer on the surface by a chemical bond.
PCT/CZ2007/000020 2006-03-28 2007-03-28 Micellar carriers for drugs with anti-cancer activity WO2007110003A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZPV2006-207 2006-03-28
CZ20060207A CZ2006207A3 (en) 2006-03-28 2006-03-28 Medicament micellar carriers exhibiting antitumor activity

Publications (2)

Publication Number Publication Date
WO2007110003A2 WO2007110003A2 (en) 2007-10-04
WO2007110003A3 true WO2007110003A3 (en) 2008-05-15

Family

ID=38230079

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CZ2007/000020 WO2007110003A2 (en) 2006-03-28 2007-03-28 Micellar carriers for drugs with anti-cancer activity

Country Status (2)

Country Link
CZ (1) CZ2006207A3 (en)
WO (1) WO2007110003A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2008661A3 (en) * 2008-10-23 2009-12-30 Zentiva, A. S Polymeric composition exhibiting synergistic activity when treating tumor diseases
CZ303072B6 (en) * 2009-02-13 2012-03-21 Zentiva, K.S. Paclitaxel and docetaxel polymeric conjugates with pH controlled release of cancerostatic
US8524783B2 (en) 2009-04-30 2013-09-03 Intezyne Technologies, Incorporated Polymer micelles containing anthracylines for the treatment of cancer
US8524784B2 (en) 2009-04-30 2013-09-03 Intezyne Technologies, Incorporated Polymer micelles containing anthracylines for the treatment of cancer
EP2438908A1 (en) * 2010-10-11 2012-04-11 Vectum Pharma, S.L. Anchoring compositions for topical applications
FR2967581B1 (en) 2010-11-19 2012-12-28 Sanofi Aventis POLYMERIC CONJUGATES OF ACTIVE INGREDIENTS, PROCESS FOR THEIR PREPARATION AND POLYMERIC INTERMEDIATES

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003053473A2 (en) * 2001-12-20 2003-07-03 Zentiva, A.S. Ph-sensitive polymeric conjugates of an anthracycline drug

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003053473A2 (en) * 2001-12-20 2003-07-03 Zentiva, A.S. Ph-sensitive polymeric conjugates of an anthracycline drug

Non-Patent Citations (16)

* Cited by examiner, † Cited by third party
Title
BADER ET AL: "Watersoluble Polymers in Medicine", DIE ANGEWANDTE MAKROMOLEKULARE CHEMIE, vol. 123/124, 1984, pages 457 - 485, XP002473699 *
BAE Y ET AL: "DESIGN OF ENVIRONMENT-SENSITIVE SUPRAMOLECULAR ASSEMBLIES FOR INTRACELLULAR DRUG DELIVERY: POLYMERIC MICELLES THAT ARE RESPONSIVE TO INTRACELLULAR PH CHANGE", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, WILEY VCH VERLAG, WEINHEIM, DE, vol. 42, no. 38, 6 October 2003 (2003-10-06), pages 4640 - 4643, XP001197447, ISSN: 1433-7851 *
CHYTIL ET AL: "Properties of HPMA copolymer-doxorubicin conjugates with pH-controlled activation: Effect of polymer chain modification", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 115, no. 1, 28 September 2006 (2006-09-28), pages 26 - 36, XP005663194, ISSN: 0168-3659 *
HRUBY M ET AL: "Polymeric micellar pH-sensitive drug delivery system for doxorubicin", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 103, no. 1, 2 March 2005 (2005-03-02), pages 137 - 148, XP004745763, ISSN: 0168-3659 *
KWON G S ET AL: "POLYMERIC MICELLES AS NEW DRUG CARRIERS", ADVANCED DRUG DELIVERY REVIEWS, AMSTERDAM, NL, vol. 21, no. 2, 1996, pages 107 - 116, XP001152000, ISSN: 0169-409X *
LUKYANOV A N ET AL: "Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs", ADVANCED DRUG DELIVERY REVIEWS, AMSTERDAM, NL, vol. 56, no. 9, 7 May 2004 (2004-05-07), pages 1273 - 1289, XP002356816, ISSN: 0169-409X *
MASAYUKI YOKOYAMA ET AL: "POLYMER MICELLES AS NOVEL DRUG CARRIER: ADRIAMYCIN-CONJUGATED POLY(ETHYLENE GLYCOL)-POLY(ASPARTIC ACID) BLOCK COPOLYMER", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 11, no. 1 - 3, January 1990 (1990-01-01), pages 269 - 278, XP000113384, ISSN: 0168-3659 *
NAKANISHI T ET AL: "Development of the polymer micelle carrier system for doxorubicin", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 74, no. 1-3, 6 July 2001 (2001-07-06), pages 295 - 302, XP004297538, ISSN: 0168-3659 *
ORIENTI I ET AL: "Microspheres of poly(2-hydroxyethylmethacrylate-co-[beta]-methacryloy loxyethyldeoxycholate) cross-linked with ethylene glycol dimethacrylate", PHARMACEUTICA ACTA HELVETIAE 1995 NL, vol. 70, no. 3, 1995, pages 241 - 246, XP002473698, ISSN: 0031-6865 *
QIU L Y ET AL: "Polymer architecture and drug delivery", PHARMACEUTICAL RESEARCH 200601 US, vol. 23, no. 1, January 2006 (2006-01-01), pages 1 - 30, XP002473715, ISSN: 0724-8741 1573-904X *
TORCHILIN V P ET AL: "Amphiphilic poly-N-vinylpyrrolidones: - synthesis, properties and liposome surface modification", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 22, no. 22, 15 November 2001 (2001-11-15), pages 3035 - 3044, XP004301382, ISSN: 0142-9612 *
UCHEGBU I F ET AL: "The lower critical solution temperature of doxorubicin polymer conjugates", PROCEEDINGS OF THE CONTROLLED RELEASE SOCIETY 1996 US, no. 23, 1996, pages 791 - 792, XP008089700, ISSN: 1022-0178 *
ULBRICH K ET AL: "POLYMERIC ANTICANCER DRUGS WITH PH-CONTROLLED ACTIVATION", ADVANCED DRUG DELIVERY REVIEWS, AMSTERDAM, NL, vol. 56, no. 7, 2004, pages 1023 - 1050, XP008068789, ISSN: 0169-409X *
YOKOYAMA M: "BLOCK COPOLYMERS AS DRUG CARRIERS", CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, vol. 9, no. 3/4, 1992, pages 213 - 248, XP008054267, ISSN: 0743-4863 *
YOO H S ET AL: "Doxorubicin-conjugated biodegradable polymeric micelles having acid-cleavable linkages", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 82, no. 1, 18 July 2002 (2002-07-18), pages 17 - 27, XP004369786, ISSN: 0168-3659 *
YOO HYUK SANG ET AL: "Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA-PEG block copolymer", JOURNAL OF CONTROLLED RELEASE, vol. 70, no. 1-2, 29 January 2001 (2001-01-29), pages 63 - 70, XP002473697, ISSN: 0168-3659 *

Also Published As

Publication number Publication date
WO2007110003A2 (en) 2007-10-04
CZ2006207A3 (en) 2008-01-16

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