WO2007109871A3 - Acridine derivatives with antitumoral activity - Google Patents

Acridine derivatives with antitumoral activity Download PDF

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Publication number
WO2007109871A3
WO2007109871A3 PCT/BR2007/000074 BR2007000074W WO2007109871A3 WO 2007109871 A3 WO2007109871 A3 WO 2007109871A3 BR 2007000074 W BR2007000074 W BR 2007000074W WO 2007109871 A3 WO2007109871 A3 WO 2007109871A3
Authority
WO
WIPO (PCT)
Prior art keywords
acridine derivatives
antitumoral activity
formula
antitumoral
activity
Prior art date
Application number
PCT/BR2007/000074
Other languages
French (fr)
Other versions
WO2007109871A2 (en
Inventor
Ivan Da Rocha Pitta
Galdino Suely Lins
De Lima Maria Do Carmo Alves
Original Assignee
Univ Fed De Pernambuco Ufpe
Ivan Da Rocha Pitta
Galdino Suely Lins
De Lima Maria Do Carmo Alves
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Fed De Pernambuco Ufpe, Ivan Da Rocha Pitta, Galdino Suely Lins, De Lima Maria Do Carmo Alves filed Critical Univ Fed De Pernambuco Ufpe
Priority to EP07719242A priority Critical patent/EP2004628A2/en
Publication of WO2007109871A2 publication Critical patent/WO2007109871A2/en
Publication of WO2007109871A3 publication Critical patent/WO2007109871A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention discloses new acridine derivatives according to general formula (I) below, useful as antitumor agents, methods for its preparation as well as pharmaceutical compositions containing the same are also disclosed: (Formula I).
PCT/BR2007/000074 2006-03-24 2007-03-23 Acridine derivatives with antitumoral activity WO2007109871A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07719242A EP2004628A2 (en) 2006-03-24 2007-03-23 Acridine derivatives with antitumoral activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BRPI0601827-0A BRPI0601827A (en) 2006-03-24 2006-03-24 molecules with antitumor activity
BRPI0601827-0 2006-03-24

Publications (2)

Publication Number Publication Date
WO2007109871A2 WO2007109871A2 (en) 2007-10-04
WO2007109871A3 true WO2007109871A3 (en) 2009-06-11

Family

ID=38541452

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR2007/000074 WO2007109871A2 (en) 2006-03-24 2007-03-23 Acridine derivatives with antitumoral activity

Country Status (3)

Country Link
EP (1) EP2004628A2 (en)
BR (1) BRPI0601827A (en)
WO (1) WO2007109871A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI1101273B1 (en) * 2011-03-10 2022-07-19 Universidade Federal De Pernambuco IMIDAZOLIDINE AND THIAZOLDINE MOLECULES WITH ANTI-T.CRUZI ACTIVITIES
WO2013053034A2 (en) * 2011-10-10 2013-04-18 Universidade Federal De Pernambuco - Ufpe Thiazacridines used in anti-cancer therapy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004024058A2 (en) * 2002-09-10 2004-03-25 Conselho Nacional De Desenvolvimento Científico E Tecnológico - Cnpq Molecules with antitumor activity and chemical synthesis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004024058A2 (en) * 2002-09-10 2004-03-25 Conselho Nacional De Desenvolvimento Científico E Tecnológico - Cnpq Molecules with antitumor activity and chemical synthesis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] XP008120457, Database accession no. 144:22847 *
DATABASE CA [online] XP008120458, Database accession no. 137:78894 *
MOURAO, R.H. ET AL.: "Synthesis and biological acitvity of novel acridinylidene and benzylidene thiazolidinediones", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 11, 2005, pages 1129 - 1133 *
SILVA, T.G. ET AL.: "Synthesis and structural elucidation of new benzylidene imidazolidines and acridinylidene thiazolidines", HETEROCYCLIC COMMUNICATIONS, vol. 7, no. 6, 2001, pages 523 - 528 *

Also Published As

Publication number Publication date
WO2007109871A2 (en) 2007-10-04
EP2004628A2 (en) 2008-12-24
BRPI0601827A (en) 2007-11-27

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