WO2007109797A3 - Cancer detection reagents and uses in pathology and diagnostics and cancer cell death - Google Patents

Cancer detection reagents and uses in pathology and diagnostics and cancer cell death Download PDF

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Publication number
WO2007109797A3
WO2007109797A3 PCT/US2007/064822 US2007064822W WO2007109797A3 WO 2007109797 A3 WO2007109797 A3 WO 2007109797A3 US 2007064822 W US2007064822 W US 2007064822W WO 2007109797 A3 WO2007109797 A3 WO 2007109797A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
detection reagents
diagnostics
subject
pathology
Prior art date
Application number
PCT/US2007/064822
Other languages
French (fr)
Other versions
WO2007109797A2 (en
Inventor
Don Adams North
Original Assignee
Sky Genetics Inc
Don Adams North
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sky Genetics Inc, Don Adams North filed Critical Sky Genetics Inc
Priority to EP07780473A priority Critical patent/EP2004862A2/en
Priority to CA002646194A priority patent/CA2646194A1/en
Publication of WO2007109797A2 publication Critical patent/WO2007109797A2/en
Publication of WO2007109797A3 publication Critical patent/WO2007109797A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cancer detection reagents have been identified through comparison of cancer mRNAs with the transcriptome of healthy cells. These cancer detection reagents may be used for a variety of purposes including diagnostics and targeted destruction of cancer cells. In diagnostic applications, peripheral blood or other tissue samples from a subject may be analyzed to generate a cancer profile for that subject. That profile may then be used to guide cancer treatment with known agents. It may also be used to generate agents capable of killing the subject's cancer cells in a targeted manner. These agents may include antibodies and siRNA, RNAi, or antisense RNA.
PCT/US2007/064822 2006-03-23 2007-03-23 Cancer detection reagents and uses in pathology and diagnostics and cancer cell death WO2007109797A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07780473A EP2004862A2 (en) 2006-03-23 2007-03-23 Cancer detection reagents and uses in pathology and diagnostics and cancer cell death
CA002646194A CA2646194A1 (en) 2006-03-23 2007-03-23 Cancer detection reagents and uses in pathology and diagnostics and cancer cell death

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US74369906P 2006-03-23 2006-03-23
US60/743,699 2006-03-23
US74726006P 2006-05-15 2006-05-15
US60/747,260 2006-05-15

Publications (2)

Publication Number Publication Date
WO2007109797A2 WO2007109797A2 (en) 2007-09-27
WO2007109797A3 true WO2007109797A3 (en) 2008-10-02

Family

ID=38523333

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/064822 WO2007109797A2 (en) 2006-03-23 2007-03-23 Cancer detection reagents and uses in pathology and diagnostics and cancer cell death

Country Status (3)

Country Link
EP (1) EP2004862A2 (en)
CA (1) CA2646194A1 (en)
WO (1) WO2007109797A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3330278A1 (en) 2012-02-08 2018-06-06 Ionis Pharmaceuticals, Inc. Modulation of rna by repeat targeting
AU2017339561B2 (en) 2016-10-07 2024-02-01 Secarna Pharmaceuticals Gmbh & Co. Kg Novel approach for treating cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006081248A2 (en) * 2005-01-25 2006-08-03 Sky Genetics, Inc. Cancer markers and detection methods

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006081248A2 (en) * 2005-01-25 2006-08-03 Sky Genetics, Inc. Cancer markers and detection methods

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
AOUACHERIA ABDEL ET AL: "In silico whole-genome scanning of cancer-associated nonsynonymous SNPs and molecular characterization of a dynein light chain tumour variant.", ONCOGENE 8 SEP 2005, vol. 24, no. 40, 8 September 2005 (2005-09-08), pages 6133 - 6142, XP002478753, ISSN: 0950-9232 *
AOUACHERIA ABDEL ET AL: "In silico whole-genome screening for cancer-related single-nucleotide polymorphisms located in human mRNA untranslated regions", BMC GENOMICS, BIOMED CENTRAL, LONDON, GB, vol. 8, no. 1, 3 January 2007 (2007-01-03), pages 2, XP021022322, ISSN: 1471-2164 *
AOUACHERIA ABDEL ET AL: "Supplementary file 1", ONCOGENE 8 SEP 2005, vol. 24, no. 40, 8 September 2005 (2005-09-08), pages 1 - 12, ISSN: 0950-9232 *
CLIFFORD ROBERT ET AL: "Expression-based genetic/physical maps of Single-Nucleotide Polymorphisms identified by the Cancer Genome Anatomy Project", GENOME RESEARCH, vol. 10, no. 8, August 2000 (2000-08-01), pages 1259 - 1265, XP002478758, ISSN: 1088-9051 *
DAVIES H ET AL: "MUTATIONS OF THE BRAF GENE IN HUMAN CANCER", NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 417, no. 6892, 27 June 2002 (2002-06-27), pages 949 - 954, XP001188240, ISSN: 0028-0836 *
LOKTIONOV ALEXANDRE: "Common gene polymorphisms, cancer progression and prognosis", CANCER LETTERS, vol. 208, no. 1, 10 May 2004 (2004-05-10), pages 1 - 33, XP002478756, ISSN: 0304-3835 *
PARK JANE ET AL: "Mutation profiling of mismatch repair-deficient colorectal cncers using an in silico genome scan to identify coding microsatellites.", CANCER RESEARCH 1 MAR 2002, vol. 62, no. 5, 1 March 2002 (2002-03-01), pages 1284 - 1288, XP002478755, ISSN: 0008-5472 *
QIU PING ET AL: "Additional file 1, Table 2", BMC CANCER, BIOMED CENTRAL, LONDON, GB, vol. 4, no. 1, 29 January 2004 (2004-01-29), pages 1 - 12, XP002478754, ISSN: 1471-2407 *
QIU PING ET AL: "Genome wide in silico SNP-tumor association analysis", BMC CANCER, BIOMED CENTRAL, LONDON, GB, vol. 4, no. 1, 29 January 2004 (2004-01-29), pages 4, XP021004639, ISSN: 1471-2407 *
SJÖBLOM TOBIAS ET AL: "The consensus coding sequences of human breast and colorectal cancers.", SCIENCE (NEW YORK, N.Y.) 13 OCT 2006, vol. 314, no. 5797, 13 October 2006 (2006-10-13), pages 268 - 274, XP002478760, ISSN: 1095-9203 *
STRAUSBERG R L: "The Cancer Genome Anatomy Project: new resources for reading the molecular signatures of cancer.", THE JOURNAL OF PATHOLOGY SEP 2001, vol. 195, no. 1, September 2001 (2001-09-01), pages 31 - 40, XP002478759, ISSN: 0022-3417 *
STRAUSBERG ROBERT L ET AL: "Sequence-based cancer genomics: Progress, lessons and opportunities.", NATURE REVIEWS GENETICS, vol. 4, no. 6, June 2003 (2003-06-01), pages 409 - 418, XP002478757, ISSN: 1471-0056 *

Also Published As

Publication number Publication date
WO2007109797A2 (en) 2007-09-27
CA2646194A1 (en) 2007-09-27
EP2004862A2 (en) 2008-12-24

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