WO2007109456A3 - Substituted biphenyl isoxazole sulfonamides as dual angiotensin endothelin receptor antagonists - Google Patents

Substituted biphenyl isoxazole sulfonamides as dual angiotensin endothelin receptor antagonists Download PDF

Info

Publication number
WO2007109456A3
WO2007109456A3 PCT/US2007/063862 US2007063862W WO2007109456A3 WO 2007109456 A3 WO2007109456 A3 WO 2007109456A3 US 2007063862 W US2007063862 W US 2007063862W WO 2007109456 A3 WO2007109456 A3 WO 2007109456A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor antagonists
endothelin receptor
substituted biphenyl
dual angiotensin
isoxazole sulfonamides
Prior art date
Application number
PCT/US2007/063862
Other languages
French (fr)
Other versions
WO2007109456A2 (en
Inventor
Natesan Murugesan
William Ewing
Zhengxiang Gu
Guixue Yu
John E Macor
Original Assignee
Pharmacopeia Inc
Natesan Murugesan
William Ewing
Zhengxiang Gu
Guixue Yu
John E Macor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacopeia Inc, Natesan Murugesan, William Ewing, Zhengxiang Gu, Guixue Yu, John E Macor filed Critical Pharmacopeia Inc
Publication of WO2007109456A2 publication Critical patent/WO2007109456A2/en
Publication of WO2007109456A3 publication Critical patent/WO2007109456A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C07D261/16—Benzene-sulfonamido isoxazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides N-isoxazolyl biphenyl sulfonamide compounds of Formula (I), wherein R1, R2, R3, R4, and R5 are as defined herein. These compounds are dual angiotensin and endothelin receptor antagonists, and as such are useful in the treatment of conditions such as hypertension and other diseases.
PCT/US2007/063862 2006-03-16 2007-03-13 Substituted biphenyl isoxazole sulfonamides as dual angiotensin endothelin receptor antagonists WO2007109456A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78295306P 2006-03-16 2006-03-16
US60/782,953 2006-03-16

Publications (2)

Publication Number Publication Date
WO2007109456A2 WO2007109456A2 (en) 2007-09-27
WO2007109456A3 true WO2007109456A3 (en) 2007-12-06

Family

ID=38519673

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/063862 WO2007109456A2 (en) 2006-03-16 2007-03-13 Substituted biphenyl isoxazole sulfonamides as dual angiotensin endothelin receptor antagonists

Country Status (1)

Country Link
WO (1) WO2007109456A2 (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200838501A (en) 2007-02-02 2008-10-01 Theravance Inc Dual-acting antihypertensive agents
WO2008106128A2 (en) 2007-02-26 2008-09-04 Vitae Pharmaceuticals, Inc. CYCLIC UREA AND CARBAMATE INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1
TWI448284B (en) 2007-04-24 2014-08-11 Theravance Inc Dual-acting antihypertensive agents
TWI406850B (en) 2007-06-05 2013-09-01 Theravance Inc Dual-acting benzoimidazole antihypertensive agents
JP5470557B2 (en) 2007-07-26 2014-04-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1
EP2200975A1 (en) 2007-09-07 2010-06-30 Theravance, Inc. Dual-acting antihypertensive agents
AR069207A1 (en) 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc CYCLIC UREAS AS INHIBITORS OF THE 11 BETA - HIDROXI-ESTEROIDE DESHIDROGENASA 1
ATE555099T1 (en) 2007-12-11 2012-05-15 Theravance Inc DUAL-ACTING BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS ANHYDROGENIC PRESSURE LOWERING AGENTS
JP5490014B2 (en) 2007-12-11 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 11β-hydroxysteroid dehydrogenase type 1 cyclic urea inhibitor
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
US8592409B2 (en) 2008-01-24 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1
WO2009096198A1 (en) * 2008-02-01 2009-08-06 Pharma Ip Limited Liability Intermediary Corporations Novel biaryl derivative
WO2009102428A2 (en) 2008-02-11 2009-08-20 Vitae Pharmaceuticals, Inc. 1,3-OXAZEPAN-2-ONE AND 1,3-DIAZEPAN-2-ONE INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1
CA2715290A1 (en) 2008-02-15 2009-08-20 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US7989484B2 (en) 2008-04-29 2011-08-02 Theravance, Inc. Dual-acting antihypertensive agents
WO2009134387A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8569292B2 (en) 2008-05-01 2013-10-29 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
US8138178B2 (en) 2008-05-01 2012-03-20 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2723032A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP2011529072A (en) 2008-07-24 2011-12-01 セラヴァンス， インコーポレーテッド Dual action antihypertensive
NZ590495A (en) 2008-07-25 2012-10-26 Vitae Pharmaceuticals Inc Dihydropyridin-phenyl-3-oxazinan-2-ones as inhibitors of 11beta-hydroxysteroid dehydrogenase 1
TW201016691A (en) 2008-07-25 2010-05-01 Boehringer Ingelheim Int Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8637505B2 (en) 2009-02-04 2014-01-28 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8927539B2 (en) 2009-06-11 2015-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
US8883778B2 (en) 2009-07-01 2014-11-11 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
EP2451782B1 (en) 2009-07-07 2016-11-09 Theravance Biopharma R&D IP, LLC Dual-acting pyrazole antihypertensive agents
EP2456762B1 (en) 2009-07-22 2013-10-16 Theravance, Inc. Dual-acting oxazole antihypertensive agents
US8481549B2 (en) 2010-01-19 2013-07-09 Theravance, Inc. Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents
US8933072B2 (en) 2010-06-16 2015-01-13 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
WO2011161128A1 (en) 2010-06-25 2011-12-29 Boehringer Ingelheim International Gmbh Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
EA201300522A1 (en) 2010-11-02 2013-11-29 Бёрингер Ингельхайм Интернациональ Гмбх PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF METABOLIC DISORDERS
US8993631B2 (en) 2010-11-16 2015-03-31 Novartis Ag Method of treating contrast-induced nephropathy
CA3121202A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
WO2022266370A1 (en) 2021-06-17 2022-12-22 Aria Pharmaceuticals, Inc. Sparsentan for treating idiopathic pulmonary fibrosis
CA3229397A1 (en) * 2021-08-26 2023-03-02 Hualing XIAO Aromatic ring-containing biological antagonist, and preparation method therefor and use thereof
JP2024539270A (en) * 2021-10-21 2024-10-28 ニコヤ セラピューティクス（シャンハイ）カンパニー リミテッド Dual antagonists and uses thereof
WO2024175082A1 (en) * 2023-02-24 2024-08-29 江苏豪森药业集团有限公司 Salt containing aromatic ring derivative antagonist, preparation method therefor, and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000001389A1 (en) * 1998-07-06 2000-01-13 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
WO2001044239A2 (en) * 1999-12-15 2001-06-21 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
US20020143024A1 (en) * 1998-07-06 2002-10-03 Natesan Murugesan Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000001389A1 (en) * 1998-07-06 2000-01-13 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
US20020143024A1 (en) * 1998-07-06 2002-10-03 Natesan Murugesan Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
WO2001044239A2 (en) * 1999-12-15 2001-06-21 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MURUGESAN N ET AL: "Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 45, 2002, pages 3829 - 3835, XP002281023, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
WO2007109456A2 (en) 2007-09-27

Similar Documents

Publication Publication Date Title
WO2007109456A3 (en) Substituted biphenyl isoxazole sulfonamides as dual angiotensin endothelin receptor antagonists
WO2007114926A3 (en) Kinase antagonists
MX2009005363A (en) Pyrimidines and their use as cxcr2 receptor antagonists.
WO2007079199A3 (en) Substituted bis-amide metalloprotease inhibitors
BRPI0605921A2 (en) organic compounds
WO2007148185A3 (en) Substituted 3 -amino- pyrrolidino-4 -lactams as dpp inhibitors
WO2006099268A3 (en) Cgrp receptor antagonists
ATE526318T1 (en) FARNESOID-X RECEPTOR AGONISTS
WO2009156462A3 (en) Organic compounds
EA201000050A1 (en) SUBSTITUTED BICYCLOPLASTIC COMPOUNDS
WO2007003962A3 (en) Gpcr agonists
WO2007003961A3 (en) Gpcr agonists
WO2006123249A3 (en) Novel oxadiazole derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors
WO2008051942A3 (en) Farnesoid x receptor agonists
IN2014DN08578A (en)
WO2007119214A3 (en) Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis
EA200900781A1 (en) 4-PHENYPYRANE-3,5-DIONA, 4-PHENYLTIOPYRANE-3,5-DIONA AND CYCLOHEXANTHRION, AS NEW HERBICIDES
WO2008014199A3 (en) Sulfonyl compounds which modulate the cb2 receptor
WO2007022518A8 (en) New uses of glucoregulatory proteins
DE602007006961D1 (en) CGRP RECEPTOR ANTAGONISTS
WO2002078693A3 (en) N-(2-arylethyl)benzylamines as antagonists of the 5-ht6 receptor
WO2009043889A3 (en) Oxadiazole derivatives
WO2006123255A3 (en) Substituted oxadiazole derivatives as positive allosteric modulators of metabotropic glutamate receptors
WO2009082701A8 (en) Hcv protease inhibitors and uses thereof
EA200701396A1 (en) TRIAZOLOPHTHALASINS AS PDE-2 INHIBITORS

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07758414

Country of ref document: EP

Kind code of ref document: A2