WO2007109183A3 - Mutations et polymorphismes de la tyrosine kinase 1 liée au fms - Google Patents
Mutations et polymorphismes de la tyrosine kinase 1 liée au fms Download PDFInfo
- Publication number
- WO2007109183A3 WO2007109183A3 PCT/US2007/006723 US2007006723W WO2007109183A3 WO 2007109183 A3 WO2007109183 A3 WO 2007109183A3 US 2007006723 W US2007006723 W US 2007006723W WO 2007109183 A3 WO2007109183 A3 WO 2007109183A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fltl
- mutations
- polymorphisms
- mutant
- various aspects
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La présente invention concerne de manière générale le test analytique d'échantillons tissulaires in vitro et plus particulièrement des aspects des polymorphismes et mutations génétiques du gène FLT1. Elle concerne de nouvelles mutations et de nouveaux polymorphismes nucléotidiques simples (SNP) du FLT1 qui sont utiles dans le diagnostic et le traitement de sujets qui en ont besoin. En conséquence, les divers aspects de la présente invention concernent des polynucléotides codant pour des mutations du FLT1 selon l'invention, des vecteurs d'expression codant pour les polypeptides FLT1 mutants de l'invention et des organismes qui expriment le FLT1 mutant et les polynucléotides polymorphes et/ou les polypeptides FLT1 mutants/polymorphes de l'invention. Les divers aspects de la présente invention concernent en outre des méthodes et des kits de diagnostic/théranostic utilisant les mutations et polymorphismes du FLT1 selon l'invention pour identifier des individus prédisposés à une maladie ou pour classifier des individus en fonction de leur réponse à un médicament, des effets secondaires ou de la dose de médicament optimale.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78413206P | 2006-03-20 | 2006-03-20 | |
US60/784,132 | 2006-03-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007109183A2 WO2007109183A2 (fr) | 2007-09-27 |
WO2007109183A3 true WO2007109183A3 (fr) | 2008-09-18 |
Family
ID=38523006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/006723 WO2007109183A2 (fr) | 2006-03-20 | 2007-03-16 | Mutations et polymorphismes de la tyrosine kinase 1 liée au fms |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2007109183A2 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2894231B1 (fr) * | 2009-08-04 | 2017-01-04 | F. Hoffmann-La Roche AG | Sensibilité aux inhibiteurs de l'angiogenèse |
WO2018090257A1 (fr) * | 2016-11-16 | 2018-05-24 | 深圳华大基因研究院 | Polypeptide et son application |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1130123A2 (fr) * | 2000-02-24 | 2001-09-05 | AstraZeneca AB | Méthode diagnostique |
EP1338655A1 (fr) * | 2000-10-03 | 2003-08-27 | Kyowa Hakko Kogyo Co., Ltd | Substance inhibant la fixation de la molecule de transduction de signal au recepteur kdr/flk-1 phosphoryle au niveau de la tyrosine a la position 1175 et technique d'utilisation |
WO2005070431A1 (fr) * | 2004-01-22 | 2005-08-04 | Novartis Ag | Derives de pyrazolo[1,5-a]pyrimidin-7-yl-amine destines a etre utilises dans le traitement de maladies dependantes de la proteine kinase |
EP1655368A1 (fr) * | 1999-04-16 | 2006-05-10 | Genentech, Inc. | Variantes du facteur de croissance cellulaire endothélial et leur usages |
-
2007
- 2007-03-16 WO PCT/US2007/006723 patent/WO2007109183A2/fr active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1655368A1 (fr) * | 1999-04-16 | 2006-05-10 | Genentech, Inc. | Variantes du facteur de croissance cellulaire endothélial et leur usages |
EP1130123A2 (fr) * | 2000-02-24 | 2001-09-05 | AstraZeneca AB | Méthode diagnostique |
US20040091912A1 (en) * | 2000-02-24 | 2004-05-13 | Astrazeneca Ab, A Swedish Corporation | Diagnostic method |
EP1338655A1 (fr) * | 2000-10-03 | 2003-08-27 | Kyowa Hakko Kogyo Co., Ltd | Substance inhibant la fixation de la molecule de transduction de signal au recepteur kdr/flk-1 phosphoryle au niveau de la tyrosine a la position 1175 et technique d'utilisation |
WO2005070431A1 (fr) * | 2004-01-22 | 2005-08-04 | Novartis Ag | Derives de pyrazolo[1,5-a]pyrimidin-7-yl-amine destines a etre utilises dans le traitement de maladies dependantes de la proteine kinase |
Non-Patent Citations (4)
Title |
---|
BREKKEN R ET AL: "VASCULAR ENDOTHELIAL GROWTH FACTOR AND VASCULAR TARGETING OF SOLID TUMORS", ANTICANCER RESEARCH, HELENIC ANTICANCER INSTITUTE, ATHENS, vol. 21, no. 6B, 1 November 2001 (2001-11-01), pages 4221 - 4230, XP009033823, ISSN: 0250-7005 * |
FONG T A T ET AL: "SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, vol. 59, no. 1, 1 January 1999 (1999-01-01), pages 99 - 106, XP002378513, ISSN: 0008-5472 * |
MENENDEZ DANIEL ET AL: "A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 103, no. 5, January 2006 (2006-01-01), pages 1406 - 1411, XP002483893, ISSN: 0027-8424 * |
ROCKWELL P ET AL: "IN VITRO NEUTRALIZATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR ACTIVATION OF FLK-1 BY A MONOCLONAL ANTIBODY", MOLECULAR AND CELLULAR DIFFERENTIATION, CRC PRESS, BOCA RATON, US, vol. 3, no. 1, 1 January 1995 (1995-01-01), pages 91 - 109, XP009065009, ISSN: 1065-3074 * |
Also Published As
Publication number | Publication date |
---|---|
WO2007109183A2 (fr) | 2007-09-27 |
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