WO2007107775A8 - Preparation d'oligonucleotides avec des proprietes photocommutables - Google Patents

Preparation d'oligonucleotides avec des proprietes photocommutables Download PDF

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Publication number
WO2007107775A8
WO2007107775A8 PCT/GB2007/001056 GB2007001056W WO2007107775A8 WO 2007107775 A8 WO2007107775 A8 WO 2007107775A8 GB 2007001056 W GB2007001056 W GB 2007001056W WO 2007107775 A8 WO2007107775 A8 WO 2007107775A8
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
photoswitchable
modulatable
properties
photo
Prior art date
Application number
PCT/GB2007/001056
Other languages
English (en)
Other versions
WO2007107775A3 (fr
WO2007107775A2 (fr
Inventor
Joseph S Vyle
James Robert Tucker
Original Assignee
Univ Belfast
Joseph S Vyle
James Robert Tucker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Belfast, Joseph S Vyle, James Robert Tucker filed Critical Univ Belfast
Publication of WO2007107775A2 publication Critical patent/WO2007107775A2/fr
Publication of WO2007107775A3 publication Critical patent/WO2007107775A3/fr
Publication of WO2007107775A8 publication Critical patent/WO2007107775A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des lieurs prévus pour attacher des composés photocommutables à un acide nucléique. Ces lieurs peuvent être utilisés pour donner des composés photocommutables où les propriétés chimiques et biologiques de poly(acide nucléique) incorporant ces composés photocommutables peuvent être modulées par la lumière. En outre, la présente invention concerne des procédés de modulation d'hybridation de séquences de poly(acide nucléique) et de liaison de facteurs, par exemple, des polymérases aux séquences de poly(acide nucléique) incorporant lesdits composés photocommutables.
PCT/GB2007/001056 2006-03-23 2007-03-23 Preparation d'oligonucleotides avec des proprietes photocommutables WO2007107775A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0605787.1 2006-03-23
GB0605787A GB0605787D0 (en) 2006-03-23 2006-03-23 "Preparation of oligonucleotides with photoswitchable properties

Publications (3)

Publication Number Publication Date
WO2007107775A2 WO2007107775A2 (fr) 2007-09-27
WO2007107775A3 WO2007107775A3 (fr) 2008-03-27
WO2007107775A8 true WO2007107775A8 (fr) 2009-07-16

Family

ID=36383996

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/001056 WO2007107775A2 (fr) 2006-03-23 2007-03-23 Preparation d'oligonucleotides avec des proprietes photocommutables

Country Status (2)

Country Link
GB (1) GB0605787D0 (fr)
WO (1) WO2007107775A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105567673A (zh) * 2014-10-31 2016-05-11 希森美康株式会社 扩增核酸的方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201220282D0 (en) * 2012-11-12 2012-12-26 Univ Edinburgh Electrochemical method
CN106905399B (zh) * 2017-03-27 2019-07-09 武汉大学 一种双链dna b-z构象相互转换的光控方法
US11421271B2 (en) * 2019-03-28 2022-08-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing using photoswitchable labels

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200528467A (en) * 2004-02-27 2005-09-01 Japan Science & Tech Agency DNA enzyme and method of controlling the activity thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105567673A (zh) * 2014-10-31 2016-05-11 希森美康株式会社 扩增核酸的方法
CN105567673B (zh) * 2014-10-31 2018-09-04 希森美康株式会社 扩增核酸的方法

Also Published As

Publication number Publication date
WO2007107775A3 (fr) 2008-03-27
GB0605787D0 (en) 2006-05-03
WO2007107775A2 (fr) 2007-09-27

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