WO2007105846A1 - A method for using cell therapy product facility and franchise market business method based on network using the same - Google Patents
A method for using cell therapy product facility and franchise market business method based on network using the same Download PDFInfo
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- WO2007105846A1 WO2007105846A1 PCT/KR2006/000970 KR2006000970W WO2007105846A1 WO 2007105846 A1 WO2007105846 A1 WO 2007105846A1 KR 2006000970 W KR2006000970 W KR 2006000970W WO 2007105846 A1 WO2007105846 A1 WO 2007105846A1
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- WIPO (PCT)
- Prior art keywords
- cell therapy
- unit
- processing unit
- room
- therapy product
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Classifications
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- G—PHYSICS
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- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/20—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- G—PHYSICS
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- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
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- G—PHYSICS
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- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
Definitions
- the present invention relates to a method for using a cell therapy product facility and a network-based franchise market business method using the same. More specifically, the present invention provides a modularized facility for production of a cell therapy product and operating method thereof and a use method and business method of a medical cell system including the above cell therapy product facility, a technology for production of a cell therapy product and a license. Consequently, the present invention enables easy production of the cell therapy product having a quality grade sufficient to transplant into patients within a short period of time at a low production cost and clinical application thereof to patients within an early time, via use of the above-mentioned cell therapy product facility.
- the present invention enables convenient installation and utilization of such a facility module in any place where a predetermined-size space is secured, by providing the facility module in a prefabricated type having specialized units according to the corresponding functions thereof. Therefore, the present invention enables accomplishment of remarkably improved quality and reliability of the product and thereby enhanced customer satisfaction.
- Cell therapy products are medicines used for the treatment, diagnosis and prevention of various diseases by a series of necessary steps involving collecting and proliferating somatic cells from living bodies of patients themselves (autologous) or other people (allogenic) or other animals (xenogenic), or differentiating stem cells into desired cell types, in order to repair impaired or defective cells or tissues and functions thereof. Therefore, such cell therapy products have a wide spectrum of applications thereof, and over recent several years, have been receiving a great deal of attention as a novel therapy having promising and unlimited potentialities for the treatment of various intractable diseases such as burns, cancers, senile dementia and the like.
- the present invention has been made in view of the above problems, and it is a first object of the present invention to provide a modularized facility for production of a cell therapy product and operating method thereof and a use method and business method of a medical cell system including the above cell therapy product facility, a technology for production of a cell therapy product and a license, and par- ticularly, a cell therapy product facility, comprising a CT (Cell Therapy) -module capable of producing the cell therapy product and a BC (Banking of Cell and Tissue)-module capable of storing hematopoietic stem cells and bone marrow cells and other cells for a prolonged period of time through appropriate processes.
- CT Cell Therapy
- BC Banking of Cell and Tissue
- a second object of the present invention is to provide a facility module for production and storage of a cell therapy product, wherein the CT and BC modules are respectively comprised of five functionally specialized units: a preparation unit, a processing unit, a microbial sterility test unit, a quality control unit and a utility unit.
- a third object of the present invention is to enable easy production of a cell therapy product having a quality grade sufficient to transplant into patients within a short period of time at a low production cost and clinical application thereof to patients within an early time, via use of the above-constituted facility module.
- a fourth object of the present invention is to enable convenient installation and utilization of such a facility module in any place where a predetermined- size space is secured, by provision of the facility module in a prefabricated type composed of specialized units according to the individual- specific functions.
- a fifth object of the present invention is to provide a system capable of producing a cell therapy product to hospitals or universities of all the countries of the world, whereby they secure treatment technologies using such a cell therapy product and thus provide extended opportunity for treating patients, and at the same time, to provide the above system to global medical market, thereby accelerating development of cell therapy products.
- a sixth object of the present invention is to provide a method for using a cell therapy product facility and a network-based franchise market business method using the same, which enables accomplishment of remarkably improved quality and reliability of the product and thereby enhanced customer satisfaction.
- a method for using a cell therapy product facility comprising producing a cell therapy product by a CT (Cell Therapy)-module composed of a plurality of separately prefabricated units having individual- specific functions and having an entrance and exit separately partitioned from each other so as to minimize occurrence of contamination; and storing hematopoietic stem cells and bone marrow cells and other cells for a prolonged period of time through appropriate processes, by a BC (Banking of Cell and Tissue)-module composed of a plurality of separately prefabricated units having individual-specific functions and having an entrance and exit separately partitioned from each other so as to minimize occurrence of contamination.
- CT Cell Therapy
- BC Banking of Cell and Tissue
- a network-based franchise market business method using a cell therapy product facility comprising providing a source to a management server from a computer connected to the cell therapy product facility via internet; transmitting a variety of licenses, authorization business, clinical data, supply and sale, management and business, education, audio and video data transmission means from the management server to the computer via internet; and controlling the cell therapy product facilities CT (Cell Therapy)-module and BC (Banking of Cell and Tissue) -module by the computer, thereby providing a technology for production of cell therapy product.
- CT Cell Therapy
- BC Banking of Cell and Tissue
- FIG. 1 is a schematic plan block diagram of a cell therapy product facility CT (Cell
- FIG. 2 is a front cross-sectional view of a preparation unit and a utility unit applied to the present invention
- FIG. 3 is a front cross-sectional view of a processing unit and a utility unit applied to the present invention
- FIGS. 4 through 6 are respectively plan, front and side views of an air handling part applied to the present invention.
- FIG. 7 is a block diagram showing clean zones of a cell therapy product facility CT
- FIG. 8 is a schematic plan block diagram view of a cell therapy product facility BC
- FIG. 9 is a front cross-sectional view of a preparation unit and utility unit of Fig. 8;
- FIG. 10 is a block diagram showing clean zones of a cell therapy product facility BC
- FIG. 11 is a block diagram of a network-based franchise market business method, using a cell therapy product facility applied to the present invention. Best Mode for Carrying Out the Invention
- the present invention is directed to a cell therapy product facility, comprising a CT
- each module 1 and 2 is designed to follow a basic layout taking into account a minimal space necessary for processes and optimal size and weight advantageous for transportation.
- the CT (Cell Therapy)-module 1 is provided with a preparation unit 10 for wearing a clean room garment to enter sterile clean zones, and preparing/sterilizing raw materials and storing finished/semi-finished products.
- the CT module 1 includes a processing unit 20 for maintaining a desired level of cleanliness to produce cell therapy products such as cultured chondrocytes and cultured osteoblasts, at the rear of the preparation unit 10.
- the facility module of the present invention also includes a microbial sterility test unit 30 for examining probable microbial contamination such as by bacteria during an incubation period for production of cell therapy products, at the rear of the processing unit 20.
- a quality control unit 40 for confirming safety and effectiveness of the cell therapy products is also provided.
- a utility unit 50 for maintenance of essential items such as a desired level of cleanliness, constant temperature and humidity, fire service and electricity for the respective units 10, 20, 30 and 40 is provided at one side of the preparation unit 10.
- the preparation unit 10, processing unit 20, microbial sterility test unit 30 and quality control unit 40 except utility unit 50 are fixedly installed with sterile panels at a predetermined height from the bottom thereof, wherein the preparation unit 10, microbial sterility test unit 30 and quality control unit 40 are provided with blank panels 68 at the top of multiple height-adjusting tools 68a arranged at regular intervals, and the processing unit 20 is provided with a grating panel 69 at the top of multiple supporting tools 69a arranged at regular intervals.
- the module of the present invention includes an air handling part 65 provided inside the utility unit 50 and connected to an air cooler 66, wherein the air handling part 65, as shown in Figs. 4 through 6, is provided with an air filter 65a for preventing entry of foreign materials and a cooling and heating coil 65b for heat exchange of fluid, a damper 65c for air volume control and a humidifier 65d for water level control, and a fan 65e for air volume control.
- the air handling part 65 is connected with a first duct 67a, a passage through which air is allowed to flow through the preparation unit 10, quality control unit 40 and microbial sterility test unit 30, wherein the first duct 67a is provided with first HEPA (High Efficiency Particulate Air) filter units 63 connected thereto at regular intervals, a second duct 67b discharging air to the inside of the processing unit 20, and a third duct 67c for entry of air installed in the respective units 10, 20, 30 and 40.
- first HEPA High Efficiency Particulate Air
- second duct 67b discharging air to the inside of the processing unit 20
- a third duct 67c for entry of air installed in the respective units 10, 20, 30 and 40.
- a plurality of second HEPA filter units 64 are provided at regular intervals.
- the inside of the preparation unit 10 is provided with a first dressing room
- a washing room 13 providing a space for washing, sterilizing and delivering articles to enter the processing unit and having an ultrapurification system
- a packaging room 14 for packaging products manufactured in the processing unit
- a semi-finished product depository 17 for storing semi-finished products manufactured during processes in liquid nitrogen
- a finished product depository 18 for final storage of finished products manufactured in the processing unit until shipment after packaging them in the packaging room 14, and first and second buffering zones 15 and 16 for providing clean conditions, serving as buffer areas with external environment.
- the facility module of the present invention further includes, as shown in Fig. 1, first and second air showers 60 and 61 in the first dressing room 11 of the preparation unit 10, and further includes a second air shower 61 in the microbial sterility test unit 30, whereby entrance of contaminating particles from the outside is prevented upon entering clean zones and dust or bacteria adhered to the workers are washed and eliminated by high-velocity clean air.
- a pass box 62 that enables only entrance and exit of articles without personnel entry, thereby preventing escape of contamination source or clean air.
- the BC (Banking of Cell and Tissue)-module 2 is provided with a preparation unit 70 for wearing a clean room garment to enter sterile clean zones, and preparing/sterilizing raw materials.
- the preparation unit 70 is provided with a first dressing room 72 for wearing a clean room garment to enter a washing room or processing unit, a washing room 73 providing a space for washing, sterilizing and delivering articles to enter the processing unit and including an ultrapu- rification system, first and second buffering zones 74 and 75 for providing clean conditions, serving as buffer areas with external environment, and a head room 71 as a buffer area to enter the processing unit.
- a processing unit 80 for processing and storing the umbilical cord is provided at the rear of the preparation unit 70.
- a microbial sterility test unit 90 for examining probable microbial contamination such as by bacteria during transportation or processing of the umbilical cord blood is also provided at the rear of the processing unit 80.
- a quality control unit 100 for confirming safety and effectiveness of the cell therapy products is also provided.
- a utility unit 110 is provided for maintenance of essential items such as a desired level of cleanliness, constant temperature and humidity, fire service and electricity for the respective units 70, 80, 90 and 100.
- the BC module of the present invention includes an air handling part 65 provided inside the utility unit 110 and connected to an air cooler 66, a first duct 67a connected to the air handling part 65 through the preparation unit 70, processing unit 80, quality control unit 100 and microbial sterility test unit 90, first and second HEPA filter units 63 and 64 connected at regular intervals to the first duct 67a, a third duct 67c for entry of air provided in the respective units 70, 80, 90 and 100, and second air showers 61 provided in the preparation unit 70 and microbial sterility test unit 90.
- the CT-module 1 for production of the cell therapy product in accordance with the present invention is comprised of 5 units, i.e., the preparation unit 10, processing unit 20, microbial sterility test unit 30, quality control unit 40 and utility unit 50.
- the preparation unit 10 is composed of a dressing room for entering sterile clean zones, a washing room for preparing and washing raw materials/auxiliary materials used to manufacture products and a depository room for storing finished/ semi-finished products of cell therapy products.
- the processing unit 20 is the place where cleanliness is kept in class 100 levels and a variety of processes for isolating cells from tissues and differentiating/proliferating cells are carried out.
- the microbial sterility test unit 30 is a germ-free testing room where cleanliness is kept in class 10000 levels and a sterility test is conducted on raw materials/auxiliary materials before/after processes and final products.
- the quality control unit 40 is the place where a variety of QC tests except a sterility test are conducted on raw materials/auxiliary materials before/after processing thereof and final products.
- the utility unit 50 is the place where equipment to constantly maintain temperature/humidity of the module and a desired level of cleanliness corresponding to the respective units is operated and details thereof will be disclosed hereinafter.
- the method for using the cell therapy product facility in accordance with the present invention comprises producing a cell therapy product by a CT (Cell Therapy)-module 1 composed of a plurality of separately prefabricated units having individual- specific functions and having an entrance and exit separately partitioned from each other so as to minimize occurrence of contamination; and storing hematopoietic stem cells and bone marrow cells and other cells for a prolonged period of time through appropriate processes, by a BC (Banking of Cell and Tissue) -module 2 composed of a plurality of separately prefabricated units having individual- specific functions and having an entrance and exit separately partitioned from each other so as to minimize occurrence of contamination.
- CT Cell Therapy
- BC Banking of Cell and Tissue
- the process of producing the cell therapy product includes wearing a clean room garment in a preparation unit 10 in order to enter sterile clean zones, and preparing/sterilizing raw materials and storing finished/semi-finished products therein; maintaining a desired level of cleanliness in a processing unit 20 in order to produce cell therapy products such as cultured chondrocytes and cultured osteoblasts; examining the presence of microbial contamination such as by bacteria during an incubation period for production of the cell therapy product, in a microbial sterility test unit 30; confirming safety and effectiveness of the cell therapy product in a quality control unit 40; and maintaining essential items such as a desired level of cleanliness, constant temperature and humidity, fire service and electricity for the respective units 10, 20, 30 and 40, in a utility unit 50.
- the following processes are carried out including wearing a first working uniform in a first dressing room 11 in order to enter a washing room or processing unit; wearing a clean room garment in a second dressing room 12 in order to enter the processing unit; washing, sterilizing and delivering articles to enter the processing unit and providing an ultrapurification system, in the washing room 13; packaging products from the processing unit in a packaging room 14; storing semi-finished products produced during the manufacturing processes in liquid nitrogen in a semi-finished product depository 17; packaging finished products from the processing unit in the packaging room, followed by final storage of finished products in a finished product depository 18 until shipment; and providing clean conditions by first and second buffering zones 15 and 16 as buffer areas with external environment.
- the first dressing room 11 of the preparation unit is provided with first and second air showers 60 and 61
- the microbial sterility test unit 30 is provided with a second air shower 61, whereby entrance of contaminating particles from the outside is prevented upon entering clean zones and dust or bacteria adhered to the workers are washed and eliminated by high-velocity clean air.
- a pass box 62 provided between the microbial sterility test unit 30 and quality control unit 40 enables only entrance and exit of articles without personnel entry, thereby preventing escape of contamination source or clean air.
- the processing unit 20 is maintained at a cleanliness level of less than 100 particles having a particle size of 0.5 D per cubic feet (ft)
- the preparation unit 10 and the microbial sterility test unit 30 except the first dressing room and finished product depository are maintained at a cleanliness level of less than 10000 particles having a particle size of 0.5 D per cubic feet (ft)
- other areas are divided into zones capable of maintaining cleanliness and differential pressure.
- cartilage isolation and primary culture were carried out as follows.
- test samples collected before/after processes and from final products were subjected to sterility tests in the microbial sterility test unit (30). Further, except a sterility test, a variety of QC tests such as endotoxin test, mycoplama test using PCR, cell count, cell viability test, virus test, cytotoxicity test and identity test were conducted in the quality control unit 40.
- QC tests such as endotoxin test, mycoplama test using PCR, cell count, cell viability test, virus test, cytotoxicity test and identity test were conducted in the quality control unit 40.
- Such processes for producing the cell therapy products were collectively carried out in the CT-module 1. After processes and QC tests for the products were complete, the chondrocyte therapeutic was transported to an operating room, followed by chondrocyte transplantation for the treatment of patients with cartilage defects.
- the BC-module 2 for storage of cell therapy product in accordance with the present invention is also comprised of 5 units, i.e., the preparation unit 70, processing unit 80, microbial sterility test unit 90, quality control unit 100 and utility unit 110.
- the preparation unit 70 is composed of a dressing room for entering sterile clean zones, and a washing room for preparing and washing raw materials/auxiliary materials necessary for manufacturing processes.
- the processing unit 80 is the place where cleanliness is kept in class 10000 levels and a variety of processes for isolating cells from tissues or blood and storing cells are carried out.
- the microbial sterility test unit 90 is a germ-free testing room where cleanliness is kept in class 10000 levels and a sterility test is conducted on raw materials/auxiliary materials before/after processing thereof and cells for final storage.
- the quality control unit 100 is the place where a variety of QC tests except a sterility test are conducted on raw materials/auxiliary materials before/after processing thereof and cells for final storage.
- the utility unit 110 is the place where equipment necessary for constant maintenance of temperature/humidity of the module and cleanliness levels corresponding to the respective units is operated and details thereof will be disclosed hereinafter.
- the process of storing hematopoietic stem cells and bone marrow cells and other cells, applied to the present invention, for a prolonged period of time through appropriate processes includes wearing a clean room garment in a preparation unit 70 in order to enter sterile clean zones, and preparing/sterilizing raw materials therein; storing/preserving the umbilical cord blood in a processing unit 80; examining the presence of microbial contamination such as by bacteria during transportation or processing of the umbilical cord blood, in a microbial sterility test unit 90; confirming safety and effectiveness of the cell therapy products in a quality control unit 100; and maintaining essential items such as a desired level of cleanliness, constant temperature and humidity, fire service and electricity for the respective units 70, 80, 90 and 100, in a utility unit 110.
- the following processes are carried out including wearing a clean room garment in a first dressing room 72 in order to enter a washing room or processing unit; washing, sterilizing and delivering articles to enter the processing unit and providing an ultrapurification system, in the washing room 73; providing clean conditions by first and second buffering zones 74 and 75 as buffer areas with external environment; and providing a buffer area to enter the processing unit by a head room 71.
- the preparation unit 70, the processing unit 80 and microbial sterility test unit 90 except a quality control unit 100, a utility unit 110 and a first dressing room 72 are maintained at a cleanliness level of less than 10000 particles having a particle size of 0.5 D per cubic feet (ft), and other areas are divided into zones capable of maintaining a desired level of cleanliness and differential pressure.
- CT-module 1 and BT-module 2 in accordance with the present invention are preferably maintained at a temperature of 22+2 0 C, and humidity of 50+5%.
- nucleated cells were isolated as follows.
- a packaging step was carried out as follows.
- test samples collected from raw materials/auxiliary materials before/after processing thereof and cells for final storage were subjected to sterility test in the microbial sterility test unit (90). Further, a variety of QC tests such as cell count, cell viability, hematopoietic stem cell count and colony-forming unit (CFU) assay were also conducted.
- CFU colony-forming unit
- the above-mentioned processes were carried out to separate and store hematopoietic stem cell from the umbilical cord blood. Therefore, even though the BC- module 2 is the facility capable of separating and storing umbilical cord blood-derived hematopoietic stem cells, such a module may also be used to process and store cell types other than hematopoietic stem cells.
- technologies for separation and storage of hematopoietic stem cells from the umbilical cord blood are introduced in conjunction with the BC-module 2, it is possible to do business associated with separation and storage of hematopoietic stem cells.
- the present invention provides a network-based franchise market business method using the cell therapy product facility, comprising providing a source to a management server 120 from a computer connected to the cell therapy product facility via internet; transmitting a variety of licenses, authorization business, clinical trial book, supply and sale, management and business, education, audio and video data transmission means from the management server 120 to the computer via internet; and controlling the cell therapy product facilities CT (Cell Therapy) -module 1 and BC (Banking of Cell and Tissue) -module 2 by the computer, thereby providing a technology for production of cell therapy product.
- CT Cell Therapy
- BC Banking of Cell and Tissue
- the present invention provides procedures and technologies for preparing the cell therapy product having a quality grade sufficient to transplant into patients, and a system including all constituents such as a modularized facility.
- the present invention supplies a system capable of producing a cell therapy product to hospitals or universities of all the countries of the world, whereby they secure treatment technologies using the cell therapy product and thereby provide extended opportunity for treating patients, and at the same time, to provide the above system to global medical market, thereby accelerating development of cell therapy products.
- the present invention provides a modularized facility for production of a cell therapy product and operating method thereof and a use method and business method of a medical cell system including the above cell therapy product facility, a technology for production of a cell therapy product and a license.
- the present invention includes a facility module for production and storage of a cell therapy product, comprising a CT (Cell Therapy) -module capable of producing a cell therapy product and a BC (Banking of Cell and Tissue)-module capable of storing hematopoietic stem cells and bone marrow cells and other cells for a prolonged period of time through appropriate processes, wherein the CT and BC modules are respectively composed of five functionally specialized units: a preparation unit, a processing unit, a microbial sterility test unit, a quality control unit and a utility unit.
- CT Cell Therapy
- BC Banking of Cell and Tissue
- the present invention enables easy production of the cell therapy product having a quality grade sufficient to transplant into patients within a short period of time at a low production cost and clinical application thereof to patients within an early time, via use of the above-mentioned facility module.
- the present invention enables convenient installation and utilization of such a facility module in any place where a predetermined- size space is secured, by providing the facility module in a prefabricated type having specialized units according to the corresponding functions thereof.
- the present invention supplies a system capable of producing a cell therapy product to hospitals or universities of all the countries of the world, whereby they secure treatment technologies that can be achieved using the cell therapy product and thereby provide extended opportunity for treating patients, and at the same time, to provide the above system to global medical market, thereby accelerating development of cell therapy products. Consequently, the present invention enables accomplishment of remarkably improved quality and reliability of the product and thereby enhanced customer satisfaction.
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Abstract
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Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2008011691A MX2008011691A (en) | 2006-03-14 | 2006-03-16 | A method for using cell therapy product facility and franchise market business method based on network using the same. |
US12/224,949 US20090018868A1 (en) | 2006-03-14 | 2006-03-16 | Method for Utilizing Cell Therapy Product Facility and Network-Based Business Model Using the Same |
EP06716420A EP1994137A4 (en) | 2006-03-14 | 2006-03-16 | A method for using cell therapy product facility and franchise market business method based on network using the same |
JP2009500272A JP2009533324A (en) | 2006-03-14 | 2006-03-16 | Method of using cell therapy equipment and franchise market business method based on network using the same |
BRPI0621492-4A BRPI0621492A2 (en) | 2006-03-14 | 2006-03-16 | method of using the facility for the production of cell therapy products and business method in the computer network based franchise market by using said facility |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2006-0023412 | 2006-03-14 | ||
KR1020060023412A KR100745362B1 (en) | 2006-03-14 | 2006-03-14 | A cell therapy product facility use method and network franchise market business method |
Publications (1)
Publication Number | Publication Date |
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WO2007105846A1 true WO2007105846A1 (en) | 2007-09-20 |
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Family Applications (1)
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PCT/KR2006/000970 WO2007105846A1 (en) | 2006-03-14 | 2006-03-16 | A method for using cell therapy product facility and franchise market business method based on network using the same |
Country Status (8)
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US (1) | US20090018868A1 (en) |
EP (1) | EP1994137A4 (en) |
JP (1) | JP2009533324A (en) |
KR (1) | KR100745362B1 (en) |
CN (1) | CN101400782A (en) |
BR (1) | BRPI0621492A2 (en) |
MX (1) | MX2008011691A (en) |
WO (1) | WO2007105846A1 (en) |
Cited By (3)
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DE102011052771A1 (en) | 2011-08-17 | 2013-02-21 | Nordenia Deutschland Gronau Gmbh | Method and device for removing soiling on profiled surfaces of intermeshing draw rolls |
US10184949B2 (en) | 2014-07-21 | 2019-01-22 | Ge Healthcare Bio-Sciences Corp. | Parallel cell processing method and facility |
WO2019173376A1 (en) * | 2018-03-06 | 2019-09-12 | Orig3N, Inc. | Ipsc-derived cell compositions, and related systems and methods for cartilage repair |
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EP2496940B1 (en) | 2009-11-05 | 2018-08-15 | Primegen Biotech, LLC dba Reprocyte | Germline stem cell banking system |
CA3031152A1 (en) * | 2016-07-21 | 2018-01-25 | Celyad | Method and apparatus for automated independent parallel batch-processing of cells |
CN108611271A (en) * | 2018-05-10 | 2018-10-02 | 朱丹 | Totally enclosed type intelligent biology production system and production method |
CN110643508A (en) * | 2018-06-26 | 2020-01-03 | 深圳市北科生物科技有限公司 | Modular automatic cell culture system and method |
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- 2006-03-16 WO PCT/KR2006/000970 patent/WO2007105846A1/en active Application Filing
- 2006-03-16 JP JP2009500272A patent/JP2009533324A/en active Pending
- 2006-03-16 EP EP06716420A patent/EP1994137A4/en not_active Withdrawn
- 2006-03-16 BR BRPI0621492-4A patent/BRPI0621492A2/en not_active Application Discontinuation
- 2006-03-16 US US12/224,949 patent/US20090018868A1/en not_active Abandoned
- 2006-03-16 MX MX2008011691A patent/MX2008011691A/en not_active Application Discontinuation
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Also Published As
Publication number | Publication date |
---|---|
US20090018868A1 (en) | 2009-01-15 |
EP1994137A1 (en) | 2008-11-26 |
EP1994137A4 (en) | 2012-05-02 |
BRPI0621492A2 (en) | 2011-12-13 |
KR100745362B1 (en) | 2007-08-02 |
JP2009533324A (en) | 2009-09-17 |
CN101400782A (en) | 2009-04-01 |
MX2008011691A (en) | 2008-12-10 |
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