WO2007103535A3 - Modèles de prédiction cellulaire permettant de détecter des toxicités - Google Patents

Modèles de prédiction cellulaire permettant de détecter des toxicités Download PDF

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Publication number
WO2007103535A3
WO2007103535A3 PCT/US2007/005985 US2007005985W WO2007103535A3 WO 2007103535 A3 WO2007103535 A3 WO 2007103535A3 US 2007005985 W US2007005985 W US 2007005985W WO 2007103535 A3 WO2007103535 A3 WO 2007103535A3
Authority
WO
WIPO (PCT)
Prior art keywords
toxicities
predictive models
models
stimuli
subset
Prior art date
Application number
PCT/US2007/005985
Other languages
English (en)
Other versions
WO2007103535A2 (fr
Inventor
Eugeni Vaisberg
Vadim Kutsyy
Jeffrey Finer
Original Assignee
Cytokinetics Inc
Eugeni Vaisberg
Vadim Kutsyy
Jeffrey Finer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0605351A external-priority patent/GB2435922A/en
Application filed by Cytokinetics Inc, Eugeni Vaisberg, Vadim Kutsyy, Jeffrey Finer filed Critical Cytokinetics Inc
Publication of WO2007103535A2 publication Critical patent/WO2007103535A2/fr
Publication of WO2007103535A3 publication Critical patent/WO2007103535A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

L'invention concerne des procédés permettant de générer des modèles destinés à prédire l'activité biologique d'une population cellulaire test soumise à des stimuli. Les modèles de l'invention peuvent être utilisés pour classer ou pour prédire l'effet des stimuli sur les cellules. Dans certains modes de réalisation, les procédés de l'invention consistent à: recevoir des données comprenant des valeurs de variables dépendantes associées aux stimuli; préparer un ensemble de populations cellulaires en fonction des données reçues; identifier un sous-ensemble de populations cellulaires à utiliser pour générer un modèle à partir des données associées à ce sous-ensemble. Ce modèle permet de prédire l'activité d'une population test.
PCT/US2007/005985 2006-03-09 2007-03-07 Modèles de prédiction cellulaire permettant de détecter des toxicités WO2007103535A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US78148406P 2006-03-09 2006-03-09
US60/781,484 2006-03-09
US78238006P 2006-03-14 2006-03-14
US60/782,380 2006-03-14
GB0605351A GB2435922A (en) 2006-03-09 2006-03-17 Cellular predictive models for cholestasis
GB0605351.6 2006-03-17

Publications (2)

Publication Number Publication Date
WO2007103535A2 WO2007103535A2 (fr) 2007-09-13
WO2007103535A3 true WO2007103535A3 (fr) 2008-09-04

Family

ID=38475582

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/005985 WO2007103535A2 (fr) 2006-03-09 2007-03-07 Modèles de prédiction cellulaire permettant de détecter des toxicités

Country Status (1)

Country Link
WO (1) WO2007103535A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8114615B2 (en) 2006-05-17 2012-02-14 Cernostics, Inc. Method for automated tissue analysis
AU2012229102B2 (en) 2011-03-17 2016-02-04 Cernostics, Inc. Systems and compositions for diagnosing Barrett's esophagus and methods of using the same
SG11201807576QA (en) * 2016-04-11 2018-10-30 Agency Science Tech & Res High throughput method for accurate prediction of compound-induced liver injury

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040086873A1 (en) * 2002-10-31 2004-05-06 Johnson Peter C. System and method of generating and storing correlated hyperquantified tissue structure and biomolecular expression datasets
US20050014217A1 (en) * 2003-07-18 2005-01-20 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
US6873914B2 (en) * 2001-11-21 2005-03-29 Icoria, Inc. Methods and systems for analyzing complex biological systems

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6873914B2 (en) * 2001-11-21 2005-03-29 Icoria, Inc. Methods and systems for analyzing complex biological systems
US20040086873A1 (en) * 2002-10-31 2004-05-06 Johnson Peter C. System and method of generating and storing correlated hyperquantified tissue structure and biomolecular expression datasets
US20050014217A1 (en) * 2003-07-18 2005-01-20 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BROXUP ET AL.: "Morphometric Evaluation of Hepatocellular Proliferative Lesions in the Rat Liver", TOXICOLOGIC PATHOLOGY, vol. 16, no. 4, 1988 *
DE LONGUEVILLE ET AL.: "Use of Low-Density Microarray for Studying Gene Expression Patterns Induced by Hepatoxicants on Primary Cultures on Rat Hepatocoytes", TOXICOLOGICAL SCIENCES, vol. 75, 2003, pages 378 - 392 *
ERLER B.S. ET AL.: "A Study of Hepatocellular Carcinoma Using Morphometric and Densitometric Image Analysis", AMERICAN JOURNAL OF CLINICAL PATHOLOGY, vol. 100, 1993, pages 151 - 157 *
ERLER B.S. ET AL.: "Methods in Laboratory Investigation: Image Analysis and Diagnostic Classification of Hepatocellular Carcinoma Using Neural Networks and Multivariate Discriminant Functions", LABORATORY INVESTIGATION, vol. 71, no. 3, 1994, pages 446 - 451 *

Also Published As

Publication number Publication date
WO2007103535A2 (fr) 2007-09-13

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