WO2007103523A3 - Antioxidant protein, compositions, and methods of use - Google Patents

Antioxidant protein, compositions, and methods of use Download PDF

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Publication number
WO2007103523A3
WO2007103523A3 PCT/US2007/005968 US2007005968W WO2007103523A3 WO 2007103523 A3 WO2007103523 A3 WO 2007103523A3 US 2007005968 W US2007005968 W US 2007005968W WO 2007103523 A3 WO2007103523 A3 WO 2007103523A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxidative stress
present
antioxidant protein
provides
antioxidant
Prior art date
Application number
PCT/US2007/005968
Other languages
French (fr)
Other versions
WO2007103523A2 (en
WO2007103523A9 (en
Inventor
Gary V Desir
Jianchao Xu
Original Assignee
Univ Yale
Gary V Desir
Jianchao Xu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale, Gary V Desir, Jianchao Xu filed Critical Univ Yale
Publication of WO2007103523A2 publication Critical patent/WO2007103523A2/en
Publication of WO2007103523A3 publication Critical patent/WO2007103523A3/en
Publication of WO2007103523A9 publication Critical patent/WO2007103523A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention provides a novel antioxidant protein (SAOP) comprising a MOCO Sulfurase C-terminal Domain (MOSC), which may be secreted and which has antioxidant activity, as demonstrated by its ability to protect cultured cells from oxidative stress, and by its ability to increase GSH concentration. The present invention also provides polynucleotides encoding the antioxidant protein, as well as vectors containing the polynucleotide under control of regulatory sequences, and corresponding host cells. The present invention also provides a composition comprising an effective amount of the antioxidant protein with a pharmaceutically acceptable carrier or excipient. The composition finds use in ameliorating oxidative stress in a mammal, and thus is useful for treating conditions characterized by or associated with oxidative stress. The present invention further provides an antibody or antigen-binding fragment that binds specifically to the antioxidant protein of the invention, which finds use in various diagnostic applications for oxidative stress.
PCT/US2007/005968 2006-03-08 2007-03-08 Antioxidant protein, compositions, and methods of use WO2007103523A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78032506P 2006-03-08 2006-03-08
US60/780,325 2006-03-08

Publications (3)

Publication Number Publication Date
WO2007103523A2 WO2007103523A2 (en) 2007-09-13
WO2007103523A3 true WO2007103523A3 (en) 2008-02-21
WO2007103523A9 WO2007103523A9 (en) 2008-04-10

Family

ID=38475572

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/005968 WO2007103523A2 (en) 2006-03-08 2007-03-08 Antioxidant protein, compositions, and methods of use

Country Status (1)

Country Link
WO (1) WO2007103523A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104059956B (en) * 2014-06-16 2018-04-10 西北民族大学 A kind of preparation method for hiding antioxidation polypeptide in sheep blood

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040034192A1 (en) * 2000-01-06 2004-02-19 Seishi Kato Human proteins having hyprophobic domains and dnas encoding these proteins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040034192A1 (en) * 2000-01-06 2004-02-19 Seishi Kato Human proteins having hyprophobic domains and dnas encoding these proteins

Also Published As

Publication number Publication date
WO2007103523A2 (en) 2007-09-13
WO2007103523A9 (en) 2008-04-10

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