WO2007100765A3 - Lysozyme-modified probiotic components and uses thereof - Google Patents

Lysozyme-modified probiotic components and uses thereof Download PDF

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Publication number
WO2007100765A3
WO2007100765A3 PCT/US2007/004925 US2007004925W WO2007100765A3 WO 2007100765 A3 WO2007100765 A3 WO 2007100765A3 US 2007004925 W US2007004925 W US 2007004925W WO 2007100765 A3 WO2007100765 A3 WO 2007100765A3
Authority
WO
WIPO (PCT)
Prior art keywords
lysozyme
modified probiotic
probiotic components
subject
methods
Prior art date
Application number
PCT/US2007/004925
Other languages
French (fr)
Other versions
WO2007100765A2 (en
Inventor
Xiao-Di Tan
Heng-Fu Bu
Xiao Wang
Original Assignee
Childrens Memorial Hospital
Xiao-Di Tan
Heng-Fu Bu
Xiao Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Memorial Hospital, Xiao-Di Tan, Heng-Fu Bu, Xiao Wang filed Critical Childrens Memorial Hospital
Publication of WO2007100765A2 publication Critical patent/WO2007100765A2/en
Publication of WO2007100765A3 publication Critical patent/WO2007100765A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06—Lysis of microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01017—Lysozyme (3.2.1.17)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to methods and compositions for treating sepsis in a subject in need thereof. The method comprises administering effective amounts of at least one lysozyme-modified probiotic component. Also provided are kits that find use in practicing the subject methods. The subject methods and compositions find use in a variety of different applications, including but not limited to the treatment of sepsis.
PCT/US2007/004925 2006-02-28 2007-02-27 Lysozyme-modified probiotic components and uses thereof WO2007100765A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77799106P 2006-02-28 2006-02-28
US60/777,991 2006-02-28

Publications (2)

Publication Number Publication Date
WO2007100765A2 WO2007100765A2 (en) 2007-09-07
WO2007100765A3 true WO2007100765A3 (en) 2007-11-22

Family

ID=38372324

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/004925 WO2007100765A2 (en) 2006-02-28 2007-02-27 Lysozyme-modified probiotic components and uses thereof

Country Status (1)

Country Link
WO (1) WO2007100765A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1403661B1 (en) 2011-01-28 2013-10-31 Probiotical Spa EFFERVESCENT COMPOSITION IN THE SOLID FORM FOR USE IN VAGINAL APPLICATIONS FOR THE TREATMENT OF VAGINAL INFECTIONS.
ITMI20110791A1 (en) 2011-05-09 2012-11-10 Probiotical Spa BACTERIA OF BACTERIA ABLE TO METABOLIZE THE OXALATES.
ITMI20110793A1 (en) 2011-05-09 2012-11-10 Probiotical Spa STRAINS OF PROBIOTIC BACTERIA AND SYNBIOTIC COMPOSITION CONTAINING THEMSELVES INTENDED FOR THE BABY FOOD.
ITMI20110792A1 (en) 2011-05-09 2012-11-10 Probiotical Spa STRAINS OF BACTERIA BELONGING TO THE BIFIDOBACTERIUM TYPE FOR USE IN THE TREATMENT OF HYPERCOLESTEROLEMIA.
ITRM20110477A1 (en) * 2011-09-09 2013-03-10 Giovanni Mogna COMPOSITION INCLUDING N-ACETYLCISTEIN AND / OR LYSOZYME MICROINCAPSULATE GASTROPROTECT IN ASSOCIATION WITH PROBIOTIC BACTERES ABLE TO RESTORE THE BARRIER EFFECT OF THE STOMACH THAT IS LOST DURING THE PHARMACOLOGICAL TREATMENT OF
ITRM20110475A1 (en) * 2011-09-09 2013-03-10 Probiotical Spa BACTERIA OF LACTIC AND / OR BIFIED BACTERIA BACTERIA, OPTIONALLY ADDED TO N-ACETYLCISTEIN AND / OR LYSOZYME MICROINCAPSULATE GASTROPROTETTO, HAVING INHIBITION ACTIVITIES / REDUCTION OF THE GROWTH OF DIFFERENT E.COLI BIOTYPES, INCLUDING E.COLI O157: H7 E
ITMI20111718A1 (en) 2011-09-23 2013-03-24 Probiotical Spa A WATERPROOF MOISTURE AND OXYGEN MATERIAL FOR PACKAGING DIETARY, COSMETIC AND MEDICINAL PRODUCTS.
ITMI20130793A1 (en) 2013-05-14 2014-11-15 Probiotical Spa COMPOSITION INCLUDING LACTIC BACTERIA FOR USE IN THE PREVENTIVE AND / OR CURATIVE TREATMENT OF THE RECURRENT CYCLES.

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0644265A1 (en) * 1993-09-16 1995-03-22 Kabushiki Kaisha Yakult Honsha Antitumor agent
JP2000095698A (en) * 1998-09-24 2000-04-04 Nichinichi Seiyaku Kk Remedy for rosacea
US20040096427A1 (en) * 2001-05-03 2004-05-20 Pinaki Panigrahi Oral gram(+) bacteria and glutamine composition for prevention and/or treatment of gastro-intestinal dysfunctions including inflammation in the gastro-intestinal tract, neonatal necrotizing enterocolitis (nec) and bacterial sepsis
UA69138A (en) * 2003-12-09 2004-08-16 O D Prolisok Ltd Liability Com Method for treating newborns with sepsis
WO2006046871A2 (en) * 2004-10-29 2006-05-04 N.V. Nutricia Peri-operative composition comprising lactobacillus rhamnosus

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0644265A1 (en) * 1993-09-16 1995-03-22 Kabushiki Kaisha Yakult Honsha Antitumor agent
JP2000095698A (en) * 1998-09-24 2000-04-04 Nichinichi Seiyaku Kk Remedy for rosacea
US20040096427A1 (en) * 2001-05-03 2004-05-20 Pinaki Panigrahi Oral gram(+) bacteria and glutamine composition for prevention and/or treatment of gastro-intestinal dysfunctions including inflammation in the gastro-intestinal tract, neonatal necrotizing enterocolitis (nec) and bacterial sepsis
UA69138A (en) * 2003-12-09 2004-08-16 O D Prolisok Ltd Liability Com Method for treating newborns with sepsis
WO2006046871A2 (en) * 2004-10-29 2006-05-04 N.V. Nutricia Peri-operative composition comprising lactobacillus rhamnosus

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 200027, Derwent World Patents Index; AN 1999-510919, XP002452780 *
HATCHER G E ET AL: "Augmentation of macrophase phagocytic activity by cell-free extracts of selected lactic acid-producing bacteria", JOURNAL OF DAIRY SCIENCE, AMERICAN DAIRY SCIENCE ASSOCIATION, SAVOY, IL, US, vol. 76, no. 9, 1993, pages 2485 - 2492, XP003007308, ISSN: 0022-0302 *
POPOVA POLY ET AL: "Stimulating effect of DEODAN (an oral preparation from Lactobacillus bulgaricus "LB51") on monocytes/macrophages and host resistance to experimental infections", INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, vol. 15, no. 1, 1993, pages 25 - 37, XP009089565, ISSN: 0192-0561 *

Also Published As

Publication number Publication date
WO2007100765A2 (en) 2007-09-07

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