WO2007097652A3 - Synthetic mannosylglycerate derivatives for the stabilisation and preservation of biomaterials - Google Patents

Synthetic mannosylglycerate derivatives for the stabilisation and preservation of biomaterials Download PDF

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Publication number
WO2007097652A3
WO2007097652A3 PCT/PT2007/000012 PT2007000012W WO2007097652A3 WO 2007097652 A3 WO2007097652 A3 WO 2007097652A3 PT 2007000012 W PT2007000012 W PT 2007000012W WO 2007097652 A3 WO2007097652 A3 WO 2007097652A3
Authority
WO
WIPO (PCT)
Prior art keywords
mannosylglycerate
derivatives
synthetic
biomaterials
stabilisation
Prior art date
Application number
PCT/PT2007/000012
Other languages
French (fr)
Other versions
WO2007097652A2 (en
Inventor
Helena Santos
Antonio Pedro Lamosa
Faria Tiago Quininha
Christopher David Maycock
Bordalo Ventura Centeno Mendes
Original Assignee
Stab Vida Investigacao E Servi
Helena Santos
Antonio Pedro Lamosa
Faria Tiago Quininha
Christopher David Maycock
Bordalo Ventura Centeno Mendes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stab Vida Investigacao E Servi, Helena Santos, Antonio Pedro Lamosa, Faria Tiago Quininha, Christopher David Maycock, Bordalo Ventura Centeno Mendes filed Critical Stab Vida Investigacao E Servi
Publication of WO2007097652A2 publication Critical patent/WO2007097652A2/en
Publication of WO2007097652A3 publication Critical patent/WO2007097652A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention consists in the utilization of synthetic mannosylglycerate derivatives, such as mannosyl-lactate or mannosylglicerate, or mixtures thereof alone or as constituents in a suitable formulation viewing the protection and/or stabilization of enzymes, proteins, antibodies, DNA or RNA molecules, biological membranes, liposomes, or other cellular components and biomaterials against aggressive conditions to the same.
PCT/PT2007/000012 2006-02-24 2007-02-23 Synthetic mannosylglycerate derivatives for the stabilisation and preservation of biomaterials WO2007097652A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT103442A PT103442A (en) 2006-02-24 2006-02-24 MANOSYL-GLYCERATE SYNTHETIC DERIVATIVES FOR THE STABILIZATION AND / OR PRESERVATION OF BIOMATERIALS
PT103442 2006-02-24

Publications (2)

Publication Number Publication Date
WO2007097652A2 WO2007097652A2 (en) 2007-08-30
WO2007097652A3 true WO2007097652A3 (en) 2008-03-06

Family

ID=38437804

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/PT2007/000012 WO2007097652A2 (en) 2006-02-24 2007-02-23 Synthetic mannosylglycerate derivatives for the stabilisation and preservation of biomaterials

Country Status (2)

Country Link
PT (1) PT103442A (en)
WO (1) WO2007097652A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7077361B2 (en) 2014-03-14 2022-05-30 ファクルダーデ・デ・シエンシャス・ダ・ユニバシダーデ・デ・リスボア Hexose derivatives, their formulations and uses

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104560946A (en) * 2013-10-10 2015-04-29 镇江拜因诺生物科技有限公司 Application of glycerolglycerate in PCR as synergist
CN104561107A (en) * 2013-10-16 2015-04-29 镇江拜因诺生物科技有限公司 Method for improving biogas yield through mannosyglycerate
CN104543378A (en) * 2013-10-16 2015-04-29 镇江拜因诺生物科技有限公司 Application of phytase stabilizer in feed processing
CA3082696A1 (en) 2017-11-13 2019-05-16 Extremochem, Lda. Neutral glycosylated amides and dianionic glucuronidated acids as stabilizers for biological molecules
CN111793664A (en) * 2020-06-19 2020-10-20 中国科学院天津工业生物技术研究所 Method for biologically preparing mannose glyceric acid
CN116251110A (en) * 2022-11-18 2023-06-13 广东药科大学 Application of beta-D-glucopyranosyl-lactic acid and derivatives thereof in preparation of medicines for treating metabolic diseases and inflammation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1125583A1 (en) * 2000-02-14 2001-08-22 Bitop Gesellschaft für biotechnische Optimierung MbH Use of compatible solutes as inhibitors of the enzymatic degradation of macromolecular biopolymers
WO2001076572A2 (en) * 2000-04-12 2001-10-18 bitop Aktiengesellschaft für biotechnische Optimierung Use of compatible solutes as substances having free radical scavenging properties
WO2002049668A1 (en) * 2000-12-21 2002-06-27 Bitop Gesellschaft Für Biotechnische Optimierung Mbh Use of compatible solutes as adjuvants for vaccines
EP0816509B1 (en) * 1996-06-28 2003-09-17 bitop Aktiengesellschaft für biotechnische Optimierung Thermostabilization, osmoprotection, and protection against desiccation of enzymes, cell components and cells by mannosyl-glycerate

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0816509B1 (en) * 1996-06-28 2003-09-17 bitop Aktiengesellschaft für biotechnische Optimierung Thermostabilization, osmoprotection, and protection against desiccation of enzymes, cell components and cells by mannosyl-glycerate
EP1125583A1 (en) * 2000-02-14 2001-08-22 Bitop Gesellschaft für biotechnische Optimierung MbH Use of compatible solutes as inhibitors of the enzymatic degradation of macromolecular biopolymers
WO2001076572A2 (en) * 2000-04-12 2001-10-18 bitop Aktiengesellschaft für biotechnische Optimierung Use of compatible solutes as substances having free radical scavenging properties
WO2002049668A1 (en) * 2000-12-21 2002-06-27 Bitop Gesellschaft Für Biotechnische Optimierung Mbh Use of compatible solutes as adjuvants for vaccines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GEORG LENTZEN ET AL: "Extremolytes: natural compounds from extremophiles for versatile applications", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER-VERLAG, BE, vol. 72, no. 4, 7 September 2006 (2006-09-07), pages 623 - 634, XP019441731, ISSN: 1432-0614 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7077361B2 (en) 2014-03-14 2022-05-30 ファクルダーデ・デ・シエンシャス・ダ・ユニバシダーデ・デ・リスボア Hexose derivatives, their formulations and uses

Also Published As

Publication number Publication date
PT103442A (en) 2007-08-31
WO2007097652A2 (en) 2007-08-30

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