WO2007095389A3 - Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs - Google Patents

Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs Download PDF

Info

Publication number
WO2007095389A3
WO2007095389A3 PCT/US2007/004253 US2007004253W WO2007095389A3 WO 2007095389 A3 WO2007095389 A3 WO 2007095389A3 US 2007004253 W US2007004253 W US 2007004253W WO 2007095389 A3 WO2007095389 A3 WO 2007095389A3
Authority
WO
WIPO (PCT)
Prior art keywords
analogs
oxides
camptothecine
oxide
treatment
Prior art date
Application number
PCT/US2007/004253
Other languages
French (fr)
Other versions
WO2007095389A2 (en
Inventor
John G Curd
John F W Keana
Alshad S Lalani
Paul B Westberg
Bradford S Goodwin
Original Assignee
Novacea Inc
John G Curd
John F W Keana
Alshad S Lalani
Paul B Westberg
Bradford S Goodwin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novacea Inc, John G Curd, John F W Keana, Alshad S Lalani, Paul B Westberg, Bradford S Goodwin filed Critical Novacea Inc
Publication of WO2007095389A2 publication Critical patent/WO2007095389A2/en
Publication of WO2007095389A3 publication Critical patent/WO2007095389A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention relates to N-oxides of camptothecin analogs having activity for treating hyperproliferative disorders. Pharmaceutical compositions comprising therapeutically effective amount of camptothecin analog N-oxides and bis N-oxides, or a pharmaceutically acceptable salt or prodrug thereof, are disclosed. Further, the invention relates to methods of using the compounds, alone or in combination with one or more other active agents or treatments, to treat hyperproliferative disorders.
PCT/US2007/004253 2006-02-17 2007-02-20 Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs WO2007095389A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77423506P 2006-02-17 2006-02-17
US60/774,235 2006-02-17

Publications (2)

Publication Number Publication Date
WO2007095389A2 WO2007095389A2 (en) 2007-08-23
WO2007095389A3 true WO2007095389A3 (en) 2009-02-19

Family

ID=38372166

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/004253 WO2007095389A2 (en) 2006-02-17 2007-02-20 Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs

Country Status (1)

Country Link
WO (1) WO2007095389A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011064152A1 (en) * 2009-11-26 2011-06-03 Universität Bern Verwaltungsdirektion Inhibitors of topoisomerase i for the treatment of autoimmune diseases
CN102477042A (en) * 2010-11-26 2012-05-30 复旦大学 10-hydroxyamptothecin derivative, and its preparation method and application
CN102850400A (en) 2011-06-30 2013-01-02 周文强 Camptothecin derivative, and preparation method, pharmaceutical composition and use thereof
KR101371354B1 (en) 2012-02-29 2014-03-10 한국식품연구원 Composition for prevention and treatment of obesity or metabolic diseases comprising 10-hydroxycamptothecin
CN103113381B (en) * 2013-02-26 2014-12-10 大连理工大学 Serial water-soluble hydroxycamptothecine naphthenic amino alcohol derivative and preparation method and use thereof
US20160375042A1 (en) * 2014-01-28 2016-12-29 Wenqiang Zhou Use of camptothecin derivative in preparing pharmaceutical used for treating multiple myeloma
CN106588946B (en) * 2017-01-25 2019-01-22 郑州大学 10-hydroxycamptothecine derivative, synthetic method and its application
CA3111403A1 (en) * 2018-09-17 2020-03-26 Canget Biotekpharma Matter of composition, synthesis, formulation and application of fl118 platform positions 7 and 9-derived analogues for treatment of human disease
CN109575044A (en) * 2018-12-21 2019-04-05 西安交通大学 2-(camptothecine -10- oxygroup) acetamides and application
WO2021173773A1 (en) 2020-02-25 2021-09-02 Mediboston, Inc. Camptothecin derivatives and conjugates thereof
CN113880855A (en) * 2021-09-02 2022-01-04 兰州大学 Preparation of 9-fluoro camptothecin derivative and application of 9-fluoro camptothecin derivative in anti-tumor aspect
CN117599058A (en) * 2023-03-09 2024-02-27 兰州大学 Application of camptothecine derivatives in preparation of medicines for treating bladder cancer
CN116444542A (en) * 2023-03-31 2023-07-18 广州医科大学 Thiophene-phenothiazine compound, synthesis method thereof and application thereof in preparation of phototherapy drugs

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513138A (en) * 1981-09-04 1985-04-23 Kabushiki Kaisha Yakult Honsha Camptothecin-1-oxide derivatives
US6306868B1 (en) * 1996-02-23 2001-10-23 Istituto Nazionale Per Lo Studio E La Cura Dei Tumori Methods for inhibiting the growth of tumors with 7-substituted camptothecin derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513138A (en) * 1981-09-04 1985-04-23 Kabushiki Kaisha Yakult Honsha Camptothecin-1-oxide derivatives
US6306868B1 (en) * 1996-02-23 2001-10-23 Istituto Nazionale Per Lo Studio E La Cura Dei Tumori Methods for inhibiting the growth of tumors with 7-substituted camptothecin derivatives

Also Published As

Publication number Publication date
WO2007095389A2 (en) 2007-08-23

Similar Documents

Publication Publication Date Title
WO2007095389A3 (en) Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs
WO2007098091A3 (en) Treatment of hyperproliferative diseases with vinca alkaloid n-oxide and analogs
WO2007098089A3 (en) Treatment of hyperproliferative diseases with methotrexate n-oxide and analogs
WO2010150995A3 (en) Compositions for treating drug addiction and improving addiction-related behavior
WO2011014255A8 (en) Treatment of crohn's disease with laquinimod
EP2562177A3 (en) Transdermally deliverable buprenorphine prodrugs and abuse-resistant compositions thereof
WO2006098603A3 (en) Composition comprising isoorientin for suppressing histamine
TN2009000137A1 (en) Substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
WO2007100675A3 (en) Collagenase for treating cellulite
WO2005070930A3 (en) Tetrahydrocarboline compounds as anticancer agents
TW200621730A (en) Chemical compounds
WO2005115432A3 (en) Treatment of ocular diseases and disorders using lantibiotic compositions
MX2010005631A (en) Novel cyclic hydrocarbon compounds for the treatment of diseases.
WO2008011174A3 (en) Jak inhibitors for treatment of myeloproliferative disorders
WO2007112000A3 (en) Treatment of pain
WO2005092009A3 (en) Acetylcholinesterase inhibitors and n-methyl-d-aspartate antagonists useful in the treatment of cognitive disorders
WO2007062093A3 (en) Combination therapy for the treatment of cancer comprising a metalloprotease inhibitor
WO2009091550A8 (en) Sulfone substituted 2,3-dihydroimidazo [1,2-c] quinazoline derivatives useful for treating hyper-proliferative disorders and diseases with angiogenesis
WO2008002514A3 (en) Combination cough treatment compounds and method of treating common coughs
WO2007121088A3 (en) Combinations of therapeutic agents for treating cancer
WO2007123511A3 (en) Dosing regimens for the treatment of cancer
WO2006086693A3 (en) Medical devices
WO2006002096A3 (en) Low doses of l-citrulline for treating diseases
WO2013085849A3 (en) Sulfate esters of noribogaine
WO2007095056A3 (en) Slow intraventricular delivery

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07751042

Country of ref document: EP

Kind code of ref document: A2