WO2007095389A3 - Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs - Google Patents

Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs Download PDF

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Publication number
WO2007095389A3
WO2007095389A3 PCT/US2007/004253 US2007004253W WO2007095389A3 WO 2007095389 A3 WO2007095389 A3 WO 2007095389A3 US 2007004253 W US2007004253 W US 2007004253W WO 2007095389 A3 WO2007095389 A3 WO 2007095389A3
Authority
WO
WIPO (PCT)
Prior art keywords
analogs
oxides
camptothecine
oxide
treatment
Prior art date
Application number
PCT/US2007/004253
Other languages
French (fr)
Other versions
WO2007095389A2 (en
Inventor
John G Curd
John F W Keana
Alshad S Lalani
Paul B Westberg
Bradford S Goodwin
Original Assignee
Novacea Inc
John G Curd
John F W Keana
Alshad S Lalani
Paul B Westberg
Bradford S Goodwin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novacea Inc, John G Curd, John F W Keana, Alshad S Lalani, Paul B Westberg, Bradford S Goodwin filed Critical Novacea Inc
Publication of WO2007095389A2 publication Critical patent/WO2007095389A2/en
Publication of WO2007095389A3 publication Critical patent/WO2007095389A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention relates to N-oxides of camptothecin analogs having activity for treating hyperproliferative disorders. Pharmaceutical compositions comprising therapeutically effective amount of camptothecin analog N-oxides and bis N-oxides, or a pharmaceutically acceptable salt or prodrug thereof, are disclosed. Further, the invention relates to methods of using the compounds, alone or in combination with one or more other active agents or treatments, to treat hyperproliferative disorders.
PCT/US2007/004253 2006-02-17 2007-02-20 Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs WO2007095389A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77423506P 2006-02-17 2006-02-17
US60/774,235 2006-02-17

Publications (2)

Publication Number Publication Date
WO2007095389A2 WO2007095389A2 (en) 2007-08-23
WO2007095389A3 true WO2007095389A3 (en) 2009-02-19

Family

ID=38372166

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/004253 WO2007095389A2 (en) 2006-02-17 2007-02-20 Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs

Country Status (1)

Country Link
WO (1) WO2007095389A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011064152A1 (en) * 2009-11-26 2011-06-03 Universität Bern Verwaltungsdirektion Inhibitors of topoisomerase i for the treatment of autoimmune diseases
CN102477042A (en) * 2010-11-26 2012-05-30 复旦大学 10-hydroxyamptothecin derivative, and its preparation method and application
CN102850400A (en) 2011-06-30 2013-01-02 周文强 Camptothecin derivative, and preparation method, pharmaceutical composition and use thereof
KR101371354B1 (en) 2012-02-29 2014-03-10 한국식품연구원 Composition for prevention and treatment of obesity or metabolic diseases comprising 10-hydroxycamptothecin
CN103113381B (en) * 2013-02-26 2014-12-10 大连理工大学 Serial water-soluble hydroxycamptothecine naphthenic amino alcohol derivative and preparation method and use thereof
EP3100734A4 (en) * 2014-01-28 2017-08-09 Zhou, Wenqiang Use of camptothecin derivative in preparing pharmaceutical used for treating multiple myeloma
CN106588946B (en) * 2017-01-25 2019-01-22 郑州大学 10-hydroxycamptothecine derivative, synthetic method and its application
WO2020061106A2 (en) * 2018-09-17 2020-03-26 Canget Biotekpharma Matter of composition, synthesis, formulation and application of fl118 platform positions 7 and 9-derived analogues for treatment of human disease
CN109575044A (en) * 2018-12-21 2019-04-05 西安交通大学 2-(camptothecine -10- oxygroup) acetamides and application
CA3168882A1 (en) 2020-02-25 2021-09-02 Mediboston, Inc. Camptothecin derivatives and conjugates thereof
CN113880855A (en) * 2021-09-02 2022-01-04 兰州大学 Preparation of 9-fluoro camptothecin derivative and application of 9-fluoro camptothecin derivative in anti-tumor aspect
CN117599058A (en) * 2023-03-09 2024-02-27 兰州大学 Application of camptothecine derivatives in preparation of medicines for treating bladder cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513138A (en) * 1981-09-04 1985-04-23 Kabushiki Kaisha Yakult Honsha Camptothecin-1-oxide derivatives
US6306868B1 (en) * 1996-02-23 2001-10-23 Istituto Nazionale Per Lo Studio E La Cura Dei Tumori Methods for inhibiting the growth of tumors with 7-substituted camptothecin derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513138A (en) * 1981-09-04 1985-04-23 Kabushiki Kaisha Yakult Honsha Camptothecin-1-oxide derivatives
US6306868B1 (en) * 1996-02-23 2001-10-23 Istituto Nazionale Per Lo Studio E La Cura Dei Tumori Methods for inhibiting the growth of tumors with 7-substituted camptothecin derivatives

Also Published As

Publication number Publication date
WO2007095389A2 (en) 2007-08-23

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