WO2007092558A2 - Sulfonamide derivatives to treat infection with hepatitis c virus - Google Patents
Sulfonamide derivatives to treat infection with hepatitis c virus Download PDFInfo
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- WO2007092558A2 WO2007092558A2 PCT/US2007/003369 US2007003369W WO2007092558A2 WO 2007092558 A2 WO2007092558 A2 WO 2007092558A2 US 2007003369 W US2007003369 W US 2007003369W WO 2007092558 A2 WO2007092558 A2 WO 2007092558A2
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- WIPO (PCT)
- Prior art keywords
- sulfonyl
- hydroxyphenyl
- compound
- proline
- chloro
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- 0 C*(CC1*)*CN1S(C)(=O)=O Chemical compound C*(CC1*)*CN1S(C)(=O)=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Definitions
- a series of sulfonamide compounds are effective pharmaceuticals for the treatment of hepatitis C infection.
- Hepatitis C is a common infection that can lead to chronic hepatitis, cirrhosis, liver failure, and hepatocellular carcinoma.
- Infection with the hepatitis C virus (HCV) leads to chronic hepatitis in at least 85% of cases, is the leading reason for liver transplantation, and is responsible for at least 10,000 deaths annually in the United States (Hepatology, 1997, 26 (Suppl. 1), 2S-10S).
- HCV hepatitis C virus
- the hepatitis C virus is a member of the Flaviviridae family, and the genome of HCV is a single-stranded linear RNA of positive sense (Hepatology, 1997, 26 (Suppl. 1), 11S-14S). HCV displays extensive genetic heterogeneity; at least 6 genotypes and more than 50 subtypes have been identified.
- the HCV genome contains a number of non-structural proteins: NS2,
- NS5B is an RNA-dependent RNA polymerase that is essential for viral replication. Therefore, the inhibition of NS5B is a suitable target for the development of therapeutic agents.
- U.S. Patent No. 3,506,646 relates to compounds that are derivatives of 6- aminosulfonyl compounds, in particular 1,2,5-benzothiadiazepine 1,1 -dioxides with fused heterocycles, the intermediates used to synthesize them, and their use as diuretic and hypotensive agents.
- WO 98/08815 relates to substituted cyclic amine metalloprotease inhibitors.
- PBTDs [1,2-b] [l,2,5]benzothiadiazepines
- WO 03/043985 describes sulfonamides as peroxisome proliferator- activated receptor agonists.
- WO 02/02554 describes sulfonyl-pyrrolidine derivatives useful for the treatment of neurological disorders.
- This invention relates to a series of sulfonamide derivatives, processes for their preparation, pharmaceutical compositions containing them, and their use in therapy.
- the compounds are believed to be useful in the treatment of hepatitis C by virtue of their ability to inhibit hepatitis C polymerase (NS5B).
- NS5B hepatitis C polymerase
- R 1 is H, -COOH, -CO 2 R 4 , cyano, tetrazole, a straight chain alkyl of 1 to 6 carbon atoms optionally substituted with OH, amine or -COOH, an optionally substituted -C(O)-Cj -C 12 -alkyl, or an optionally substituted -C(O)- C 6 -Ci 2 -aryl, wherein R 4 is a Ci -C 12 -alkyl, C 6 -Ci 2 -aryl, C 3 -Ci 2 -cycloalkyl, or C 2 -Cg-heteroaryl, any of which may be optionally substituted;
- R 2 is an aryl or a heteroaryl group optionally substituted with one to five substituents selected from the group consisting of halogen, -NO 2 , -CN, -N 3 ,
- R 3 is H, an alkyl of 1-6 carbon atoms, a branched alkyl of 1-8 carbon atoms, a cycloalkyl of 3 to 6 carbon atoms, phenyl, a C 2 -C 9 -heteroaryl, an alkenyl of 2-6 carbon atoms, or an alkynyl of 2-6 carbon atoms;
- X is CH 2 , CHOR 3 , or S
- n 1 or 2;
- A is CH 3 -, CH 3 CH 2 - or a haloalkyl of 1 to 2 carbon atoms
- B is a halogen
- Ri is H, -COOH, -CN 3 tetrazole, -C(O)R 4 , or a hydroxyalkyl of 1 to 4 carbon atoms, wherein R 4 is an alkyl of 1 to 4 carbon atoms or an optionally substituted phenyl;
- R 5 is H, OH Or-OCH 3 ;
- Xi-X 5 are independently H, a halogen, OH, NH 2 , an alkyl of 1 to 4 carbon atoms, -NH-C(O)-R 3 , wherein R 3 is an alkyl of 1 to 4 carbon atoms, a C ⁇ -
- Ci 2 -aryl a cycloalkyl of 3 to 6 carbon atoms, or a Cj-Cjj-heteroaryl;
- R is H, -COOH, -CN, tetrazole, -C(O)R 4 , or a hydroxyalkyl of 1 to 4 carbon atoms, wherein R 4 is an alkyl of 1 to 4 carbon atoms or an optionally substituted phenyl; and
- Xi-X 5 are independently H, a halogen, OH, NH 2 , an alkyl of 1 to 4 carbon atoms, -NH-C(O)R 3 , wherein R 3 is an alkyl of 1 to 4 carbon atoms, a Ce-
- Ci 2 -aryl a cycloalkyl of 3 to 6 carbon atoms, or a C 2 -C 9 -heteroaryl
- R is H, -COOH, -CN, tetrazole, -C(O)R 4 , or a hydroxyalkyl of 1 to 4 carbon atoms, wherein R 4 is an alkyl of 1 to 4 carbon atoms or an optionally substituted phenyl; and
- X 1 to X 5 are independently H, a halogen, OH, NH 2 , an alkyl of 1 to 4 carbon atoms, -NH-C(O)R 3 , wherein R 3 is an alkyl of 1 to 4 carbon atoms, a C ⁇ > -
- Ci2-aryl a cycloalkyl of 3 to 6 carbon atoms, or a C 2 -C 9 -heteroaryl
- the present invention is also directed to pharmaceutical compositions comprising a compound of the present invention and a pharmaceutically acceptable carrier.
- the present invention also includes methods of treating or preventing a hepatitis C infection in humans, comprising administering an effective amount of a compound of formula (Ia):
- Ri is H, -COOH, -CO 2 R 4 , cyano, tetrazole, a straight chain alkyl of 1 to 6 carbon atoms optionally substituted with OH, amine, or -COOH, an optionally substituted -C(O)-Ci -C 12 -alkyl, or an optionally substituted -C(O)-Cr,-Ci2-aryl, wherein R 4 is a Ci-Ci 2 -alkyl 5 C ⁇ -Cn-aryl, C3-Ci2-cycloalkyl, or C 2 -Cc > -heteroaryl; [0047] R 2 is a C 6 -C )2 -aryl or a C 2 -Cg-heteroaryl group optionally substituted with one to five substituents selected from the group consisting of halogen, -NO 2 ,
- R 3 is H, an alkyl of 1-6 carbon atoms, a branched alkyl of 1-8 carbon atoms, a cycloalkyl of 3 to 6 carbon atoms, phenyl, a C 2 -C 9 -heteroaryl, an alkenyl of 2-6 carbon atoms, or an alkynyl of 2-6 carbon atoms;
- X is CH 2 , CHOR 3 , or S
- n 1 or 2;
- alkyl includes straight chain moieties with a length of up to 12 carbon atoms, but preferably 1 to 6 carbon atoms, and more preferably 1 to 4 carbons.
- alkyl also includes branched moieties of 3 to 12 carbon atoms, but preferably 1 to 8 carbon atoms.
- alkenyl refers to a radical aliphatic hydrocarbon containing one double bond and includes both straight and branched alkenyl moieties of 2 to 7 carbon atoms. Such alkenyl moieties may exist in the E or Z configurations; the compounds of this invention include both configurations.
- alkynyl includes both straight chain and branched moieties containing 2 to 7 carbon atoms having at least one triple bond.
- cycloalkyl refers to alicyclic hydrocarbon groups having 3 to 12 carbon atoms and includes but is not limited to: cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, norbornyl, or adamantyl.
- cycloalkyl groups are 3 to 6 carbon atoms.
- aryl is defined as an aromatic hydrocarbon moiety having at least one aromatic ring, is mono-, bi- or tri-cyclic, and may be substituted or unsubstituted.
- An aryl group may be selected from but is not limited to: phenyl, ⁇ -naphthyl, ⁇ -naphthyl, biphenyl, anthryl, tetrahydronaphthyl, phenanthryl, fluorenyl, indanyl, biphenylenyl, acenaphthenyl, acenaphthylenyl, or phenanthrenyl.
- An aryl group may be optionally substituted with substituents selected from, but not limited to, the group consisting of alkyl, haloalkyl, acyl, alkoxycarbonyl, alkoxy, haloalkoxy, alkoxyalkyl, alkoxyalkoxy, cyano, halogen, hydroxy, nitro, trifluoromethyl, trifluoromethoxy, trifluoropropyl, amino, alkylamino, dialkylamino, dialkylaminoalkyl, hydroxyalkyl, alkoxyalkyl, alkylthio, mercapto, haloalkylthio, aryl, aryloxy, arylthio, heterocycloalkoxy, heterocycloalkylthio, -SO 3 H, -SO 2 NH 2 , -O 2 NHalkyl, -SO 2 N(alkyl) 2 , -CO 2 H, CO 2 NH 2 , CO 2 NHalky
- Preferred substituents for aryl and heterocyc ' loalkyl include: alkyl, halogen, amino, alkylamino, dialkylamino, trifluoromethyl, trifluoromethoxy, arylalkyl, and alkylaryl.
- an aryl group consists of 6 to 12 carbon atoms, though phenyl is the most preferred moiety.
- heteroaryl is defined as: (1) an aromatic heterocyclic ring system (monocyclic or bicyclic) where the heteroaryl moieties are selected from furan, thiophene, indole, azaindole, oxazole, thiazole, isoxazole, isothiazole, imidazole, N-methylimidazole, pyridine, pyrimidine, pyrazine, pyrrole, N-methylpyrrole, pyrazole, N-methylpyrazole, 1,3,4- oxadiazole, 1 ,2,4-triazole, 1 -methyl- 1 ,2,4-triazole, lH-tetrazole, 1- methyltetrazole, benzoxazole, benzothiazole, benzofuran, benzisoxazole, benzimidazole, N-methylbenzimidazole, azabenzimidazole, ind
- hydroxyalkyl is defined as an alkyl, as defined above, substituted with a hydroxy! group.
- the compounds of this invention may contain an asymmetric carbon atom and one or more asymmetric centers, and may thus give rise to optical isomers and diastereomers. While shown without respect to stereochemistry in formulas (I), (II), (III), and (IV), the present invention includes all optical isomers and diastereomers, racemic and resolved, enantiomerically pure R and S stereoisomers, and other mixtures of the R and S stereoisomers and pharmaceutically acceptable salts thereof.
- alkali metal salts such as sodium, lithium, and potassium
- N-tetraalkylammonium salts such as N-tetrabutylammonium salts.
- salts can be formed from organic and inorganic acids.
- salts can be formed from acetic, propionic, lactic, citric, tartaric, succinic, fumaric, maleic, malonic, mandelic, malic, phthalic, hydrochloric, hydrobromic, phosphoric, nitric, sulfuric, methanesulfonic, napthalenesulfonic, benzenesulfonic, toluenesulfonic, camphorsulfonic, and similarly known acceptable acids.
- a preferred embodiment of the compounds of formula (I) is wherein X is
- Another preferred embodiment of the compounds of formula (I) is wherein X is CH 2 OR 3 and R 3 is H or CH 3 , especially where n is 1.
- R is H, -COOH, -CN, tetrazole, -CH 2 OH, -C(O)-CH 3 or -C(O)-phenyl, but even more preferred is where Ri is -COOH.
- R 2 is optionally substituted phenyl, especially where the phenyl ring is substituted by at least one substituent selected from OH, halogen, Ci-Ci2-alkyl, amino, and -
- a preferred embodiment of the compounds of formula (II) is wherein R 5 is H, OH, Or-OCH 3 .
- Another preferred embodiment of the compounds of formula (II) is wherein R 1 is -COOH.
- Yet another preferred embodiment of the compounds of formula (II) is wherein at least one of X r X 5 is OH or -NH-C(O)-R 3 .
- a preferred embodiment of the compounds of formula (III) is wherein Ri is -COOH.
- XrXs are independently selected from H, NH 2 , OH, halogen and alkyl, especially where at least one OfXpX 5 is OH.
- a preferred embodiment of the compounds of formula (IV) is wherein Ri is -COOH or H.
- X 1 -X 5 are independently selected from H, halogen, NH 2 , alkyl and OH.
- Preferred compounds of the present invention include:
- compositions of the present invention inhibit the hepatitis C RNA-dependent RNA polymerase NS5B, and are therefore useful for the treatment of hepatitis C infection.
- the present invention accordingly provides a pharmaceutical composition that comprises a compound selected from formulas (I), (II), (III) and (IV) in combination or association with a pharmaceutically acceptable carrier.
- the compositions are preferably adapted for oral or subcutaneous administration. However, they may be adapted for other modes of administration.
- a composition of the invention is in the form of a unit dose. Suitable unit dose forms include tablets, capsules and powders in sachets or vials.
- Such unit dose forms may contain from 0.1 to 100 mg of a compound of the invention, and preferably from 2 to 50 mg. Still further preferred unit dosage forms contain 5 to 25 mg of a compound of the present invention.
- the compounds of the present invention can be administered orally at a dose range of about 0.01 to 100 mg/kg, or preferably at a dose range of 0.1 to 10 mg/kg.
- Such compositions may be administered from ] to 6 times a day, more usually from 1 to 4 times a day.
- the compositions of the invention may be formulated with conventional excipients, such as a filler, a disintegrating agent, a binder, a lubricant, a flavoring agent and the like.
- the present invention further provides a compound of the invention for use as an active therapeutic substance.
- Compounds of formulas (Ia), (II), (III), and (TV) are of particular use for the treatment of infection with hepatitis C virus.
- the present invention further provides a method of treating hepatitis C infection in humans, which comprises administering to the infected individual an effective amount of a compound of formulas (Ia), (II), (III), and (IV) or a pharmaceutical composition of the invention.
- Reagents (a) EDCI, HOBT, DIEA, DMF, RT, 6h; (b) 20% piperidine in DMF,
- Scheme 1 shows how compounds of formula (I) can be prepared on a solid support using a resin, for example Wang resin.
- the Fmoc protected amino acid of interest 2 was attached to the resin using coupling agents, for example EDCI, HOBT in the presence of a base, and DIEA in a polar solvent.
- DMF may be used as the polar solvent, but one skilled in the art would be aware of other appropriate solvents. After washing the excess reagents and solvent, the amino acid attached to the resin was deprotected using base in DMF.
- Appropriate bases include alkylamine bases, for example piperidine, but skilled artisans would be aware of other possible bases to use.
- the free amino acid was reacted with the sulfonyl chloride of interest 5 in a solvent such as pyridine.
- a deprotection step was employed before cleaving the product from the resin using trifluoroacetic acid and DCM.
- One skilled in the art would of be aware of the possible protecting groups that can be used to protect various functional groups from the acidic cleavage conditions.
- (2S)-l-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]pyrrolidine-2-carbonitrile [0079] A mixture of (2S)-pyrolidine-2-carbonitrile hydrochloride (34mg, 0.2 mmol) and 3,5-dichloro-2-hydroxy-benzenesulfonyl chloride (57mg, 0.22mmol) in 2 mL of CHjCVpyridine (1:1) was stirred at room temperature for 16 hours.
- Example 23 was prepared following the same procedure described for Example 2, except pyrolidine was substituted for (2S)- ⁇ yrolidine-2-carbonitrile hydrochloride.
- Step 1 To a solution of L-proline methyl ester hydrochloride (8.24 g;
- Step 2 The ester from step 1 was taken up in ethanol (175 mL) and 1 N sodium hydroxide was added and stirred overnight. The reaction mixture was then concentrated, diluted with water and extracted with ethyl acetate. The aqueous layer was acidified with 2N HCl to yield the desired compound as white solid (7.3 g; 89%). mp 107.4 0 C; IH NMR (CDC13) ⁇ 7.6 (d, IH) 5 7.5 (d, IH), 4.5 (dd, IH), 3.4(m, 2H) 5 2.3 (m, 2H), 2.0 (m, 2H); MS (ESI) m/z 337.82;
- Examples 3-10, 12-17, 18-19, 20-22, 24-58 were prepared in solid phase as described below for Example 20, using appropriately protected amino acids and sulfonyl chlorides, as shown in Scheme 1.
- Example 20 l-[(2-amino-5-chloro-4-methylphenyl)sulfonyl]-L-proline [0084] Step 1. 5-Chloro-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl- benzenesulfonic acid. To a solution of 5-Chloro-2-amino-4-methyl- benzenesulfonic acid (3.3 g; 15.13 mmol) in water (40 mL) and sodium bicarbonate (2.8 g) was added a solution of 9-fluorenylmethoxycarbonyl chloride (4.3 g; 16.7 mmol) in dioxane (40 mL) at 0 0 C.
- Step 4 Deprotection of Fmoc Group.
- the resin (5.5 mmol), prepared as described in step 1 above, was treated with a solution of 20% piperidine in DMF (2 x 50 ml, 10 min for the first time and 30 min for the second time) to remove the Fmoc protecting group from the resin.
- the mixture was filtered and the resin was washed with DMF (3 x 50 ml), MeOH (3 x 50ml), and CH 2 Cl 2 (3 x 50ml).
- Step 5 Reaction with (4-Chloro-2-chlorosulfonyl-5-methyl-phenyl)- carbamic acid 9H-fluoren-9-ylmethyl ester.
- the resin (5.5 mmol) obtained from step 5 was reacted again with a solution of 20% piperidine in DMF (2 x 50 ml, 10 min for the first time and 30 min for the second time). The mixture was filtered and the resin was washed with DMF (3 x 50 ml), MeOH (3 x 50ml), CH 2 Cl 2 (3 x 50 ml), and dried.
- Step 7 Cleavage from resin.
- the above resin was treated with 1:1 TFAiCH 2 Cl 2 (50ml) and was shaken at room temperature for 4 h. The mixture was filtered and the resin was washed with CH 2 Cl 2 (3 x 10ml). The combined CH 2 Cl 2 was concentrated and purified by HPLC.
- 1 H NMR (DMSO-d6) ⁇ 7.4 (s 3 IH), 6.8 (s, IH), 6.3 (s, 2H) 3 4.3 (m, IH), 3.2 (t, 2H), 2.2 (s, 3H), 2.1 (m, IH), 1.9 (m, IH), 1.65-1.8 (m, 2H).
- HRMS calcd for Ci 2 Hi 5 ClN 2 O 4 S 3 319.05139; found (ESI-FTMS, [M+H]), 319.05179.
- NS5B from the BK strain (Ib subtype) is expressed in E. coli as a protein in which the 21 C-terminal amino acids are replaced with a short linker and a hexahistidine tag (GSHHHHHH).
- the purified protein is mixed with radioactive nucleotides and allowed to replicate a heteropolymeric RNA substrate, primed by an endogenous short hairpin, resulting in an approximately 760 nt product.
- the radioactive product is captured on a filter and quantitated after removal of the unincorporated nucleotides.
- Millipore Multiscreen liner for use in MicroBeta 1450-106 cassette (Wallac)
- RNAse-free water (GIBCO-BRL #10977-023)
- RNA Spin down a tube of RNA (5 ⁇ g/tube stored in 75% ethanol and 0.3 M sodium acetate) in a microcentrifuge for 20 min. at 4 0 C.
- RNA remove as much ethanol from the tube as possible by inverting the tube. Be gentle, pellet RNA may not adhere to the tube. Vacuum dry the RNA.
- Resuspend the RNA by adding 1 ml of DEPC water, close the cap of the tube tightly.
- To dissolve RNA incubate RNA solution on ice for -60 min. and gently vortex. Spin briefly to ensure all RNA solution is down to the bottom of the tube before opening cap. Gently transfer RNA solution into a 5 ml or larger tube. Add another 3 ml of DEPC water (total 4 ml of volume).
- step (8) Repeat step (8) three more times.
- Percent inhibition is calculated after background subtraction as a percent reduction of activity relative to the positive control (average value of the plate excluding the negative controls). For the primary screen hits were chosen as showing >75 % inhibition.
- Table 2 shows the in vitro inhibitory activity for the compounds of the present invention towards HCV polymerase.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07763134A EP1981845A2 (en) | 2006-02-08 | 2007-02-08 | Sulfonamide derivatives to treat infection with hepatitis c virus |
AU2007212293A AU2007212293A1 (en) | 2006-02-08 | 2007-02-08 | Sulfonamide derivatives to treat infection with hepatitis C virus |
BRPI0707558-8A BRPI0707558A2 (en) | 2006-02-08 | 2007-02-08 | compound and all crystalline forms and pharmaceutically acceptable salts thereof, pharmaceutical composition, and method for treating or preventing a hepatitis c infection in humans |
CA002640229A CA2640229A1 (en) | 2006-02-08 | 2007-02-08 | Sulfonamide derivatives to treat infection with hepatitis c virus |
JP2008554337A JP2009526065A (en) | 2006-02-08 | 2007-02-08 | Sulfonamide derivatives for treating infection with hepatitis C virus |
Applications Claiming Priority (2)
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US77190406P | 2006-02-08 | 2006-02-08 | |
US60/771,904 | 2006-02-08 |
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WO2007092558A2 true WO2007092558A2 (en) | 2007-08-16 |
WO2007092558A3 WO2007092558A3 (en) | 2007-12-27 |
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PCT/US2007/003369 WO2007092558A2 (en) | 2006-02-08 | 2007-02-08 | Sulfonamide derivatives to treat infection with hepatitis c virus |
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US (1) | US20070225344A1 (en) |
EP (1) | EP1981845A2 (en) |
JP (1) | JP2009526065A (en) |
CN (1) | CN101379030A (en) |
AU (1) | AU2007212293A1 (en) |
BR (1) | BRPI0707558A2 (en) |
CA (1) | CA2640229A1 (en) |
WO (1) | WO2007092558A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2494991A1 (en) | 2007-05-04 | 2012-09-05 | Vertex Pharmaceuticals Incorporated | Combination therapy for the treatment of HCV infection |
EP3650447A1 (en) * | 2018-11-08 | 2020-05-13 | Universite de Nantes | New selective modulators of insect nicotinic acetylcholine receptors |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2865962A1 (en) * | 2012-02-29 | 2013-09-06 | Institute For Hepatitis And Virus Research | Inhibitors of hepatitis b virus covalently closed circular dna formation and their method of use |
WO2018086531A1 (en) * | 2016-11-08 | 2018-05-17 | 正大天晴药业集团股份有限公司 | Sulfonamides compound serving as cccdna inhibitor |
EP4361148A1 (en) * | 2021-06-25 | 2024-05-01 | Albius Sciences Alpha Private Limited | Heterocycloalkyl-substituted polyheteroazole derivative as medical drug for treatment and/or prevention of rs virus infectious disease |
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GB1223619A (en) * | 1968-09-04 | 1971-02-24 | Shell Int Research | 4-hydroxybenzenesulphonyl derivatives, the preparation thereof and compositions containing them |
US5612360A (en) * | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
JPH10338680A (en) * | 1997-06-06 | 1998-12-22 | Takeda Chem Ind Ltd | Thiazole derivative, its production and use thereof |
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WO2004013120A1 (en) * | 2002-07-29 | 2004-02-12 | F. Hoffmann-La Roche Ag | Novel benzodioxoles |
WO2004073599A2 (en) * | 2003-02-18 | 2004-09-02 | Pfizer Inc. | Inhibitors of hepatitis c virus, compositions and treatments using the same |
WO2005049620A1 (en) * | 2003-11-20 | 2005-06-02 | Astrazeneca Ab | Novel compounds |
WO2005068460A1 (en) * | 2003-12-22 | 2005-07-28 | Schering Corporation | Isothiazole dioxides as cxc- and cc- chemokine receptor ligands |
WO2005113542A2 (en) * | 2004-05-20 | 2005-12-01 | Elan Pharmaceuticals, Inc. | N-cyclic sulfonamido inhibitors of gamma secretase |
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US3505546A (en) * | 1968-10-14 | 1970-04-07 | Gen Electric | Gas cooled dynamoelectric machine with cage type stator frame |
JPS5822111B2 (en) * | 1977-10-29 | 1983-05-06 | 協和醗酵工業株式会社 | Citrus fruit modifier |
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2007
- 2007-02-08 JP JP2008554337A patent/JP2009526065A/en active Pending
- 2007-02-08 AU AU2007212293A patent/AU2007212293A1/en not_active Abandoned
- 2007-02-08 EP EP07763134A patent/EP1981845A2/en not_active Withdrawn
- 2007-02-08 CA CA002640229A patent/CA2640229A1/en not_active Abandoned
- 2007-02-08 BR BRPI0707558-8A patent/BRPI0707558A2/en not_active Application Discontinuation
- 2007-02-08 CN CNA2007800044366A patent/CN101379030A/en active Pending
- 2007-02-08 US US11/703,631 patent/US20070225344A1/en not_active Abandoned
- 2007-02-08 WO PCT/US2007/003369 patent/WO2007092558A2/en active Application Filing
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Cited By (4)
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EP2494991A1 (en) | 2007-05-04 | 2012-09-05 | Vertex Pharmaceuticals Incorporated | Combination therapy for the treatment of HCV infection |
EP3650447A1 (en) * | 2018-11-08 | 2020-05-13 | Universite de Nantes | New selective modulators of insect nicotinic acetylcholine receptors |
WO2020094754A1 (en) * | 2018-11-08 | 2020-05-14 | Universite De Nantes | New selective modulators of insect nicotinic acetylcholine receptors |
CN113631551A (en) * | 2018-11-08 | 2021-11-09 | 南特大学 | Novel competitive modulators of insect nicotinic acetylcholine receptors |
Also Published As
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CN101379030A (en) | 2009-03-04 |
US20070225344A1 (en) | 2007-09-27 |
JP2009526065A (en) | 2009-07-16 |
CA2640229A1 (en) | 2007-08-16 |
EP1981845A2 (en) | 2008-10-22 |
AU2007212293A1 (en) | 2007-08-16 |
BRPI0707558A2 (en) | 2011-05-10 |
WO2007092558A3 (en) | 2007-12-27 |
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