WO2007089685A3 - Compositions and methods for inducing adipose tissue cell death - Google Patents

Compositions and methods for inducing adipose tissue cell death Download PDF

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Publication number
WO2007089685A3
WO2007089685A3 PCT/US2007/002362 US2007002362W WO2007089685A3 WO 2007089685 A3 WO2007089685 A3 WO 2007089685A3 US 2007002362 W US2007002362 W US 2007002362W WO 2007089685 A3 WO2007089685 A3 WO 2007089685A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
cell death
adipose tissue
tissue cell
Prior art date
Application number
PCT/US2007/002362
Other languages
French (fr)
Other versions
WO2007089685A2 (en
Inventor
Mary Anne Della-Fera
Clifton A Baile
Jeong-Yeh Yang
Original Assignee
Univ Georgia Res Found
Mary Anne Della-Fera
Clifton A Baile
Jeong-Yeh Yang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgia Res Found, Mary Anne Della-Fera, Clifton A Baile, Jeong-Yeh Yang filed Critical Univ Georgia Res Found
Publication of WO2007089685A2 publication Critical patent/WO2007089685A2/en
Publication of WO2007089685A3 publication Critical patent/WO2007089685A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Compositions and methods of inducing apoptosis in adipocyte tissue cells, treating obesity, including cell death of bone marrow adipocytes, and treating osteoporosis in host are provided. The said compositions comprise at least one garlic extract compound in combination with at least one conjugated linoleic acid.
PCT/US2007/002362 2006-01-30 2007-01-30 Compositions and methods for inducing adipose tissue cell death WO2007089685A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76331006P 2006-01-30 2006-01-30
US60/763,310 2006-01-30

Publications (2)

Publication Number Publication Date
WO2007089685A2 WO2007089685A2 (en) 2007-08-09
WO2007089685A3 true WO2007089685A3 (en) 2007-12-06

Family

ID=38327953

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/002362 WO2007089685A2 (en) 2006-01-30 2007-01-30 Compositions and methods for inducing adipose tissue cell death

Country Status (1)

Country Link
WO (1) WO2007089685A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8343753B2 (en) 2007-11-01 2013-01-01 Wake Forest University School Of Medicine Compositions, methods, and kits for polyunsaturated fatty acids from microalgae
JP6964416B2 (en) * 2017-03-01 2021-11-10 日清ファルマ株式会社 Progesterone production promoter

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6630157B1 (en) * 1997-07-22 2003-10-07 Viatris Gmbh & Co. Kg. Therapeutic and dietary compositions containing essential fatty acids and bioactive disulphides
US6852343B2 (en) * 2000-10-31 2005-02-08 Pierre Fabre Dermo-Cosmetique Antiadipose topical treatment composition based on garlic bulbs extracts, and cosmetic and therapeutic uses
US20050260250A1 (en) * 2004-05-24 2005-11-24 Ott David M Medicinal products incorporating bound organosulfur groups

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6630157B1 (en) * 1997-07-22 2003-10-07 Viatris Gmbh & Co. Kg. Therapeutic and dietary compositions containing essential fatty acids and bioactive disulphides
US6852343B2 (en) * 2000-10-31 2005-02-08 Pierre Fabre Dermo-Cosmetique Antiadipose topical treatment composition based on garlic bulbs extracts, and cosmetic and therapeutic uses
US20050260250A1 (en) * 2004-05-24 2005-11-24 Ott David M Medicinal products incorporating bound organosulfur groups

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NELSON-DOOLEY ET AL.: "Novel treatments for obesity and asteoporosis: targeting apoptotic pathways in adipocytes", CURRENT MEDICINAL CHEMISTRY, vol. 12, no. 19, 2005, pages 2215 - 2225, XP008063180, DOI: doi:10.2174/0929867054864886 *

Also Published As

Publication number Publication date
WO2007089685A2 (en) 2007-08-09

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