WO2007087215A3 - N-acetyl-cysteine and its derivatives as an antitussive - Google Patents

N-acetyl-cysteine and its derivatives as an antitussive Download PDF

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Publication number
WO2007087215A3
WO2007087215A3 PCT/US2007/001278 US2007001278W WO2007087215A3 WO 2007087215 A3 WO2007087215 A3 WO 2007087215A3 US 2007001278 W US2007001278 W US 2007001278W WO 2007087215 A3 WO2007087215 A3 WO 2007087215A3
Authority
WO
WIPO (PCT)
Prior art keywords
cysteine
acetyl
derivatives
antitussive
mammal
Prior art date
Application number
PCT/US2007/001278
Other languages
French (fr)
Other versions
WO2007087215A2 (en
Inventor
Roger Berlin
Alexandra Kropotova
Original Assignee
Wyeth Corp
Roger Berlin
Alexandra Kropotova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp, Roger Berlin, Alexandra Kropotova filed Critical Wyeth Corp
Publication of WO2007087215A2 publication Critical patent/WO2007087215A2/en
Publication of WO2007087215A3 publication Critical patent/WO2007087215A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to a method of suppressing coughing in a mammal through the administration of a safe and effective amount of N-acetyl-cysteine, or its derivatives, to such mammal.
PCT/US2007/001278 2006-01-23 2007-01-19 N-acetyl-cysteine and its derivatives as an antitussive WO2007087215A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76132106P 2006-01-23 2006-01-23
US60/761,321 2006-01-23

Publications (2)

Publication Number Publication Date
WO2007087215A2 WO2007087215A2 (en) 2007-08-02
WO2007087215A3 true WO2007087215A3 (en) 2007-12-06

Family

ID=38068677

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/001278 WO2007087215A2 (en) 2006-01-23 2007-01-19 N-acetyl-cysteine and its derivatives as an antitussive

Country Status (1)

Country Link
WO (1) WO2007087215A2 (en)

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BEERS M ET AL: "Merck Manual", 1999, MERCK, WHITEHOUSE STATION, NJ, XP002436365 *
CHALUMEAU M ET AL: "[Mucolytic agents for acute respiratory tract infections in infants: A pharmaco-epidemiological problem?]", ARCHIVES DE PEDIATRIE, vol. 9, no. 11, November 2002 (2002-11-01), pages 1128 - 1136, XP008079270, ISSN: 0929-693X *
PARFITT, K: "Martindale", 1999, PP, LONDON, UK, XP002436364 *
VÖLKL K P ET AL: "[Therapy of respiratory tract diseases with N-acetylcysteine. An open therapeutic observation study of 2,512 patients]", FORTSCHRITTE DER MEDIZIN 30 JUN 1992, vol. 110, no. 18, 30 June 1992 (1992-06-30), pages 346 - 350, XP008079266, ISSN: 0015-8178 *

Also Published As

Publication number Publication date
WO2007087215A2 (en) 2007-08-02

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