WO2007086093A3 - Inhibitors of cell migration mediated by h-prune-gsk-3 complex and uses in antitumoral therapy - Google Patents

Inhibitors of cell migration mediated by h-prune-gsk-3 complex and uses in antitumoral therapy Download PDF

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Publication number
WO2007086093A3
WO2007086093A3 PCT/IT2007/000049 IT2007000049W WO2007086093A3 WO 2007086093 A3 WO2007086093 A3 WO 2007086093A3 IT 2007000049 W IT2007000049 W IT 2007000049W WO 2007086093 A3 WO2007086093 A3 WO 2007086093A3
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WIPO (PCT)
Prior art keywords
prune
gsk
complex
cell migration
inhibitors
Prior art date
Application number
PCT/IT2007/000049
Other languages
French (fr)
Other versions
WO2007086093A8 (en
WO2007086093A2 (en
Inventor
Massimo Zollo
Akira Kikuchi
Original Assignee
Bio Flag S R L
Massimo Zollo
Akira Kikuchi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Flag S R L, Massimo Zollo, Akira Kikuchi filed Critical Bio Flag S R L
Priority to EP07706243A priority Critical patent/EP1978992A2/en
Publication of WO2007086093A2 publication Critical patent/WO2007086093A2/en
Publication of WO2007086093A3 publication Critical patent/WO2007086093A3/en
Publication of WO2007086093A8 publication Critical patent/WO2007086093A8/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention concerns new inhibitors of cell migration mediated by h-prune-GSK-3 complex and uses thereof for the prevention and treatment of tumour metastases.
PCT/IT2007/000049 2006-01-25 2007-01-25 Inhibitors of cell migration mediated by h-prune-gsk-3 complex and uses in antitumoral therapy WO2007086093A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07706243A EP1978992A2 (en) 2006-01-25 2007-01-25 Inhibitors of cell migration mediated by h-prune-gsk-3 complex and uses in antitumoral therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000037A ITRM20060037A1 (en) 2006-01-25 2006-01-25 INHIBITORS OF CELL MIGRATION MEDIATED BY COMPLEX BETWEEN H-PRUNE AND GSK-3 RELATED USES IN ANTITUMORAL THERAPY
ITRM2006A000037 2006-01-25

Publications (3)

Publication Number Publication Date
WO2007086093A2 WO2007086093A2 (en) 2007-08-02
WO2007086093A3 true WO2007086093A3 (en) 2008-01-17
WO2007086093A8 WO2007086093A8 (en) 2009-07-23

Family

ID=38184881

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2007/000049 WO2007086093A2 (en) 2006-01-25 2007-01-25 Inhibitors of cell migration mediated by h-prune-gsk-3 complex and uses in antitumoral therapy

Country Status (3)

Country Link
EP (1) EP1978992A2 (en)
IT (1) ITRM20060037A1 (en)
WO (1) WO2007086093A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002046385A2 (en) * 2000-12-07 2002-06-13 Incyte Genomics, Inc. Enzymes
WO2003031568A2 (en) * 2001-08-17 2003-04-17 Incyte Genomics, Inc. Intracellular signaling molecules
WO2005056043A2 (en) * 2003-12-11 2005-06-23 Massimo Zollo Use of enzymatic inhibitors of h-prune for the prevention and treatment of the metastases of tumours overexpressing h-prune

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002046385A2 (en) * 2000-12-07 2002-06-13 Incyte Genomics, Inc. Enzymes
WO2003031568A2 (en) * 2001-08-17 2003-04-17 Incyte Genomics, Inc. Intracellular signaling molecules
WO2005056043A2 (en) * 2003-12-11 2005-06-23 Massimo Zollo Use of enzymatic inhibitors of h-prune for the prevention and treatment of the metastases of tumours overexpressing h-prune

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DANGELO A ET AL: "THE HUMAN CYCLIC NUCLEOTIDES PHOSPHODIESTERASE (PDE) PRUNE PROTEIN: A DUAL CELLULAR COMPARTMENT LOCALIZATION AND FUNCTIONAL PROPERTIES", AMERICAN JOURNAL OF HUMAN GENETICS, AMERICAN SOCIETY OF HUMAN GENETICS, CHICAGO, IL, US, vol. 71, no. 4, SUPPL, October 2002 (2002-10-01), pages 513, XP009047949, ISSN: 0002-9297 *
KOBAYASHI TSUYOSHI ET AL: "Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions.", MOLECULAR AND CELLULAR BIOLOGY FEB 2006, vol. 26, no. 3, February 2006 (2006-02-01), pages 898 - 911, XP002449255, ISSN: 0270-7306 *

Also Published As

Publication number Publication date
EP1978992A2 (en) 2008-10-15
ITRM20060037A1 (en) 2007-07-26
WO2007086093A8 (en) 2009-07-23
WO2007086093A2 (en) 2007-08-02

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