WO2007084425A3 - Flexible and modular microfluidic device - Google Patents

Flexible and modular microfluidic device Download PDF

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Publication number
WO2007084425A3
WO2007084425A3 PCT/US2007/000960 US2007000960W WO2007084425A3 WO 2007084425 A3 WO2007084425 A3 WO 2007084425A3 US 2007000960 W US2007000960 W US 2007000960W WO 2007084425 A3 WO2007084425 A3 WO 2007084425A3
Authority
WO
WIPO (PCT)
Prior art keywords
inserts
flexible
microfluidic device
microfeatures
reagent
Prior art date
Application number
PCT/US2007/000960
Other languages
French (fr)
Other versions
WO2007084425A9 (en
WO2007084425A2 (en
Inventor
Peng Zhou
Lincoln Young
Original Assignee
Kionix Inc
Peng Zhou
Lincoln Young
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kionix Inc, Peng Zhou, Lincoln Young filed Critical Kionix Inc
Priority to EP07716595.9A priority Critical patent/EP1979097B1/en
Priority to CN2007800025115A priority patent/CN101495236B/en
Priority to AU2007207681A priority patent/AU2007207681B2/en
Priority to JP2008551300A priority patent/JP5250425B2/en
Publication of WO2007084425A2 publication Critical patent/WO2007084425A2/en
Publication of WO2007084425A9 publication Critical patent/WO2007084425A9/en
Publication of WO2007084425A3 publication Critical patent/WO2007084425A3/en

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
    • F04B43/14—Machines, pumps, or pumping installations having flexible working members having peristaltic action having plate-like flexible members
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B1/00—Devices without movable or flexible elements, e.g. microcapillary devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0055—Operating means specially adapted for microvalves actuated by fluids
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/028—Modular arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

The systems and methods described herein include a microfluidic chip having a plurality of microfeatures interconnected to provide a configurable fluid transport system for processing at least one reagent. Inserts are provided to removably interfit into one or more of the microfeatures of the chip, wherein the inserts include sites for interactions with the reagent. As will be seen from the following description, the microfluidic chip and the inserts provide an efficient an accurate approach for conducting parallel assays.
PCT/US2007/000960 2006-01-19 2007-01-12 Flexible and modular microfluidic device WO2007084425A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP07716595.9A EP1979097B1 (en) 2006-01-19 2007-01-12 Flexible and modular microfluidic device
CN2007800025115A CN101495236B (en) 2006-01-19 2007-01-12 Microfluidic chips and assay systems
AU2007207681A AU2007207681B2 (en) 2006-01-19 2007-01-12 Microfluidic chips and assay systems
JP2008551300A JP5250425B2 (en) 2006-01-19 2007-01-12 Microfluidic chip and analysis system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76055206P 2006-01-19 2006-01-19
US60/760,552 2006-01-19

Publications (3)

Publication Number Publication Date
WO2007084425A2 WO2007084425A2 (en) 2007-07-26
WO2007084425A9 WO2007084425A9 (en) 2007-11-29
WO2007084425A3 true WO2007084425A3 (en) 2009-04-02

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ID=38137391

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/000960 WO2007084425A2 (en) 2006-01-19 2007-01-12 Flexible and modular microfluidic device

Country Status (6)

Country Link
US (8) US7976795B2 (en)
EP (1) EP1979097B1 (en)
JP (1) JP5250425B2 (en)
KR (1) KR20080085898A (en)
CN (1) CN101495236B (en)
WO (1) WO2007084425A2 (en)

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