WO2007081895A3 - Preparation of substituted 2-hydroxygibba-1(10a), 2, 4, 4b-tetraen-6-ones - Google Patents

Preparation of substituted 2-hydroxygibba-1(10a), 2, 4, 4b-tetraen-6-ones Download PDF

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Publication number
WO2007081895A3
WO2007081895A3 PCT/US2007/000431 US2007000431W WO2007081895A3 WO 2007081895 A3 WO2007081895 A3 WO 2007081895A3 US 2007000431 W US2007000431 W US 2007000431W WO 2007081895 A3 WO2007081895 A3 WO 2007081895A3
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WO
WIPO (PCT)
Prior art keywords
hydroxygibba
tetraen
ones
substituted
preparation
Prior art date
Application number
PCT/US2007/000431
Other languages
French (fr)
Other versions
WO2007081895A2 (en
Inventor
Sarah Elizabeth Brewer
Steven Fraser Oliver
Jeremy Peter Scott
Gavin William Stewart
Narayan Variankaval
Debra Jane Wallace
Original Assignee
Merck & Co Inc
Merck Sharp & Dohme
Sarah Elizabeth Brewer
Steven Fraser Oliver
Jeremy Peter Scott
Gavin William Stewart
Narayan Variankaval
Debra Jane Wallace
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Merck Sharp & Dohme, Sarah Elizabeth Brewer, Steven Fraser Oliver, Jeremy Peter Scott, Gavin William Stewart, Narayan Variankaval, Debra Jane Wallace filed Critical Merck & Co Inc
Publication of WO2007081895A2 publication Critical patent/WO2007081895A2/en
Publication of WO2007081895A3 publication Critical patent/WO2007081895A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/73—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/86—Ring systems containing bridged rings containing four rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The instant invention describes processes for synthesizing substituted 2-hydroxygibba-1(10a),2,4,4b-tetraen-6-ones.
PCT/US2007/000431 2006-01-09 2007-01-05 Preparation of substituted 2-hydroxygibba-1(10a), 2, 4, 4b-tetraen-6-ones WO2007081895A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75724906P 2006-01-09 2006-01-09
US60/757,249 2006-01-09

Publications (2)

Publication Number Publication Date
WO2007081895A2 WO2007081895A2 (en) 2007-07-19
WO2007081895A3 true WO2007081895A3 (en) 2007-09-07

Family

ID=38121653

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/000431 WO2007081895A2 (en) 2006-01-09 2007-01-05 Preparation of substituted 2-hydroxygibba-1(10a), 2, 4, 4b-tetraen-6-ones

Country Status (1)

Country Link
WO (1) WO2007081895A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9487535B2 (en) * 2012-04-12 2016-11-08 Xenon Pharmaceuticals Inc. Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001082923A1 (en) * 2000-02-14 2001-11-08 Merck & Co., Inc. Estrogen receptor modulators
WO2006050399A2 (en) * 2004-11-01 2006-05-11 Merck & Co., Inc. Synthesis of 1,5-disubstituted-2-hydroxy-gibbatetraen-6-ones

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001082923A1 (en) * 2000-02-14 2001-11-08 Merck & Co., Inc. Estrogen receptor modulators
WO2006050399A2 (en) * 2004-11-01 2006-05-11 Merck & Co., Inc. Synthesis of 1,5-disubstituted-2-hydroxy-gibbatetraen-6-ones

Also Published As

Publication number Publication date
WO2007081895A2 (en) 2007-07-19

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