WO2007079317A3 - Utilisation d’hypno-sedatifs pour traiter l’obesite ou maintenir la perte de poids - Google Patents

Utilisation d’hypno-sedatifs pour traiter l’obesite ou maintenir la perte de poids Download PDF

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Publication number
WO2007079317A3
WO2007079317A3 PCT/US2006/061679 US2006061679W WO2007079317A3 WO 2007079317 A3 WO2007079317 A3 WO 2007079317A3 US 2006061679 W US2006061679 W US 2006061679W WO 2007079317 A3 WO2007079317 A3 WO 2007079317A3
Authority
WO
WIPO (PCT)
Prior art keywords
treating obesity
weight loss
maintaining weight
sedative hypnotics
administering
Prior art date
Application number
PCT/US2006/061679
Other languages
English (en)
Other versions
WO2007079317A2 (fr
Inventor
Phillip B Chappell
David C Gruben
Original Assignee
Neurocrine Biosciences Inc
Phillip B Chappell
David C Gruben
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc, Phillip B Chappell, David C Gruben filed Critical Neurocrine Biosciences Inc
Publication of WO2007079317A2 publication Critical patent/WO2007079317A2/fr
Publication of WO2007079317A3 publication Critical patent/WO2007079317A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L’invention concerne un procédé et des thérapies associées pour traiter l’obésité ou un trouble de l’alimentation associé en administrant un composé actif du récepteur GABA-A, tel qu’un hypno-sédatif, seul ou en combinaison avec un autre hypno-sédatif ou un agent anti-obésité. Spécifiquement, l’invention concerne un procédé pour traité l’obésité ou un trouble de l’alimentation associé en administrant de l’indiplon.
PCT/US2006/061679 2005-12-06 2006-12-06 Utilisation d’hypno-sedatifs pour traiter l’obesite ou maintenir la perte de poids WO2007079317A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74275105P 2005-12-06 2005-12-06
US60/742,751 2005-12-06

Publications (2)

Publication Number Publication Date
WO2007079317A2 WO2007079317A2 (fr) 2007-07-12
WO2007079317A3 true WO2007079317A3 (fr) 2007-09-07

Family

ID=38141425

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/061679 WO2007079317A2 (fr) 2005-12-06 2006-12-06 Utilisation d’hypno-sedatifs pour traiter l’obesite ou maintenir la perte de poids

Country Status (1)

Country Link
WO (1) WO2007079317A2 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999066919A1 (fr) * 1998-06-19 1999-12-29 Mcneil-Ppc, Inc. Preparation pharmaceutique contenant un sel d'acetaminophene et au moins un autre principe actif
US20050182268A1 (en) * 2004-02-13 2005-08-18 Jean-Claude Souvie Process for the synthesis of (7-methoxy-3, 4-dihydro-1-naphthalenyl) acetonitrile and its application in the synthesis of agomelatine
US20050234093A1 (en) * 2003-06-25 2005-10-20 H. Lundbeck A/S Treatment of depression and other affective disorders
FR2869542A1 (fr) * 2004-04-29 2005-11-04 Marie Madeleine Jeannet Gagnon Traitement medical destine a faciliter la perte de poids et l'affinement localise (communement appele "cellulite")
WO2006105455A2 (fr) * 2005-03-31 2006-10-05 Phase 2 Discovery Methodes de traitement utilisant certains derives de melatonine
WO2006133543A1 (fr) * 2005-06-17 2006-12-21 Everslim Formulations Ltd. Suppléments alimentaires pour perte de poids, énergie durant la journée et relaxation la nuit

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999066919A1 (fr) * 1998-06-19 1999-12-29 Mcneil-Ppc, Inc. Preparation pharmaceutique contenant un sel d'acetaminophene et au moins un autre principe actif
US20050234093A1 (en) * 2003-06-25 2005-10-20 H. Lundbeck A/S Treatment of depression and other affective disorders
US20050182268A1 (en) * 2004-02-13 2005-08-18 Jean-Claude Souvie Process for the synthesis of (7-methoxy-3, 4-dihydro-1-naphthalenyl) acetonitrile and its application in the synthesis of agomelatine
FR2869542A1 (fr) * 2004-04-29 2005-11-04 Marie Madeleine Jeannet Gagnon Traitement medical destine a faciliter la perte de poids et l'affinement localise (communement appele "cellulite")
WO2006105455A2 (fr) * 2005-03-31 2006-10-05 Phase 2 Discovery Methodes de traitement utilisant certains derives de melatonine
WO2006133543A1 (fr) * 2005-06-17 2006-12-21 Everslim Formulations Ltd. Suppléments alimentaires pour perte de poids, énergie durant la journée et relaxation la nuit

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
FILE S E: "Effects of benzodiazepines and naloxone on food intake and food preference in the rat", APPETITE 1980 UNITED KINGDOM, vol. 1, no. 3, 1980, pages 215 - 224, XP009085582 *
GADDE KISHORE M ET AL: "Bupropion treatment of olanzapine-associated weight gain - An open-label, prospective trial", JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, vol. 26, no. 4, August 2006 (2006-08-01), pages 409 - 413, XP009085605, ISSN: 0271-0749 *
GRIMM V E ET AL: "THE EFFECTS OF CHRONIC DIAZEPAM TREATMENT ON BODY WEIGHT AND FOOD INTAKE IN RATS", INTERNATIONAL JOURNAL OF NEUROSCIENCE, vol. 18, no. 1-2, 1983, pages 127 - 136, XP009085584, ISSN: 0020-7454 *
MCLAUGHLIN C ET AL: "CHOLECYSTOKININ AMPHETAMINE AND DIAZEPAM AND FEEDING IN LEAN AND OBESE ZUCKER RATS", PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, vol. 10, no. 1, 1979, pages 87 - 94, XP002438687, ISSN: 0091-3057 *
TEWS J K: "DIETARY GABA DECREASES BODY WEIGHT OF GENETICALLY OBESE MICE", LIFE SCIENCES, PERGAMON PRESS, OXFORD, GB, vol. 29, no. 24, 14 December 1981 (1981-12-14), pages 2535 - 2542, XP001098279, ISSN: 0024-3205 *
YUTRZENKA G J ET AL: "Substitution of temazepam and midazolam in pentobarbital-dependent rats.", PHYSIOLOGY & BEHAVIOR JUL 1989, vol. 46, no. 1, July 1989 (1989-07-01), pages 55 - 60, XP002438686, ISSN: 0031-9384 *

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Publication number Publication date
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