WO2007078263A3 - The strain streptomyces toxytricini lipstatin-producing microorganism and preparation of lipstatin with inscribed strain - Google Patents

The strain streptomyces toxytricini lipstatin-producing microorganism and preparation of lipstatin with inscribed strain Download PDF

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Publication number
WO2007078263A3
WO2007078263A3 PCT/SK2006/050008 SK2006050008W WO2007078263A3 WO 2007078263 A3 WO2007078263 A3 WO 2007078263A3 SK 2006050008 W SK2006050008 W SK 2006050008W WO 2007078263 A3 WO2007078263 A3 WO 2007078263A3
Authority
WO
WIPO (PCT)
Prior art keywords
lipstatin
strain
preparation
inscribed
producing microorganism
Prior art date
Application number
PCT/SK2006/050008
Other languages
French (fr)
Other versions
WO2007078263A2 (en
Inventor
Ivan Varga
Blanka Gondova
Jana Gajdosikova
Ludmila Kovacova
Original Assignee
Biotika As
Ivan Varga
Blanka Gondova
Jana Gajdosikova
Ludmila Kovacova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotika As, Ivan Varga, Blanka Gondova, Jana Gajdosikova, Ludmila Kovacova filed Critical Biotika As
Publication of WO2007078263A2 publication Critical patent/WO2007078263A2/en
Publication of WO2007078263A3 publication Critical patent/WO2007078263A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Technical solution is related to industry production microorganism Streptomyces toxytricini CCM 7349 and method of lipstatin biotechnology preparation by this strain. Production strain listed above with use of two step vegetative inoculum produce lipstatin in concentration from 3,0 to 3,2 g/kg fermentation broth after 180 till 230 hours of cultivation under temperature at 28°C, under optimal mixing above 450 rpm, aeration 1 till 1,25 vvm and optimal addition of linoleic acid and 8% solution of L-Leucine.
PCT/SK2006/050008 2006-01-03 2006-12-18 The strain streptomyces toxytricini lipstatin-producing microorganism and preparation of lipstatin with inscribed strain WO2007078263A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SKPP0002-2006 2006-01-03
SK2-2006A SK22006A3 (en) 2006-01-03 2006-01-03 Streptomyces toxytricini strain producing the lipstatine and the production of the lipstatine by the said strain.

Publications (2)

Publication Number Publication Date
WO2007078263A2 WO2007078263A2 (en) 2007-07-12
WO2007078263A3 true WO2007078263A3 (en) 2007-09-07

Family

ID=38198149

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SK2006/050008 WO2007078263A2 (en) 2006-01-03 2006-12-18 The strain streptomyces toxytricini lipstatin-producing microorganism and preparation of lipstatin with inscribed strain

Country Status (2)

Country Link
SK (1) SK22006A3 (en)
WO (1) WO2007078263A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2755736T3 (en) 2008-03-26 2020-04-23 Biocon Ltd Improved fermentation process for a higher coefficient of lipase inhibitor compared to consumed fatty acid
EP2141236A1 (en) 2008-07-03 2010-01-06 KRKA, D.D., Novo Mesto Process for production of lipstatin and microorganisms therefore
CN101948450B (en) * 2010-10-13 2013-04-24 鲁南制药集团股份有限公司 Method for preparing orlistat
CN102268466B (en) * 2011-07-23 2013-06-12 鲁南新时代生物技术有限公司 Method for fermentation production of lipstatin and culture medium components thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0129748A1 (en) * 1983-06-22 1985-01-02 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Hexadecanoic acid and hexadecadienoic-acid derivatives
US20020110873A1 (en) * 1996-04-26 2002-08-15 Adelbert Bacher Process for the production of lipstatin and tetrahydrolipstatin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0129748A1 (en) * 1983-06-22 1985-01-02 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Hexadecanoic acid and hexadecadienoic-acid derivatives
US20020110873A1 (en) * 1996-04-26 2002-08-15 Adelbert Bacher Process for the production of lipstatin and tetrahydrolipstatin

Also Published As

Publication number Publication date
WO2007078263A2 (en) 2007-07-12
SK22006A3 (en) 2007-08-02

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