WO2007076779B1 - Arrangement and method for determining the optimum medicament dosage in particular for diabetes - Google Patents

Arrangement and method for determining the optimum medicament dosage in particular for diabetes

Info

Publication number
WO2007076779B1
WO2007076779B1 PCT/DE2006/002202 DE2006002202W WO2007076779B1 WO 2007076779 B1 WO2007076779 B1 WO 2007076779B1 DE 2006002202 W DE2006002202 W DE 2006002202W WO 2007076779 B1 WO2007076779 B1 WO 2007076779B1
Authority
WO
WIPO (PCT)
Prior art keywords
arrangement
insulin
determining
optimal
blood glucose
Prior art date
Application number
PCT/DE2006/002202
Other languages
German (de)
French (fr)
Other versions
WO2007076779A2 (en
WO2007076779A3 (en
Inventor
Horst Ahlers
Original Assignee
Horst Ahlers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Horst Ahlers filed Critical Horst Ahlers
Publication of WO2007076779A2 publication Critical patent/WO2007076779A2/en
Publication of WO2007076779A3 publication Critical patent/WO2007076779A3/en
Publication of WO2007076779B1 publication Critical patent/WO2007076779B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement

Abstract

The invention relates to a data recording arrangement and a method for determining optimal medicament dosages, in particular of insulin for diabetes. The arrangement is designed along the lines of an object recognition method and records features from life situations of an individual and from electrochemical voltages measured non-invasively on the skin. Said voltages are recorded as empirical feature vectors in an electronic memory with the optimal insulin amounts for a given blood glucose concentration. A new feature vector arises from a new life situation and is compared with the stored feature vectors using suitable statistical search methods and hence leads to the values stored there for the oprimal insulin amounts and the corresponding blood glucose concentrations for the closest learnt feature vector.

Claims

GEÄNDERTE ANSPRÜCHE beim Internationalen Büro eingegangen am 21. August 2007 (21.08.07) AMENDED CLAIMS received by the International Bureau on 21 August 2007 (21.08.07)
1. Anordnung und Verfahren zur Ermittlung optimaler Medikamentendosierungen, insbesondere Insulin bei Diabetes, dadurch gekennzeichnet, dass Merkmale aus auf der Haut mittels Elektroden nichtinvasiv ermittelten elektrochemischen Spannungen und optional Merkmale aus Lebenssituationen mit der für eine bestimmte Blutglucosekonzentration optimalen Medikamenten- bzw. Insulindosis für jedes Individuum als angelernte Merkmalvektoren in einer Anlernphase zusammen angeordnet in ein Speichermedium transferiert sind und dass diese Merkmale der Anlernphase dann mit den Merkmalen eines neuen Merkmalvektors ohne Blutglucosekonzentration und optimale Medikamenten- bzw. Insulindosis der Erkennungsphase mit einem Suchalgorithmus aus der Objekterkennungstheorie auf größtmögliche Übereinstimmung verglichen sind und dass in dem so ermittelten nächstgelegenen Vektor der Anlernphase die dort vermerkten Werte von Blutglucosekonzentration und optimaler Medikamentenbzw. Insulindosis als Ergebnis gelten.1. Arrangement and method for determining optimal drug dosages, in particular insulin in diabetes, characterized in that features on the skin by means of electrodes non-invasively determined electrochemical stresses and optional features of life situations with the optimal for a given blood glucose concentration drug or insulin dose for each individual are arranged as taught-in feature vectors in a learning phase arranged together in a storage medium and that these characteristics of the learning phase are then compared with the characteristics of a new feature vector without blood glucose concentration and optimal drug or insulin dose of the detection phase with a search algorithm from the object recognition theory to the greatest possible agreement and that in the thus determined nearest vector of the learning phase, the values of blood glucose concentration and optimal medicament or blood glucose concentration recorded there are shown. Insulin dose as a result.
2. Anordnung und Verfahren zur Ermittlung der optimalen Medikamentendosierung, insbesondere Insulin bei Diabetes nach Anspruch 1 , dadurch gekennzeichnet, dass die Lebenssituationen beliebig über eine Zeit verteilt sind.2. Arrangement and method for determining the optimal drug dosage, in particular insulin in diabetes according to claim 1, characterized in that the life situations are arbitrarily distributed over a time.
3. Anordnung und Verfahren zur Ermittlung der optimalen Medikamentendosierung, insbesondere Insulin bei Diabetes nach vorherigen Ansprüchen, dadurch gekennzeichnet, dass die Lebenssituationen herbeigeführt sind.3. Arrangement and method for determining the optimal drug dosage, especially insulin in diabetes according to previous claims, characterized in that the life situations are brought about.
4. Anordnung und Verfahren zur Ermittlung der optimalen Medikamentendosierung, insbesondere Insulin bei Diabetes nach vorherigen Ansprüchen, dadurch gekennzeichnet, dass für den Suchalgorithmus nur die elektrochemischen Spannungen verwendet sind.4. Arrangement and method for determining the optimal drug dosage, in particular insulin in diabetes according to previous claims, characterized in that only the electrochemical voltages are used for the search algorithm.
5. Anordnung und Verfahren zur Ermittlung der optimalen Medikamentendosierung, insbesondere Insulin bei Diabetes nach vorherigen Ansprüchen, dadurch gekennzeichnet, dass nichtinvasiv gewonnene Merkmale, wie optochemische und/oder gaschemische zusätzlich oder allein zu den elektrochemischen Spannungen verwendet sind.5. Arrangement and method for determining the optimal dosage of medication, in particular insulin in diabetes according to previous claims, characterized in that non-invasively obtained features, such as optochemical and / or gas mixtures are additionally or solely used to the electrochemical stresses.
6. Anordnung und Verfahren zur Ermittlung der optimalen Medikamentendosierung, insbesondere Insulin bei Diabetes nach vorherigen Ansprüchen, dadurch gekennzeichnet, dass ein neuer Merkmalvektor nach Verifizierung von Insulinmenge und Blutglucosekonzentration in den angelernten Merkmalvektor übernommen ist.6. Arrangement and method for determining the optimal dosage of medication, in particular insulin in diabetes according to previous claims, characterized in that a new feature vector is taken after verification of insulin quantity and blood glucose concentration in the learned characteristic vector.
7. Anordnung und Verfahren zur Ermittlung der optimalen Medikamentendosierung, insbesondere Insulin bei Diabetes nach vorherigen Ansprüchen, dadurch gekennzeichnet, dass Anordnung und Verfahren in ein Gerät integriert sind.7. Arrangement and method for determining the optimal drug dosage, in particular insulin in diabetes according to previous claims, characterized in that the arrangement and method are integrated into one device.
8. Anordnung und Verfahren zur Ermittlung der optimalen Medikamentendosierung, insbesondere Insulin bei Diabetes nach vorherigen Ansprüchen, dadurch gekennzeichnet, dass Anordnung und Verfahren das Internet mit einbinden. 8. Arrangement and method for determining the optimal drug dosage, in particular insulin in diabetes according to previous claims, characterized in that the arrangement and method integrate the Internet.
PCT/DE2006/002202 2005-12-09 2006-12-07 Arrangement and method for determining the optimum medicament dosage in particular for diabetes WO2007076779A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200510059444 DE102005059444A1 (en) 2005-12-09 2005-12-09 Medication e.g. insulin, optimal dosage determining method for diabetes, involves comparing characteristics vectors with search algorithm from object recognizing theory with new characteristics vectors for largest possible correlation
DE102005059444.1 2005-12-09

Publications (3)

Publication Number Publication Date
WO2007076779A2 WO2007076779A2 (en) 2007-07-12
WO2007076779A3 WO2007076779A3 (en) 2007-09-07
WO2007076779B1 true WO2007076779B1 (en) 2007-11-01

Family

ID=38056066

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2006/002202 WO2007076779A2 (en) 2005-12-09 2006-12-07 Arrangement and method for determining the optimum medicament dosage in particular for diabetes

Country Status (2)

Country Link
DE (1) DE102005059444A1 (en)
WO (1) WO2007076779A2 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544212B2 (en) * 2001-07-31 2003-04-08 Roche Diagnostics Corporation Diabetes management system
EP1351181B1 (en) * 2002-06-10 2003-10-29 Medvantis Medical Services GmbH Computer system and method for acquiring data to determine the progression of a chronic disease
DE10315848A1 (en) * 2003-04-02 2004-10-14 Ahlers, Horst, Dr. Electronic tongue, to determine characteristics of bodies with a given residual moisture and/or residual electrolytes, uses information technology with sensor electrodes of different materials to register voltage changes and vectors

Also Published As

Publication number Publication date
DE102005059444A1 (en) 2007-06-14
WO2007076779A2 (en) 2007-07-12
WO2007076779A3 (en) 2007-09-07

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