WO2007075800A3 - Methods and systems for the delivery of corticosteroids - Google Patents

Methods and systems for the delivery of corticosteroids Download PDF

Info

Publication number
WO2007075800A3
WO2007075800A3 PCT/US2006/048630 US2006048630W WO2007075800A3 WO 2007075800 A3 WO2007075800 A3 WO 2007075800A3 US 2006048630 W US2006048630 W US 2006048630W WO 2007075800 A3 WO2007075800 A3 WO 2007075800A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery
corticosteroid
systems
methods
inhalable
Prior art date
Application number
PCT/US2006/048630
Other languages
French (fr)
Other versions
WO2007075800A2 (en
Inventor
Malcolm R Hill
Original Assignee
Tika Laekemedel Ab
Malcolm R Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tika Laekemedel Ab, Malcolm R Hill filed Critical Tika Laekemedel Ab
Priority to EP06847838A priority Critical patent/EP1971347A2/en
Priority to JP2008547497A priority patent/JP2009520822A/en
Publication of WO2007075800A2 publication Critical patent/WO2007075800A2/en
Publication of WO2007075800A3 publication Critical patent/WO2007075800A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to methods and systems for the delivery of a corticosteroid comprising (1) an inhalable aqueous mixture comprising a corticosteroid and a solubility enhancer and (2) an inhalable nebulizer, wherein the delivery of the aqueous mixture comprising the corticosteroid by the nebulizer results in an enhanced pharmacokinetic profile of the corticosteroid as compared to conventional inhalable therapies and/or increase lung deposition.
PCT/US2006/048630 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids WO2007075800A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP06847838A EP1971347A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids
JP2008547497A JP2009520822A (en) 2005-12-20 2006-12-19 Methods and systems for delivering corticosteroids

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US75276505P 2005-12-20 2005-12-20
US75233205P 2005-12-20 2005-12-20
US75273505P 2005-12-20 2005-12-20
US60/752,765 2005-12-20
US60/752,332 2005-12-20
US60/752,735 2005-12-20
US77399806P 2006-02-15 2006-02-15
US77399906P 2006-02-15 2006-02-15
US60/773,999 2006-02-15
US60/773,998 2006-02-15
US82009606P 2006-07-21 2006-07-21
US82009206P 2006-07-21 2006-07-21
US82009406P 2006-07-21 2006-07-21
US60/820,092 2006-07-21
US60/820,094 2006-07-21
US60/820,096 2006-07-21

Publications (2)

Publication Number Publication Date
WO2007075800A2 WO2007075800A2 (en) 2007-07-05
WO2007075800A3 true WO2007075800A3 (en) 2008-11-20

Family

ID=38218568

Family Applications (6)

Application Number Title Priority Date Filing Date
PCT/US2006/048631 WO2007075801A2 (en) 2005-12-20 2006-12-19 Method and system for the delivery of corticosteroids having an enhanced pharmacokinetic profile
PCT/US2006/048630 WO2007075800A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids
PCT/US2006/048927 WO2007075963A2 (en) 2005-12-20 2006-12-19 Systems and methods for the delivery of corticosteroids
PCT/US2006/048735 WO2007075859A2 (en) 2005-12-20 2006-12-19 Systems and methods for the delivery of corticosteroids having an increased lung deposition
PCT/US2006/048629 WO2007075799A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
PCT/US2006/048628 WO2007075798A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids having an increased lung deposition

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2006/048631 WO2007075801A2 (en) 2005-12-20 2006-12-19 Method and system for the delivery of corticosteroids having an enhanced pharmacokinetic profile

Family Applications After (4)

Application Number Title Priority Date Filing Date
PCT/US2006/048927 WO2007075963A2 (en) 2005-12-20 2006-12-19 Systems and methods for the delivery of corticosteroids
PCT/US2006/048735 WO2007075859A2 (en) 2005-12-20 2006-12-19 Systems and methods for the delivery of corticosteroids having an increased lung deposition
PCT/US2006/048629 WO2007075799A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
PCT/US2006/048628 WO2007075798A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids having an increased lung deposition

Country Status (5)

Country Link
EP (6) EP1971345A2 (en)
JP (6) JP2009520828A (en)
BR (1) BRPI0620225A2 (en)
CA (2) CA2634413A1 (en)
WO (6) WO2007075801A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
CN101911139B (en) * 2007-11-16 2013-03-20 粒子监测系统有限公司 System and method for calibration verification of an optical particle counter
WO2010042701A2 (en) * 2008-10-10 2010-04-15 Schering Corporation Corticosteroid compositions and methods of treatments thereof
US20150202308A1 (en) * 2014-01-17 2015-07-23 Nephron Pharmaceuticals Corporation Budesonide formulation
NZ724902A (en) * 2014-03-28 2023-03-31 Univ Liege Composition comprising cyclodextrin and budesonide derivatives for the treatment and prophylaxis of pulmonary inflammations
EP2923702A1 (en) * 2014-03-28 2015-09-30 Universite De Liege Composition of cyclodextrin with budesonide derivatives for treatment and prevention of pulmonary inflammatory disease
US11672781B2 (en) 2018-05-07 2023-06-13 Prana Biosciences Inc Metaxalone formulations
EP3906263A4 (en) 2019-01-03 2022-08-31 Underdog Pharmaceuticals, Inc. Cyclodextrin dimers, compositions thereof, and uses thereof
CN113491677B (en) * 2020-03-18 2023-09-26 南京知和医药科技有限公司 Novel medicinal antiviral drug inhalant preparation and preparation method thereof
WO2022217029A1 (en) * 2021-04-09 2022-10-13 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for delivering pharmaceutical agents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020183292A1 (en) * 2000-10-31 2002-12-05 Michel Pairet Pharmaceutical compositions based on anticholinergics and corticosteroids
US20050009795A1 (en) * 2000-12-04 2005-01-13 Bernard Cuenoud Mixtures or organic compounds for the treatment of airway diseases

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192528A (en) * 1985-05-22 1993-03-09 Liposome Technology, Inc. Corticosteroid inhalation treatment method
US5376645A (en) * 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
US5874418A (en) * 1997-05-05 1999-02-23 Cydex, Inc. Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use
US6598603B1 (en) * 1997-12-31 2003-07-29 Astra Aktiebolag Method for treating respiratory diseases
CN1527830A (en) * 2001-01-31 2004-09-08 �Ʒ� Ether derivatives useful as inhibitors of PDE4 isozymes
US20030055023A1 (en) * 2001-03-20 2003-03-20 Rajewski Roger A. Formulations containing etomidate and a sulfoalkyl ether cyclodextrin
US20030055026A1 (en) * 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
US7244742B2 (en) * 2002-08-17 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co Kg Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic
AU2003299590B8 (en) * 2002-12-09 2010-04-08 Abraxis Bioscience, Llc Compositions and methods of delivery of pharmacological agents
US20050065141A1 (en) * 2003-07-31 2005-03-24 Odink Debra A. Carbapenems useful in treating and preventing pulmonary infections, pharmaceutical compositions thereof and modes of administration thereof
CN1905870A (en) * 2003-11-21 2007-01-31 康宾纳特克斯公司 Methods and reagents for the treatment of inflammatory disorders
MX348041B (en) * 2003-12-31 2017-05-25 Cydex Pharmaceuticals Inc Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020183292A1 (en) * 2000-10-31 2002-12-05 Michel Pairet Pharmaceutical compositions based on anticholinergics and corticosteroids
US20050009795A1 (en) * 2000-12-04 2005-01-13 Bernard Cuenoud Mixtures or organic compounds for the treatment of airway diseases

Also Published As

Publication number Publication date
CA2634413A1 (en) 2007-07-05
EP1971348A2 (en) 2008-09-24
JP2009520827A (en) 2009-05-28
JP2009520822A (en) 2009-05-28
WO2007075800A2 (en) 2007-07-05
WO2007075798A9 (en) 2007-08-23
WO2007075799A2 (en) 2007-07-05
EP1973550A2 (en) 2008-10-01
BRPI0620225A2 (en) 2011-11-01
WO2007075963A3 (en) 2008-11-27
EP1971346A2 (en) 2008-09-24
WO2007075801A3 (en) 2008-12-31
EP1971345A2 (en) 2008-09-24
CA2634398A1 (en) 2007-07-05
JP2009520821A (en) 2009-05-28
JP2009520823A (en) 2009-05-28
JP2009520828A (en) 2009-05-28
WO2007075859A3 (en) 2008-12-11
WO2007075963A2 (en) 2007-07-05
WO2007075859A2 (en) 2007-07-05
WO2007075801A2 (en) 2007-07-05
EP1971347A2 (en) 2008-09-24
JP2009524590A (en) 2009-07-02
WO2007075798A2 (en) 2007-07-05
EP1971349A2 (en) 2008-09-24
WO2007075799A3 (en) 2009-01-15
WO2007075798A3 (en) 2008-11-20

Similar Documents

Publication Publication Date Title
WO2007075800A3 (en) Methods and systems for the delivery of corticosteroids
WO2005074990A3 (en) Methods of preventing and treating sars using low ph respiratory tract compositions
WO2007095339A3 (en) Methods of manufacturing corticosteroid solutions
WO2007091266A3 (en) Alpha-i antitrypsin for treating exacerbation episodes of pulmonary diseases
WO2008053221A3 (en) Process for preparing indol- 5 -oxy- quinazoline derivatives and intermediates
WO2004078144A3 (en) Diphenylethylene compounds and uses thereof
WO2006105401A3 (en) Medicaments and methods combining an anticholinergic, a corticosteroid, and a long acting beta agonist
WO2006117300A3 (en) Crystalline forms of tiotropium bromide
WO2005067893A3 (en) Pharmaceutical compositions comprising midazolam in a high concentration
WO2012110770A3 (en) Combination of glycopyrrolate and a beta2 -agonist
WO2006026747A3 (en) Diphenylethylene compounds and uses thereof
TN2012000446A1 (en) Pyridine and pyrazine derivative for the treatment of cf
WO2007053698A3 (en) Methods of reducing alcohol-induced dose dumping for opioid sustained release oral dosage forms
WO2008000483A3 (en) Phenol derivatives for the treatment of respiratory diseases
WO2005116086A3 (en) Glucosamine and glucosamine/anti-inflammatory mutual prodrugs, compositions, and methods
WO2006117299A3 (en) Novel crystalline forms of tiotropium bromide
WO2008132723A3 (en) Therapeutic delivery of inhibitory nucleic acid molecules to the respiratory system
WO2009134524A3 (en) Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations
WO2007071313A3 (en) Combination of anticholinergics, glucocorticoids, beta2-ag0nists, pde4 inhibitor and antileukotriene for the treatment of inflammatory diseases
ATE421325T1 (en) COMBINATION OF METHYLXANTHINE COMPOUNDS AND STEROIDS FOR THE TREATMENT OF CHRONIC RESPIRATORY DISEASES
WO2007022408A3 (en) Combination methods of saha and targretin for treating cancer
WO2008048589A3 (en) Compounds and methods for treatment of hcv
WO2007057714A3 (en) Pharmaceutical compositions comprising methotrexate
WO2005086915A3 (en) Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor
WO2006028963A3 (en) Substituted heterocyclic compounds and uses thereof

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2008547497

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2006847838

Country of ref document: EP