WO2007074491B1 - HETEROTRICYCLIC AMIDE DERIVATIVES AS NEUROKININ-l (NKl) RECEPTOR LIGANDS - Google Patents

HETEROTRICYCLIC AMIDE DERIVATIVES AS NEUROKININ-l (NKl) RECEPTOR LIGANDS

Info

Publication number
WO2007074491B1
WO2007074491B1 PCT/IT2006/000860 IT2006000860W WO2007074491B1 WO 2007074491 B1 WO2007074491 B1 WO 2007074491B1 IT 2006000860 W IT2006000860 W IT 2006000860W WO 2007074491 B1 WO2007074491 B1 WO 2007074491B1
Authority
WO
WIPO (PCT)
Prior art keywords
compound according
carboxamide
benzyl
bis
quinoline
Prior art date
Application number
PCT/IT2006/000860
Other languages
French (fr)
Other versions
WO2007074491A1 (en
WO2007074491A8 (en
Inventor
Andrea Cappelli
Germano Giuliani
Maurizio Anzini
Salvatore Vomero
Original Assignee
Univ Siena
Andrea Cappelli
Germano Giuliani
Maurizio Anzini
Salvatore Vomero
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Siena, Andrea Cappelli, Germano Giuliani, Maurizio Anzini, Salvatore Vomero filed Critical Univ Siena
Publication of WO2007074491A1 publication Critical patent/WO2007074491A1/en
Publication of WO2007074491B1 publication Critical patent/WO2007074491B1/en
Publication of WO2007074491A8 publication Critical patent/WO2007074491A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention relates to compounds of formula 1, method of preparation and uses thereof.

Claims

AMENDED CLAIMS received bv the International Bureau on June 15, 2007 (15.06.07)
1. Compound of general formula 1 :
Figure imgf000002_0001
wherein
X, Y, Z are CH or N; R1 is H, CH3 or a linear alkyl group;
R2 and R3 represent an hydrogen, an halogen, an hydrocarbon group, or an hydroxyl group;
R4 represents an hydrogen, an halogen, a linear alkyl group or an hydroxyl group; and pharmaceutically acceptable salts thereof produced from inorganic or organic acids.
2. The compound according to claim 1 wherein R2 and R3 are a trifluoromethyl or a methoxy group.
3. The compound according to claim 1 wherein R4 is F or CH3.
4. The compound according to claim 1 being N-[3,5-Bis(trifluorometbyl)benzyl]-5- phenylpyrrolo[l,2-a]quinoline-4-carboxamide,
5. The compound according to claim 1 being N-[3,5-Bis(trifluoromethyl)benzyl]-N- methy!-5-phenylpyrrolo[1 ,2-a]quinoline-4-carboxamide.
6. The compound according to claim 1 being N-[3,5-Bis(trif]uoromethyl)benzyl]-5- ρhenylimidazo[l,2- a]quinoline-4-carboxamide.
7. The compound according to claim 1 being N-[3;,5-bis(trifluoromethyl)benzyl]-N-methyl- 5-phenylimidazo[ 1 ,2-a]quinoline-4-carboxamide.
8. Compound according to claim 1 being N-[3,5-Bis(lrifluoromethyl)benzyl]-5- phenyIimidazo[1,5-a]quinoIine-4-carboxamide.
PCT/IT2006/000860 2005-12-28 2006-12-20 HETEROTRICYCLIC AMIDE DERIVATIVES AS NEUROKININ-l (NKl) RECEPTOR LIGANDS WO2007074491A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75494005P 2005-12-28 2005-12-28
US60/754,940 2005-12-28

Publications (3)

Publication Number Publication Date
WO2007074491A1 WO2007074491A1 (en) 2007-07-05
WO2007074491B1 true WO2007074491B1 (en) 2007-08-16
WO2007074491A8 WO2007074491A8 (en) 2007-09-20

Family

ID=37891438

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2006/000860 WO2007074491A1 (en) 2005-12-28 2006-12-20 HETEROTRICYCLIC AMIDE DERIVATIVES AS NEUROKININ-l (NKl) RECEPTOR LIGANDS

Country Status (1)

Country Link
WO (1) WO2007074491A1 (en)

Cited By (3)

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US9493450B2 (en) 2014-02-13 2016-11-15 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
US9493442B2 (en) 2014-02-13 2016-11-15 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors

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ES2672099T3 (en) 2011-07-04 2018-06-12 Irbm - Science Park S.P.A. NK-1 receptor antagonists for the treatment of corneal neovascularization
AU2015217073B2 (en) 2014-02-13 2019-08-22 Incyte Holdings Corporation Cyclopropylamines as LSD1 inhibitors
US9695167B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors
US9695180B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
TWI687419B (en) 2014-07-10 2020-03-11 美商英塞特公司 Imidazopyridines and imidazopyrazines as LSD1 inhibitors
US9758523B2 (en) 2014-07-10 2017-09-12 Incyte Corporation Triazolopyridines and triazolopyrazines as LSD1 inhibitors
EA201792205A1 (en) 2015-04-03 2018-02-28 Инсайт Корпорейшн HETEROCYCLIC COMPOUNDS AS LSD1 INHIBITORS
WO2017027678A1 (en) 2015-08-12 2017-02-16 Incyte Corporation Salts of an lsd1 inhibitor
BR112018071585B1 (en) 2016-04-22 2024-01-02 Incyte Corporation FORMULATIONS OF AN LSD1 INHIBITOR, THEIR USES AND METHOD OF PREPARATION THEREOF
AU2019223237A1 (en) 2018-02-26 2020-09-03 Ospedale San Raffaele S.R.L. NK-1 antagonists for use in the treatment of ocular pain
WO2020047198A1 (en) 2018-08-31 2020-03-05 Incyte Corporation Salts of an lsd1 inhibitor and processes for preparing the same
WO2021180885A1 (en) 2020-03-11 2021-09-16 Ospedale San Raffaele S.R.L. Treatment of stem cell deficiency

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0318727D0 (en) * 2003-08-08 2003-09-10 Smithkline Beecham Corp Novel compounds
US7592453B2 (en) * 2004-04-28 2009-09-22 Takeda Pharmaceutical Company Limited Fused quinoline derivative and use thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9493450B2 (en) 2014-02-13 2016-11-15 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
US9493442B2 (en) 2014-02-13 2016-11-15 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors

Also Published As

Publication number Publication date
WO2007074491A1 (en) 2007-07-05
WO2007074491A8 (en) 2007-09-20

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