WO2007071839A3 - Potentialisation de l'apoptose par des anticorps monoclonaux dont la teneur en fucose est inferieure a 65 % - Google Patents

Potentialisation de l'apoptose par des anticorps monoclonaux dont la teneur en fucose est inferieure a 65 % Download PDF

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Publication number
WO2007071839A3
WO2007071839A3 PCT/FR2006/002767 FR2006002767W WO2007071839A3 WO 2007071839 A3 WO2007071839 A3 WO 2007071839A3 FR 2006002767 W FR2006002767 W FR 2006002767W WO 2007071839 A3 WO2007071839 A3 WO 2007071839A3
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WIPO (PCT)
Prior art keywords
apoptosis
potentiation
monoclonal antibodies
mla
composition
Prior art date
Application number
PCT/FR2006/002767
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English (en)
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WO2007071839A2 (fr
Inventor
Nathalie Fournier
Romeuf Christophe De
Original Assignee
Lab Francais Du Fractionnement
Nathalie Fournier
Romeuf Christophe De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lab Francais Du Fractionnement, Nathalie Fournier, Romeuf Christophe De filed Critical Lab Francais Du Fractionnement
Priority to US12/097,686 priority Critical patent/US20090305228A1/en
Priority to BRPI0619994-1A priority patent/BRPI0619994A2/pt
Priority to CA002633331A priority patent/CA2633331A1/fr
Priority to EP06841970A priority patent/EP1969368A2/fr
Priority to AU2006328798A priority patent/AU2006328798B2/en
Priority to JP2008545047A priority patent/JP2009519302A/ja
Publication of WO2007071839A2 publication Critical patent/WO2007071839A2/fr
Publication of WO2007071839A3 publication Critical patent/WO2007071839A3/fr
Priority to IL192195A priority patent/IL192195A0/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)

Abstract

La présente invention se rapporte à l'utilisation d'une composition d'anticorps anti MLA-DR exprimés dans la ligne YB210, dont la teneur en fucose est inférieure à 65% pour induire in vitro l'apoptose.
PCT/FR2006/002767 2005-12-16 2006-12-15 Potentialisation de l'apoptose par des anticorps monoclonaux dont la teneur en fucose est inferieure a 65 % WO2007071839A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US12/097,686 US20090305228A1 (en) 2005-12-16 2006-12-15 Potentiation of Apoptosis by Monoclonal Antibodies
BRPI0619994-1A BRPI0619994A2 (pt) 2005-12-16 2006-12-15 potencialização da apoptose por anticorpos monoclonais
CA002633331A CA2633331A1 (fr) 2005-12-16 2006-12-15 Potentialisation de l'apoptose par des anticorps monoclonaux dont la teneur en fucose est inferieure a 65 %
EP06841970A EP1969368A2 (fr) 2005-12-16 2006-12-15 Potentialisation de l' apoptose par des anticorps monoclonaux
AU2006328798A AU2006328798B2 (en) 2005-12-16 2006-12-15 Potentiation of apoptosis by monoclonal antibodies
JP2008545047A JP2009519302A (ja) 2005-12-16 2006-12-15 モノクローナル抗体によるアポトーシスの増強作用
IL192195A IL192195A0 (en) 2005-12-16 2008-06-15 Potentiation of apoptosis by monoclonal antibodies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0512815A FR2895086B1 (fr) 2005-12-16 2005-12-16 Potentialisation de l'apoptose par des anticorps monoclonaux
FR0512815 2005-12-16

Publications (2)

Publication Number Publication Date
WO2007071839A2 WO2007071839A2 (fr) 2007-06-28
WO2007071839A3 true WO2007071839A3 (fr) 2007-08-23

Family

ID=36932747

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2006/002767 WO2007071839A2 (fr) 2005-12-16 2006-12-15 Potentialisation de l'apoptose par des anticorps monoclonaux dont la teneur en fucose est inferieure a 65 %

Country Status (11)

Country Link
US (1) US20090305228A1 (fr)
EP (1) EP1969368A2 (fr)
JP (1) JP2009519302A (fr)
KR (1) KR20080106164A (fr)
CN (1) CN101375160A (fr)
AU (1) AU2006328798B2 (fr)
BR (1) BRPI0619994A2 (fr)
CA (1) CA2633331A1 (fr)
FR (1) FR2895086B1 (fr)
IL (1) IL192195A0 (fr)
WO (1) WO2007071839A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999058147A1 (fr) * 1998-05-08 1999-11-18 Universite Catholique De Louvain APOPTOSE DE CELLULES TUEUSES HUMAINES NAÏVES PAR FORMATION DE LIAISONS CROISEES ENTRE LEURS MOLECULES FcγRllla ET UN ISOTYPE lgG2b DU RAT (LO-CD2a/BTI-322) OU SON ANTICORPS MONOCLONAL HUMANISE igG1
WO2001077181A2 (fr) * 2000-04-12 2001-10-18 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Anticorps monoclonaux anti-rhesus d

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5783186A (en) * 1995-12-05 1998-07-21 Amgen Inc. Antibody-induced apoptosis
FR2844455B1 (fr) * 2002-09-13 2007-12-14 Lab Francais Du Fractionnement Traitement des pathologies echappant a la reponse immune par des anticorps optimises
FR2844513B1 (fr) * 2002-09-13 2007-08-03 Lab Francais Du Fractionnement Anticorps pour adcc et induisant la production de cytokines.
US7595165B2 (en) * 2002-09-13 2009-09-29 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Method of measuring activation of effector cells
FR2858235B1 (fr) * 2003-07-31 2006-02-17 Lab Francais Du Fractionnement Utilisation d'anticorps optimises en adcc pour traiter les patients faibles repondeurs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999058147A1 (fr) * 1998-05-08 1999-11-18 Universite Catholique De Louvain APOPTOSE DE CELLULES TUEUSES HUMAINES NAÏVES PAR FORMATION DE LIAISONS CROISEES ENTRE LEURS MOLECULES FcγRllla ET UN ISOTYPE lgG2b DU RAT (LO-CD2a/BTI-322) OU SON ANTICORPS MONOCLONAL HUMANISE igG1
WO2001077181A2 (fr) * 2000-04-12 2001-10-18 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Anticorps monoclonaux anti-rhesus d

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BOYLE J J: "Human macrophages kill human mesangial cells by Fas-L-induced apoptosis when triggered by antibody via CD16", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 137, no. 3, September 2004 (2004-09-01), pages 529 - 537, XP002397821, ISSN: 0009-9104 *
OSHIMI Y ET AL: "Necrosis and apoptosis associated with distinct Ca2+ response patterns in target cells attacked by human natural killer cells.", THE JOURNAL OF PHYSIOLOGY. 1 SEP 1996, vol. 495 ( Pt 2), 1 September 1996 (1996-09-01), pages 319 - 329, XP002398688, ISSN: 0022-3751 *
ROTHMAN R J ET AL: "Antibody-dependent cytotoxicity mediated by natural killer cells is enhanced by castanospermine-induced alterations of IgG glycosylation.", MOLECULAR IMMUNOLOGY DEC 1989, vol. 26, no. 12, December 1989 (1989-12-01), pages 1113 - 1123, XP002435543, ISSN: 0161-5890 *
SHINKAWA T ET AL: "The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 278, no. 5, 31 January 2003 (2003-01-31), pages 3466 - 3473, XP002965857, ISSN: 0021-9258 *
TAKESHITA SEIICHIRO ET AL: "Intravenous immunoglobulin preparations promote apoptosis in hpopolysaccharide-stimulated neutrophils via an oxygen-dependent pathway in vitro", APMIS, vol. 113, no. 4, April 2005 (2005-04-01), pages 269 - 277, XP002397822, ISSN: 0903-4641 *

Also Published As

Publication number Publication date
JP2009519302A (ja) 2009-05-14
AU2006328798A1 (en) 2007-06-28
CN101375160A (zh) 2009-02-25
WO2007071839A2 (fr) 2007-06-28
US20090305228A1 (en) 2009-12-10
AU2006328798B2 (en) 2012-02-09
FR2895086A1 (fr) 2007-06-22
FR2895086B1 (fr) 2012-10-05
BRPI0619994A2 (pt) 2011-10-25
EP1969368A2 (fr) 2008-09-17
CA2633331A1 (fr) 2007-06-28
IL192195A0 (en) 2008-12-29
KR20080106164A (ko) 2008-12-04

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