WO2007070996A3 - Liga and ligb proteins (leptospiral ig-like (lig) domains) for vaccination and diagnosis - Google Patents

Liga and ligb proteins (leptospiral ig-like (lig) domains) for vaccination and diagnosis Download PDF

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Publication number
WO2007070996A3
WO2007070996A3 PCT/BR2006/000283 BR2006000283W WO2007070996A3 WO 2007070996 A3 WO2007070996 A3 WO 2007070996A3 BR 2006000283 W BR2006000283 W BR 2006000283W WO 2007070996 A3 WO2007070996 A3 WO 2007070996A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
ligb
liga
diagnosis
leptospiral
Prior art date
Application number
PCT/BR2006/000283
Other languages
French (fr)
Other versions
WO2007070996A2 (en
Inventor
Marco Alberto Medeiros
Reis Mitemayer Galvao Dos
Silva Everton Fagonde Da
Alan John Alexander Mcbride
Julio Henrique Rosa Croda
Joao Gabriel Rosa Ramos
Odir Antonio Dellagostin
Flavia Weykamp Cruz Mcbride
Albert Icksang Ko
Original Assignee
Fundacao Oswaldo Cruz
Marco Alberto Medeiros
Reis Mitemayer Galvao Dos
Silva Everton Fagonde Da
Alan John Alexander Mcbride
Julio Henrique Rosa Croda
Joao Gabriel Rosa Ramos
Odir Antonio Dellagostin
Flavia Weykamp Cruz Mcbride
Albert Icksang Ko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundacao Oswaldo Cruz, Marco Alberto Medeiros, Reis Mitemayer Galvao Dos, Silva Everton Fagonde Da, Alan John Alexander Mcbride, Julio Henrique Rosa Croda, Joao Gabriel Rosa Ramos, Odir Antonio Dellagostin, Flavia Weykamp Cruz Mcbride, Albert Icksang Ko filed Critical Fundacao Oswaldo Cruz
Priority to CA002634214A priority Critical patent/CA2634214A1/en
Priority to EP06828120A priority patent/EP2024497A4/en
Publication of WO2007070996A2 publication Critical patent/WO2007070996A2/en
Publication of WO2007070996A3 publication Critical patent/WO2007070996A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/20—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention refers to isolated DNA (deoxyribonucleic acid) molecules that encode for LigA and LigB proteins. The invention further refers to the use of fragments of these proteins in the diagnosis, and formulation of vaccines for prevention of infections caused by Leptospira in humans and animals.
PCT/BR2006/000283 2005-12-19 2006-12-19 Liga and ligb proteins (leptospiral ig-like (lig) domains) for vaccination and diagnosis WO2007070996A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002634214A CA2634214A1 (en) 2005-12-19 2006-12-19 Liga and ligb proteins (leptospiral ig-like (lig) domains) for vaccination and diagnosis
EP06828120A EP2024497A4 (en) 2005-12-19 2006-12-19 LIGA AND LIGB PROTEINS (IG LEPTOSPIRE TYPE DOMAINS (LIG)) FOR IMMUNIZATION AND DIAGNOSIS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BRPI0505529-6A BRPI0505529A (en) 2005-12-19 2005-12-19 alloy and ligb (leptospiral ig-like (lig) domains) proteins for vaccination and diagnosis
BRPI0505529-6 2005-12-19

Publications (2)

Publication Number Publication Date
WO2007070996A2 WO2007070996A2 (en) 2007-06-28
WO2007070996A3 true WO2007070996A3 (en) 2007-09-20

Family

ID=38189000

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR2006/000283 WO2007070996A2 (en) 2005-12-19 2006-12-19 Liga and ligb proteins (leptospiral ig-like (lig) domains) for vaccination and diagnosis

Country Status (4)

Country Link
EP (1) EP2024497A4 (en)
BR (1) BRPI0505529A (en)
CA (1) CA2634214A1 (en)
WO (1) WO2007070996A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003098214A1 (en) * 2002-05-17 2003-11-27 Fundação Oswaldo Cruz - FIOCRUZ Proteins with repetitive bacterial-ig-like (big) domains present in leptospira species
WO2004032599A2 (en) * 2002-10-10 2004-04-22 Cornell Research Foundation, Inc. Novel immunogenic proteins of leptospira

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003098214A1 (en) * 2002-05-17 2003-11-27 Fundação Oswaldo Cruz - FIOCRUZ Proteins with repetitive bacterial-ig-like (big) domains present in leptospira species
WO2004032599A2 (en) * 2002-10-10 2004-04-22 Cornell Research Foundation, Inc. Novel immunogenic proteins of leptospira

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] 31 May 2007 (2007-05-31), XP008117444, retrieved from NCBI Database accession no. (gbAY190126.2) *
MATSUNAGA J. ET AL.: "Pathogenic Leptospira species express surface-exposed proteins belonging to the bacterial immunoglobulin superfamily", MOL. MICROBIOL., vol. 49, no. 4, August 2003 (2003-08-01), pages 929 - 945, XP002348166 *
NASCIMENTO ET AL.: "Comparative Genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis", J. BACTERIOL., vol. 186, no. 7, April 2004 (2004-04-01), pages 2164 - 2172, XP008127207 *
See also references of EP2024497A4 *

Also Published As

Publication number Publication date
CA2634214A1 (en) 2007-06-28
EP2024497A4 (en) 2010-03-17
BRPI0505529A (en) 2007-09-25
EP2024497A2 (en) 2009-02-18
WO2007070996A2 (en) 2007-06-28

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