WO2007067611A3 - Methods of treating cardiac reperfusion disease - Google Patents

Methods of treating cardiac reperfusion disease Download PDF

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Publication number
WO2007067611A3
WO2007067611A3 PCT/US2006/046538 US2006046538W WO2007067611A3 WO 2007067611 A3 WO2007067611 A3 WO 2007067611A3 US 2006046538 W US2006046538 W US 2006046538W WO 2007067611 A3 WO2007067611 A3 WO 2007067611A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
treating cardiac
cardiac reperfusion
reperfusion disease
compositions
Prior art date
Application number
PCT/US2006/046538
Other languages
French (fr)
Other versions
WO2007067611A2 (en
Inventor
Howard Weiner
Daniel Frenkel
Victor J Dzau
Alok S Pachori
Original Assignee
Brigham & Womens Hospital
Howard Weiner
Daniel Frenkel
Victor J Dzau
Alok S Pachori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham & Womens Hospital, Howard Weiner, Daniel Frenkel, Victor J Dzau, Alok S Pachori filed Critical Brigham & Womens Hospital
Publication of WO2007067611A2 publication Critical patent/WO2007067611A2/en
Publication of WO2007067611A3 publication Critical patent/WO2007067611A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Organic Chemistry (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Described herein are methods and compositions for treating or preventing cardiac reperfusion diseases. The methods include administering, e.g., mucosally, e.g., nasally, a therapeutically effective amount of a composition comprising a cardiac autoantigen, e.g., a troponin polypeptide. Also described are compositions and kits including troponin, e.g., for use in the methods described herein.
PCT/US2006/046538 2005-12-07 2006-12-06 Methods of treating cardiac reperfusion disease WO2007067611A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74824705P 2005-12-07 2005-12-07
US60/748,247 2005-12-07

Publications (2)

Publication Number Publication Date
WO2007067611A2 WO2007067611A2 (en) 2007-06-14
WO2007067611A3 true WO2007067611A3 (en) 2008-03-06

Family

ID=38123450

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/046538 WO2007067611A2 (en) 2005-12-07 2006-12-06 Methods of treating cardiac reperfusion disease

Country Status (1)

Country Link
WO (1) WO2007067611A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210038687A1 (en) * 2019-08-07 2021-02-11 Wayne State University Compositions and methods relating to a c-terminal peptide of troponin i with activity as a myofilament ca2+ desensitizer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0753312A1 (en) * 1993-09-29 1997-01-15 Kirin Beer Kabushiki Kaisha Arteriosclerosis remedy
WO1997030085A1 (en) * 1996-02-16 1997-08-21 Children's Medical Center Corporation Troponin subunits and fragments useful as angiogenesis inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0753312A1 (en) * 1993-09-29 1997-01-15 Kirin Beer Kabushiki Kaisha Arteriosclerosis remedy
WO1997030085A1 (en) * 1996-02-16 1997-08-21 Children's Medical Center Corporation Troponin subunits and fragments useful as angiogenesis inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FRENKEL D ET AL: "Neuroprotection by IL-10-producing MOG CD4+ T cells following ischemic stroke Preserve the Neuron. Brain Atrophy, Axonal Loss, Remyelination and Stem Cells in MS. European Charcot Foundation Symposium", JOURNAL OF THE NEUROLOGICAL SCIENCES 15 JUN 2005 NETHERLANDS, vol. 233, no. 1-2, 15 June 2005 (2005-06-15), pages 125 - 132, XP004932292, ISSN: 0022-510X *
SCIRICA BENJAMIN M ET AL: "Troponins in acute coronary syndromes.", SEMINARS IN VASCULAR MEDICINE NOV 2003, vol. 3, no. 4, November 2003 (2003-11-01), pages 363 - 374, XP009047291, ISSN: 1528-9648 *

Also Published As

Publication number Publication date
WO2007067611A2 (en) 2007-06-14

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