WO2007065036A3 - Therapeutic conjugates and methods of using same - Google Patents

Therapeutic conjugates and methods of using same Download PDF

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Publication number
WO2007065036A3
WO2007065036A3 PCT/US2006/046459 US2006046459W WO2007065036A3 WO 2007065036 A3 WO2007065036 A3 WO 2007065036A3 US 2006046459 W US2006046459 W US 2006046459W WO 2007065036 A3 WO2007065036 A3 WO 2007065036A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
same
compositions
therapeutic conjugates
gabapentin
Prior art date
Application number
PCT/US2006/046459
Other languages
French (fr)
Other versions
WO2007065036A2 (en
Inventor
Timothy J Fultz
Yuqiang Wang
Original Assignee
Neuromolecular Pharmaceuticals
Timothy J Fultz
Yuqiang Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuromolecular Pharmaceuticals, Timothy J Fultz, Yuqiang Wang filed Critical Neuromolecular Pharmaceuticals
Publication of WO2007065036A2 publication Critical patent/WO2007065036A2/en
Publication of WO2007065036A3 publication Critical patent/WO2007065036A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides novel gabapentin-aminoadamantane derivative combinations (e.g. gabapentin-memantine) combinatorial compositions, methods of making the compositions, and methods for the treatment and prevention of neurological diseases, e.g., epilepsy, and neuropathic and chronic pain, using the compositions of the invention.
PCT/US2006/046459 2005-12-02 2006-12-04 Therapeutic conjugates and methods of using same WO2007065036A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74196205P 2005-12-02 2005-12-02
US60/741,962 2005-12-02

Publications (2)

Publication Number Publication Date
WO2007065036A2 WO2007065036A2 (en) 2007-06-07
WO2007065036A3 true WO2007065036A3 (en) 2008-07-31

Family

ID=37806190

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/046459 WO2007065036A2 (en) 2005-12-02 2006-12-04 Therapeutic conjugates and methods of using same

Country Status (1)

Country Link
WO (1) WO2007065036A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010507648A (en) 2006-10-25 2010-03-11 ラモット アット テル−アビブ ユニバーシティー リミテッド Novel psychotropic drug with glutamic acid NMDA activity
US8828665B2 (en) 2007-02-16 2014-09-09 Ark Diagnostics, Inc. Compounds and methods for use in detecting gabapentin
WO2010048423A1 (en) 2008-10-24 2010-04-29 Ark Diagnostics, Inc. Levetiracetam immunoassays
US9970929B2 (en) 2013-01-18 2018-05-15 Ark Diagnostics, Inc. Voriconazole immunoassays
EP2956444B1 (en) 2013-02-13 2018-05-30 ARK Diagnostics, Inc. Posaconazole immunoassays
CN118239847A (en) * 2014-05-29 2024-06-25 广州喜鹊医药有限公司 Preparation method of amantadine nitrate compound with neuroprotection effect
WO2019104020A1 (en) * 2017-11-22 2019-05-31 Panorama Research, Inc. Aminoadamantyl nitrate compounds and their use to treat cns disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020142998A1 (en) * 2000-10-06 2002-10-03 Cundy Kenneth C. Bile-acid conjugates for providing sustained systemic concentrations of drugs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020142998A1 (en) * 2000-10-06 2002-10-03 Cundy Kenneth C. Bile-acid conjugates for providing sustained systemic concentrations of drugs

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BRYANS ET AL: "Identification of novel ligands for the Gabapentin binding site", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 41, 1 January 1998 (1998-01-01), pages 183818 - 45, XP002139354, ISSN: 0022-2623 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SHI, WEI-GUO ET AL: "Design and synthesis of mutual prodrugs for relieving neuropathic pain (II)", XP002482875, retrieved from STN Database accession no. 2007:1408625 *
HONG-JU Y ET AL: "Effect of gabapentin derivates on mechanical allodynia-like behaviour in a rat model of chronic sciatic constriction injury", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 14, no. 10, 17 May 2004 (2004-05-17), pages 2537 - 2541, XP004841234, ISSN: 0960-894X *
OTAGIRI M ET AL: "Improving the pharmacokinetic and pharmacodynamic properties of a drug by chemical conversion to a chimera drug", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 62, no. 1-2, 1 November 1999 (1999-11-01), pages 223 - 229, XP004363020, ISSN: 0168-3659 *
SHARMA V ET AL: "Prodrugs and mutual prodrugs: Synthesis of some new pyrazolone and oxadiazole analogues of a few non-steroidal anti-inflammatory drugs", PHARMAZIE 20030201 DE, vol. 58, no. 2, 1 February 2003 (2003-02-01), pages 99 - 103, XP008092471, ISSN: 0031-7144 *
SHI W ET AL: "DESIGN, SYNTHESIS, AND PRELIMINARY EVALUATION OF GABAPENTIN-PREGABALIN MUTUAL PRODRUGS IN RELIEVING NEUROPATHIC PAIN", ARCHIV DER PHARMAZIE, VCH VERLAGSGESELLSCHAFT MBH, WEINHEIM, DE, vol. 338, no. 8, 1 January 2005 (2005-01-01), pages 358 - 364, XP008067446, ISSN: 0365-6233 *
YOON MYUNG HA ET AL: "Antinociceptive interactions between intrathecal gabapentin and MK801 or NBQX in rat formalin test", JOURNAL OF KOREAN MEDICAL SCIENCE, vol. 20, no. 2, April 2005 (2005-04-01), pages 307 - 312, XP002482874, ISSN: 1011-8934 *
ZHONGGUO XINYAO ZAZHI , 16(20), 1689-1692 CODEN: ZXZHA6; ISSN: 1003-3734, 2007 *
ZOIDIS G ET AL: "The novel GABA adamantane derivative (AdGABA): design, synthesis, and activity relationship with gabapentin", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 13, no. 8, 15 April 2005 (2005-04-15), pages 2791 - 2798, XP004802818, ISSN: 0968-0896 *

Also Published As

Publication number Publication date
WO2007065036A2 (en) 2007-06-07

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