WO2007063428A3 - Pharmaceutical compositions comprising carboxyalkylsulfonic acids - Google Patents

Pharmaceutical compositions comprising carboxyalkylsulfonic acids Download PDF

Info

Publication number
WO2007063428A3
WO2007063428A3 PCT/IB2006/004011 IB2006004011W WO2007063428A3 WO 2007063428 A3 WO2007063428 A3 WO 2007063428A3 IB 2006004011 W IB2006004011 W IB 2006004011W WO 2007063428 A3 WO2007063428 A3 WO 2007063428A3
Authority
WO
WIPO (PCT)
Prior art keywords
carboxyalkylsulfonic
acids
pharmaceutical compositions
abeta
disease
Prior art date
Application number
PCT/IB2006/004011
Other languages
French (fr)
Other versions
WO2007063428A2 (en
Inventor
Xianqi Kong
Julie Laurin
Original Assignee
Neurochem Int Ltd
Xianqi Kong
Julie Laurin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurochem Int Ltd, Xianqi Kong, Julie Laurin filed Critical Neurochem Int Ltd
Priority to CA002624693A priority Critical patent/CA2624693A1/en
Priority to EP06842398A priority patent/EP1937239A2/en
Priority to JP2008532908A priority patent/JP2009510050A/en
Priority to AU2006321294A priority patent/AU2006321294A1/en
Publication of WO2007063428A2 publication Critical patent/WO2007063428A2/en
Publication of WO2007063428A3 publication Critical patent/WO2007063428A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Pharmaceutical compositions and methods for using carboxyalkylsulfonic acids, and pharmaceutically acceptable solvates thereof are described. The compounds of the invention are particularly useful as neuroprotective agents and for the prevention and/or treatment Abeta-amyloid related diseases, including Alzheimer's disease.
PCT/IB2006/004011 2005-09-30 2006-10-02 Pharmaceutical compositions comprising carboxyalkylsulfonic acids WO2007063428A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002624693A CA2624693A1 (en) 2005-09-30 2006-10-02 Pharmaceutical compositions comprising carboxyalkylsulfonic acids
EP06842398A EP1937239A2 (en) 2005-09-30 2006-10-02 Pharmaceutical compositions comprising carboxyalkylsulfonic acids
JP2008532908A JP2009510050A (en) 2005-09-30 2006-10-02 Pharmaceutical compositions and methods comprising carboxyalkyl sulfonic acids
AU2006321294A AU2006321294A1 (en) 2005-09-30 2006-10-02 Pharmaceutical compositions comprising carboxyalkylsulfonic acids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72289105P 2005-09-30 2005-09-30
US60/722,891 2005-09-30

Publications (2)

Publication Number Publication Date
WO2007063428A2 WO2007063428A2 (en) 2007-06-07
WO2007063428A3 true WO2007063428A3 (en) 2008-01-17

Family

ID=38092635

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/004011 WO2007063428A2 (en) 2005-09-30 2006-10-02 Pharmaceutical compositions comprising carboxyalkylsulfonic acids

Country Status (5)

Country Link
EP (1) EP1937239A2 (en)
JP (1) JP2009510050A (en)
AU (1) AU2006321294A1 (en)
CA (1) CA2624693A1 (en)
WO (1) WO2007063428A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996028187A1 (en) * 1995-03-15 1996-09-19 Queen's University At Kingston Method for treating amyloidosis
JP2002020393A (en) * 2000-06-30 2002-01-23 Sumitomo Pharmaceut Co Ltd Sulfonic acid derivative
WO2004113275A2 (en) * 2003-06-23 2004-12-29 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
WO2005000288A2 (en) * 2003-06-23 2005-01-06 Neurochem (International) Limited Treatment of protein aggregation disorders

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996028187A1 (en) * 1995-03-15 1996-09-19 Queen's University At Kingston Method for treating amyloidosis
JP2002020393A (en) * 2000-06-30 2002-01-23 Sumitomo Pharmaceut Co Ltd Sulfonic acid derivative
WO2004113275A2 (en) * 2003-06-23 2004-12-29 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
WO2005000288A2 (en) * 2003-06-23 2005-01-06 Neurochem (International) Limited Treatment of protein aggregation disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ITAKURA, YASUSHI ET AL: "Phosphatidylcholine sulfonic acid-modified nerve nutrition factors", XP002457505, retrieved from STN Database accession no. 2002:63505 *

Also Published As

Publication number Publication date
CA2624693A1 (en) 2007-06-07
EP1937239A2 (en) 2008-07-02
JP2009510050A (en) 2009-03-12
AU2006321294A1 (en) 2007-06-07
WO2007063428A2 (en) 2007-06-07

Similar Documents

Publication Publication Date Title
WO2004062625A3 (en) Macrocyclic beta-secretase inhibitors for treatment of alzheimer's disease
WO2005004803A3 (en) Phenylcarboxylate beta-secretase inhibitors for the treatment of alzheimer's disease
WO2005004802A3 (en) N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease
EP1940373B8 (en) 1-fluoro-1-deoxy-scyllo-inositol for the treatment of alzheimer's disease
WO2005018545A3 (en) Macrocyclic beta-secretase inhibitors for the treatment of alzheimer's disease
WO2005032471A3 (en) Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease
WO2005065195A3 (en) Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of alzheimer's disease
WO2005051914A8 (en) Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease
HK1087398A1 (en) 1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases
EP1562897A4 (en) Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer s disease
EP1841426A4 (en) Tertiary carbinamines having substituted heterocycles, which are active as inhibitors of beta-secretase, for the treatment of alzheimer's disease
PT2527315E (en) Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes and parkinson's disease
WO2004006858A3 (en) Compounds, compositions, and methods employing same
WO2006078576A3 (en) Aminomethyl beta-secretase inhibitors for the treatment of alzheimer's disease
AU2005313582A8 (en) Malonamide derivatives as inhibitors of gamma-secretase for the treatment of Alzheimer's disease
WO2006057945A3 (en) 2,3,4,6-substituted pyridyl derivative compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
WO2006055434A3 (en) Macrocyclic tertiary amine beta-secretase inhibitors for the treatment of alzheimer's disease
WO2007058862A3 (en) Imidazolidinone compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
HK1104280A1 (en) Derivatives of 1-phenylalkanecarboxylic acids for the treatment of neurodegenerative diseases
WO2006019685A3 (en) Compounds and their preparation for the treatment of alzheimer's disease by inhibiting beta-amyloid peptide production
WO2005092062A3 (en) Compounds for neurodegenerative disorders
WO2007019078A3 (en) Tricyclic beta-secretase inhibitors for the treatment of alzheimer's disease
AU2003303141A1 (en) Hydroxypropyl amides for the treatment of alzheimer's disease
WO2008004100A3 (en) Therapeutic compounds
WO2007019080A3 (en) Tricyclic beta-secretase inhibitors for the treatment of alzheimer's disease

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 2006842398

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2008532908

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2624693

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2006321294

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2006321294

Country of ref document: AU

Date of ref document: 20061002

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2006321294

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 2006842398

Country of ref document: EP