WO2007063290A3 - Method of processing a biological image - Google Patents

Method of processing a biological image Download PDF

Info

Publication number
WO2007063290A3
WO2007063290A3 PCT/GB2006/004444 GB2006004444W WO2007063290A3 WO 2007063290 A3 WO2007063290 A3 WO 2007063290A3 GB 2006004444 W GB2006004444 W GB 2006004444W WO 2007063290 A3 WO2007063290 A3 WO 2007063290A3
Authority
WO
WIPO (PCT)
Prior art keywords
cytoplasm
micronuclei
processing
nuclei
search
Prior art date
Application number
PCT/GB2006/004444
Other languages
French (fr)
Other versions
WO2007063290A2 (en
Inventor
Nicholas Thomas
Geert Kalusche
Original Assignee
Ge Healthcare Uk Ltd
Nicholas Thomas
Geert Kalusche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Uk Ltd, Nicholas Thomas, Geert Kalusche filed Critical Ge Healthcare Uk Ltd
Publication of WO2007063290A2 publication Critical patent/WO2007063290A2/en
Publication of WO2007063290A3 publication Critical patent/WO2007063290A3/en

Links

Classifications

    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/695—Preprocessing, e.g. image segmentation
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification

Abstract

A method of processing an image of a biological sample containing nuclei, cytoplasm and micronuclei, each of the nuclei being surrounded by cytoplasm, determines the incidence of micronuclei in the sample. The cytoplasm has a maximum distance, which is the largest extent of the cytoplasm from its nucleus occurring in the image. The method includes the steps of setting a search distance at a value less than the maximum distance, searching for micronuclei within the search distance from the nuclei and annotating the micronuclei found in the search.
PCT/GB2006/004444 2005-11-30 2006-11-28 Method of processing a biological image WO2007063290A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0524334.0A GB0524334D0 (en) 2005-11-30 2005-11-30 Method of processing a biological image
GB0524334.0 2005-11-30

Publications (2)

Publication Number Publication Date
WO2007063290A2 WO2007063290A2 (en) 2007-06-07
WO2007063290A3 true WO2007063290A3 (en) 2007-09-27

Family

ID=35601462

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/004444 WO2007063290A2 (en) 2005-11-30 2006-11-28 Method of processing a biological image

Country Status (2)

Country Link
GB (1) GB0524334D0 (en)
WO (1) WO2007063290A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050002552A1 (en) * 2003-04-30 2005-01-06 Pfizer Inc Automated in vitro cellular imaging assays for micronuclei and other target objects

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050002552A1 (en) * 2003-04-30 2005-01-06 Pfizer Inc Automated in vitro cellular imaging assays for micronuclei and other target objects

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A. V. LOZANO, J. A. MÁRQUEZ, A. E. BUENFIL, AND M. E. GONSEBATT: "Design of an Automated-Counting System of Cell Micronuclei in Micrographs", AIP CONFERENCE PROCEEDINGS - MEDICAL PHYSICS: EIGHTH MEXICAN SYMPOSIUM ON MEDICAL PHYSICS, vol. 724, 30 September 2004 (2004-09-30), pages 124 - 127, XP002443947 *
LOZANO A ET AL: "Pattern analysis of cell micronuclei images to evaluate their use as indicators of cell damage", PROCEEDINGS OF THE 25TH. ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. CANCUN, MEXICO, SEPT. 17, vol. VOL. 4 OF 4. CONF. 25, 17 September 2003 (2003-09-17), pages 731 - 734, XP010693432, ISBN: 0-7803-7789-3 *
TATES A ET AL: "The present state of the automated micronucleus test for lymphocytes", INTERNATIONAL JOURNAL OF RADIATION BIOLOGY AND RELATED STUDIES IN PHYSICS, CHEMISTRY AND MEDICINE, FRANCIS AND TAYLOR, BASINGSTOKE, GB, vol. 58, November 1990 (1990-11-01), pages 813 - 825, XP008081460, ISSN: 0020-7616 *
VARGA D. ET AL.: "An automated scoring procedure for the micronucleus test by image analysis", MUTAGENESIS, vol. 19, no. 5, 2004, pages 391 - 397, XP002443946 *

Also Published As

Publication number Publication date
GB0524334D0 (en) 2006-01-04
WO2007063290A2 (en) 2007-06-07

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