WO2007060692A3 - Compositions pour l'accroissement de la biodisponibilite de peptides ou de proteines et procede associe - Google Patents

Compositions pour l'accroissement de la biodisponibilite de peptides ou de proteines et procede associe Download PDF

Info

Publication number
WO2007060692A3
WO2007060692A3 PCT/IN2006/000468 IN2006000468W WO2007060692A3 WO 2007060692 A3 WO2007060692 A3 WO 2007060692A3 IN 2006000468 W IN2006000468 W IN 2006000468W WO 2007060692 A3 WO2007060692 A3 WO 2007060692A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
proteins
compositions
increasing bioavailability
saccharide
Prior art date
Application number
PCT/IN2006/000468
Other languages
English (en)
Other versions
WO2007060692A2 (fr
Inventor
Ramanathan Halasya
Original Assignee
Brain N Beyond Biotech Pvt Ltd
Ramanathan Halasya
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brain N Beyond Biotech Pvt Ltd, Ramanathan Halasya filed Critical Brain N Beyond Biotech Pvt Ltd
Publication of WO2007060692A2 publication Critical patent/WO2007060692A2/fr
Publication of WO2007060692A3 publication Critical patent/WO2007060692A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C07H11/04—Phosphates; Phosphites; Polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention a trait à un composé de formule I: (A)-(L)-(B) dans laquelle (B) est un groupe fonctionnel hydrophobe; (L) est une liaison covalente entre le saccharide (A) et le groupe fonctionnel hydrophobe (B); (A) est un saccharide qui est non substitué au niveau du groupe hydroxyle de la position anomère.
PCT/IN2006/000468 2005-11-24 2006-11-23 Compositions pour l'accroissement de la biodisponibilite de peptides ou de proteines et procede associe WO2007060692A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1718/CHE/2005 2005-11-24
IN1718CH2005 2005-11-24

Publications (2)

Publication Number Publication Date
WO2007060692A2 WO2007060692A2 (fr) 2007-05-31
WO2007060692A3 true WO2007060692A3 (fr) 2009-05-14

Family

ID=38067641

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2006/000468 WO2007060692A2 (fr) 2005-11-24 2006-11-23 Compositions pour l'accroissement de la biodisponibilite de peptides ou de proteines et procede associe

Country Status (1)

Country Link
WO (1) WO2007060692A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008297927A1 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of Trp6-Triptorelin and D-Leu6-Leuprolide as therapeutic agents
WO2012158962A2 (fr) 2011-05-18 2012-11-22 Eumederis Pharmaceuticals, Inc. Agents pharmaceutiques peptidiques améliorés
CN111701028A (zh) 2011-05-18 2020-09-25 梅德瑞斯糖尿病有限责任公司 用于胰岛素抵抗的改进的肽医药
EP3434696A1 (fr) 2012-11-20 2019-01-30 Mederis Diabetes, LLC Produits pharmaceutiques peptidiques améliorés pour la résistance à l'insuline
DK3444281T3 (da) * 2012-11-20 2022-02-07 Eumederis Pharmaceuticals Inc Forbedrede peptidlægemidler
CN117180445A (zh) 2014-05-28 2023-12-08 梅德瑞斯糖尿病有限责任公司 针对胰岛素抵抗的改良肽药物
IL311775A (en) 2018-01-03 2024-05-01 Mederis Diabetes Llc Improved peptide drugs for the treatment of NASH and other disorders

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003086475A1 (fr) * 2002-04-12 2003-10-23 A & D Bioscience, Inc. Conjugues comprenant des ligands specifiques a des cellules cancereuses, un sucre et des agents de diagnostic, ainsi que leurs utilisations
WO2004002457A2 (fr) * 2002-06-27 2004-01-08 A & D Bioscience, Inc. Conjugues comprenant un anti-inflammatoire non steroidien et un sucre et applications de ceux-ci
WO2007052308A2 (fr) * 2005-11-03 2007-05-10 Brain N' Beyond Biotech Pvt. Ltd. Agents biologiquement actifs glyco-phosphoryles

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003086475A1 (fr) * 2002-04-12 2003-10-23 A & D Bioscience, Inc. Conjugues comprenant des ligands specifiques a des cellules cancereuses, un sucre et des agents de diagnostic, ainsi que leurs utilisations
WO2004002457A2 (fr) * 2002-06-27 2004-01-08 A & D Bioscience, Inc. Conjugues comprenant un anti-inflammatoire non steroidien et un sucre et applications de ceux-ci
WO2007052308A2 (fr) * 2005-11-03 2007-05-10 Brain N' Beyond Biotech Pvt. Ltd. Agents biologiquement actifs glyco-phosphoryles

Also Published As

Publication number Publication date
WO2007060692A2 (fr) 2007-05-31

Similar Documents

Publication Publication Date Title
WO2007060692A3 (fr) Compositions pour l'accroissement de la biodisponibilite de peptides ou de proteines et procede associe
WO2008012542A3 (fr) Dérivatisation d'érythropoïétine
WO2006127896A3 (fr) Facteur ix glycopegyle
EP2549276A3 (fr) Couplage covalente et réversible de molecules fonctionelles
WO2008084411A3 (fr) Saccharides modifiés
WO2006120208A8 (fr) Procedes de preparation de derives de benzylbenzene a substitution glucopyranosyl et intermediaires obtenus selon ces procedes
WO2007090623A3 (fr) Ternary synergistic fungicidal compositions
WO2006074467A3 (fr) Facteur de stimulation de colonie de granulocytes glycopegylatees
EP2374481A3 (fr) Nouveaux réactifs et procédé pour conjuguer des molécules biologiques
WO2006020372A3 (fr) Modification enzymatique de glycopeptides
WO2009043027A3 (fr) Formes tentaculaires de polyoxazoline activée et leurs procédés de synthèse
WO2006087143A8 (fr) Nouveaux procedes de preparation d'un 2h-chromene
WO2003006070A3 (fr) Conjugues de chelateurs ameliores
WO2008062478A3 (fr) Procédé perfectionné pour préparer du montélukast sodique pur par des intermédiaires purs ainsi que nouveaux sels d'amines
WO2008127305A3 (fr) Procédé d'isolement de biomacromolécules utilisant un faible ph et des cations divalents
WO2007038425A3 (fr) Composes antiviraux
WO2007016029A3 (fr) Diazepinoquinolines, synthese de ces dernieres et intermediaires correspondants
AU2003248652A1 (en) Methods for improving a binding characteristic of a molecule
WO2004050663A3 (fr) Procede ameliore de preparation de cefuroxime sodique
WO2007029084A3 (fr) Composes de carpapenem: operation amelioree de fabrication
WO2006117800A3 (fr) Nouveaux derives de 3, 4-propylenedioxythiophene comprenant des groupes fonctionnels pendants
WO2011051733A3 (fr) Composés et leurs utilisations dans des dosages de liaison aux protéines
WO2006122020A3 (fr) Procede de production de 4-biphenylyazetidin-2-ones
WO2007013043A3 (fr) Procedes d'elaboration d'acide 7-amino-3-vinyl cephalosporanique
WO2007103548A3 (fr) Nouvelles préparations d'antibiotiques

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06832307

Country of ref document: EP

Kind code of ref document: A2