WO2007058950A3 - Biological interface system with neural signal classification systems and methods - Google Patents

Biological interface system with neural signal classification systems and methods Download PDF

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Publication number
WO2007058950A3
WO2007058950A3 PCT/US2006/043815 US2006043815W WO2007058950A3 WO 2007058950 A3 WO2007058950 A3 WO 2007058950A3 US 2006043815 W US2006043815 W US 2006043815W WO 2007058950 A3 WO2007058950 A3 WO 2007058950A3
Authority
WO
WIPO (PCT)
Prior art keywords
neural
feature space
spike
multicellular signals
neural signal
Prior art date
Application number
PCT/US2006/043815
Other languages
French (fr)
Other versions
WO2007058950A2 (en
Inventor
Daniel J Sebald
Almut Branner
Kirk F Korver
Andras Pungor
J Christopher Flaherty
Original Assignee
Cyberkinetics Neurotechnology
Daniel J Sebald
Almut Branner
Kirk F Korver
Andras Pungor
J Christopher Flaherty
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cyberkinetics Neurotechnology, Daniel J Sebald, Almut Branner, Kirk F Korver, Andras Pungor, J Christopher Flaherty filed Critical Cyberkinetics Neurotechnology
Publication of WO2007058950A2 publication Critical patent/WO2007058950A2/en
Publication of WO2007058950A3 publication Critical patent/WO2007058950A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/388—Nerve conduction study, e.g. detecting action potential of peripheral nerves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • A61B5/0017—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system transmitting optical signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0204—Operational features of power management
    • A61B2560/0214—Operational features of power management of power generation or supply
    • A61B2560/0219—Operational features of power management of power generation or supply of externally powered implanted units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/725—Details of waveform analysis using specific filters therefor, e.g. Kalman or adaptive filters
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Artificial Intelligence (AREA)
  • Signal Processing (AREA)
  • Psychiatry (AREA)
  • Physiology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Evolutionary Computation (AREA)
  • Mathematical Physics (AREA)
  • Fuzzy Systems (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

Systems and methods for neural signal classification for the processing of multicellular signals of a patient are disclosed. The system includes a preprocessing device operatively coupled to an input channel and configured to receive multicellular signals collected from a sensor, at least a portion of the sensor configured to be disposed within the brain of a patient. The preprocessing device is also configured to filter the multicellular signals to extract a neural signal portion of the multicellular signals, the neural signal portion including a neural spike portion and a local field potential portion. The system also includes a neural spike processing device operatively coupled to the preprocessing device. The system is configured to project information associated with a neural spike onto a feature space, the feature space indicative of a correlation of the neural spike with a benchmark signal. The system is also configured to adaptively determining a spike sorting statistical model for the feature space samples. The system is further configured to identify one or more types of voluntary stimuli based on analysis of the feature space, wherein the projected information is grouped in clusters, each cluster defining a particular type of voluntary stimuli.
PCT/US2006/043815 2005-11-10 2006-11-09 Biological interface system with neural signal classification systems and methods WO2007058950A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73515805P 2005-11-10 2005-11-10
US60/735,158 2005-11-10

Publications (2)

Publication Number Publication Date
WO2007058950A2 WO2007058950A2 (en) 2007-05-24
WO2007058950A3 true WO2007058950A3 (en) 2007-08-02

Family

ID=37762692

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/043815 WO2007058950A2 (en) 2005-11-10 2006-11-09 Biological interface system with neural signal classification systems and methods

Country Status (1)

Country Link
WO (1) WO2007058950A2 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
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US8352385B2 (en) * 2007-05-25 2013-01-08 Massachusetts Institute Of Technology Low-power analog-circuit architecture for decoding neural signals
US9545519B2 (en) 2009-07-20 2017-01-17 Imec Active interface device
EP2278329B1 (en) * 2009-07-20 2014-04-30 Imec Active interface device
GB2487758A (en) * 2011-02-03 2012-08-08 Isansys Lifecare Ltd Health monitoring electrode assembly
US9326720B2 (en) * 2011-02-09 2016-05-03 The Charles Stark Draper Laboratory, Inc. Wireless, implantable electro-encephalography system
US9486332B2 (en) 2011-04-15 2016-11-08 The Johns Hopkins University Multi-modal neural interfacing for prosthetic devices
US20140249646A1 (en) * 2011-08-29 2014-09-04 Neurodan A/S System for recording electroneurographic activity
JP6149269B2 (en) 2011-10-04 2017-06-21 スマートステント ピーティーワイ リミテッド Sensing or stimulating tissue activity
CN102824169A (en) * 2012-08-27 2012-12-19 中国科学院半导体研究所 Implantable neural signal recording system based on body channel transmission technology
US9591981B2 (en) 2012-12-04 2017-03-14 Biosense Webster (Isreal) Ltd. Multi-channel ECG measurement
CN107072569A (en) * 2014-10-16 2017-08-18 新加坡科技研究局 Spike detection module based on frame
US10080898B2 (en) 2015-05-29 2018-09-25 Medtronic, Inc. Simultaneous physiological sensing and stimulation with saturation detection
US10434308B2 (en) 2015-05-29 2019-10-08 Medtronic, Inc. Impedance matching and electrode conditioning in patient interface systems
DE102015108859B4 (en) * 2015-06-03 2018-12-27 Cortec Gmbh Method and system for processing data streams
CN108513542B (en) 2015-10-20 2020-09-18 墨尔本大学 Medical device for sensing and/or stimulating tissue
CN105662598B (en) * 2015-12-31 2017-12-29 清华大学 A kind of cerebral cortex Orientation of functions device, method and system
WO2018195083A1 (en) 2017-04-18 2018-10-25 The University Of Melbourne Endovascular device for sensing and or stimulating tissue
CN107545241B (en) * 2017-07-19 2022-05-27 百度在线网络技术（北京）有限公司 Neural network model training and living body detection method, device and storage medium
CN110521617B (en) * 2018-05-25 2022-06-17 中国科学院深圳先进技术研究院 Animal behavior monitoring system
US11622727B2 (en) 2019-05-09 2023-04-11 Tim Chifong Lei Process and hardware implementation of adaptive real-time neural spike sorting
CN110432900B (en) * 2019-07-01 2020-07-10 华中科技大学 Multi-view learning method and system for rhesus monkey eye movement decision decoding
IT201900010524A1 (en) * 2019-07-01 2021-01-01 Afros Spa Monitored mixing and dosing head
CN112381174B (en) * 2020-12-01 2024-02-02 杭州电子科技大学 Neural signal classification method for multi-electrode array
CN113057656B (en) * 2021-03-29 2022-02-01 浙江大学 Method, device and system for detecting brain nerve spike potential signal on line based on self-adaptive threshold

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0753284A2 (en) * 1995-07-10 1997-01-15 Director-General of the Agency of Industrial Science and Technology Single-nerve-action-potential-measuring apparatus
WO2000009008A1 (en) * 1998-08-17 2000-02-24 Emory University System and methods for controlling devices by brain signals
WO2005051189A2 (en) * 2003-11-25 2005-06-09 Cyberkinetics, Inc. Neural system with embedded id

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0753284A2 (en) * 1995-07-10 1997-01-15 Director-General of the Agency of Industrial Science and Technology Single-nerve-action-potential-measuring apparatus
WO2000009008A1 (en) * 1998-08-17 2000-02-24 Emory University System and methods for controlling devices by brain signals
WO2005051189A2 (en) * 2003-11-25 2005-06-09 Cyberkinetics, Inc. Neural system with embedded id

Also Published As

Publication number Publication date
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