WO2007057665A3 - Detection of human platelet antigen (hpa) antibodies - Google Patents

Detection of human platelet antigen (hpa) antibodies Download PDF

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Publication number
WO2007057665A3
WO2007057665A3 PCT/GB2006/004262 GB2006004262W WO2007057665A3 WO 2007057665 A3 WO2007057665 A3 WO 2007057665A3 GB 2006004262 W GB2006004262 W GB 2006004262W WO 2007057665 A3 WO2007057665 A3 WO 2007057665A3
Authority
WO
WIPO (PCT)
Prior art keywords
hpa
antibodies
detection
human platelet
gpiiia
Prior art date
Application number
PCT/GB2006/004262
Other languages
French (fr)
Other versions
WO2007057665A2 (en
Inventor
Prachi Stafford
Nicholas Watkins
Willem Ouwehand
Original Assignee
Cambridge Entpr Ltd
Prachi Stafford
Nicholas Watkins
Willem Ouwehand
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0523266A external-priority patent/GB0523266D0/en
Priority claimed from GB0611806A external-priority patent/GB0611806D0/en
Application filed by Cambridge Entpr Ltd, Prachi Stafford, Nicholas Watkins, Willem Ouwehand filed Critical Cambridge Entpr Ltd
Priority to EP06808552A priority Critical patent/EP1969006A2/en
Publication of WO2007057665A2 publication Critical patent/WO2007057665A2/en
Publication of WO2007057665A3 publication Critical patent/WO2007057665A3/en
Priority to US12/121,059 priority patent/US20090317413A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/70557—Integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/222—Platelet disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/226—Thrombotic disorders, i.e. thrombo-embolism irrespective of location/organ involved, e.g. renal vein thrombosis, venous thrombosis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

This invention relates to recombinant GPIIIa molecules that lack the ligand binding A domain and bind to HPA-1 antibodies in monomeric form. These GPIIIa molecules can be recombinantly expressed at high levels and may be useful, for example, in the detection of HPA-1 antibodies. Such detection may be useful, for example, in the diagnosis and therapy of HPA antibody disorders such as Neonatal Alloimmune Immune Thrombocytpenia (NAIT), Post Transfusion Purpura (PTP) and Platelet Refractoriness (PR).
PCT/GB2006/004262 2005-11-15 2006-11-15 Detection of human platelet antigen (hpa) antibodies WO2007057665A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP06808552A EP1969006A2 (en) 2005-11-15 2006-11-15 Detection of human platelet antigen (hpa) antibodies
US12/121,059 US20090317413A1 (en) 2005-11-15 2008-05-15 Detection of human platelet antigen (hpa) antibodies

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0523266.5 2005-11-15
GB0523266A GB0523266D0 (en) 2005-11-15 2005-11-15 Materials and methods
GB0611806.1 2006-06-14
GB0611806A GB0611806D0 (en) 2006-06-14 2006-06-14 Materials and methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/121,059 Continuation US20090317413A1 (en) 2005-11-15 2008-05-15 Detection of human platelet antigen (hpa) antibodies

Publications (2)

Publication Number Publication Date
WO2007057665A2 WO2007057665A2 (en) 2007-05-24
WO2007057665A3 true WO2007057665A3 (en) 2007-08-02

Family

ID=38024314

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/004262 WO2007057665A2 (en) 2005-11-15 2006-11-15 Detection of human platelet antigen (hpa) antibodies

Country Status (2)

Country Link
EP (1) EP1969006A2 (en)
WO (1) WO2007057665A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115989412A (en) * 2020-04-27 2023-04-18 西西欧艾(杭州)生物医药有限责任公司 Rapid and simple antibody detection using covalently immobilized self-assembled polypeptides

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000020634A1 (en) * 1998-10-01 2000-04-13 Nova Molecular, Inc. Methods for treating or identifying a subject at risk for a neurological disease by determining the presence of a variant gpiiia and/or variant gpiib allele
EP1201757A2 (en) * 1988-12-22 2002-05-02 Genentech, Inc. Method for preparing water soluble polypeptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1201757A2 (en) * 1988-12-22 2002-05-02 Genentech, Inc. Method for preparing water soluble polypeptides
WO2000020634A1 (en) * 1998-10-01 2000-04-13 Nova Molecular, Inc. Methods for treating or identifying a subject at risk for a neurological disease by determining the presence of a variant gpiiia and/or variant gpiib allele

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), 44TH ANNUAL MEETING OF THE AMERICAN SOCIETY OF HEMATOLOGY; PHILADELPHIA, PA, USA; DECEMBER 06-10, 2002, pages Abstract No. 207, ISSN: 0006-4971 *
BLOOD, vol. 102, no. 11, 16 November 2003 (2003-11-16), 45TH ANNUAL MEETING OF THE AMERICAN SOCIETY OF HEMATOLOGY; SAN DIEGO, CA, USA; DECEMBER 06-09, 2003, pages 126a, ISSN: 0006-4971 *
BLOOD, vol. 106, no. 11, Part 1, November 2005 (2005-11-01), 47TH ANNUAL MEETING OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY; ATLANTA, GA, USA; DECEMBER 10 -13, 2005, pages 67A, ISSN: 0006-4971 *
BODARY S C ET AL: "EXPRESSION OF RECOMBINANT PLATELET GLYCOPROTEIN IIBIIIA RESULTS IN A FUNCTIONAL FIBRINOGEN-BINDING COMPLEX", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 264, no. 32, 1989, pages 18859 - 18862, XP002191982, ISSN: 0021-9258 *
BOWDITCH R D ET AL: "Reactivity of autoantibodies from chronic ITP patients with recombinant glycoprotein IIIa peptides", BRITISH JOURNAL OF HAEMATOLOGY 1995 UNITED KINGDOM, vol. 91, no. 1, 1995, pages 178 - 184, XP009084204, ISSN: 0007-1048 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), PETERSON JULIE A ET AL: ""Rare" Platelet Alloantigen Incompatibility Should Be Examined in Unresolved Cases of Neonatal Alloimmune Thrombocytopenic Purpura (NATP).", XP002435052, Database accession no. PREV200300337344 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2003 (2003-11-16), PETERSON JULIE A ET AL: "Antibodies from three patients with quinine-induced immune thrombocytopenia recognize a soluble recombinant portion of GPIIIa comprising only the PSI/Hybrid domains.", XP002435051, Database accession no. PREV200400181157 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; November 2005 (2005-11-01), STAFFORD PRACHI ET AL: "Recombinant mini-beta 3 integrin fragments for the detection of HPA-1 antibodies.", XP002435053, Database accession no. PREV200600182588 *

Also Published As

Publication number Publication date
WO2007057665A2 (en) 2007-05-24
EP1969006A2 (en) 2008-09-17

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