WO2007054977A3 - Method and composition for skin depigmentation - Google Patents

Method and composition for skin depigmentation Download PDF

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Publication number
WO2007054977A3
WO2007054977A3 PCT/IN2006/000439 IN2006000439W WO2007054977A3 WO 2007054977 A3 WO2007054977 A3 WO 2007054977A3 IN 2006000439 W IN2006000439 W IN 2006000439W WO 2007054977 A3 WO2007054977 A3 WO 2007054977A3
Authority
WO
WIPO (PCT)
Prior art keywords
ser
leu
thioglycosylated
tyr
cysteine
Prior art date
Application number
PCT/IN2006/000439
Other languages
French (fr)
Other versions
WO2007054977A2 (en
Inventor
Ramanathan Halasya
Original Assignee
Brain N Beyond Biotech Pvt Ltd
Ramanathan Halasya
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brain N Beyond Biotech Pvt Ltd, Ramanathan Halasya filed Critical Brain N Beyond Biotech Pvt Ltd
Publication of WO2007054977A2 publication Critical patent/WO2007054977A2/en
Publication of WO2007054977A3 publication Critical patent/WO2007054977A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/08—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium
    • C07H5/10—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium to sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to a compound of formula I: [(C)-(L')]n-(A)-[(L)-(B)]m wherein (A) is a thioglycosylated cysteine of formula IIa or IIb: IIa IIb; (B) is a melanogenosis-inhibiting peptide comprising peptide sequence selected from a group consisting of: (i). Glu-Asp-Tyr-His-Ser-Leu-Tyr-Gln-Ser-His-Leu; (ii). Ser-Gly-Gly-Tyr-Leu-Pro-Pro-Leu; and (iii). His-Ser-C(O)-NH-(CH2)k-CH2-C(O)-NH-Ser-His; (C) is a tyrosinase inhibitor; n is 0 or 1; m is 0 or 1; m + n is 1 or 2;k is 2-10; X1 is O or NH; R1, R2, R7, and R8 are each, independently, selected from H, and a bond in a linkage group between (A) and (L); R3, R4, R5, R6, R9, R10, R11, and R12 are each, independently, selected from H, a saccharide, and a bond in a linkage group between (A) and (L'); (L) is a linker which forms linkage groups with thioglycosylated cysteine (A) and melanogenosis-inhibiting peptide (B); and (L') is a linker which forms linkage groups with thioglycosylated cysteine (A) and tyrosinase inhibitor (C).
PCT/IN2006/000439 2005-11-09 2006-11-08 Method and composition for skin depigmentation WO2007054977A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1639/CHE/2005 2005-11-09
IN1639CH2005 2005-11-09

Publications (2)

Publication Number Publication Date
WO2007054977A2 WO2007054977A2 (en) 2007-05-18
WO2007054977A3 true WO2007054977A3 (en) 2009-05-14

Family

ID=38023689

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2006/000439 WO2007054977A2 (en) 2005-11-09 2006-11-08 Method and composition for skin depigmentation

Country Status (1)

Country Link
WO (1) WO2007054977A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009065008A1 (en) 2007-11-14 2009-05-22 Omp, Inc. Skin treatment compositions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997035998A1 (en) * 1996-03-28 1997-10-02 Trustees Of Boston University Methods of modulating melanin synthesis
US6365137B1 (en) * 1999-04-06 2002-04-02 Collaborative Laboratories, Inc. Skin whitening agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997035998A1 (en) * 1996-03-28 1997-10-02 Trustees Of Boston University Methods of modulating melanin synthesis
US6365137B1 (en) * 1999-04-06 2002-04-02 Collaborative Laboratories, Inc. Skin whitening agents

Also Published As

Publication number Publication date
WO2007054977A2 (en) 2007-05-18

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