WO2007053659A3 - Method of screening for hepatocellular carcinoma - Google Patents

Method of screening for hepatocellular carcinoma Download PDF

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Publication number
WO2007053659A3
WO2007053659A3 PCT/US2006/042591 US2006042591W WO2007053659A3 WO 2007053659 A3 WO2007053659 A3 WO 2007053659A3 US 2006042591 W US2006042591 W US 2006042591W WO 2007053659 A3 WO2007053659 A3 WO 2007053659A3
Authority
WO
WIPO (PCT)
Prior art keywords
hcc
screening
hepatocellular carcinoma
detecting
serpinl1
Prior art date
Application number
PCT/US2006/042591
Other languages
French (fr)
Other versions
WO2007053659A2 (en
Inventor
Xin Wei Wang
Huliang Jia
Qing-Hai Ye
Lun-Xiu Qin
Zhao-You Tang
Original Assignee
Us Gov Health & Human Serv
Zhongshan Hospital
Xin Wei Wang
Huliang Jia
Qing-Hai Ye
Lun-Xiu Qin
Zhao-You Tang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Zhongshan Hospital, Xin Wei Wang, Huliang Jia, Qing-Hai Ye, Lun-Xiu Qin, Zhao-You Tang filed Critical Us Gov Health & Human Serv
Publication of WO2007053659A2 publication Critical patent/WO2007053659A2/en
Publication of WO2007053659A3 publication Critical patent/WO2007053659A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A method of screening for hepatocellular carcinoma (HCC) comprising detecting in a sample the expression of three or more HCC biomarkers selected from the group consisting of Gpc3, Mdk, Serpinl1, PeglO, and Qp-c, or detecting in a sample the expression of Serpinl1 or Qp-c, as well as a method for monitoring the progression or regression of HCC in a subject, a method for screening a compound for anti-HCC activity, and an array and kit useful for detecting HCC.
PCT/US2006/042591 2005-11-01 2006-11-01 Method of screening for hepatocellular carcinoma WO2007053659A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73233205P 2005-11-01 2005-11-01
US60/732,332 2005-11-01

Publications (2)

Publication Number Publication Date
WO2007053659A2 WO2007053659A2 (en) 2007-05-10
WO2007053659A3 true WO2007053659A3 (en) 2007-08-09

Family

ID=37769862

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/042591 WO2007053659A2 (en) 2005-11-01 2006-11-01 Method of screening for hepatocellular carcinoma

Country Status (1)

Country Link
WO (1) WO2007053659A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11851476B2 (en) 2011-10-31 2023-12-26 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101812507B (en) * 2009-12-04 2012-07-04 复旦大学附属中山医院 Gene chip for predicting liver cancer metastasis and recurrence risk and manufacturing method and using method thereof
CN104956224B (en) 2012-11-20 2017-12-12 美国政府卫生与公共服务部 Measure Midkine or the horizontal measure for being used to diagnose growth of multiple effect growth factor
WO2017005771A1 (en) * 2015-07-07 2017-01-12 Universite de Bordeaux Use of glypican-3-targeting micrornas for treating liver cancer
WO2017207545A1 (en) * 2016-05-31 2017-12-07 Institut National De La Sante Et De La Recherche Medicale (Inserm) Molecular signature of hepatocellular carcinoma

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002029103A2 (en) * 2000-10-02 2002-04-11 Gene Logic, Inc. Gene expression profiles in liver cancer
EP1215500A1 (en) * 1999-09-10 2002-06-19 Takashi Muramatsu Early cancer tumor marker
WO2003010336A2 (en) * 2001-07-25 2003-02-06 Sabine Debuschewitz Molecular markers for hepatocellular carcinoma
WO2003100429A2 (en) * 2002-05-23 2003-12-04 Sunnybrook And Women's College Health Sciences Centre Diagnosis of hepatocellular carcinoma

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1215500A1 (en) * 1999-09-10 2002-06-19 Takashi Muramatsu Early cancer tumor marker
WO2002029103A2 (en) * 2000-10-02 2002-04-11 Gene Logic, Inc. Gene expression profiles in liver cancer
WO2003010336A2 (en) * 2001-07-25 2003-02-06 Sabine Debuschewitz Molecular markers for hepatocellular carcinoma
WO2003100429A2 (en) * 2002-05-23 2003-12-04 Sunnybrook And Women's College Health Sciences Centre Diagnosis of hepatocellular carcinoma
US20050233392A1 (en) * 2002-05-23 2005-10-20 Jorge Filmus Diagnosis of hepatocellular carcinoma

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
GE XIJIN ET AL: "Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues.", GENOMICS AUG 2005, vol. 86, no. 2, August 2005 (2005-08-01), pages 127 - 141, XP002424692, ISSN: 0888-7543 *
HIPPO YOSHITAKA ET AL: "Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma.", CANCER RESEARCH 1 APR 2004, vol. 64, no. 7, 1 April 2004 (2004-04-01), pages 2418 - 2423, XP002424694, ISSN: 0008-5472 *
MIDORIKAWA Y ET AL: "PRINCIPAL COMPONENT ANALYSIS ON HEPATOCELLULAR CARCINOMA", PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, NEW YORK, NY, US, vol. 44, 11 July 2003 (2003-07-11), pages 477, XP008026851, ISSN: 0197-016X *
SONG X-J ET AL: "THE SERIUM LEVEL OF MIDKINE, A HEPARIN-BINDING GROWTH FACTOR, AS A TUMOR MARKER", BIOMEDICAL RESEARCH, vol. 18, no. 5, October 1997 (1997-10-01), pages 375 - 381, XP008033461 *
TSOU ANN-PING ET AL: "Overexpression of a novel imprinted gene, PEG10, in human hepatocellular carcinoma and in regenerating mouse livers.", JOURNAL OF BIOMEDICAL SCIENCE 2003, vol. 10, no. 6 Pt 1, 2003, pages 625 - 635, XP002424695, ISSN: 1021-7770 *
XU X-R ET AL: "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 98, no. 26, 18 December 2001 (2001-12-18), pages 15089 - 15094, XP002231180, ISSN: 0027-8424 *
YAMAUCHI NAOKO ET AL: "The glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinoma.", MODERN PATHOLOGY : AN OFFICIAL JOURNAL OF THE UNITED STATES AND CANADIAN ACADEMY OF PATHOLOGY, INC DEC 2005, vol. 18, no. 12, May 2005 (2005-05-01), pages 1591 - 1598, XP002424693, ISSN: 0893-3952 *
YANAI ITAI ET AL: "Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification.", BIOINFORMATICS (OXFORD, ENGLAND) 1 MAR 2005, vol. 21, no. 5, 1 March 2005 (2005-03-01), pages 650 - 659, XP002424691, ISSN: 1367-4803 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11851476B2 (en) 2011-10-31 2023-12-26 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain

Also Published As

Publication number Publication date
WO2007053659A2 (en) 2007-05-10

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