WO2007052436A1

WO2007052436A1 - Microcapsule and method of producing the same

Info

Publication number: WO2007052436A1
Application number: PCT/JP2006/319947
Authority: WO
Inventors: Masato Tanaka
Original assignee: Niigata University
Priority date: 2005-10-31
Filing date: 2006-10-05
Publication date: 2007-05-10
Also published as: JP4734661B2; JPWO2007052436A1

Abstract

It is intended to provide a novel microcapsule, which can control the speed of the sustained release of the active ingredient thereof when applied to the skin, and a method of producing the same. A microcapsule which comprises a water-insoluble ethylcellulose (1) having the active ingredient (2), polyisopropylacrylamide (3) and methylcellulose (4) encapsulated therein. The sustained release properties of the active ingredient (2) can be controlled by changing the mixing ratio of the temperature-responsive polyisopropylacrylamide (3) and the water-absorbing methylcellulose (4) to the water-insoluble ethylcellulose (1) serving as the matrix of the microcapsule depending on the conditions such as the skin temperature and environmental moisture changes.

Description

Micro force pushell and manufacturing method thereof

Technical field

TECHNICAL FIELD [0001] The present invention relates to a microcapsule for use in cosmetics and a method for producing the same.

[0002] Conventionally, as an active ingredient to be blended into cosmetics, there are some which are chemically unstable when blended as they are or have an adverse effect on other ingredients, which is a problem in blending into cosmetics. It was.

[0003] As a method for solving this problem, an active ingredient blended in a cosmetic is encapsulated in a microcapsule in a stable state, and the active ingredient is released after being applied to the skin. 1 and so on. The microcapsule disclosed in Patent Document 1 encapsulates an active ingredient in a resin that can be disintegrated by a change in pH, and releases the effective component by a change in pH.

Patent Document 1: JP-A-7-96166

Disclosure of the invention

Problems to be solved by the invention

However, the microcapsules disclosed in Patent Document 1 release active ingredients depending on the pH, and the microcapsules rapidly disintegrate and release the active ingredients under suitable pH conditions. Therefore, it has been difficult to control the sustained release of the active ingredient so that the active ingredient is gradually released over a long time when applied to the skin.

[0005] Accordingly, an object of the present invention is to provide a novel microcapsule and a method for producing the same that can control the rate of sustained release of an active ingredient when applied to the skin.

Means for solving the problem

[0006] The microcapsule of the present invention is characterized by containing an active ingredient and polyisopropylacrylamide. [0007] Further, it is characterized in that it contains methylcellulose, and the content of methylcellulose is not more than twice the content of polyisopropylacrylamide.

[0008] The active ingredient includes at least one of hydroquinone, polyphenol, collagen, Coenzyme Q10, glucan, and catechin.

[0009] A microcapsule comprising a water-insoluble ethylcellulose strength encapsulating an active ingredient, polyisopropylacrylamide, and methylcellulose.

[0010] The cosmetic of the present invention is characterized in that it contains a microphone mouth capsule containing an active ingredient and polyisopropylacrylamide.

[0011] Further, the microcapsule contains methylcellulose, and the contained mass of methylcellulose is not more than twice the contained mass of polyisopropylacrylamide.

[0012] In addition, the microcapsule includes at least one of hydroquinone, polyphenol, collagen, coenzyme Q10, glucan, and catechin as the active ingredient.

Further, it is characterized by containing a microcapsule composed of a water-insoluble ethylcellulose cellulose encapsulating an active ingredient, polyisopropylacrylamide, and methylcellulose.

[0013] The method for producing a microcapsule of the present invention comprises dissolving an active ingredient, water-insoluble ethylcellulose, polyisopropylacrylamide, and methylcellulose in a solvent, and microcapsulating this by a spray-dry method. It is characterized by.

[0014] Further, the solvent is ethanol.

[0015] The active ingredient includes at least one of hydroquinone, polyphenol, collagen, Coenzyme Q10, glucan, and catechin.

The invention's effect

[0016] The microcapsule of the present invention contains an active ingredient and polyisopropylacrylamide, so that it is effective by using polypropylpropylacrylamide that is temperature responsive to conditions of skin temperature and moisture environmental changes. Controlled release of ingredients can be controlled.

[0017] Further, the microcapsule of the present invention comprises a water-insoluble ethyl cellulose containing an active ingredient, polyisopropylacrylamide, and methylcellulose, so that the temperature of the skin can be increased. The mixing ratio of temperature-responsive polyisopropyl acrylamide, water-absorbing methylcellulose, and water-insoluble ethylcellulose mouthwater that forms the microcapsule matrix is changed according to the conditions of environmental changes in water and moisture. This makes it possible to control the sustained release of the active ingredient.

[0018] The method for producing a microcapsule of the present invention comprises dissolving an active ingredient, water-insoluble ethylcellulose, polyisopropylacrylamide, and methylcellulose in a solvent, and microencapsulating this by a spray-dry method. Thus, the microcapsule of the present invention can be produced very easily.

Brief Description of Drawings

FIG. 1 is a schematic view of a microcapsule of the present invention.

FIG. 2 is an electron micrograph of a microcapsule of the present invention obtained when polyisopropylacrylamide in Example 1 is lg and methylcellulose is 0.5% by mass.

FIG. 3 is an electron micrograph of a microcapsule of the present invention obtained when polyisopropylacrylamide in Example 1 is lg and methylcellulose is 0.5% by mass.

FIG. 4 is an electron micrograph of microcapsules obtained when polyisopropylacrylamide in Example 1 is 0, 0.25, 0.5, 5 lg and methylcellulose is 0 mass%.

FIG. 5 is a graph showing the capsule capsule efficiency of microcapsules in Example 2.

FIG. 6 is a graph showing the average particle size of microcapsules in Example 3.

FIG. 7 is a graph showing the temperature dependence of the release rate of microcapsule noduloquinone in Example 4.

FIG. 8 is a graph showing the temperature dependence of the release rate of microcapsule noduloquinone in Example 4.

FIG. 9 is a graph showing the change with time of the release rate of hydroquinone of the microcapsules in Example 5.

FIG. 10 is an electron micrograph of microcapsules in Example 5.

FIG. 11 is a graph showing the change over time in the release rate of microcapsules in the microcapsules in Example 6. FIG. 12 is an electron micrograph of microcapsules in Example 6.

FIG. 13 is a graph showing the change over time in the release rate of microcapsule noduloquinone in Example 7.

FIG. 14 is an electron micrograph of microcapsules in Example 8.

FIG. 15 is a graph showing changes over time in the release rate of hydroquinone and grape polyphenol in microcapsules in Example 9.

Explanation of symbols

[0020] 1 Water-insoluble ethylcellulose

2 Active ingredient

3 Polyisopropylacrylamide

4 Metino Resenorelose

BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, a microcapsule and a manufacturing method thereof according to the present invention will be described with reference to the accompanying drawings.

[0022] The microcapsule of the present invention contains, as essential components, an active ingredient and polyisopropyl atylamide.

[0023] In Fig. 1 showing a schematic diagram of one embodiment of the microcapsule of the present invention, 1 is water-insoluble ethylcellulose (EC) serving as a matrix of the mouth-opening capsule,

Polyisopropylacrylamide (PNIPA) 3 and methylcellulose (MC) 4 are included.

[0024] In this embodiment, the active ingredient 2, polyisopropyl acrylamide 3, and methyl cellulose 4 are included in the water-insoluble ethyl cellulose 1. These active ingredients 2, polyisopropyl acrylamide 3, methyl cellulose 4 May be exposed on the surface of the water-soluble ethylcellulose 1. Further, the matrix is not limited to the water-insoluble ethyl cellulose 1.

[0025] When the microcapsules are used in cosmetics such as foundations, the active ingredient 2 is formulated as, for example, a hydroquinone having a function of decolorizing skin freckles and spots, that is, a whitening effect, and other cosmetics. Which can be collagen, coenzyme Q10, glucan, catechin, etc. Can be configured. Further, if the active ingredient 2 is composed of a plurality of components as required, a plurality of functions can be imparted to the microcapsules. When the microcapsule is applied to the skin, the active ingredient 2 in the microcapsule is gradually released by the moisture of the sweat! /.

[0026] Polyisopropylacrylamide 3 has temperature responsiveness, promotes the release of active ingredient 2 at low temperatures, and suppresses the release of active ingredient 2 at 40 ° C near body temperature. Polyisopropyl atylamide 3 is added to gradually release active ingredient 2 over a long period of time.

[0027] Methylcellulose 4 is added to supplement the water absorption of microcapsules and promote the release of active ingredient 2 because the action of suppressing the release of active ingredient 2 of polyisopropylacrylamide 3 is too strong. is there. In addition, methylcellulose 4 plays an important role in improving the efficiency of capsules during the production of microcapsules. That is, adding methyl cell mouth 4 increases the encapsulation efficiency, that is, the yield of active ingredient 2 in the microcapsule. For example, when active ingredient 2 is hydroquinone, the encapsulation efficiency is increased. Becomes 100%.

[0028] The encapsulation efficiency indicates the ratio of the amount of the active ingredient 2 taken into the microcapsule out of the charged amount of the active ingredient 2 at the time of producing the microcapsule.

[0029] Then, depending on the conditions of skin temperature and moisture environmental change, polyisopropyl acrylamide 3 having temperature responsiveness, methyl cellulose 4 having water absorbency, and water-insoluble ethyl which is a matrix of microcapsules. By changing the mixing ratio of cellulose 1, the sustained release of active ingredient 2 can be controlled. The average particle size of the microcapsules can be controlled by the amount of polyisopropylacrylamide 3 and methylcellulose 4 added. In addition, since the matrix is water-insoluble ethyl cellulose, the active ingredient 2 can be gradually released in a stable state for a long time without the microcapsules being disintegrated by moisture such as sweat.

[0030] It should be noted that methylcellulose 4 is preferably added as necessary, and the content of methylcellulose is preferably not more than twice the content of polyisopropylacrylamide. The content of methylcellulose is 2 of the content of polyisopropylacrylamide. This is because, when the ratio exceeds twice, the action of polyisopropylacrylamide 3 to suppress the release of active ingredient 2 is completely canceled by the action of promoting the release of active ingredient 2 of methylcellulose 2.

[0031] Further, when methylcellulose 4 having a molecular weight of 1 X 10 ⁵ or less is added, the shape of the microcapsule becomes a spherical shape with less unevenness, and when the addition amount of methylcellulose 4 is increased, the surface of the microsphere having a dense spherical shape is increased. Capsules are obtained. On the other hand, when the molecular weight is gradually increased from 1 × 10 ^{5 while the} amount of applied force of methyl cellulose 4 is constant, irregularities increase on the surface of the microcapsule. Alternatively, when the molecular weight of polyisopropylacrylamide 3 is increased, microcapsules having a fine spherical surface and good moisture responsiveness can be obtained.

[0032] Thus, the shape of the microcapsule can be controlled by the molecular weight of the methylcellulose 2 to be added and the amount of the added cellulose, that is, the molecular weight of the polyisopropylacrylamide 3. Therefore, for example, use a spherical microcapsule when smooth feel and gloss are required, and use a mic mouth capsule with a large surface area and a large surface area when large adhesion is required. Depending on the application, micro power cells with various shapes can be used.

[0033] The microcapsules of the present invention can be obtained by dissolving an active ingredient, water-insoluble ethylcellulose, polyisopropylacrylamide, and methylcellulose in a solvent and microcapsulating them by a spray drying method. .

[0034] As the solvent, a solvent in which the active ingredient is not altered is preferably used. In consideration of applying microcapsules to the skin, it is preferable to use one that is as safe as possible for the skin. For example, in the case where the active ingredient is hydroquinone, hydroquinone is water-soluble and is altered when dissolved in water. Therefore, ethanol that does not affect the stability of hydroquinone and is safe for the skin is preferably used.

[0035] Since the spray drying method is a known technique, a detailed description thereof is omitted. For example, the inlet temperature is 90 ° C, the outlet temperature is 50 ° C, and the pressure is 0. IMPa. Thus, the microcapsules of the present invention can be manufactured.

[0036] As described above, the microcapsule of the present invention contains the active ingredient 2 and the polyisopropyl atylamide 3, so that the temperature varies depending on the temperature of the skin and the environmental change conditions of moisture. Responsive polyisopropylacrylamide 3 can control the sustained release of active ingredient 2.

[0037] Further, according to the microcapsule of the present invention, it comprises the water-insoluble ethyl cellulose 1 encapsulating the active ingredient 2, the polyisopropylacrylamide 3 and the methyl cellulose 4, so that the skin temperature and moisture can be controlled. The mixing ratio of temperature-responsive polyisopropylene pyracrylamide 3, water-absorbing methylcellulose 4, and water-insoluble ethylcellulose mouthwater 1 that is a matrix of microcapsules is changed according to the conditions of environmental changes. Thus, the sustained release of the active ingredient 2 can be controlled.

[0038] Further, in the method for producing a microcapsule of the present invention, an active ingredient, water-insoluble ethylcellulose, polyisopropylacrylamide, and methylcellulose are dissolved in a solvent, and this is microencapsulated by a spray dry method. Thus, the microcapsules of the present invention can be produced very easily.

Example 1

[0039] Microcapsules were prepared in various amounts using hydroquinone as an active ingredient.

[0040] 50 g of a 90% ethanol aqueous solution or 80% ethanol aqueous solution as a solvent, 2 g of water-insoluble ethylcellulose, 0 to 1.5 g of polyisopropylacrylamide, and 0 to 1.5 g of methylcellulose in a microcapsule 1. Add 5 wt% hydroquinone and add 0.5-0.85 g of hydroquinone in the microcapsule to 20 wt% and dissolve, melt at an inlet temperature of 90 ° C and an outlet temperature of 50 ° C. A microcapsule was prepared by a spray drying method under the conditions of pressure 0. IMPa.

[0041] FIGS. 2 and 3 show electron micrographs of microcapsules obtained when polyisopropylacrylamide is lg and methylcellulose is 0.5% by mass. It was confirmed that according to the method for producing a micro force capsule of the present invention, a spherical microcapsule having a very dense surface was obtained.

FIG. 4 shows an electron microscope (SEM) of microcapsules obtained when polyisopropylacrylamide (PNIPA) is 0, 0.25, 0.5, 5 lg and methylcellulose is 0 mass%. ) Show photos. By increasing the loading force of polyisopropylacrylamide, It was confirmed that the surface of the squid capsule became dense and closer to a spherical shape. Example 2

[0043] The capsule efficiency of the microcapsules prepared in Example 1 was examined.

[0044] Figure 5 shows that when the amount of polyisopropylacrylamide applied is varied (black squares) without methyl cellulose, the amount of polyisopropylacrylamide added is constant lg, and the strength of methylcellulose is increased. The encapsulation efficiency E is shown when the amount of drought is changed (white circle).

[0045] As shown in FIG. 5, when methyl cellulose is not supported (black square), the encapsulation efficiency E does not reach 100% even if the amount of polyisopropyl acrylamide (PNIPA) is changed! On the other hand, when methyl cellulose is added to polyisopropyl acrylamide (white circle), the encapsulation efficiency E is 100% even if the amount of methyl cellulose is small, regardless of the amount of methyl cellulose (MC) added. It was.

[0046] It was confirmed that by adding methylcellulose, the encapsulation efficiency, that is, the yield of hydroquinone in the microcapsule, was 100%.

Example 3

[0047] The average particle size of the microcapsules prepared in Example 1 was examined. As shown in Fig. 6, in the case where no methylcellulose was added (black squares), the average particle size Dp increased as the amount of polyisopropylacrylamide (PNIPA) was increased. This is thought to be caused by the viscosity of the microcapsules being increased by polyisopropylacrylamide. In addition, when methylcellulose was added to polyisopropyl acrylamide lg (white circle), the average particle diameter Dp became smaller as the amount of applied force of methylcellulose (MC) was increased. This is thought to be because the surface tension of the microcapsules is lowered by methylcellulose.

[0048] Increasing the amount of added force of polyisopropylacrylamide increases the average particle size Dp. Increasing the amount of applied force of methylcellulose decreases the average particle size Dp. It was confirmed that the average particle size of the microcapsules can be controlled by the amount of the additive. Example 4

[0049] The temperature dependence of the hydroquinone release rate of the microcapsules prepared in Example 1 was adjusted. Be.

[0050] Figure 7 shows that when methylcellulose is not added and polyisopropylacrylamide is added at 0.25 g, the temperature is set to room temperature (black square), and only the temperature is set to 40 ° C in the same composition (white circle) ) Shows the release rate R of hydroquinone when 0.5% by mass of methylcellulose and 0.25g of polyisopropylacrylamide are added to make the temperature 40 ° C (white square) and the microcapsules are in water. .

[0051] As shown in FIG. 7, at room temperature (black squares) with 0.25 g of polyisopropylacrylamide without the addition of methylcellulose, the release rate R of hydroquinone increases rapidly with time t. The release rate R after about 1 hour was about 80%. In the same formulation, when only the temperature was 40 ° C (open circle), the release rate R of hydroquinone was suppressed, and the release rate R after 1 hour was about 45%. Furthermore, when 0.5% by weight of methylcellulose and 0.25g of polyisopropylacrylamide were heated to 40 ° C (white squares), the addition rate of methylcellulose promoted the release rate R of hydroquinone. The release rate R after about 1 hour was about 60%.

[0052] As a comparative example, FIG. 8 shows that when methylcellulose and polyisopropylacrylamide were not used, the temperature was set to room temperature (black square), and only the temperature was set to 40 ° C in the same composition (open circle). The release rate R of hydroquinone is shown when only 0.5% by mass of methylcellulose is used and the temperature is 40 ° C (white square).

[0053] As shown in FIG. 8, when methylcellulose and polyisopropylacrylamide are not available! /, At room temperature (black squares), the release rate R of hydroquinone increases with the passage of time t. The release rate R was about 80%. Compared with the case of Fig. 7 where polyisopropylacrylamide was added, the rise of the release rate R was slow. In the same composition, when only the temperature was 40 ° C (open circle), the release rate R of hydroquinone was suppressed, and the release rate R after about 1 hour was about 55%. Furthermore, when 0.5% by mass of methylcellulose is added and the temperature is 40 ° C (white squares), the effect of promoting the release rate R of hydroquinone by the addition of methylcellulose is observed, and the release after 1 hour has passed. The rate R is about 70%.

[0054] Polyisopropylacrylamide promotes the release of neuroquinone at low temperatures, and near body temperature At 40 ° C, it was confirmed that the release of rho and idroquinone was suppressed. Methyl cellulose was also confirmed to promote the release of hydroquinone. Therefore, it was found that the sustained release of hydroquinone can be controlled by the amount of addition of polyisopropylacrylamide and methylcellulose. Example 5

[0055] The effect of the concentration of methylcellulose in the microcapsules on the release rate of hydroquinone was examined.

[0056] 2 g of water-insoluble ethyl cellulose, 0.25 g of polyisopropyl acrylamide having a molecular weight of 5.0 X 10 ⁵ and 70 g of hydroquinone were blended, and the other conditions were the same as in Example 1. Capsules were made.

[0057] Further, a microphone mouth capsule was prepared by adding methyl cellulose having a molecular weight of 3.0 X 10 ^{4 to} the above blending conditions. Regarding the blending amount of methylcellulose, 0.25 g, the double amount of 0.50 g, and the triple amount of 0.75 g of polyisopropylacrylamide were prepared.

[0058] Next, the prepared microcapsules were held in water at room temperature of 25 ° C and 40 ° C, respectively, and the change over time in the release rate of nitro and idroquinone into water was measured. The result is shown in Fig. 9.

[0059] When methylcellulose was not added and when 0.25 g of methylcellulose equivalent to polyisopropylacrylamide was added, release of hydroquinone was slow at 40 ° C than normal temperature. When 0.50 g of methylcellulose, twice that of polyisopropylacrylamide, was added, the release rate was almost the same at room temperature and 40 ° C. When 0.75 g of methylcellulose, which is 3 times that of polyisopropylacrylamide, was added, the release of hydroquinone became slower at normal temperature.

[0060] From these results, the release rate of hydroquinone increases as the content of methylcellulose increases, and when the content of methylcellulose exceeds twice the content of polyisopropylacrylamide, It was confirmed that isopropylacrylamide can completely counteract the release of hydroquinone by the action of promoting the release of hydroquinone from methylcellulose. Therefore, of methylcellulose It has been found that the content mass is preferably less than twice the mass content of polyisopropylacrylamide.

[0061] FIG. 10 shows an SEM photograph of the produced microcapsules. It was confirmed that when the amount of methylcellulose added was increased, spherical microcapsules with a dense surface were obtained. Example 6

[0062] The influence of the molecular weight of methylcellulose in the microcapsules on the release rate of hydroquinone was examined.

[0063] The same conditions as in Example 1 were used except that water-insoluble ethylcellulose was mixed with 2. Og, molecular weight 5. OX 10 ⁵ polyisopropylacrylamide 0.25 g, hydroquinone 0.70 g. Microcapsules were prepared.

[0064] In addition to the above blending conditions, molecular weight 3. OX 10 ⁴ methylcellulose, or molecular weight 1.1

Microcapsules were prepared by adding 0.5 g of X 10 ⁵ methylcellulose.

[0065] Next, the prepared microcapsules were held in water at room temperature of 25 ° C, and the change over time in the release rate of hydroquinone into water was measured. The results are shown in Fig. 11.

[0066] Although the molecular weight force of methylcellulose was small and the water absorption was slightly better, it was strong with little difference in the change with time in the release rate of hydroquinone.

[0067] FIG. 12 shows an SEM photograph of the produced microcapsules. When methylcellulose with a molecular weight of 1 X 10 ⁵ or less is added, the shape of the microcapsules becomes less irregular! /, And the shape of the microcapsules increases as the molecular weight increases. Was confirmed. Therefore, it was confirmed that the shape of the microcapsules can be controlled by the molecular weight of methylcellulose.

Example 7

[0068] The effect of the molecular weight of polyisopropylacrylamide in the microcapsules on the release rate of hydroquinone was examined.

[0069] A mixture of water-insoluble ethylcellulose 2. Og, polyisopropylacrylamide 0.25 g, hydroquinone 0.7 g, and molecular weight 3.0 x 10 ⁴ methylcellulose 0.5 g, Microcapsules were produced under the same conditions as in Example 1. The molecular weight of polyisopropyl acrylamide was 1.0 × 10 ⁴ , 2.5 × 10 ⁵ , and 5.0 × 10 ⁵ . [0070] Next, the prepared microcapsules were held in water at room temperature of 25 ° C and 40 ° C, respectively, and the change over time in the release rate of nitro and idroquinone into water was measured. The results are shown in Fig. 13.

[0071] It was confirmed that as the molecular weight of polyisopropylacrylamide was increased, the release rate of hydroquinone at 40 ° C was suppressed, and a good temperature response was exhibited. Therefore, it was proved that the sustained release of hydroquinone can be controlled by the molecular weight of polyisopropyl acrylamide.

Example 8

[0072] The effect of the amount of polyisopropylacrylamide added in the microcapsule on the shape of the microcapsule was examined.

[0073] A microcapsule was prepared under the same conditions as in Example 1 except that 2 g of water-insoluble ethylcellulose and 0.25 g of methylcellulose were added.

[0074] In addition, 0.25g, 0.5g, and lg-added methyl cellulose were prepared under the above blending conditions.

[0075] FIG. 14 shows an SEM photograph of the produced microcapsules. It was confirmed that spherical microcapsules with a finer surface could be obtained as the amount of polyisopropyl acrylamide added was increased.

Example 9

[0076] The type of active ingredient in the microcapsule and its effect on the release rate of idroquinone were examined.

B, J.

[0077] A mixture of water-insoluble ethylcellulose 2. Og, molecular weight 5. OX 10 ⁵ polyisopropylacrylamide 0.25 g, molecular weight 3.0 X 10 ⁴ methylcellulose 0.5 g. Microcapsules were produced under the same conditions as in Example 1 except that 0.7 g of idroquinone (HQ) or grape polyphenol (PF) was added.

[0078] Next, the produced microcapsules were held in water at normal temperatures of 25 ° C and 40 ° C, respectively, and the change over time in the release rate of rho, idroquinone or grape polyphenol into water was measured. The results are shown in Fig. 15.

[0079] Both hydroquinone and grape polyphenols were used at 40 ° C above normal temperature. It was confirmed that the release rate R was suppressed. Therefore, it was clear that the release rate could be controlled regardless of the type of active ingredient.

Claims

The scope of the claims

[I] A microcapsule comprising an active ingredient and polyisopropylacrylamide.

[2] The microcapsenore according to claim 1, characterized in that it contains methylcellulose, and the content of methylcellulose is not more than twice the content of polyisopropylacrylamide.

[3] The microcapsenore according to claim 1, wherein the active ingredient includes at least one of hydroquinone, polyphenol, collagen, coenzyme Q10, glucan, and catechin.

[4] A microcapsule comprising a water-insoluble ethylcellulose strength encapsulating an active ingredient, polyisopropylacrylamide, and methylcellulose.

5. The microcapsenore according to claim 4, wherein the active ingredient includes at least one of hydroquinone, polyphenol, collagen, coenzyme Q10, glucan, and catechin.

[6] A cosmetic comprising microcapsules containing an active ingredient and polyisopropylacrylamide.

[7] The cosmetic according to claim 6, wherein the microcapsules contain methylcellulose, and the content of methylcellulose is not more than twice the content of polyisopropylacrylamide.

[8] The microcapsule according to claim 6, wherein the microcapsule contains at least one of hydroquinone, polyphenol, collagen, coenzyme Q10, glucan, and catechin as the active ingredient. Cosmetics.

[9] A cosmetic comprising microcapsules such as water-insoluble ethylcellulose containing an active ingredient, polyisopropylacrylamide, and methylcellulose.

10. The microcapsule according to claim 9, wherein the microcapsule contains at least one of hydroquinone, polyphenol, collagen, coenzyme Q10, glucan, and catechin as the active ingredient. Cosmetics.

[II] Active ingredient, water-insoluble ethyl cellulose, polyisopropylacrylamide, methyl A method for producing a microcapsule, comprising dissolving cellulose in a solvent and microcapsulating it by a spray drying method.

12. The method for producing a micropower cell according to claim 11, wherein the solvent is ethanol.

13. The method for producing a microcapsule according to claim 11, wherein the active ingredient contains at least one of hydroquinone, polyphenol, collagen, coenzyme Q10, glucan, and catechin.