WO2007051995A3 - Tert-butylammonium salt or adamntylammonium salt of ortho-substituted benzoic acid derivatives - Google Patents

Tert-butylammonium salt or adamntylammonium salt of ortho-substituted benzoic acid derivatives Download PDF

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Publication number
WO2007051995A3
WO2007051995A3 PCT/GB2006/004035 GB2006004035W WO2007051995A3 WO 2007051995 A3 WO2007051995 A3 WO 2007051995A3 GB 2006004035 W GB2006004035 W GB 2006004035W WO 2007051995 A3 WO2007051995 A3 WO 2007051995A3
Authority
WO
WIPO (PCT)
Prior art keywords
salt
tert
adamntylammonium
ortho
benzoic acid
Prior art date
Application number
PCT/GB2006/004035
Other languages
French (fr)
Other versions
WO2007051995A2 (en
Inventor
Mikael Ulf Johan Dahlstrom
Bengt Ohlsson
Original Assignee
Astrazeneca Ab
Astrazeneca Uk Ltd
Mikael Ulf Johan Dahlstrom
Bengt Ohlsson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Astrazeneca Uk Ltd, Mikael Ulf Johan Dahlstrom, Bengt Ohlsson filed Critical Astrazeneca Ab
Publication of WO2007051995A2 publication Critical patent/WO2007051995A2/en
Publication of WO2007051995A3 publication Critical patent/WO2007051995A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A tert-butylammonium salt or an adamantylammonium salt of a compound of formula I wherein n is 0, 1 or 2 and R1 represents halo, a C1-4alkyl group which is optionally substituted by one or more fluoro, a C1-4alkoxy group which is optionally substituted by one or more fluoro and wherein when n is 2 the substituents R1 may be the same or different; R2 represents a C2-8alkyl group which is optionally interrupted by oxygen; Y is absent or represents methylene; and X is O or S.
PCT/GB2006/004035 2005-11-03 2006-10-31 Tert-butylammonium salt or adamntylammonium salt of ortho-substituted benzoic acid derivatives WO2007051995A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0522433.2A GB0522433D0 (en) 2005-11-03 2005-11-03 Therapeutic agents
GB0522433.2 2005-11-03

Publications (2)

Publication Number Publication Date
WO2007051995A2 WO2007051995A2 (en) 2007-05-10
WO2007051995A3 true WO2007051995A3 (en) 2007-07-12

Family

ID=35516264

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/004035 WO2007051995A2 (en) 2005-11-03 2006-10-31 Tert-butylammonium salt or adamntylammonium salt of ortho-substituted benzoic acid derivatives

Country Status (3)

Country Link
GB (1) GB0522433D0 (en)
TW (1) TW200800864A (en)
WO (1) WO2007051995A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3112073A1 (en) * 2018-10-11 2020-04-16 Basf As Aromatic compounds and pharmaceutical uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004000790A1 (en) * 2002-06-20 2003-12-31 Astrazeneca Ab Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004000790A1 (en) * 2002-06-20 2003-12-31 Astrazeneca Ab Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
G. DAVIES: "Changing the salt, changing the drug", THE PHARMACEUTICAL JOURNAL, vol. 266, 2001, pages 322 - 323, XP002428056 *

Also Published As

Publication number Publication date
WO2007051995A2 (en) 2007-05-10
TW200800864A (en) 2008-01-01
GB0522433D0 (en) 2005-12-14

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