WO2007050950A2 - Silicon-urea-azolides, their preparation and use in the preparation of silicones with isocyanate terminal groups - Google Patents

Silicon-urea-azolides, their preparation and use in the preparation of silicones with isocyanate terminal groups Download PDF

Info

Publication number
WO2007050950A2
WO2007050950A2 PCT/US2006/042105 US2006042105W WO2007050950A2 WO 2007050950 A2 WO2007050950 A2 WO 2007050950A2 US 2006042105 W US2006042105 W US 2006042105W WO 2007050950 A2 WO2007050950 A2 WO 2007050950A2
Authority
WO
WIPO (PCT)
Prior art keywords
azolide
atoms
silicone
isocyanate
branched
Prior art date
Application number
PCT/US2006/042105
Other languages
French (fr)
Other versions
WO2007050950A3 (en
Inventor
Peter Bissinger
Wolf Steiger
Original Assignee
3M Innovative Properties Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Company filed Critical 3M Innovative Properties Company
Priority to EP06836607A priority Critical patent/EP1940851B1/en
Priority to US12/091,552 priority patent/US8124714B2/en
Priority to CA002626130A priority patent/CA2626130A1/en
Priority to AT06836607T priority patent/ATE463499T1/en
Priority to DE602006013497T priority patent/DE602006013497D1/en
Priority to JP2008538030A priority patent/JP2010507688A/en
Publication of WO2007050950A2 publication Critical patent/WO2007050950A2/en
Publication of WO2007050950A3 publication Critical patent/WO2007050950A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/38—Polysiloxanes modified by chemical after-treatment
    • C08G77/382—Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon
    • C08G77/388—Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0834—Compounds having one or more O-Si linkage
    • C07F7/0838—Compounds with one or more Si-O-Si sequences
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/22—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
    • C08G77/26—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen nitrogen-containing groups

Definitions

  • the invention relates to Silicon-Urea-Azolides and their preparation and the production of silicon isocyanates from Silicon-Urea-Azolides.
  • Silicone-Isocyanates are valuable chemical building blocks combining properties of silicones and reactivity of isocyanates that are widely applicable in chemical industry.
  • As an isocyanate component they can be used in many reactive formulations, e.g., to form poly- urethanes or polyureas.
  • Silicone-Isocyanates for application of Silicone-Isocyanates as an reactive intermediate an isolable and cheaper intermediate step like Silicon-Urea-Azolides in the sequence to Silicone-Isocyanates could be useful.
  • US 3,936,484 describes the production of polyisocyanates from substituted ureas.
  • the described synthetic methods are directed towards the classical organic low molecular weight diisocyanates (mainly TDI) by pyrolysis of N,N'-bis-ureas.
  • TDI organic low molecular weight diisocyanates
  • the amines released by pyrolysis are not stabilized by mesomeric structures.
  • Starting ureas are thermally stable and decomposition temperatures therefore are drastic (230 - 350 °C) and the yields are low, which in case of difunctional ureas leads to high fractions of undesired mono isocy- anates.
  • US 5,886,205 describes the synthesis of siloxane isocyanates by decomposition of ure- thanes that are produced by reaction of diorgano carbonates and siloxane amines.
  • the decomposition temperature is high (in the examples around 250 °C) leading to undesired thermal degradation and discoloration.
  • JP 2001-48855 describes the synthesis of "relatively high molecular" siloxane isocyanates by converting Siloxane-Amines into aryl urethanes (using diarylcarbonate). Thermal decomposition of the urethanes gives high yield of Silicone-Isocyanates. The reactions disclosed require rather elevated temperatures and are time consuming. Molecular weights are often unsatisfactorily low.
  • JP 60-140342 and JP 60-140343 describe silverhalogenide containing photographic formulations comprising silicones with pendant reactive groups. Among numerous more precisely specified species in the general description azolides are mentioned.
  • the invention relates to an azolide according to the general formula I
  • A is an azole ring connected to the carbonyl group via an N atom
  • R 4 is H or a linear or branched or cyclic alkyl group with 1 to 24 C-atoms
  • X is a monomeric, oli- gomeric or polymeric radical with the functionality n containing at least one Si atom and n is 1 to about 100000.
  • the invention further relates to a process for the production of an azolide according to the general formula I
  • an amino compound according to the general formula (H 2 N-) n X with X being a monomeric, oligomeric or polymeric radical with the functionality n containing at least 1 Si-atom, R 4 is H or a linear or branched or cyclic alkyl group with 1 to 24 C-atoms and n is 1 to 100000, is reacted in one or more steps with one or more compounds which form an azolide according to formula I.
  • the invention also relates to a process for the production of Silicone-Isocyanates wherein an azolide according to the general formula I
  • A is an azole ring connected to the carbonyl group via an N atom
  • X is a mono- meric, oligomeric or polymeric radical with the functionality n containing at least 1 Si- atom
  • R 4 is H or a linear or branched or cyclic alkyl group with 1 to 24 C-atoms and n is 1 to 100000, is decomposed at elevated temperatures.
  • Silicon-Urea-Azolides according to the invention are available from the corresponding Silicone-Amines. They can be prepared, e.g., by reaction of the latter with carbonyl bisazolides or by cold phosgenation in the presence of a stoichiometric amount of tertiary base to scavenge HCl and subsequent reaction of the chlorocarbamate with imidazole in the presence of a stoichiometric amount of base to capture HCl.
  • the process for the production of silicon isocyanates according to the invention thus can have one or more of the following advantages: facile introduction of organic isocyanate function at silicone containing molecules, especially of silicon containing polymers at elevated molecular weights (e.g., above about 500 g/Mole), no hard to separate metal catalysts easy to separate by-products, low cost and commercially available raw material basis, - comparable viscosity of the Silicone-Isocyanates to Silicone-Amines of comparable chain length, simple processes (if desired: no solvents, no extraction or cleaning procedures), almost no side reactions, broad applicability - high degree of functionalization.
  • silicone refers to the definition given in H.F. Mark et al. "Encyclopedia of Polymer Science and Engeneering” 2 nd Edition, Volume 15, p 204, (ISBN: 0-471-80947-0 (v. 15)) 1989 John Wiley & Sons, which is expressly mentioned as a valuable source of information on the meaning of the term “silicone” and the disclosure of which is regarded as being part of the disclosure of the present text.
  • Silicone-Amines refers to silicones having at least one silicon atom carrying an organic residue comprising a primary amino group (-NH 2 ).
  • the molecule does prefera- bly not comprise other protic or nucleophilic groups (e.g.: OH, COOH, NH, SH), insofar as they are not protected, which are able to react with isocyanate groups.
  • Silicone-Carbinols refers to silicones having at least one silicon atom carrying an organic residue comprising an alcohol group (-OH).
  • Silicon-Urea-Azolides refers to silicones having at least one silicon atom carrying an organic residue comprising a urea group with a terminal nitrogen which is part of an azole ring as described in the definition for azolides.
  • Azolide relates to heterocyclic amides, ureas or urethanes in which the amide nitrogen is part of an azole ring, such as imidazole, pyrazole, triazole, tetrazole, benzimi- dazole, benzotriazole, and their substituted derivatives", according to H. A. Staab ,,Azolides in organic synthesis and biochemistry", Wiley- VCH, 1998 [ISBN: 3-527- 29314-0].
  • Carbonyl-Bisazolide relates to ureas, where both nitrogen atoms are part of an azole ring as described in the definition of azolides.
  • Azolide-Groups according to the definition of Staab are heterocyclic amides in which the amide nitrogen is part of an azole ring. According to that and the way they are referred to in the cited documents this primarily means azolides of carboxylic acids L not mixed ureas as described in the present text.. The invention will now be explained in further detail.
  • the invention relates to an azolide according to the general formula I
  • A is an azole ring connected to the carbonyl group via an N atom
  • R 4 is H or a linear or branched or cyclic alkyl group with 1 to 24 C-atoms
  • X is a monomeric, oli- gomeric or polymeric radical with the functionality n containing at least one Si atom and n is 1 to about 100000.
  • the invention relates to all types of azolides containing at least one Si atom according to formula I. It is, however, preferred, if the azolide is a molecule with a molecular weight of at least about 250, preferably at least about 350 or at least about 500 or at least about 800 or at least about 1000. Generally, the azolides can be monomeric compounds or oligomeric compounds or polymeric compounds.
  • X can thus be monomeric, oligomeric or polymeric.
  • X is an oligomeric or polymeric radical with a molecular weight of at least 200 and at least 2 repe- tition units with at least 1 Si-atom per repetition unit.
  • X can, e.g., be a linear or branched, saturated or unsaturated or cyclic polysiloxane.
  • the Silicone-Urea-Azolide comprises a structure R ⁇ R 2 SiOy 2 and/or a structure R 1 R 2 SiO 2 Q and/or a structure R 2 Si0 3/2
  • R 1 independently is H, or a linear, branched, cyclic or aromatic saturated or unsaturated facultatively partly or fully fluorinated organic residue with 1 to 30 C-atoms that may contain 0 to 5 O atoms
  • R 3 is a bifunctional organic radical alkylen, arylen or mixed with 1 to 18 carbon atoms that may contain 0 to 5 O atoms and A is an azole ring.
  • the Silicone-Urea-Azolide comprises one or more of the following silicone structures: a) Linear or branched (R 1 2 R 2 SiO 1/ 2) 2 (R 1 R 2 SiO 2/2 ) x where R 1 independently is
  • R 3 is a bifunctional organic radical alkylene, arylene or mixed with 1 to 18 carbon atoms that may contain 0 to 5 O atoms
  • A is an azole ring
  • R 1 independently is H, or a linear, branched, cyclic or aromatic saturated or unsaturated facultatively partly or fully fluorinated organic residue with 1 to 30 C-atoms that may contain
  • R 3 is a bifunctional organic radical alkylene, arylene or mixed with 1 to 18 carbon atoms that may contain 0 to 5 O atoms;
  • R 1 being H, methyl, ethyl, vinyl, ethynyl, propyl, iso-propyl, allyl, propenyl, all isomers of butyl, hexyl, octyl, lauryl and octadecyl, cyclohexyl, phenyl, ethylphenyl, triluormethyl, 3,3,3-trifluorpropyl, methoxy, ethoxy, propoxy, isopropoxy, 2-methoxy- ethoxy, 2-ethoxy-ethoxy;
  • R 2 independently is R 1 but at least one R 2 group up to all R 2 groups is/are R 3 -NH-C( ⁇ O)-A;
  • R 3 is methylene, ethylene, propylene, butylenes, hexylene, octylene, decylene, undecylene, phen
  • R 1 being H 3 methyl, ethyl, vinyl, propyl, iso-propyl, allyl, all isomers of butyl, hexyl, octyl, lauryl and octadecyl, cyclo- hexyl phenyl, ethylphenyl, triluormethyl, 3,3,3-trifluorpropyl;
  • R 3 is methylene, ethyl- ene, propylene, butylenes, hexylene, octylene, decylene, undecylene, phenylene, ethyle- nephenylene;
  • A is imidazolyl, triazolyl, benzimidazolyl, benzotriazolyl;
  • the radicals R 1 and R 2 can be equipped with any type of substituent or sub- stituents provided they do not interfere with any other constituents or substituents of the composition and do not interfere with the urea azolide group.
  • the term "interfere” as used in the context of the present text relates to any influence of such a substituent on at least one of the other substituents or constituents of the composition or the reaction to form an isocyanate, or both, which is detrimental to the properties of either the urea azolide product or an isocyanate formed from the urea azolide.
  • the term “detrimental” as used in the context of the present text relates to a change of properties that negatively affect the usefulness of the precursors or the cured product in their intended use.
  • polysiloxane polymers do not comprise uniform chain lengths but show a dis- tribution of various chain lengths as represented by the polydispersity index.
  • the polydispersity index ranges from 1.1 to 20 and preferably from 1.2 to 10.
  • Suitable silicone backbones for carrying one or more azolide groups are 1,3-bis- (methylene)- 1 , 1 ,3 ,3 -tetramethyl-disiloxane, 1 -3-bis-(3 -propylene)- 1 , 1 ,3 ,3-tetrame- thyldisiloxane, l,3,5,7-tetrakis-(methylene)-l,3,5,7-tetramethyl-cyclotetrasiloxane,
  • a Silicon-Urea- Azolide according to the invention carries at least one azolide group.
  • a Silicon-Urea- Azolide according to the invention can carry only one type of azolide. It is, however, also possible, that a Silicon-Urea-Azolide carries two or more different types of azolide groups.
  • Preferred azolide groups have an imidazole, pyrazole, benzimidazole, tria- zole, tetrazole or benzotriazole ring. It can be preferred, if no dimeric imidazoles or imidazole derivatives are present.
  • the ring can be substituted or unsubstituted, especially substituted with C 1-4 -alkylgroups, phenyl groups or halogen like F, Cl or Br.
  • the azolide groups can generally be pendant, terminal or both. It can in some instances be preferred, if a linear oligomer or polymer backbone is carrying the azolide groups as terminal groups.
  • A being an azole ring connected to the carbonyl group via an N atom or where the amino compound according to the formula (H 2 N-) n X is reacted in a first step with phosgene, optionally together with a trialkylamine to scavenge HCl, and in a second step with an azole under formation of an azolide according to the general formula I, where X has the meaning as defined in formula I.
  • X is a polymeric radical with a molecular weight of at least 200 and at least 2 repetition units with at least 1 Si-atom per repetition unit.
  • variable X stands for oligomeric and polymeric backbones as described in the context of the present invention.
  • Preferred amino compounds are Silicone-Amines that comprise at least one or more features selected from the following group of features: a) at least one Si-O-Si bond, b) one or more groups HN(R )- (as defined in formula (I)) connected to Si atom(s) via an organic spacer, c) no additional nucleophilic functional groups capable of reacting with isocy- anates at room temperature faster than the NH-bond in a urea group (e. g. OH-, NH-, SH-, COOH-).
  • Suitable amino silicones of the general formula (H 2 N-) n X are l,3-bis-(aminomethyl)- 1,1 ,3 ,3 -tetramethyl-disiloxane, 1 -3 -bis-(3 -aminopropyl)- 1 , 1 ,3 ,3 -tetramethyldisiloxane,
  • T is a linear or branched hydrocarbon or an aryl residue that may contain an oxygen atom and/or an ether group with 6 to 14 C-atoms and a valency of c
  • Y is a linear or branched alkylene group with 1 to 10 C-atoms or a cycloalkyl group with 4 to 14 C-atoms
  • R 1 is a linear or branched alkyl or fluoroalkyl group with 1 to 8 C-atoms or a cycloalkyl or aryl group with 6 to 14 C-atoms
  • R 2 is a linear or branched alkylene group that may contain a carbonyl group with 1 to 8 C-atoms
  • F is R 1 or -Y-(O-R 2 ) d -T e -[(O-R 2 ) b -NHR 3 ] C with at least one residue -Y-(O-R 2 ) d -T e -[(O-R 2 )
  • Rhodorsil 21643 and 21644 from Rh ⁇ ne-Poulenc or AMS-132, 152, and 162 from Gelest (CAS: 99363-37-8) or
  • PDMS polydimethyldisiloxane
  • silicone amines are reacted with carbonyl-bisazolides in a ratio of at least 1 mol carbonyl bisazolide per 1 equivalent of silicone amine.
  • an excess of carbonyl bisazolid can be advantageous in order to avoid chain extension. The process, however, under appropriate conditions gives good results even with a very low excess.
  • chain extension is desirable as described in US 3,179,633 or WO 02/077072 or EP 1 496 079.
  • urea segmented terminal SiIi- cone-Urea- Azolides can easily and conveniently be prepared.
  • There chain extended urea segmented terminal Silicone-Urea- Azolides decompose thermally selectively at ther terminal Urea-Azolide group resulting in chain extended urea segmented terminal Silicone- Isocyanates.
  • the reaction can be conducted with or without solvents. If a solvent is used, it should be a solvent which is inert with regard to the azolide reaction. In some cases THF as a com- patibilizer results in accelerated reaction of the carbonyl bisazolide with the silicone amine. Further suitable solvents are cyclohexane, toluene, chloroform or dichloromethane or mixtures of two or more of those.
  • the reaction temperature can generally between 0 and about 120°C. It can be preferred, if the reaction is conducted at a temperature of between about 5 and about 100 0 C or between about 10 and about 40 °C or up to the boiling point of the solvent at normal pressure, if any solvent is used.
  • Reaction times can be varied. It has proven to be advantageous to let the reaction run be- tween about 0,5 to about 50, e.g., between about 1 and about 30 h, or between about 2 to about 20 h or about 5 to about 1O h. If the Silicone-Urea- Azolide is not going to be isolated, the reaction time can basically be chosen freely.
  • the invention also relates to a process for the production of an Silicone-Urea- Azolide ac- cording to the general formula (I) wherein an amino compound according to the general formula (H(R 4 )N) n X, X being a monomeric, oligomeric or polymeric radical with the functionality n containing at least one Si atom and n is 1 to about 100000, is reacted in one or more steps with one or more compounds to form an azolide according to formula (I).
  • an amino compound according to the general formula (H(R 4 )N) n X is preferably reacted with a compound according to the general formula
  • A being an azole ring connected to the carbonyl group via an N atom or where the amino compound according to the general formula (H(R 4 )N) n X is reacted in a first step with phosgene, optionally together with a trialkylamine and in a second step with an azole under formation of an Silicone-Urea-Azolide according to general formula (I).
  • the amino compound preferably comprises at least one or more features selected from the following group of features: a) at least one Si-O-Si bond, b) one or more groups HN(R 4 )- (as defined in formula (I)) connected to Si atom(s) via an organic spacer, c) no additional nucleophilic functional groups capable of reacting with isocynates at room temperature faster than the NH-bond in a urea group (e. g. OH-, NH-, SH-, COOH-).
  • a independently is selected from the group consisting of pyrazole, imidazole, triazole, benzimidazole, benzotriazole, tetrazole, especially imidazole, triazole, benzimidazole, benzotriazole.
  • the molar ratio of amino groups to carbonyl- bisazolide can generally be chosen freely. However, good results have, e.g., been achieved when the molar ratio of amino groups to carbonyl-bisazolide is in the range of about 1 : 2 to about 1 : 1.
  • any type of solvent can be used in the inventive process which does not detrimentally infuence the process itself. It can be preferred, if a solvent or solvent mixture is used that compatibalizes amino compound and carbonyl-bisazolide or if a solvent or solvent mixture is used that does not or not fully compatibalizes amino compound and car- bonyl-bisazolide. It is also possible not to use any solvent at all.
  • Silicon-Urea-Azolides can be dissociated by application of heat to give Silicone- Isocyanates and azoles.
  • the Silicone-Isocyanates can be obtained by separation of the az- ole from the equilibrium. This can be done most conveniently by using a thin film evapo- rator or a short path distiller where pyrolytic decomposition and removal of the azole generated can be achieved conveniently by applying vacuum.
  • the temperature of the feed is at about -50 to about 200 0 C or at about -20 to about 150 °C or at about 0 to about 100 °C or at about 10 to about 70 °C
  • the temperature of the evaporator is at about 50 to about 300 °C or at about 70 to about 250 °C or at about 80 to about 200 0 C or at about 90 to about 180 °C
  • the temperature of the collector is at about -50 to about 200 °C or at about 0 to about 150 °C or at about 20 to about 100 0 C or at about 30 to about 90 °C.
  • Another way to obtain the isocyanates can be to shock-freeze a heated silicone urea azolide and thereby force the azolide to crystallize which removes the azolide from the equilibrium. Filtration or centrifugation can also be used to separate the crystallized azole. Whereas regardless of the process chosen in many cases one decomposition and separation step is sufficient to obtain satisfactory product quality in some cases multiple repetition can be advantageous to obtain the desired purity.
  • Silicon-Urea-Azolides are useful compounds. In most cases they react the same way the corresponding isocyanates do, although noticeably slower. For this reason, however, SiIi- con-Urea-Azolides cannot be considered as "blocked” or "capped” isocyanates because those at room temperature should usually be unreactive and only by thermal activation react as isocyanates.
  • the described Silicone-Urea-Azolides are useful for many different purposes. It has, e.g., proven to be expedient to use the Silicone-Urea-Azolides for the production of Silicone- Isocyanates.
  • the inventon thus also relates to a process for production of Silicone- Isocyanates wherein a Silicone-Urea-Azolide is decomposed at an elevated temperature. It has further proven to be possible and successful, if the product is not isolated after com- pletion of the reaction but the produced Silicone-Isocyanate and the Azole are separated at decomposition temperature.
  • the resulting Azole can preferably be removed under vacuum.
  • it can further be preferred, if at one point within a matrix of temperature and pressure defined between 60 ° C to 180 ° C and 10 "5 mbar to 200 mbar predominantly Azole and Silicone-Isocyanate are produced.
  • the invention thus not only relates to the production of Silicone-Urea-Azolide and the subsequent generation of Silicone-Isocyanate in a successive step.
  • the yield of this process for the production of Silicone-Isocyanate is generally above about 80 %, in many cases yields of more than 90% or more than 95 % can be obtained. It is noteworthy that the obtained Silicone-Isocy ' anate generally is comparatively pure. Due to the reaction path it is generally essentially free of heavy metals and noble metals. Preferably, the Silicone-Isocyanate contains less than 100 ppm by weight or less than 50 ppm by weight or less than 10 ppm by weight of one or more noble metals, preferably Pt.
  • the content of Azolide given by the weight of the residue A of formula (I) is generally between about 50 ppm and about 1 %, preferably below 0,5 or below 0,1 or below 0,05 %. It is preferred if the obtained Silicone-Isocyanate contains at least about 50 or about 100 ppm or about 200 ppm of Azole or at least about 50 or about 100 ppm or about 200 ppm of Azolide or both.
  • the Silicone-Urea-Azolides and the Silicone-Isocyanates according to the invention or produced according to the invention can generally be used for the production of different types of materials or in different types of processes, e.g., industrial or dental/healthcare, or the like.
  • the Silicone-Urea-Azolides and the Silicone-Isocyanates according to the invention or produced according to the invention can be employed in any process where conventional Silicone-Isocyanates have been used.
  • the Silicone-Urea- Azolides and the Silicone-Isocyanates according to the invention or produced according to the invention can be used for the production of any type of three dimensional object or can be used in the field of adhesives.
  • the preparations can especially be used in very different dental materials employed in dental medicine or dental technology.
  • Preferred areas of use of such dental materials are single-phase and two-phase impression-taking in dental medicine and bite registration.
  • the invention is further illustrated by way of examples.
  • CDI Carbonyl-bisimidazolide, a carbonyl bisazolide with CAS-#: [530-62-1]
  • the degree of functionalization usually is substantially greater than 90 % (if not indicated otherwise).
  • Example 3 Silicone-Urea-Azolide At room temperature 39,1 g (0,241 Mole) CDI (FLUKA, > 97 %) are dispersed in 250 ml Cyclohexane and 150 ml dry THF. Temperature drops as part of CDI dissolves. 400 g (80,3 mMole)PDMS diamine (Clariant 66M66, M: 4.980) are added to the suspension under stirring within 90 min. After one additional hour of stirring the suspension is filtrated and diluted with 500 ml Cyclohexane. The clear slightly viscous liquid is washed 5 times with 100 ml of water dried with Na2SO4 filtrated again and evaporated from the solvent. Clear off-white to amber liquid is obtained.
  • Example 4 Silicone-Urea-Azolide At room temperature 25 g (0, 152 Mole) 1 , 1 '-Carbonyldi-(1 ,2,4)-triazol CAS-# [41864-22- 6] (CDT, FLUKA, ⁇ 95 %) are dispersed in 200 ml dry THF. Temperature drops as part of CDT dissolves. 285,7 g (100 mMole) PDMS diamine (3M St. Paul, M: 5.710) are dis- solved in 200 ml Cyclohexane and added to the suspension under stirring within 90 min. After additional 16 hours of stirring the suspension is diluted with 300 ml Cyclohexane and filtrated. The clear filtrate is evaporated from the solvent.
  • Example 8 Silicone-Urea-Azolide At room temperature 32,42 g (0,20 Mole) CDI (FLUKA, > 97 %) are dispersed in 150 ml Toluene. At RT 24,85 g (0,10 Mole ) l,3,-Bis-(3-aminopropyl)-l,l,3,3-tetramethyl- disiloxane (Lancaster 97 %) are added to the suspension under stirring within 30 min. During addition temperature of the reaction mixture is kept at 23 ° C with an ice bath. After addition a clear two phase reaction mixture remains. The lower layer is separated and sol- vent is removed. Clear brownish yellow oil is obtained.
  • CDI (FLUKA 5 > 97 %) are dispersed in 500 ml dry THF.
  • Example 11 Silicone-Urea-Azolide At room temperature 16,2 g (0,100 Mole) CDI (FLUKA, > 97 %) are placed in a dry round bottom flask at RT. The flask is immersed into an ice-bath and 119 g (25 mMole) PDMS diamine (ABCR, DMS-A21, M: 4760) are added under stirring within 10 min. Af- ter additional 4 days of stirring the suspension is filtrated. Clear- yellow liquid is obtained.
  • Example 14 Silicone-Isocyanate First run: 230 g of H are passed over a KDL 5 Short Path Distillator at
  • Second run 19O g of first run product are passed over a KDL 5 Short Path Distillator at T(Feed): 50 ° C Pressure: 2xlO "2 mbar
  • Example 18 Silicone-Isocyanate 100 g of 17 are passed over a KDL 5 Short Path Distillator at
  • CDI (FLUECA, > 97 %) are dispersed in 250 ml Cyclohexane and 25 ml dry THF. Temperature drops as part of CDI dissolves to give a white suspension. The flask is immersed into an ice-bath and 1000 g (113 mMole) PDMS diamine (3M, base equivalent 17710 g/Mole) are added under stirring within 120 min. After additional 16 hours of stirring the suspension is filtrated. The clear filtrate is evaporated form the solvent. Clear pale yellow liquid is obtained.
  • Example 21 Silicone-Urea-Azolide At room temperature 8,51 g (0,0525 Mole) CDI (FLUKA, > 97 %) are dispersed in 120 ml Cyclohexane and 12 ml dry THF. Temperature drops as part of CDI dissolves to give a white suspension. The flask is immersed into an ice-bath and 119 g (50 mEquivalent) PDMS diamine (ABCR, base equivalent 2381 g/Mole) are added under stirring within 120 min. After additional 16 hours of stirring the suspension is filtrated. The clear filtrate is evaporated from the solvent. Clear pale yellow liquid is obtained.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Silicon Polymers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention relates to and their preparation and the production of Silicon-Isocyanates from Silicon-Urea-Azolides.

Description

Silicon-Urea-Azolides, their preparation and use
The invention relates to Silicon-Urea-Azolides and their preparation and the production of silicon isocyanates from Silicon-Urea-Azolides.
Silicone-Isocyanates are valuable chemical building blocks combining properties of silicones and reactivity of isocyanates that are widely applicable in chemical industry. As an isocyanate component, they can be used in many reactive formulations, e.g., to form poly- urethanes or polyureas.
The prior art discloses several procedures for the preparation of Silicone-Isocyanates. Most of them, however, exhibit one or more aspects preventing a facile applicability. Although there is a need for Silicone-Isocyanates they are not readily available on the market.
For application of Silicone-Isocyanates as an reactive intermediate an isolable and cheaper intermediate step like Silicon-Urea-Azolides in the sequence to Silicone-Isocyanates could be useful.
US 3,170,891 describes synthesis of Silcon-Isocyanates by hydrosilation of unsaturated isocyanates to Si-H functional Silicones. The problem with this reaction lies in the fact that both the unsaturated isocyanates needed as an educt as well as the platinum catalyst are very expensive. Moreover, the reaction often is not nearly quantitative, especially with educts of elevated molecular weights. Additionally, there are side reactions and it is diffi- cult to remove unreacted educt and catalyst due to the polymeric character of the product and its sensitivity to nucleophiles. US 3,179,622 describes Silicone-Isocyanates made by step-growth poymerisation of si- loxane amines or siloxane carbinols with an excess of organic diisocyanates. Inevitably, minor amounts of the mostly problematic diisocyanates remain in the product which are difficult to remove. The urea- or urethane-groups resulting from the step growth reaction increase the viscosity of the product (by several magnitudes) compared to material of comparable molecular weight without those urea or urethane groups.
US 3,936,484 describes the production of polyisocyanates from substituted ureas. The described synthetic methods are directed towards the classical organic low molecular weight diisocyanates (mainly TDI) by pyrolysis of N,N'-bis-ureas. The amines released by pyrolysis are not stabilized by mesomeric structures. Starting ureas are thermally stable and decomposition temperatures therefore are drastic (230 - 350 °C) and the yields are low, which in case of difunctional ureas leads to high fractions of undesired mono isocy- anates.
US 5,886,205 describes the synthesis of siloxane isocyanates by decomposition of ure- thanes that are produced by reaction of diorgano carbonates and siloxane amines. The decomposition temperature is high (in the examples around 250 °C) leading to undesired thermal degradation and discoloration.
JP 2001-48855 describes the synthesis of "relatively high molecular" siloxane isocyanates by converting Siloxane-Amines into aryl urethanes (using diarylcarbonate). Thermal decomposition of the urethanes gives high yield of Silicone-Isocyanates. The reactions disclosed require rather elevated temperatures and are time consuming. Molecular weights are often unsatisfactorily low.
US 5,886,205 discloses that the production of Silicone-Isocyanates via phosgenation fails because the side product cracks siloxane bonds. Whereas in Japanese patent publication No. 5-8713 (1993) it is disclosed to use tertiary amines to remove HCl, the use of phos- gene and the corrosivity of chloride containing reaction mixtures at high temperatures or exhaust gases remain problematic.
H. A. Staab ,,Azolides in organic synthesis and biochemistry", Wiley- VCH, 1998 [ISBN: 3-52729314-0] S.172, 188, 273-279 describes the decomposability of organic molecular Urea-Imidazolides to give isocyanates and imidazol. It is also mentioned that in some cases even at room temperature the substance shows an isocyanate band around 2250 cm"1 in the IR spectrum, proving that the equilibrium is at least partly on the isocyanate side. Isocyanates are isolated in some cases by distillation of the isocyanates from the mixture - although with moderate to poor yields (83 % at most). The comparatively low yields for isocyanates actually do not recommend an application of this reaction to polymeric substances. Since purification by distillation is impossible for polymeric substrates, keeping in mind that 83 % yield in mono isocyanates means statistically 69 % yield with diisocy- anates and even less for higher functional isocyanates.
G.S. GoMn, V.G. Poddubnyi, A.N. Kol'tsova, Vysokomol. Soedin Ser. B 17(4) (1975) 322-3 describe a polymeric silicon urea triazolide, by reacting silicon isocyanate with a bridged Bis-Triazolide. The polymers are described as showing increased solubility in organic solvents and as lowering the softening point of formulations. No thermal reversi- bility of the reaction is mentioned. No azolides from monomeric azoles are disclosed.
DE 42 08 40 2 Al describes the production of Silicone-Isocyanates by condensation of an isocyanate functional dichlorosilane with dihydroxy tetramethyldisiloxane. The preparative scope of this reaction is very limited. The process requires two commercially unavail- able raw materials and releases HCl with similar detrimental effects as found with phos- genation.
Expired documents JP 60-140342 and JP 60-140343 describe silverhalogenide containing photographic formulations comprising silicones with pendant reactive groups. Among numerous more precisely specified species in the general description azolides are mentioned.
There has thus been a need for a compound which allows for an easy accessibility of SiIi- cone-Isocyanates. There has also been a need for an easy to use process which can supply such a compound in large amounts and high yields with a high degree of isocyanate functionality and a broad variability of molecular weight.
Summary of the invention
The invention relates to an azolide according to the general formula I
Figure imgf000006_0001
wherein A is an azole ring connected to the carbonyl group via an N atom, R4 is H or a linear or branched or cyclic alkyl group with 1 to 24 C-atoms, X is a monomeric, oli- gomeric or polymeric radical with the functionality n containing at least one Si atom and n is 1 to about 100000.
The invention further relates to a process for the production of an azolide according to the general formula I
Figure imgf000006_0002
wherein an amino compound according to the general formula (H2N-)nX, with X being a monomeric, oligomeric or polymeric radical with the functionality n containing at least 1 Si-atom, R4 is H or a linear or branched or cyclic alkyl group with 1 to 24 C-atoms and n is 1 to 100000, is reacted in one or more steps with one or more compounds which form an azolide according to formula I.
The invention also relates to a process for the production of Silicone-Isocyanates wherein an azolide according to the general formula I
Figure imgf000007_0001
where A is an azole ring connected to the carbonyl group via an N atom, X is a mono- meric, oligomeric or polymeric radical with the functionality n containing at least 1 Si- atom, R4 is H or a linear or branched or cyclic alkyl group with 1 to 24 C-atoms and n is 1 to 100000, is decomposed at elevated temperatures.
The Silicon-Urea-Azolides according to the invention are available from the corresponding Silicone-Amines. They can be prepared, e.g., by reaction of the latter with carbonyl bisazolides or by cold phosgenation in the presence of a stoichiometric amount of tertiary base to scavenge HCl and subsequent reaction of the chlorocarbamate with imidazole in the presence of a stoichiometric amount of base to capture HCl.
The described reaction with carbonyl bisazolides in most cases very specifically leads to Silicone-Urea-Azolides with little or no formation of symmetrical urea coming from dou- ble reaction with silicone amine. At room temperature within a short time a nearly quantitative reaction of all amino groups present can often be observed. The reaction can be conducted in compatibilitzing solvents like THF, non compatibilizing solvents like cyclo- hexane, mixtures of two or more of these types of solvents or with no solvent at all. Condensation catalysts, though applicable, are not necessarily required.
By heating Silicon-Urea-Azolides under vacuum, the urea groups decompose even at mild conditions reaching equilibrium very fast so that the continuous separation of azole from the vapour phase is possible. The reaction rates are high. Within the contact time of one or several cycles in a thin-film evaporator or short path distiller almost quantitative decom- position and simultaneous removal of the azole can often be achieved. Again, no catalysts are required for the decomposition reaction. The process for the production of silicon isocyanates according to the invention thus can have one or more of the following advantages: facile introduction of organic isocyanate function at silicone containing molecules, especially of silicon containing polymers at elevated molecular weights (e.g., above about 500 g/Mole), no hard to separate metal catalysts easy to separate by-products, low cost and commercially available raw material basis, - comparable viscosity of the Silicone-Isocyanates to Silicone-Amines of comparable chain length, simple processes (if desired: no solvents, no extraction or cleaning procedures), almost no side reactions, broad applicability - high degree of functionalization.
The following terms are used in the present text according to the following definitions:
The term "Silicone" refers to the definition given in H.F. Mark et al. "Encyclopedia of Polymer Science and Engeneering" 2nd Edition, Volume 15, p 204, (ISBN: 0-471-80947-0 (v. 15)) 1989 John Wiley & Sons, which is expressly mentioned as a valuable source of information on the meaning of the term "silicone" and the disclosure of which is regarded as being part of the disclosure of the present text.
The term "Silicone-Amines" refers to silicones having at least one silicon atom carrying an organic residue comprising a primary amino group (-NH2). The molecule does prefera- bly not comprise other protic or nucleophilic groups (e.g.: OH, COOH, NH, SH), insofar as they are not protected, which are able to react with isocyanate groups.
The term "Silicone-Carbinols" refers to silicones having at least one silicon atom carrying an organic residue comprising an alcohol group (-OH).
The term "Silicone-Isocyanates" refers to silicones having at least one silicon atom carrying an organic residue comprising an isocyanate group (-N=C=O).
The term "Silicon-Urea-Azolides" refers to silicones having at least one silicon atom carrying an organic residue comprising a urea group with a terminal nitrogen which is part of an azole ring as described in the definition for azolides.
The term "Azolide" relates to heterocyclic amides, ureas or urethanes in which the amide nitrogen is part of an azole ring, such as imidazole, pyrazole, triazole, tetrazole, benzimi- dazole, benzotriazole, and their substituted derivatives", according to H. A. Staab ,,Azolides in organic synthesis and biochemistry", Wiley- VCH, 1998 [ISBN: 3-527- 29314-0].
The term "Carbonyl-Bisazolide" relates to ureas, where both nitrogen atoms are part of an azole ring as described in the definition of azolides.
Azolide-Groups according to the definition of Staab are heterocyclic amides in which the amide nitrogen is part of an azole ring. According to that and the way they are referred to in the cited documents this primarily means azolides of carboxylic acids L not mixed ureas as described in the present text.. The invention will now be explained in further detail.
Detailed description of the invention
The invention relates to an azolide according to the general formula I
Figure imgf000010_0001
wherein A is an azole ring connected to the carbonyl group via an N atom, R4 is H or a linear or branched or cyclic alkyl group with 1 to 24 C-atoms, X is a monomeric, oli- gomeric or polymeric radical with the functionality n containing at least one Si atom and n is 1 to about 100000.
Generally, the invention relates to all types of azolides containing at least one Si atom according to formula I. It is, however, preferred, if the azolide is a molecule with a molecular weight of at least about 250, preferably at least about 350 or at least about 500 or at least about 800 or at least about 1000. Generally, the azolides can be monomeric compounds or oligomeric compounds or polymeric compounds.
X can thus be monomeric, oligomeric or polymeric. In a preferred embodiment, X is an oligomeric or polymeric radical with a molecular weight of at least 200 and at least 2 repe- tition units with at least 1 Si-atom per repetition unit. X can, e.g., be a linear or branched, saturated or unsaturated or cyclic polysiloxane.
It can be preferred, if Silicone-Urea-Azolides according to formula (I) comprise at least one or more features selected from the following group of features: a) at least one Si-O-Si bond, b) one or more groups A-C(=O)N(R4)- (as defined in formula (I)) connected to Si atom(s) via an organic spacer, c) no additional nucleophilic functional groups capable of reacting with isocynates at room temperature faster than the NH-bond in a urea group (e. g. OH-, NH-,
SH-, COOH-), d) a boiling point at normal pressure (1013 mbar) of > 280 ° C and/or undergoing decomposition at such a temperature, e) thermal decomposition at least at one point within a matrix of temperature and pressure defined between 60 ° C to 180 ° C and 10"5 mbar to 200 mbar resulting in predominantly Azole and Silicone-Isocyanate and f) a Molecular weight of more than 230 g/mole.
It can further be preferred if the Silicone-Urea-Azolide comprises a structure R^R2SiOy2 and/or a structure R1R2SiO2Q and/or a structure R2Si03/2 where R1 independently is H, or a linear, branched, cyclic or aromatic saturated or unsaturated facultatively partly or fully fluorinated organic residue with 1 to 30 C-atoms that may contain 0 to 5 O atoms; R2 independently is R3-NH-C(=O)-A; R3 is a bifunctional organic radical alkylen, arylen or mixed with 1 to 18 carbon atoms that may contain 0 to 5 O atoms and A is an azole ring.
It can further be preferred if the Silicone-Urea-Azolide comprises one or more of the following silicone structures: a) Linear or branched (R1 2R2SiO1/2)2(R1R2SiO2/2)x where R1 independently is
H, or a linear, branched, cyclic or aromatic saturated or unsaturated faculta- tively partly or fully fluorinated organic residue with 1 to 30 C-atoms that may contain 0 to 5 O atoms; R2 independently is R1 but at least one R2 group up to all R2 groups is/are R3-NH-C(=O)-A; R3 is a bifunctional organic radical alkylene, arylene or mixed with 1 to 18 carbon atoms that may contain 0 to 5 O atoms; A is an azole ring; the linear chain may be branched by up to 5 moieties of the structure R2Si02/2 and/or SiO4Z2; x= 0 to 100000; b) cyclic (R1R2SiO2Z2)In where R1 independently is H, or a linear, branched, cyclic or aromatic saturated or unsaturated facultatively partly or fully fluorinated organic residue with 1 to 30 C-atoms that may contain 0 to 5 O atoms; R2 independently is R1 but at least one R2 group up to all R2 groups is/are R3-NH-C(=O)-A; R3 is a bifunctional organic radical alkylene, ary- lene or mixed with 1 to 18 carbon atoms that may contain 0 to 5 O atoms; A is an azole ring; m = 3 to 1000; c) polycyclic (R2Si03/2)0, or (R^R2SiO i/2)p(Si04/2)q where R1 independently is H, or a linear, branched, cyclic or aromatic saturated or unsaturated facultatively partly or fully fluorinated organic residue with 1 to 30 C-atoms that may contain 0 to 5 O atoms; R2 independently is R1 but at least one R2 group up to all R2 groups is/are R.3-NH-C(=O)-A; R3 is a bifunctional organic radical alkylene, arylene or mixed with 1 to 18 carbon atoms that may contain 0 to 5 O atoms; A is an azole ring; o is 6 to 100000 p = 1 to q and q is 6 to 100000.
Also preferred can be linear and cyclic siloxanes according to the above described structures with R1 being H, methyl, ethyl, vinyl, ethynyl, propyl, iso-propyl, allyl, propenyl, all isomers of butyl, hexyl, octyl, lauryl and octadecyl, cyclohexyl, phenyl, ethylphenyl, triluormethyl, 3,3,3-trifluorpropyl, methoxy, ethoxy, propoxy, isopropoxy, 2-methoxy- ethoxy, 2-ethoxy-ethoxy; R2 independently is R1 but at least one R2 group up to all R2 groups is/are R3 -NH-C(^O)-A; R3 is methylene, ethylene, propylene, butylenes, hexylene, octylene, decylene, undecylene, phenylene, ethylenephenylene; A is pyrazolyl, imidazolyl, triazolyl, benzimidazolyl, benzotriazolyl, tetrazolyl; x = 0 to 10000; m = 3 to 100. Also preferred can be linear and cyclic siloxanes with R1 being H3 methyl, ethyl, vinyl, propyl, iso-propyl, allyl, all isomers of butyl, hexyl, octyl, lauryl and octadecyl, cyclo- hexyl phenyl, ethylphenyl, triluormethyl, 3,3,3-trifluorpropyl; R2 independently is R1 but at least one R2 group up to all R2 groups is/are R3-NH-C(=0)-A; R3 is methylene, ethyl- ene, propylene, butylenes, hexylene, octylene, decylene, undecylene, phenylene, ethyle- nephenylene; A is imidazolyl, triazolyl, benzimidazolyl, benzotriazolyl; x = 0 to 10000; m = 3 to 100.
Generally, the radicals R1 and R2 can be equipped with any type of substituent or sub- stituents provided they do not interfere with any other constituents or substituents of the composition and do not interfere with the urea azolide group. The term "interfere" as used in the context of the present text relates to any influence of such a substituent on at least one of the other substituents or constituents of the composition or the reaction to form an isocyanate, or both, which is detrimental to the properties of either the urea azolide product or an isocyanate formed from the urea azolide. The term "detrimental" as used in the context of the present text relates to a change of properties that negatively affect the usefulness of the precursors or the cured product in their intended use.
In general, polysiloxane polymers do not comprise uniform chain lengths but show a dis- tribution of various chain lengths as represented by the polydispersity index. Depending an the preparation process, the polydispersity index ranges from 1.1 to 20 and preferably from 1.2 to 10.
Suitable silicone backbones for carrying one or more azolide groups are 1,3-bis- (methylene)- 1 , 1 ,3 ,3 -tetramethyl-disiloxane, 1 -3-bis-(3 -propylene)- 1 , 1 ,3 ,3-tetrame- thyldisiloxane, l,3,5,7-tetrakis-(methylene)-l,3,5,7-tetramethyl-cyclotetrasiloxane,
1 ,3,5,7-tetrakis-(3-propylene)-l ,3,5,7-tetramethyl-cyclotetrasiloxane, 1 ,3,5,7,9-pentakis- (methylene)-l,3,5,7,9-pentamethyl-cyclopentasiloxane, l,3,5,7,9-pentakis-(3-propylene)- 1,3,5,7,9-pentamethyl-cyclopentasiloxane, 1,3,5,7,9,1 l-hexakis-(methyllene)-l,3, 5,7,9,11- hexamethyl-cyclohexasiloxane, 1,3,5,7,9,1 l-hexakis-(3-propylene)-l,3,5,7,9,l 1- hexamethyl-cyclohexasiloxan, α,ω-alkylene-terminated silicones like α,ω-(methylene)- polydimethylsiloxan, α,ω-(3-propylene)-polydimethylsiloxan and α-alkylene-, ω- trimethylsiloxy terminated silicones like α-methylene-ω- trimethylsiloxypolydimethylsiloxane, α-ethylene-ω-trimethylsiloxypolydimethylsiloxane or α-propylene-ω-trimethylsiloxypolydimethylsiloxane and the like, copolymers of unre- active silicones with alkylene-alkyl-silicones like (3-propylene-methylsiloxan)-co- (dimethylsiloxan) or 1-methylene-methylsiloxane-ω-dimethylsiloxane. The alkylene groups of the above described silicone cycles and polymers carry the azolide groups at the respective alkylene moieties.
A Silicon-Urea- Azolide according to the invention carries at least one azolide group. A Silicon-Urea- Azolide according to the invention can carry only one type of azolide. It is, however, also possible, that a Silicon-Urea-Azolide carries two or more different types of azolide groups. Preferred azolide groups have an imidazole, pyrazole, benzimidazole, tria- zole, tetrazole or benzotriazole ring. It can be preferred, if no dimeric imidazoles or imidazole derivatives are present. The ring can be substituted or unsubstituted, especially substituted with C1-4-alkylgroups, phenyl groups or halogen like F, Cl or Br.
If the backbone of a silicon containing polymer carrying azolide groups is linear or branched, the azolide groups can generally be pendant, terminal or both. It can in some instances be preferred, if a linear oligomer or polymer backbone is carrying the azolide groups as terminal groups.
For the preparation of the Silicon-Urea- Azolides, generally all types of reactions are possible which result in the attachment of at least one azolide group to a silicon containing molecule, preferably a silicone. According to the inventive process, it can be preferred, if an amino compound according to the formula (H2N-)nX is reacted with a compound according to the general formula
Figure imgf000015_0001
with A being an azole ring connected to the carbonyl group via an N atom or where the amino compound according to the formula (H2N-)nX is reacted in a first step with phosgene, optionally together with a trialkylamine to scavenge HCl, and in a second step with an azole under formation of an azolide according to the general formula I, where X has the meaning as defined in formula I.
In a preferred embodiment X is a polymeric radical with a molecular weight of at least 200 and at least 2 repetition units with at least 1 Si-atom per repetition unit. Generally, the variable X stands for oligomeric and polymeric backbones as described in the context of the present invention.
Preferred amino compounds are Silicone-Amines that comprise at least one or more features selected from the following group of features: a) at least one Si-O-Si bond, b) one or more groups HN(R )- (as defined in formula (I)) connected to Si atom(s) via an organic spacer, c) no additional nucleophilic functional groups capable of reacting with isocy- anates at room temperature faster than the NH-bond in a urea group (e. g. OH-, NH-, SH-, COOH-).
It can further be preferred if an amino compound comprises one or more of the following silicone structures: a) Linear or branched
Figure imgf000016_0001
where R1 independently is H, or a linear, branched, cyclic or aromatic saturated or unsaturated facultatively partly or fully fluorinated organic residue with 1 to 30 C-atoms that may contain 0 to 5 O atoms; R5 independently is R1 but at least one R5 group up to all R5 groups is/are R3 -NH2; R3 is a bifunctional organic al- kylene, arylene or mixed radical with 1 to 18 carbon atoms that may contain 0 to 5 O atoms; the linear chain may be branched by up to 5 moieties of the structure R5SiO2Z2 and/or SiO4/2; x= 0 to 100000; b) cyclic (R1R5SiO2Z2)Hi where R1 independently is H, or a linear, branched, cyclic or aromatic saturated or unsaturated facultatively partly or fully fluorinated organic residue with 1 to 30 C-atoms that may contain 0 to 5 O atoms; R5 independently is R1 but at least one R5 group up to all R2 groups is/are R -NH2; R is a bifunctional organic radical alkylene, arylene or mixed with 1 to 18 carbon atoms that may contain 0 to 5 O atoms; m = 3 to 1000; c) polycyclic (R5Si03/2)0, or (R1 2R5SiO1/2)p(SiO4/2)q where R1 independently is H5 or a linear, branched, cyclic or aromatic saturated or unsaturated facultatively partly or fully fluorinated organic residue with 1 to 30 C-atoms that may contain 0 to 5 O atoms; R5 independently is R1 but at least one R5 group up to all R5 groups is/are R3 -NH2; R3 is a bifunctional organic alkylene, arylene or mixed radical with 1 to 18 carbon atoms that may contain 0 to 5 O atoms, o is 6 to 100000 p = 1 to q and q is 6 to 100000.
Suitable amino silicones of the general formula (H2N-)nX are l,3-bis-(aminomethyl)- 1,1 ,3 ,3 -tetramethyl-disiloxane, 1 -3 -bis-(3 -aminopropyl)- 1 , 1 ,3 ,3 -tetramethyldisiloxane,
1 ,3 ,5 ,7-tetrakis-(aminomethyl)- 1 ,3 ,5 ,7-tetramethyl-cyclotetrasiloxane, 1 ,3 ,5,7-tetrakis-(3 - aminopropyl)-l,3,5,7-tetramethyl-cyclotetrasiloxane, l,3,5,7,9-pentakis-(aminomethyl)-
1,3,5,7,9-pentamethyl-cyclopentasiloxane, l,3;5,7,9-pentakis-(3-aminopropyl)-l,3, 5,7,9- pentamethyl-cyclopentasiloxane, 1,3,5,7,9,1 l-hexakis-(aminomethyl)-l,3, 5,7,9,11- hexamethyl-cyclohexasiloxane, 1,3,5,7,9,1 l-hexakis-(3-aminopropyl)-l,3, 5,7,9,11- hexamethyl-cyclohexasiloxane, α,ω-alkyRerminated silicones like α,co-(aminomethyl)- polydimethylsiloxane, α,ω-(3-aminopropyl)-polydimethylsiloxane, copolymers of unreac- tive silicones with aminoalkyl-alkyl-silicones like (3~aminopropyl-methylsiloxane)-co- (dimethylsiloxane).
Further preferred structures are for example R^Si-O-[SiR Vθ-]aSiRVY-(O-R2)d-Te-[(O- R2)b-NHR3]C or [HR3N-(R2-O)b]c-Te-(R2-O)d-Y-[SiR1 2-O-]aSiR1 2-Y-(O-R2)d-Te-[(O-R2)b- NHR3]c or R1SSi-O- {[SiR^-O-],, [SiR4(-Y-(O-R2)d-Te-[(O-R2)b-NHR3]c)-O-]m} -SiR1S or
Figure imgf000017_0001
wherein T is a linear or branched hydrocarbon or an aryl residue that may contain an oxygen atom and/or an ether group with 6 to 14 C-atoms and a valency of c, Y is a linear or branched alkylene group with 1 to 10 C-atoms or a cycloalkyl group with 4 to 14 C-atoms, R1 is a linear or branched alkyl or fluoroalkyl group with 1 to 8 C-atoms or a cycloalkyl or aryl group with 6 to 14 C-atoms, R2 is a linear or branched alkylene group that may contain a carbonyl group with 1 to 8 C-atoms, F is R1 or -Y-(O-R2)d-Te-[(O-R2)b-NHR3]C with at least one residue -Y-(O-R2)d-Te-[(O-R2)b-NHR3]C per molecule, R3 is a linear or branched alkyl or fluoroalkyl group with 1 to 8 C-atoms or a cycloalkyl or aryl group with 6 to 14 C-atoms or H R4 is R1 or Methoxy or Ethoxy, 1 < a < 10.000, 0 < b < 500, 1 < c < 6, 0 < d < 500, e is 0 or 1, 0 < n < 500, 0 < m < 100 where m+n exceed 5 and x is 0, 1, 2, 3, 4, 5 or 6.
Also suitable and often preferred are:
Figure imgf000018_0001
like PDMS Diamine 5k, 10k or 15k from 3M or Tegomer A-Si 2120 or 2130 from Th. Goldschmidt or DMS-Al 1, A12, A15, A25 or A32 from Gelest (CAS: 106214-84-0)
Figure imgf000018_0002
like Rhodorsil 21643 and 21644 from Rhόne-Poulenc or AMS-132, 152, and 162 from Gelest (CAS: 99363-37-8) or
Figure imgf000018_0003
with x = 0 to 20, synthesized from Si-H cycles by hydrosilylation with acrylonitrile and subsequent reaction with LiAlH4. Also preferred can be an amino functionalized polydialkyl disiloxane, especially α,ω- polydimethyldisiloxane (PDMS) with a molecular weight of between about 800 and about 50000, especially between about 100 and about 20000, e.g., between about 2000 and about 10000.
In a further embodiment, silicone amines are reacted with carbonyl-bisazolides in a ratio of at least 1 mol carbonyl bisazolide per 1 equivalent of silicone amine. In some cases an excess of carbonyl bisazolid can be advantageous in order to avoid chain extension. The process, however, under appropriate conditions gives good results even with a very low excess.
For some applications chain extension is desirable as described in US 3,179,633 or WO 02/077072 or EP 1 496 079. By variation of the ratio of carbonyl-bisazolide per equivalent of Silicone-Amine from 1 : 1 towards 1 : 2 chain extended, urea segmented terminal SiIi- cone-Urea- Azolides can easily and conveniently be prepared. There chain extended urea segmented terminal Silicone-Urea- Azolides decompose thermally selectively at ther terminal Urea-Azolide group resulting in chain extended urea segmented terminal Silicone- Isocyanates.
Generally all types of bisazolides can be used according to the invention. It is, however, preferred to used carbonyl bisazolides. Prferred substances are l,l '-carbonyl-diimidazol (CDI) CAS-#: [530-62-1], U '-carbonyl-dibenzimidazol CAS-#: [14667-54-0], 1,1 '- carbonyl-di-(l,2,4)-triazol CAS-#: [41864-22-6], l,l '-carbonyl-bis-(2-methylimidazol) CAS-#: [13551-83-29), U '-carbonyl-dibenzotriazol CAS-#: [68985-05-7]. The com- pounds can be used alone or as a mixture of two or more of them.
The reaction can be conducted with or without solvents. If a solvent is used, it should be a solvent which is inert with regard to the azolide reaction. In some cases THF as a com- patibilizer results in accelerated reaction of the carbonyl bisazolide with the silicone amine. Further suitable solvents are cyclohexane, toluene, chloroform or dichloromethane or mixtures of two or more of those.
The reaction temperature can generally between 0 and about 120°C. It can be preferred, if the reaction is conducted at a temperature of between about 5 and about 100 0C or between about 10 and about 40 °C or up to the boiling point of the solvent at normal pressure, if any solvent is used.
Using temperatures below room temperature (about 23 °C) is possible though generally unnecessary. Elevated temperatures of up to 80°C can facilitate and accelerate the reaction which can be advantageous especially if the process is performed without solvent. In many cases imidazole crystallizes from the solvent free Silicon-Urea-Azolides during standing. The product can be filtered or washed or cleaned in any other desired way. However, gen- erally filtered silicone urea azolide is ready for use for most purposes. Sometimes even filtration can be done without, especially if a thermolytic decomposition leading to SiIi- cone-Isocyanate is desired.
Reaction times can be varied. It has proven to be advantageous to let the reaction run be- tween about 0,5 to about 50, e.g., between about 1 and about 30 h, or between about 2 to about 20 h or about 5 to about 1O h. If the Silicone-Urea- Azolide is not going to be isolated, the reaction time can basically be chosen freely.
The invention also relates to a process for the production of an Silicone-Urea- Azolide ac- cording to the general formula (I) wherein an amino compound according to the general formula (H(R4)N)nX, X being a monomeric, oligomeric or polymeric radical with the functionality n containing at least one Si atom and n is 1 to about 100000, is reacted in one or more steps with one or more compounds to form an azolide according to formula (I). In the inventive process, an amino compound according to the general formula (H(R4)N)nX is preferably reacted with a compound according to the general formula
Figure imgf000021_0001
with A being an azole ring connected to the carbonyl group via an N atom or where the amino compound according to the general formula (H(R4)N)nX is reacted in a first step with phosgene, optionally together with a trialkylamine and in a second step with an azole under formation of an Silicone-Urea-Azolide according to general formula (I).
The amino compound preferably comprises at least one or more features selected from the following group of features: a) at least one Si-O-Si bond, b) one or more groups HN(R4)- (as defined in formula (I)) connected to Si atom(s) via an organic spacer, c) no additional nucleophilic functional groups capable of reacting with isocynates at room temperature faster than the NH-bond in a urea group (e. g. OH-, NH-, SH-, COOH-).
It can further be preferred if an amino compound comprises one or more of the following silicone structures: a) Linear or branched (R1 2R2SiO1/2)2(R1R2SiO2/2)x where R1 independently is H, or a linear, branched, cyclic or aromatic saturated or unsaturated facultatively partly or fully fluorinated organic residue with 1 to 30 C-atoms that may contain 0 to 5 O atoms; R2 independently is R1 but at least one R2 group up to all R2 groups is/are R3-NH-C(=O)-A; R3 is a bifunctional organic radical alkylene, arylene or mixed with 1 to 18 carbon atoms that may contain 0 to 5 O atoms; A is an azole ring; the linear chain may be branched by up to 5 moieties of the structure R2Si02/2 and/or SiO4/2; x= 0 to 100000; b) cyclic (R1R2SiO2Z2)H1 where R1 independently is H, or a linear, branched, cyclic or aromatic saturated or unsaturated facultatively partly or fully fluorinated organic residue with 1 to 30 C-atoms that may contain 0 to 5 O atoms; R2 independently is R1 but at least one R2 group up to all R2 groups is/are R3-NH-C(=0)-A; R3 is a bifunctional organic radical alkylene, ary- lene or mixed with 1 to 18 carbon atoms that may contain 0 to 5 O atoms; A is an azole ring; m = 3 to 1000; c) polycyclic (R SiO3/2)0, or (R 2R SiOi/2)p(SiO4/2)q where R independently is H, or a linear, branched, cyclic or aromatic saturated or unsaturated facultatively partly or fully fluorinated organic residue with 1 to 30 C-atoms that may contain 0 to 5 O atoms; R2 independently is R1 but at least one R2 group up to all R2 groups is/are R3-NH-C(=O)-A; R3 is a bifunctional organic radical alkylene, arylene or mixed with 1 to 18 carbon atoms that may contain 0 to 5 O atoms; A is an azole ring; o is 6 to 100000 p = 1 to q and q is 6 to 100000.
It can be preferred, if A independently is selected from the group consisting of pyrazole, imidazole, triazole, benzimidazole, benzotriazole, tetrazole, especially imidazole, triazole, benzimidazole, benzotriazole.
In a process according to the invention, the molar ratio of amino groups to carbonyl- bisazolide can generally be chosen freely. However, good results have, e.g., been achieved when the molar ratio of amino groups to carbonyl-bisazolide is in the range of about 1 : 2 to about 1 : 1. Generally, any type of solvent can be used in the inventive process which does not detrimentally infuence the process itself. It can be preferred, if a solvent or solvent mixture is used that compatibalizes amino compound and carbonyl-bisazolide or if a solvent or solvent mixture is used that does not or not fully compatibalizes amino compound and car- bonyl-bisazolide. It is also possible not to use any solvent at all.
Silicon-Urea-Azolides can be dissociated by application of heat to give Silicone- Isocyanates and azoles. The Silicone-Isocyanates can be obtained by separation of the az- ole from the equilibrium. This can be done most conveniently by using a thin film evapo- rator or a short path distiller where pyrolytic decomposition and removal of the azole generated can be achieved conveniently by applying vacuum.
When using a short path distillator, it has proven to be successful when the temperature of the feed is at about -50 to about 200 0C or at about -20 to about 150 °C or at about 0 to about 100 °C or at about 10 to about 70 °C, the temperature of the evaporator is at about 50 to about 300 °C or at about 70 to about 250 °C or at about 80 to about 200 0C or at about 90 to about 180 °C and the temperature of the collector is at about -50 to about 200 °C or at about 0 to about 150 °C or at about 20 to about 100 0C or at about 30 to about 90 °C.
Another way to obtain the isocyanates, can be to shock-freeze a heated silicone urea azolide and thereby force the azolide to crystallize which removes the azolide from the equilibrium. Filtration or centrifugation can also be used to separate the crystallized azole. Whereas regardless of the process chosen in many cases one decomposition and separation step is sufficient to obtain satisfactory product quality in some cases multiple repetition can be advantageous to obtain the desired purity.
Silicon-Urea-Azolides are useful compounds. In most cases they react the same way the corresponding isocyanates do, although noticeably slower. For this reason, however, SiIi- con-Urea-Azolides cannot be considered as "blocked" or "capped" isocyanates because those at room temperature should usually be unreactive and only by thermal activation react as isocyanates.
The described Silicone-Urea-Azolides are useful for many different purposes. It has, e.g., proven to be expedient to use the Silicone-Urea-Azolides for the production of Silicone- Isocyanates. The inventon thus also relates to a process for production of Silicone- Isocyanates wherein a Silicone-Urea-Azolide is decomposed at an elevated temperature. It has further proven to be possible and successful, if the product is not isolated after com- pletion of the reaction but the produced Silicone-Isocyanate and the Azole are separated at decomposition temperature. It is thus a preferred feature of the process for the production of Silicone-Isocyanates that the decomposition of the Silicone-Urea-Azolide is accompanied by separation of the products Silicone-Isocyanate and azole at decomposition temperature.
The resulting Azole can preferably be removed under vacuum. In the inventive process, it can further be preferred, if at one point within a matrix of temperature and pressure defined between 60 ° C to 180 ° C and 10"5 mbar to 200 mbar predominantly Azole and Silicone-Isocyanate are produced.
The invention thus not only relates to the production of Silicone-Urea-Azolide and the subsequent generation of Silicone-Isocyanate in a successive step. The invention also relates to a process for the production of a Silicone-Isocyanate, wherein a mixture of Silicone-Amine and A-C(=O)-A is reacted and decomposed to form Silicone-Isocyanate without isolating the intermediate Silicone-Urea-Azolide. In can be preferred, if this reaction is performed without using a solvent.
The yield of this process for the production of Silicone-Isocyanate is generally above about 80 %, in many cases yields of more than 90% or more than 95 % can be obtained. It is noteworthy that the obtained Silicone-Isocy'anate generally is comparatively pure. Due to the reaction path it is generally essentially free of heavy metals and noble metals. Preferably, the Silicone-Isocyanate contains less than 100 ppm by weight or less than 50 ppm by weight or less than 10 ppm by weight of one or more noble metals, preferably Pt. In the Silicone-Isocyanate the content of Azolide, given by the weight of the residue A of formula (I) is generally between about 50 ppm and about 1 %, preferably below 0,5 or below 0,1 or below 0,05 %. It is preferred if the obtained Silicone-Isocyanate contains at least about 50 or about 100 ppm or about 200 ppm of Azole or at least about 50 or about 100 ppm or about 200 ppm of Azolide or both.
The Silicone-Urea-Azolides and the Silicone-Isocyanates according to the invention or produced according to the invention can generally be used for the production of different types of materials or in different types of processes, e.g., industrial or dental/healthcare, or the like. Generally, the Silicone-Urea-Azolides and the Silicone-Isocyanates according to the invention or produced according to the invention can be employed in any process where conventional Silicone-Isocyanates have been used. Thus, the Silicone-Urea- Azolides and the Silicone-Isocyanates according to the invention or produced according to the invention can be used for the production of any type of three dimensional object or can be used in the field of adhesives.
The preparations can especially be used in very different dental materials employed in dental medicine or dental technology. Preferred areas of use of such dental materials are single-phase and two-phase impression-taking in dental medicine and bite registration.
The invention is further illustrated by way of examples.
Examples All procedures are performed under dry nitrogen. All Short Path Distillations performed an a KDL 5 (UIC GmbH, Am neuen Berg 4, D-63755 Alzenau-Hδrstein) Short Path Dis- tillator. ,
CDI: Carbonyl-bisimidazolide, a carbonyl bisazolide with CAS-#: [530-62-1]
All procedures are performed under dry nitrogen. AU Short Path Distillations performed on a KDL 5 (UIC GmbH, Am Neuen Berg 4, D-63755 Alzenau-Hδrstein) Short Path Dis- tillator. Yields can be generally diminished by losses due to stripping of low molecular contents and due to manipulation and residues in the apparatus.
Although mass yields in some cases are only moderate due to losses in the apparatus, the degree of functionalization usually is substantially greater than 90 % (if not indicated otherwise).
Example 1: Silicone-Urea-Azolide
At room temperature 24,32 g (0,15 Mole) CDI (FULKA, > 97 %) are dispersed in 500 ml Cyclohexane. 50 ml dry THF are added. 177,2 g (30 mMole) PDMS diamine (3M St. Paul, M: 5.740) are added to the suspension under stirring within 90 min. After one addi- tional hour of stirring the suspension is filtrated and the clear slightly viscous liquid is washed 3 times with 250 ml of water dried with Na2SO4 filtrated again and evaporated from the solvent. Clear off-white to amber liquid is obtained. Yield: 171,9 g (97 % of theory); Viscosity: 1.2 Pa*s; 1H NMR δ (CH2-N(H)C(O)-): 3,45 ppm (vs. TMS in CDCl3). Example 2: Sϋicone-Isocyanate
140 g of I are passed over a KDL 5 Short Path Distillator at
T(Feed): 50 ° C Pressure: 1 mbax
-1 (Evaporator)- 120 ° C Duration: 3 h
T(CoIlector)" 50 ° C
During the reaction imidazole crystallizes at the central cooler, while clear liquid product is collected. Clear off-white to amber liquid is obtained. Yield: 130,7 g (96 % of theory); Viscosity: 0.2 Pa*s; NCO-Equivalent: 3.580 g/Mole; 1H NMR δ (CH2-NCO): 3,24 ppm (vs. TMS in CDCl3).
Example 3: Silicone-Urea-Azolide At room temperature 39,1 g (0,241 Mole) CDI (FLUKA, > 97 %) are dispersed in 250 ml Cyclohexane and 150 ml dry THF. Temperature drops as part of CDI dissolves. 400 g (80,3 mMole)PDMS diamine (Clariant 66M66, M: 4.980) are added to the suspension under stirring within 90 min. After one additional hour of stirring the suspension is filtrated and diluted with 500 ml Cyclohexane. The clear slightly viscous liquid is washed 5 times with 100 ml of water dried with Na2SO4 filtrated again and evaporated from the solvent. Clear off-white to amber liquid is obtained. Yield: 371 g (89 % of theory); Viscosity: 1.2 Pa*s; 1HNMR δ (CH2-N(H)C(O)-): 3,45 ppm (vs. TMS in CDCl3).
Example 4: Silicone-Urea-Azolide At room temperature 25 g (0, 152 Mole) 1 , 1 '-Carbonyldi-(1 ,2,4)-triazol CAS-# [41864-22- 6] (CDT, FLUKA, ~ 95 %) are dispersed in 200 ml dry THF. Temperature drops as part of CDT dissolves. 285,7 g (100 mMole) PDMS diamine (3M St. Paul, M: 5.710) are dis- solved in 200 ml Cyclohexane and added to the suspension under stirring within 90 min. After additional 16 hours of stirring the suspension is diluted with 300 ml Cyclohexane and filtrated. The clear filtrate is evaporated from the solvent. Clear pale yellow liquid is obtained. Yield: 272,5 g (93 % of theory); Viscosity: 0,24 Pa*s; IH NMR δ (CH2- N(H)C(O)-): 3,41 ppm (vs. TMS in CDCl3).
Example 5: Silicone-Isocyanate
250 g of 4 are passed over a KDL 5 Short Path Distillator at
T(Feed): 30 ° C Pressure: 10"5 mbar
1 (Evaporator)- 140 0 C Throughput: 100 g/h
T(CollectorV 60 ° C Agitation: 400 rpm
During the reaction little triazole crystallizes at the central cooler, white clear liquid prod- uct is collected. Clear off-white to amber liquid is obtained. 1H NMR shows that only ~ 16 % of azolide has been converted to Isocyanate.
Example 6: Silicone-Urea-Azolide
6ai At room temperature 15,9 g (0,098 Mole) CDI (FLUKA, > 97 %) are dispersed in 500 ml Cyclohexane and 50 ml dry THF. 500 g (39,13 mMole) PDMS diamine (ABCR, DMS- A32, M: 25.550) are added to the suspension under stirring within 60 min. After additional 16 hours of stirring the suspension is diluted with 500 ml Cyclohexane and filtrated. The clear filtrate is evaporated from the solvent. Clear pale yellow liquid is obtained. Yield:
500,5 g (99 % of theory); Viscosity: 9,9 Pa*s; 1R NMR δ (CH2-N(H)C(O)-): 3,45 ppm (vs. TMS in CDCl3). 6b_i Reproduction of the experiment: Yield: 500 g (99 % of theory); Viscosity: 10,6 Pa*s; 1H NMR δ (CH2-N(H)C(O)-): 3,47 ppm (vs. TMS in CDCl3).
Example 7: Silicone-Isocyanate
7a: 500 g of 6a are passed over a KDL 5 Short Path Distillator at
T(Feed): 6O 0 C Pressure: 2xlO"2 mbar
T(Evaporator): 12O 0 C Duration: 3 h
T(Collector): 60 ° C
During the reaction imidazole crystallizes at the central cooler, while clear liquid product is collected. Clear off-white to amber liquid is obtained. Yield: 452,4 g (91 % of theory); Viscosity: 3,8 Pa*s; NCO-Equivalent: 16.050 g/Mole; 1H NMR δ (CH2-NCO): 3,30 ppm (vs. TMS in CDCl3).
7b: 500 g of 6b are passed two times over a KDL 5 Short Path Distillator at
T(Feed): 23 ° C Pressure: 10"2 rnbar T(Evaporator): 120 ° C Duration: 3 h
T(coUector): 80 ° C Agitation: 480 rpm
During the reaction imidazole crystallizes at the central cooler, while clear liquid product is collected. Clear off-white to amber liquid is obtained. Yield: 415 g (83 % of theory); Viscosity: 3,8 Pa*s; NCO-Quivalent: 15.170 g/Mole; Refractive index (nD 20): 1,4065; 1H NMR δ (CH2-NCO): 3,30 pm (vs. TMS in CDCl3).
Example 8: Silicone-Urea-Azolide At room temperature 32,42 g (0,20 Mole) CDI (FLUKA, > 97 %) are dispersed in 150 ml Toluene. At RT 24,85 g (0,10 Mole ) l,3,-Bis-(3-aminopropyl)-l,l,3,3-tetramethyl- disiloxane (Lancaster 97 %) are added to the suspension under stirring within 30 min. During addition temperature of the reaction mixture is kept at 23 ° C with an ice bath. After addition a clear two phase reaction mixture remains. The lower layer is separated and sol- vent is removed. Clear brownish yellow oil is obtained. Yield: 58,5 g (with imidazole and traces of toluene); 1HNMR δ (CH2-N(H)C(O)-): 3,50 ppm (vs. TMS in CDCl3).
Example 9: Silicone-Urea-Azolide
At room temperature 60,81 g (0,375 Mole) CDI (FLUKA5 > 97 %) are dispersed in 500 ml dry THF. 282,25 g (250 mEquivalent) (3-aminoρropyl-methylsiloxan)-(dimenthylsiloxan)- copolymer (ABCR, AMS-162, Base-Equivalent: 1.129) are added to the suspension under stirring within 180 min. After additional 3 hours of stirring the suspension is filtrated and evaporated from the solvent. The remaining suspension is diluted with 500 ml Cyclohex- ane and filtrated again. The clear filtrate is evaporated from the solvent. Clear yellow liquid is obtained. Yield: 286,1 g (99 % of theory); Viscosity: 5,3 Pa*s; Refractive index (nD 20): 1,4301; 1H NMR δ (CH2-N(H)C(O)-): 3,42 ppm (vs. TMS in CDCl3).
Example 10: Silicone-Isocyanate
250 g of 9 are passed over a KDL 5 Short Path Distillator at
T(Feed): 50 ° C Pressure: 2xlO"2 mbar
J- (Evaporator)' 150 0 C Feed: 150 g/h
70 ° C Agitation: 500 rpm
During the reaction imidazole crystallizes at the central cooler, while clear liquid product is collected. Clear off-white to amber liquid is obtained. Yield: 216,5 g (91 % of theory); Viscosity: 0,25 Pa*s; NCO-Equivalent: 1.480 g/Mole; 1H NMR δ (CH2-NCO): 3,29 ppm (vs. TMS in CDCl3).
Example 11: Silicone-Urea-Azolide At room temperature 16,2 g (0,100 Mole) CDI (FLUKA, > 97 %) are placed in a dry round bottom flask at RT. The flask is immersed into an ice-bath and 119 g (25 mMole) PDMS diamine (ABCR, DMS-A21, M: 4760) are added under stirring within 10 min. Af- ter additional 4 days of stirring the suspension is filtrated. Clear- yellow liquid is obtained. Yield: 99,3 g (80 % of theory); Viscosity: 1,7 Pa*s; Refractive index (nD 20): 1,4162; 1H NMR δ (CH2-N(H)C(O)-): 3,47 ppm (vs. TMS in CDCl3).
Example 12: Silicone-Isocyanate
85 g of JJ, are passed over a KDL 5 Short Path Distillator at
T(Feed): 40 ° C Pressure: 2x10 mbar
-I (Evaporator)' 130 ° C Feed: 150 g/h
70 0 C Agitation: 500 rpm
During the reaction imidazole crystallizes at the central cooler, while clear liquid product is collected. Clear off-white to amber liquid is obtained. Yield: 78 g (96 % of theory); Viscosity: 0,17 Pa*s; NCO-Equivalent: 3.120 g/Mole; 1H NMR δ (CH2-NCO): 3,30 ppm (vs. TMS in CDCl3).
Example 13: Silicone-Urea-Azolide
At room temperature 52,45 g (0,20 Mole) l,l '-Carbonyl-dibenzimidazol (CDBI) CAS-#: [14667-54-0] (prepared from phosgene and benzimidazole; > 95 %) are dispersed in 250 ml Cyclohexane and 25 ml dry THF. Temperature drops as part of CDBI dissolves to give a white viscous suspension. 238,1 g (50 mMole) PDMS diamine (ABCR DMS-A21, M:
4760) are added to the suspension under stirring within 60 min. After additional 16 hours of stirring the suspension is filtrated. The clear filtrate is evaporated form the solvent. Clear pale yellow liquid is obtained. Yield: 250,5 g (99 % of theory); Viscosity: 2,0 Pa*s;
Refractive index (nD 20): 1,421; 1H NMR δ (CH2-N(H)C(O)-): 3,54 ppm (vs. TMS in
CDCl3).
Example 14: Silicone-Isocyanate First run: 230 g of H are passed over a KDL 5 Short Path Distillator at
T(Feed): 50 ° C Pressure: 2xlO"2 mbar
J- (Evaporator)" 14O 0 C Feed: 150 g/h
Trcollector)- 80 ° C Agitation: 500 rpm
During the reaction imidazole crystallizes at the central cooler, while clear liquid product is collected. Clear off-white to amber liquid is obtained. Yield: 223 g (97 % of theory); Viscosity: 0,49 Pa*s; NCO-Equivalent: 4.710 g/Mole; Refractive index (nD 20): 1,4153; 1H NMR δ (CH2-NCO): 3,30 ppm (vs. TMS in CDCl3) still azolide present (~ 30 %).
Second run: 19O g of first run product are passed over a KDL 5 Short Path Distillator at T(Feed): 50 ° C Pressure: 2xlO"2 mbar
1 (Evaporator)- 140 0 C Feed: 150 g/h
80 ° C Agitation: 500 rpm
During the reaction imidazole crystallizes at the central cooler, while clear liquid product is collected. Clear off-white to amber liquid is obtained. Yield: 189 g (95 % of theory); Viscosit<. 0,229 Pa*s; NCO-Equivalent: 3.830 g/Mole; Refractive index (nD 20): 1,4110; 1H NMR δ (CH2-NCO): 3,30 ppm (vs. TMS in CDCl3).
Example 15; Silicone-Urea-Azolide
At room temperature 34 g (0,21 MoIe)CDI (FLUKA, > 97 %) are dispersed in 250 ml Cyclohexane and 25 ml dry THF. Temperature drops as part of CDI dissolves to give a white suspension. The flask is immersed into an ice-bath and 238,1 g (50 mMole) PDMS diamine (ABCR, DMS-A21, M: 4760) are added under stirring within 30 min. After addi- tional 16 hours of stirring the suspension is filtrated. The clear filtrate is evaporated form the solvent. Clear pale yellow liquid is obtained. Yield: 249,6 g (101 % of theory); Viscosity: 1,7 Pa*s; Refractive index (nD 20): 1,4173; 1HNMR δ (CH2-N(H)C(O)-): 3,50 ppm (vs. TMS in CDCl3); Chlorine content: 633 ppm.
Example 16: Silicone-Isocyanate
238 g of 15 are passed over a KDL 5 Short Path Distillator at
T(Feed): 40 ° C Pressure: 2xlO'2 mbar
1 (Evaporator)- 130 ° C Feed: 150 g/h
T(Collector): 70 ° C Agitation: 500 rpm During the reaction imidazole crystallizes at the central cooler, while clear liquid product is collected. Clear off-white to amber liquid is obtained. Yield: 210 g (88 % of theory); Viscosity: 0,17 Pa*s; NCO-equivalent: 3.026 g/Mole; 1H NMR δ (CH2-NC): 3,30 ppm (vs. TMS in CDCl3); Refractive index (nD 20): 1,4095; Chlorine content: 27 ppm.
Example 17: Silicone-Urea-Azolide
In a dry round bottom flask at room temperature 24,73 g (0,05 Mole) Phosgene in toluene (~ 20 %, FLUKA, contains 4,95 g COCl2) are dissolved in additional 100 ml of toluene. Within 60 min at 5 ° C and cooling a mixture of 119,05 g (25 mMole) PDMS diamine (ABCR, DMS-A21, M: 4760) and 10,12 g Triethylamine (100 mMole, ACROS, > 99 %) and 150 ml toluene are added under stirring within 60 min. Temperature stays below 8 0 C and Triethylamine hydrochloride precipitates. The suspension is stirring an additional hour at 8 ° C.
At 5 ° C to the obtained suspension containing PDMS chloroformic amide a solution of 3,472 g imidazole (51 mMole; ACROS > 99 %), and 5,06 g Triethylamine (50 mMole, ACROS, > 99 %) in 50 ml acetone is added within 10 minutes. Temperature rises to 10 ° C where the mixture is stirred additional 2 hours. Temperature rises slowly to RT during additional 16 hours of stirring whereafter the suspension is filtrated. The clear filtrate is evaporated from the solvent. Clear pale yellow liquid is obtained. Yield: 118,4 g (96 % of theory); Viscosity: 2,5 Pa*s; 1H NMR δ (CH2-N(H)C(O)-): 3,45 ppm (vs. TMS in CDCl3); Chlorine content: 1100 ppm.
Example 18: Silicone-Isocyanate 100 g of 17 are passed over a KDL 5 Short Path Distillator at
T(Feed): 40 ° C Pressure: 2xlO"2 mbar
T(Evaporator): 130 ° C Feed: 150 g/h ■^collector): 70 ° C Agitation: 500 rpm
During the reaction imidazole crystallizes at the central cooler, while clear liquid product is collected. Clear off-white to amber liquid is obtained. Yield: 78,7 g (81 % of theory); Viscosity: 0,38 Pa*s; NCO-Equivalent: 3.814 g/Mole; 1H NMR δ (CH2-NCO): 3,30 ppm (vs. TMS in CDCL3) with noticable chain extension; Refractive' index (nD 20): 1,4094; Chlorine content: 19 ppm.
Example 19: Silicone-Urea-Azolide
At room temperature 21 g (0,130 Mole) CDI (FLUECA, > 97 %) are dispersed in 250 ml Cyclohexane and 25 ml dry THF. Temperature drops as part of CDI dissolves to give a white suspension. The flask is immersed into an ice-bath and 1000 g (113 mMole) PDMS diamine (3M, base equivalent 17710 g/Mole) are added under stirring within 120 min. After additional 16 hours of stirring the suspension is filtrated. The clear filtrate is evaporated form the solvent. Clear pale yellow liquid is obtained. Yield: 1000,1 g (99,5 % of theory); Viscosity: 21,9 Pa*s; Refractive index (nD 20): 1,4072; 1H NMR δ (CH2- N(H)C(O)-): 3,50 ppm (vs. TMS in CDCl3).
Example 20: Silicone-Isocyanate
1000 g of 19 are passed over a KDL 5 Short Path Distillator at
T(Feed): 40 ° C Pressure: 2xlO"2 mbar
1 (Evaporator)' 13O 0 C Feed: 200 g/h
T(CoIIeCtOr)-- 9O 0 C Agitation: 500 rpm
During the reaction imidazole crystallizes at the central cooler, while clear liquid product is collected. Clear off-white to amber liquid is obtained. Yield: 880 g ( 88 % of theory); Viscosity: 8,4 Pa*s; NCO-Equivalent: 18825 g/Mole; 1H NMR δ (CH2-NCO): 3,30 ppm (vs. TMS in CDCl3); Refractive index (nD 20): 1,4060.
Example 21: Silicone-Urea-Azolide At room temperature 8,51 g (0,0525 Mole) CDI (FLUKA, > 97 %) are dispersed in 120 ml Cyclohexane and 12 ml dry THF. Temperature drops as part of CDI dissolves to give a white suspension. The flask is immersed into an ice-bath and 119 g (50 mEquivalent) PDMS diamine (ABCR, base equivalent 2381 g/Mole) are added under stirring within 120 min. After additional 16 hours of stirring the suspension is filtrated. The clear filtrate is evaporated from the solvent. Clear pale yellow liquid is obtained. Yield: 118 g (97 % of theory); Viscosity: 1,40 Pa*s; Refractive index (nD 20): 1,4166; 1H NMR δ (CH2- N(H)C(O)-): 3,50 ppm (vs. TMS in CDCl3); Chlorine content: 191 ppm.
Example 22; Silicone-Isocyanate
118 g of 21 are passed over a KDL 5 Short Path Distillator at
T(Feed): 23 ° C Pressure: 2x10"2 mbar
-I (Evaporator)- 130 0 C Feed: 100 g/h
T(Collector)- 90 ° C Agitation: 500 rpm
During the reaction imidazole crystallizes at the central cooler, while clear liquid product is collected. Clear off- white to amber liquid is obtained. Yield: 76 g; Viscosity: 0,16 Pa* s; NCO-Equivalent: 2965 g/Mole; 1H NMR δ (CH2-NCO): 3,30 ppm (vs. TMS in CDCl3); Refractive index (nD 20): 1,409.
Example 23: Silicone-Urea-Azolide
At room temperature 151,54 g (0,935 MoIe)CDI (FLUKA5 >97 %) are dispersed in 1000 ml Cyclohexane and 100 ml dry THF. Temperature drops as part of CDI dissolves to give a white suspension. The flask is immersed into an ice-bath and 200 g (467,3 mEquivalent) PDMS diamine (ABCR, base equivalent 428 g/Mole) are added under stirring within 120 min. After additional 16 hours of stirring the suspension is filtrated. The clear filtrate is evaporated from the solvent. After filtration clear pale yellow liquid is obtained. Yield: 230 g; Viscosity: 2,2 Pa*s; Refractive index (nD 20): 1,4579; 1H NMR δ (CH2-N(H)C(O)-): 3,50 ppm (vs. TMS in CDCl3).
Example 24: Silicone-Isocyanate
230 g of 23 are passed over a KDL 5 Short Path Distillator (first run) at
T(Feed): 23 ° C Pressure: 2x10" mbar
J- (Evaporator)- 140 ° C Feed: 80 g/h
T(Collector)' 90 ° C Agitation: 500 rpm
During the reaction imidazole crystallizes at the central cooler, while clear liquid product is collected. Clear off-white to amber liquid is obtained. Yield: 96,2 g residual 10 % of imidazolide.
Second run under same conditions using material form first run: Yield: 90 g; Viscosity: 0,023 Pa*s; NCO-Equivalent: 820 g/Mole; 1H NMR δ (CH2-NCO): 3,30 ppm (vs. TMS in CDCl3); Refractive index (nD 20): 1,4157. Example 25: Silicone-Isocyanate
At room temperature 17 g (0,1048 Mole) CDI (FLUKA, >97 %) are dispersed in 238,1 g (100 mEquivalent) PDMS diamine (ABCR, base equivalent 2381 g/Mole) are added under stirring in one portion. The off-white suspension shows selfh-hating and is passed over a ICDL 5 Short Path Distillator (first run) while stirring at
T(Feed): 25 - 55 ° C Pressure: 2xlO"2 mbar
1 (Evaporator)' 140 0 C Feed: 150 g/h
T(Collector): 90 ° C Agitation: 500 rpm
During the reaction imidazole crystallizes at the central cooler, while clear liquid product is collected. Clear off-white to amber liquid is obtained. Yield: 219 g residual 10 % of imidazolide. Second run under same conditions using material from first run: Yield: 212 g; Viscosity: 0,46 Pa*s; NCO-Equivalent; 4650 g/Mole; 1H NMR δ (CH2-NCO): 3,30 ppm (vs. TMS in CDCl3) about 20 to 30 % chain extension; Refractive index (nD 20): 1,410.

Claims

Claims
1. Azolide according to the general formula I
Figure imgf000041_0001
wherein A is an azole ring connected to the carbonyl group via an N atom, R4 is H or a linear or branched or cyclic alkyl group with 1 to 24 C-atoms, X is an oli- gomeric or polymeric radical with the functionality n, wherein n is 1 to about 100000, having a molecular weight of at least 200 and at least 2 repetition units with at least 1 Si-atom per repetition unit.
2. Azolide according to claim 1 comprising at least one Si-O-Si bond,
3. Azolide according to any of the preceding claims, wherein A is an imidazole, pyra- zole, benzimidazole, triazole, tetrazole or benzotriazole ring.
4. Azolide according to one any of the preceding the claims, wherein X is a linear or branched, saturated or unsaturated polysiloxane.
5. Azolide according to any of the preceding claims, wherein formula I comprises one or more of the following silicone structures: a) linear or branched (R1 2R2SiO1/2)2(R1R2SiO2/2)x where R1 independently is H, or a linear, branched, cyclic or aromatic saturated or unsaturated faculta- tively partly or fully fluorinated organic residue with 1 to 30 C-atoms that may contain 0 to 5 O atoms; R2 independently is R1 but at least one R2 group up to all R2 groups is/are R3-NH-C(=O)-A; R3 is a bifunctional organic, radical alkylene, arylene or mixed with 1 to 18 carbon atoms that may contain 0 to 5 O atoms; A is an azole ring; the linear chain may be branched by up to 5 moieties of the structure R2Si02/2 and/or SiO4/2; x= 0 to 100000; b) cyclic (R1R2Si02/2)m where R independently is H, or a linear, branched, cyclic or aromatic saturated or unsaturated facultatively partly or fully fluorinated organic residue with 1 to 30 C-atoms that may contain 0 to 5 O atoms; R2 independently is R1 but at least one R2 group up to all R2 groups is/are R -NH-C(=P)-A; R is a bifunctional organic radical alkylene, arylene or mixed with 1 to 18 carbon atoms that may contain 0 to 5 O atoms; A is an azole ring; M = 3 to 1000; c) polycyclic (R2Si03/2)0, or (R1 2R2SiO1/2)p(SiO4/2)q where R1 independently is
H, or a linear, branched, cyclic or aromatic saturated or unsaturated facultatively partly or fully fluorinated organic residue with 1 to 30 C-atoms that may contain 0 to 5 O atoms; R independently is R but at least one R group up to all R groups is/are R -NH-C(=O)-A; R is a bifunctional or- ganic radical alkylene, arylene or mixed with 1 to 18 carbon atoms that may contain 0 to 5 O atoms; A is an azole ring; o is 6 to 100000 p = 1 to q and q is 6 to 100000.
6. Azolide according to any of the preceding claims, wherein one or more groups A- C(=O)N(R4)- as defined in formula (I) are connected to one or more Si atoms via an organic spacer.
7. Azolide according to any of the preceding claims, wherein the azolide contains no nucleophilic functional groups capable of reacting with isocynates at room temperature faster than the NH-bond in a urea group.
8. Azolide according to any of the preceding claims, wherein the azolide has a boiling point at normal pressure (about 1013 mbar) of > about 280 ° C or is undergoing decomposition at such a temperature or both.
9. Azolide according to any of the preceding claims, wherein the azolide thermally decomposes at least at one point within a matrix of temperature and pressure defined between about 60 α C to about 180 ° C and about 10"5 mbar to about 200 mbar resulting in predominantly Azole and Silicone-Isocyanate.
10. Azolide according to any of the preceding claims, wherein the azolide has a mo- lecular weight of more than about 230 g/mole.
11. Process for the production of an azolide according to the general formula I
Figure imgf000043_0001
wherein A is an azole ring connected to the carbonyl group via an N atom, R is H or a linear or branched or cyclic alkyl group with 1 to 24 C-atoms, X is an oli- gomeric or polymeric radical with the functionality n, wherein n is 1 to about 100000, having a molecular weight of at least 200 and at least 2 repetition units with at least 1 Si-atom per repetition unit, wherein an amino compound according to the general formula (H2N-)nX is reacted in one or more steps with one or more compounds to form an azolide according to formula I.
12. Process according to claim 11, wherein the amino compound according to the formula (H2N-)nX is reacted with a compound according to the general formula
Figure imgf000044_0001
with A being an azole ring connected to the carbonyl group via an N atom or where the amino compound according to the formula (H2N-)nX is reacted in a first step with phosgene, optionally together with a trialkylamine, and in a second step with an azole under formation of an azolide according to the general formula I.
13. Process according to one of the claims 11 or 12, wherein formula I comprises one or more of the following silicone structures: a) linear or branched
Figure imgf000044_0002
where R1 independently is
H, or a linear, branched, cyclic or aromatic saturated or unsaturated facultatively partly or fully fluorinated organic residue with 1 to 30 C-atoms that may contain 0 to 5 O atoms; R2 independently is R1 but at least one R2 group up to all R groups is/are R -NH-C(=O)-A; R is a bifunctional or- ganic radical alkylene, arylene or mixed with 1 to 18 carbon atoms that may contain 0 to 5 O atoms; A is an azole ring; the linear chain may be branched by up to 5 moieties of the structure R2SiO2Z2 and/or SiO4Z2; x= 0 to 100000; b) cyclic (R1R2SiO2Z2)In where R1 independently is H, or a linear, branched, cyclic or aromatic saturated or unsaturated facultatively partly or fully fluorinated organic residue with 1 to 30 C-atoms that may contain 0 to 5 O atoms; R2 independently is R1 but at least one R2 group up to all R2 groups is/are R3-NH-C(=O)-A; R3 is a bifunctional organic radical alkylene, ary- lene or mixed with 1 to 18 carbon atoms that may contain 0 to 5 O atoms; A is an azole ring; m = 3 to 1000; c) polycyclic (R2Si03/2)0, or
Figure imgf000045_0001
where R1 independently is H, or a linear, branched, cyclic or aromatic saturated or unsaturated facultatively partly or fully fluorinated organic residue with 1 to 30 C-atoms that may contain 0 to 5 O atoms; R2 independently is R1 but at least one R2 group up to all R2 groups is/are R3-NH-C(=0)-A; R3 is a bifunctional organic radical alkylene, arylene or mixed with 1 to 18 carbon atoms that may contain 0 to 5 O atoms; A is an azole ring; o is 6 to 100000 p = 1 to q and q is 6 to 100000.
14. Process according to one of the claims 11 to 13, wherein the azolide contains no nucleophilic functional groups capable of reacting with isocynates at room tem- perature faster than the NH-bond in a urea group.
15. Process according to one of the claims 11 to 14, wherein the azolide has a boiling point at normal pressure (about 1013 mbar) of > about 280 ° C or is undergoing decomposition at such a temperature or both.
16. Process according to one of the claims 11 to 15, wherein the azolide thermally decomposes at least at one point within a matrix of temperature and pressure defined between about 60 °C to about 180 °C and about 10"5 mbar to about 200 mbar resulting in predominantly Azole and Silicone-Isocyanate.
17. Process according to one of the claims 11 to 16, wherein A is an imidazole, pyra- zole, benzimidazole, triazole, tetrazole or benzotriazole ring.
18. Process for the production of Silicone-Isocyanates, wherein an azolide according to the general formula I
Figure imgf000046_0001
wherein A is an azole ring connected to the carbonyl group via an N atom, R4 is H or a linear or branched or cyclic alkyl group with 1 to 24 C-atoms, X is an oli- gomeric or polymeric radical with the functionality n, wherein n is 1 to about 100000, having a molecular weight of at least 200 and at least 2 repetition units with at least 1 Si-atom per repetition unit, is decomposed at elevated temperatures.
19. Process according to claim 18, wherein the decomposition under formation of an isocyanate and an azole takes place in the absence of solvent
20. Process according to claim 18 or 19, wherein the azole is removed under vacuum.
21. Process according to one of the claims 18 to 20, wherein the decomposition takes place at a temperature in a range of about 60 to about 180 0C or at a pressure of from about 1* 10"5 mbar to about 200 mbar or both.
22. Process according to claim 18 to 21, wherein the decomposition under formation of an isocyanate and an azole takes place in the absence of solvent and the azole is removed under vacuum.
23. Process for the production of a Silicone-Isocyanate, wherein a mixture of Silicone- Amine and A-C(=O)-A is reacted and decomposed to form Silicone-Isocyanate without isolating an intermediate Silicone-Urea-Azolide, wherein A is defined as in claim 12.
24. Process according to claim 23, wherein the reaction and decomposition is performed in the absence of a solvent.
25. Silicone-Isocyanate containing less than 100 ppm by weight of noble metals.
26. Silicone-Isocyanate according to claim 25, wherein the Silicone-Isocyanate contains 50 ppm by weight to about 1 % by weight of azole or at least about 50 or 50 ppm by weight to about 1 % by weight of azolide or both.
27. Use of an azolide according to one of the claims 1 to 10 or of an azolide produced according to one of the claims 11 to 17 or of a Silicone-Isocyanate obtainable according to one of the claims 18 to 24 or of a Silicone-Isocyanate according to one of the claims 25 or 26, for the production of a three dimensional object or for the production of an adhesive.
28. Use of an azolide according to one of the claims 1 to 10 or of an azolide produced according to one of the claims 11 to 17 or of a Silicone-Isocyanate obtainable according to one of the claims 18 to 24 or of a Silicone-Isocyanate according to one of the claims 25 or 26, in the field of dental care or healthcare.
PCT/US2006/042105 2005-10-27 2006-10-27 Silicon-urea-azolides, their preparation and use in the preparation of silicones with isocyanate terminal groups WO2007050950A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP06836607A EP1940851B1 (en) 2005-10-27 2006-10-27 Silicon-urea-azolides, their preparation and use
US12/091,552 US8124714B2 (en) 2005-10-27 2006-10-27 Silicon-urea-azolides, their preparation and use in the preparation of silicones with isocyanate terminal groups
CA002626130A CA2626130A1 (en) 2005-10-27 2006-10-27 Silicon-urea-azolides, their preparation and use in the preparation of silicones with isocyanate terminal groups
AT06836607T ATE463499T1 (en) 2005-10-27 2006-10-27 SILICON-UREA-AZOLIDES, THEIR PRODUCTION AND USE
DE602006013497T DE602006013497D1 (en) 2005-10-27 2006-10-27 SING
JP2008538030A JP2010507688A (en) 2005-10-27 2006-10-27 Silicon-urea-azolides, their preparation, and their use in the preparation of silicones with isocyanate end groups

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05023543.1 2005-10-27
EP05023543A EP1780213A1 (en) 2005-10-27 2005-10-27 Silicon-urea-azolides, their preparation and use in the preparation of silicones with isocyanate terminal groups

Publications (2)

Publication Number Publication Date
WO2007050950A2 true WO2007050950A2 (en) 2007-05-03
WO2007050950A3 WO2007050950A3 (en) 2007-06-14

Family

ID=36263862

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/042105 WO2007050950A2 (en) 2005-10-27 2006-10-27 Silicon-urea-azolides, their preparation and use in the preparation of silicones with isocyanate terminal groups

Country Status (7)

Country Link
US (1) US8124714B2 (en)
EP (2) EP1780213A1 (en)
JP (1) JP2010507688A (en)
AT (1) ATE463499T1 (en)
CA (1) CA2626130A1 (en)
DE (1) DE602006013497D1 (en)
WO (1) WO2007050950A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008000140A1 (en) 2008-01-23 2009-07-30 Wacker Chemie Ag Process for the preparation of isocyanate-terminated siloxanes
EP2377847A1 (en) * 2010-04-14 2011-10-19 3M Innovative Properties Company Process for producing isocyanates

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1392849A (en) * 1971-10-23 1975-04-30 Bayer Ag Penicillins their production and their medicinal use
WO1991018006A1 (en) * 1990-05-15 1991-11-28 Diatron Corporation Fluorescent porphyrin, and fluorescent phthalocyanine - polyethylene glycol, polyol, and saccharide derivatives as fluorescent probes
WO1993019366A1 (en) * 1992-03-23 1993-09-30 Diatron Corporation Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US607901A (en) * 1898-07-26 Island
US3179633A (en) * 1962-01-26 1965-04-20 Du Pont Aromatic polyimides from meta-phenylene diamine and para-phenylene diamine
US3179622A (en) * 1962-03-26 1965-04-20 Dow Corning Polysiloxane isocyanates
US3170891A (en) * 1962-09-14 1965-02-23 Dow Corning Silicone isocyanates
US3607901A (en) 1967-09-20 1971-09-21 Gen Electric Method of making isocyanatoalkyl-substituted silanes
US3936484A (en) 1974-09-25 1976-02-03 Atlantic Richfield Company Production of isocyanates from substituted ureas
US3986484A (en) * 1974-11-18 1976-10-19 Dyer Glenn L Camshaft for controlling variably opening valves
FR2513644B1 (en) * 1981-09-30 1985-06-21 Rhone Poulenc Spec Chim POLYSILOXANIC AND POLYURETHANIC SEQUENCE COPOLYMERS USED IN PARTICULAR AS THERMOPLASTIC ELASTOMERS
JPS60140342A (en) 1983-12-28 1985-07-25 Fuji Photo Film Co Ltd Silver halide photosensitive material
JPS60140343A (en) 1983-12-28 1985-07-25 Fuji Photo Film Co Ltd Silver halide photosensitive material
US5157095A (en) * 1989-11-09 1992-10-20 The Research Foundation Of State University Of New York Hydrosilylation of unsaturated aliphatic isocyanates
JP3299549B2 (en) 1991-06-28 2002-07-08 マツダ株式会社 Vehicle slip control device
DE4208402A1 (en) 1992-03-16 1993-09-23 Hartmut Dr Frank New polysiloxane block copolymers - useful as stationary phase for gas or liq. chromatography or electrophoresis, and for modifying glass or quartz surfaces
JP4171530B2 (en) * 1996-04-15 2008-10-22 三井化学ポリウレタン株式会社 Method for producing silicon-containing isocyanate compound
JP2001048855A (en) 1999-08-11 2001-02-20 Takeda Chem Ind Ltd Production of isocyanate group-containing compound, isocyanate group-containing compound and isocyanate group-containing polysiloxane compound
US6632537B2 (en) * 2001-01-17 2003-10-14 A. Andrew Shores Silicone and ionically modified isocyanate adduct
DE10113980A1 (en) 2001-03-22 2002-10-02 Consortium Elektrochem Ind Silane-terminated polydiorganosiloxane-urethane copolymer
DE502004000020D1 (en) 2003-07-10 2005-08-11 Wacker Chemie Gmbh Crosslinkable siloxane-urea copolymers
US20060207930A1 (en) * 2005-03-15 2006-09-21 Yeager Gary W Interfacial composite structure and method of making them

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1392849A (en) * 1971-10-23 1975-04-30 Bayer Ag Penicillins their production and their medicinal use
WO1991018006A1 (en) * 1990-05-15 1991-11-28 Diatron Corporation Fluorescent porphyrin, and fluorescent phthalocyanine - polyethylene glycol, polyol, and saccharide derivatives as fluorescent probes
WO1993019366A1 (en) * 1992-03-23 1993-09-30 Diatron Corporation Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
COSTA A M ET AL: "Hybrids of macrolides and nucleobases or nucleosides" TETRAHEDRON LETTERS, vol. 41, no. 18, April 2000 (2000-04), pages 3371-3375, XP004198041 ISSN: 0040-4039 *
DATABASE CA [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; GOL'DIN G S ET AL: "Synthesis of organosilicon and organic poly(carbamidotriazoles)" XP002382575 retrieved from STN Database accession no. 83:79677 cited in the application -& VYSOKOMOLEKULYARNYE SOEDINENIYA, SERIYA B: KRATKIE SOOBSHCHENIYA, vol. 17, no. 4, 1975, pages 322-323, XP009066430 ISSN: 0507-5483 *
GLOCKNER P ET AL: "Synthesis and rheological behavior of cross-linkable poly[N-(methacryl-2-ethyl)-N ' -(3-amino(1,2,4-triazole-2-yl))urea-co methyl methacrylate]" MACROMOLECULES, vol. 35, no. 6, 12 March 2002 (2002-03-12), pages 2050-2054, XP002382484 ISSN: 0024-9297 *
IVANOV M G ET AL: "The effect of solvents on the kinetics of transamination of N-aryl-3-methylpyrazole-1-carboxamides" JOURNAL OF ORGANIC CHEMISTRY OF THE USSR, vol. 28, no. 3.2, 1992, pages 456-460, XP009066797 ISSN: 0022-3271 *
MARTIN D ET AL: "Acylierung von Heterocyclen mit Kohlensäurederivaten. VII. Synthesen von Benzimidazolo[2,1-b](1,3,5)thiadiazinen" JOURNAL FÜR PRAKTISCHE CHEMIE, vol. 326, no. 1, 1984, pages 159-164, XP009066799 *
OTTING W ET AL: "Reaktionsfähige heterocyclische Amide der Kohlensäure, IV. IR-Spektroskopische Untersuchung der Dissoziation heterocyclischer N-carbonsäureanilide" LIEBIGS ANNALEN DER CHEMIE, vol. 622, 1959, pages 23-30, XP009066873 *
RASPOET G ET AL: "Experimental and Theoretical Evidence for a Concerted Catalysis by Water Clusters in the Hydrolysis of Isocyanates" JOURNAL OF ORGANIC CHEMISTRY, vol. 63, no. 20, 2 October 1998 (1998-10-02), pages 6867-6877, XP002382483 ISSN: 0022-3263 *
STAAB H A ET AL: "Azolides in Organic Synthesis and Biochemistry" 1988, WILEY VCH , WEINHEIM, GERMANY , XP009066427 ISBN: 3-527-29314-0 cited in the application page 172 page 188 page 273 - page 279 *
VOSTOKOV I A ET AL: "Reaction of isocyanates with pyrazol-5-ones" CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 26, no. 8, 1990, pages 884-886, XP009066433 ISSN: 0009-3122 *
WIPF P ET AL: "Synthesis of chemoreversible prodrugs of ara-C with variable time-release profiles. Biological evaluation of their apoptotic activity." BIOORGANIC & MEDICINAL CHEMISTRY, vol. 4, no. 10, October 1996 (1996-10), pages 1585-1596, XP009066434 ISSN: 0968-0896 *

Also Published As

Publication number Publication date
EP1940851B1 (en) 2010-04-07
EP1780213A1 (en) 2007-05-02
EP1940851A2 (en) 2008-07-09
CA2626130A1 (en) 2007-05-03
JP2010507688A (en) 2010-03-11
DE602006013497D1 (en) 2010-05-20
US20090258999A1 (en) 2009-10-15
WO2007050950A3 (en) 2007-06-14
US8124714B2 (en) 2012-02-28
ATE463499T1 (en) 2010-04-15

Similar Documents

Publication Publication Date Title
US5639845A (en) Method for the preparation of a fluorine-containing organopolysiloxane
US4417068A (en) Process for the addition of organic silicon compounds with SiH groups to compounds with olefinic double bonds
JP2005509042A (en) Process for the preparation of functionalized oligomeric silsesquioxanes and their use
JP4400938B2 (en) Method for producing isocyanatoorganosilane
US11028232B2 (en) Process for preparing siloxanes containing oxamido ester groups
JP2000026609A (en) Preparation of alkoxy group-terminated polydiorganosiloxane
EP3237495A1 (en) Aminosiloxanes of high purity
EP0573282B1 (en) Fluorine-containing organosilicon compounds
KR101895020B1 (en) Method for producing organosilicon compounds having amino groups
EP0327773A1 (en) Polysiloxazanes, process for producing same and their use as precursors for ceramics and ceramic materials
EP0639576B1 (en) Organopolysiloxanes having a silanol group and process of making them
EP1940851B1 (en) Silicon-urea-azolides, their preparation and use
FR2578256A1 (en) SILYL CARBAMATES, PROCESS FOR THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF BIS (AMINOALKYL) DISILOXANES.
US8304569B2 (en) Method for producing isocyanate-terminated siloxanes
JP2004051847A (en) Method for producing silsesquioxane compound
US4602094A (en) Process for preparing amidosilanes and amidosiloxanes
CA1067493A (en) Silacyclopentenyl-bis-epsilon-caprolactam
EP0748849A1 (en) Silicone compositions with sterically hindered cyclic amines, usable for light and thermal stabilization of polymers
JP7335188B2 (en) Organosilicon compound containing isocyanate group and method for producing organosilicon compound containing isocyanate group
FR2727973A1 (en) NEW SILICONE COMPOUNDS WITH STERICALLY ENCLOSED CYCLIC AMINE FUNCTIONS, USEFUL FOR LIGHT AND THERMAL STABILIZATION OF POLYMERS
EP0373059B1 (en) Ceramic precursor compositions based on polysilazanes and ceramics obtained by pyrolysis of these compositions
JPH07258416A (en) Both end-functional diphenylsiloxane oligomer and method for producing the same
JP2006036697A (en) Method for producing amino-terminated organosilicon compound
JPH0717752B2 (en) Process for producing alkoxy-functional organopolysiloxane
CN102361879A (en) Process for the synthesis of 1,3-bis(aminoalkyl)disiloxanes

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2006836607

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2626130

Country of ref document: CA

ENP Entry into the national phase

Ref document number: 2008538030

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 12091552

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE