WO2007050059A9 - Oligonucleotides immunomodulateurs courts - Google Patents

Oligonucleotides immunomodulateurs courts Download PDF

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Publication number
WO2007050059A9
WO2007050059A9 PCT/US2005/038449 US2005038449W WO2007050059A9 WO 2007050059 A9 WO2007050059 A9 WO 2007050059A9 US 2005038449 W US2005038449 W US 2005038449W WO 2007050059 A9 WO2007050059 A9 WO 2007050059A9
Authority
WO
WIPO (PCT)
Prior art keywords
immunolomodulatory
oligonucleotides
short
short immunolomodulatory
immunolomodulatory oligonucleotides
Prior art date
Application number
PCT/US2005/038449
Other languages
English (en)
Other versions
WO2007050059A2 (fr
Inventor
Sudhir Agrawal
Ekambar R Kandimalla
Dong Yu
Lakshmi Bhagat
Original Assignee
Idera Pharmaceuticals
Sudhir Agrawal
Ekambar R Kandimalla
Dong Yu
Lakshmi Bhagat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idera Pharmaceuticals, Sudhir Agrawal, Ekambar R Kandimalla, Dong Yu, Lakshmi Bhagat filed Critical Idera Pharmaceuticals
Priority to PCT/US2005/038449 priority Critical patent/WO2007050059A2/fr
Publication of WO2007050059A2 publication Critical patent/WO2007050059A2/fr
Publication of WO2007050059A9 publication Critical patent/WO2007050059A9/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/17—Immunomodulatory nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3183—Diol linkers, e.g. glycols or propanediols
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/336—Modified G

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/US2005/038449 2005-10-25 2005-10-25 Oligonucleotides immunomodulateurs courts WO2007050059A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/US2005/038449 WO2007050059A2 (fr) 2005-10-25 2005-10-25 Oligonucleotides immunomodulateurs courts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2005/038449 WO2007050059A2 (fr) 2005-10-25 2005-10-25 Oligonucleotides immunomodulateurs courts

Publications (2)

Publication Number Publication Date
WO2007050059A2 WO2007050059A2 (fr) 2007-05-03
WO2007050059A9 true WO2007050059A9 (fr) 2009-01-29

Family

ID=37968245

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/038449 WO2007050059A2 (fr) 2005-10-25 2005-10-25 Oligonucleotides immunomodulateurs courts

Country Status (1)

Country Link
WO (1) WO2007050059A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2968531A1 (fr) 2014-11-21 2016-05-26 Northwestern University Absorption cellulaire specifique a une sequence de conjugues nanoparticulaires d'acides nucleiques spheriques
US11433131B2 (en) 2017-05-11 2022-09-06 Northwestern University Adoptive cell therapy using spherical nucleic acids (SNAs)

Also Published As

Publication number Publication date
WO2007050059A2 (fr) 2007-05-03

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