WO2007048100A3 - Angio-inhibitory peptides derived from human timp-2 - Google Patents

Angio-inhibitory peptides derived from human timp-2 Download PDF

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Publication number
WO2007048100A3
WO2007048100A3 PCT/US2006/060059 US2006060059W WO2007048100A3 WO 2007048100 A3 WO2007048100 A3 WO 2007048100A3 US 2006060059 W US2006060059 W US 2006060059W WO 2007048100 A3 WO2007048100 A3 WO 2007048100A3
Authority
WO
WIPO (PCT)
Prior art keywords
angio
peptides derived
inhibitory peptides
human timp
proteins
Prior art date
Application number
PCT/US2006/060059
Other languages
French (fr)
Other versions
WO2007048100A2 (en
Inventor
William G Stetler-Stevenson
Dong-Wan Seo
Original Assignee
Us Gov Health & Human Serv
William G Stetler-Stevenson
Dong-Wan Seo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, William G Stetler-Stevenson, Dong-Wan Seo filed Critical Us Gov Health & Human Serv
Publication of WO2007048100A2 publication Critical patent/WO2007048100A2/en
Publication of WO2007048100A3 publication Critical patent/WO2007048100A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides proteins and polypeptides with anti-angiogenic activity. The proteins may be prepared by recombinant or other synthetic means and may be formulated in compositions as needed to facilitate their use. The invention further provides methods of inhibiting or reducing angiogenesis as well as the treatment of angiogenesis mediated diseases.
PCT/US2006/060059 2005-10-18 2006-10-18 Angio-inhibitory peptides derived from human timp-2 WO2007048100A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72814605P 2005-10-18 2005-10-18
US60/728,146 2005-10-18

Publications (2)

Publication Number Publication Date
WO2007048100A2 WO2007048100A2 (en) 2007-04-26
WO2007048100A3 true WO2007048100A3 (en) 2008-02-07

Family

ID=37963410

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2006/060059 WO2007048100A2 (en) 2005-10-18 2006-10-18 Angio-inhibitory peptides derived from human timp-2
PCT/US2006/060061 WO2007048102A2 (en) 2005-10-18 2006-10-18 Angio-inhibitory peptides derived from human timp-2

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2006/060061 WO2007048102A2 (en) 2005-10-18 2006-10-18 Angio-inhibitory peptides derived from human timp-2

Country Status (1)

Country Link
WO (2) WO2007048100A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2016001573A (en) * 2013-08-07 2016-09-07 Astute Medical Inc Assays for timp2 having improved performance in biological samples.
US11718682B2 (en) 2017-04-05 2023-08-08 Astute Medical, Inc. Assays for TIMP2 having improved performance in biological samples

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990011287A1 (en) * 1989-03-21 1990-10-04 The United States Of America, Represented By The Secretary, United States Department Of Commerce Matrix metalloproteinase inhibitor peptides
WO2003057884A1 (en) * 2002-01-08 2003-07-17 Leadbio Inc. Human serum albumin-timp2 fusion protein, a polynucleotide encoding the same and a method of producing the human serum albumin-timp2 fusion protein
WO2004060275A2 (en) * 2002-12-19 2004-07-22 Kimberly-Clark Worldwide, Inc. Wound care compositions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990011287A1 (en) * 1989-03-21 1990-10-04 The United States Of America, Represented By The Secretary, United States Department Of Commerce Matrix metalloproteinase inhibitor peptides
WO2003057884A1 (en) * 2002-01-08 2003-07-17 Leadbio Inc. Human serum albumin-timp2 fusion protein, a polynucleotide encoding the same and a method of producing the human serum albumin-timp2 fusion protein
WO2004060275A2 (en) * 2002-12-19 2004-07-22 Kimberly-Clark Worldwide, Inc. Wound care compositions

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FERNANDEZ CECILIA A ET AL: "Structural and functional uncoupling of the enzymatic and angiogenic inhibitory activities of tissue inhibitor of metalloproteinase-2 (TIMP-2). Loop 6 is a novel angiogenesis inhibitor.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 42, 17 October 2003 (2003-10-17), pages 40989 - 40995, XP002435349, ISSN: 0021-9258 *
SEO D-W ET AL: "TIMP-2 mediated inhibition of angiogenesis: An MMP-independent mechanism", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 114, no. 2, 25 July 2003 (2003-07-25), pages 171 - 180, XP002313229, ISSN: 0092-8674 *

Also Published As

Publication number Publication date
WO2007048100A2 (en) 2007-04-26
WO2007048102A2 (en) 2007-04-26
WO2007048102A3 (en) 2007-12-27

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