WO2007047577A3 - Use of calcitonin-related peptide (cgrp) antagonists or release inhibitors for the treatment of sleep-related breathing disorders - Google Patents

Use of calcitonin-related peptide (cgrp) antagonists or release inhibitors for the treatment of sleep-related breathing disorders Download PDF

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Publication number
WO2007047577A3
WO2007047577A3 PCT/US2006/040364 US2006040364W WO2007047577A3 WO 2007047577 A3 WO2007047577 A3 WO 2007047577A3 US 2006040364 W US2006040364 W US 2006040364W WO 2007047577 A3 WO2007047577 A3 WO 2007047577A3
Authority
WO
WIPO (PCT)
Prior art keywords
cgrp
antagonists
sleep
calcitonin
breathing disorders
Prior art date
Application number
PCT/US2006/040364
Other languages
French (fr)
Other versions
WO2007047577A2 (en
Inventor
David W Carley
Miodrag Radulovacki
Original Assignee
Univ Illinois
David W Carley
Miodrag Radulovacki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois, David W Carley, Miodrag Radulovacki filed Critical Univ Illinois
Publication of WO2007047577A2 publication Critical patent/WO2007047577A2/en
Publication of WO2007047577A3 publication Critical patent/WO2007047577A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/225—Calcitonin gene related peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Abstract

This invention is directed to methods for preventing or ameliorating sleep-related breathing disorders. The method comprises administration to a patient in need thereof an effective dose of one or more calcitonin gene-related peptide (CGRP) receptor antagonists or release inhibitors. The CGRP receptor antagonist or combination of CGRP receptor antagonists can be administered in conjunction with one or more serotonin receptor agonists, one or more cannabinoid receptor agonists, one or more serotonin reuptake inhibitors, a combination of reuptake inhibitors, other agents, or any combination of the foregoing.
PCT/US2006/040364 2005-10-14 2006-10-13 Use of calcitonin-related peptide (cgrp) antagonists or release inhibitors for the treatment of sleep-related breathing disorders WO2007047577A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72690005P 2005-10-14 2005-10-14
US60/726,900 2005-10-14

Publications (2)

Publication Number Publication Date
WO2007047577A2 WO2007047577A2 (en) 2007-04-26
WO2007047577A3 true WO2007047577A3 (en) 2007-07-12

Family

ID=37866260

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/040364 WO2007047577A2 (en) 2005-10-14 2006-10-13 Use of calcitonin-related peptide (cgrp) antagonists or release inhibitors for the treatment of sleep-related breathing disorders

Country Status (1)

Country Link
WO (1) WO2007047577A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8420779B2 (en) 2007-05-22 2013-04-16 Amgen Inc. Compositions and methods for producing bioactive fusion proteins
WO2023177823A1 (en) * 2022-03-17 2023-09-21 Vasoceuticals, Inc. Combined use of individual compounds for treatment of chronic pain disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002080903A1 (en) * 2001-04-06 2002-10-17 The Board Of Trustees Of The University Of Illinois Functional role for cannabinoids in autonomic stability during sleep
US6727242B2 (en) * 1998-02-27 2004-04-27 The Board Of Trustees Of The University Of Illinois Pharmacological treatment for sleep apnea

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6727242B2 (en) * 1998-02-27 2004-04-27 The Board Of Trustees Of The University Of Illinois Pharmacological treatment for sleep apnea
WO2002080903A1 (en) * 2001-04-06 2002-10-17 The Board Of Trustees Of The University Of Illinois Functional role for cannabinoids in autonomic stability during sleep

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ARULMANI ET AL: "Calcitonin gene-related peptide and its role in migraine pathophysiology", EUROPEAN JOURNAL OF PHARMACOLOGY, AMSTERDAM, NL, vol. 500, no. 1-3, 1 October 2004 (2004-10-01), pages 315 - 330, XP005480426, ISSN: 0014-2999 *
BAUMAN N M ET AL: "Effect of intravenous calcitonin gene-related peptide antagonist on the laryngeal chemoreflex in piglets.", OTOLARYNGOLOGY--HEAD AND NECK SURGERY : OFFICIAL JOURNAL OF AMERICAN ACADEMY OF OTOLARYNGOLOGY-HEAD AND NECK SURGERY JUL 1999, vol. 121, no. 1, July 1999 (1999-07-01), pages 1 - 6, XP002427117, ISSN: 0194-5998 *
FRIBERG D ET AL: "Abnormal afferent nerve endings in the soft palatal mucosa of sleep apnoics and habitual snorers", REGULATORY PEPTIDES, ELSEVIER SCIENCE BV, NL, vol. 71, no. 1, 23 July 1997 (1997-07-23), pages 29 - 36, XP002256079, ISSN: 0167-0115 *

Also Published As

Publication number Publication date
WO2007047577A2 (en) 2007-04-26

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